Click here to switch to the map view.

The map label for this gene is nuoN [H]

Identifier: 190571409

GI number: 190571409

Start: 1084885

End: 1086333

Strand: Reverse

Name: nuoN [H]

Synonym: WPa_1017

Alternate gene names: 190571409

Gene position: 1086333-1084885 (Counterclockwise)

Preceding gene: 190571412

Following gene: 190571408

Centisome position: 73.28

GC content: 33.2

Gene sequence:

>1449_bases
ATGCAATTACCAATTCTACAAGTTATTATACCAATAATTGCATCGATGTTCTGCTTTCTTACCAGGAAACATAAGGTGTC
CTGGTTTATCTCTTTTTTTACAACGGCAGCTACTTTCTTTATTTCATTAATGTTGCTAGTGAAAACATACAATGGTGAAA
TTATAACTTATTATCTTGGAGATTGGGCTCCTCCATACGGAATAGAGTTGAGAATCGACATATTGAACTCCTTGATTCTA
ACTTTGGTGAATTTTATAGCGCTGATTAGTGTGCTTTATAGCTTTCATATTAATGAAAAAGAGATTAGCAAAAACAAAAT
CATTGGTTTTTATTCTCTATTTTTACTGTGCTTGAGTGGATTACTTGGAATTTTAGTAACAAACGATATATTCAACCTTT
ATGTCTTTTTAGAAATTTCATCTCTTTCTTCTTATGTTTTAGTTTCAATGGGAAGGGATAAGAAAGCTTTAGTTGCAGCA
TTTGAATACCTCATTAGTGGTACTGTAGGAGCAACATTTTACTTGTTTGGCATCGGCCTTTTATACTCTATGACCGGAAC
GCTCAACATGTCTGACATGGCTGAAAGAATAGTACCATTATACGATAATAACATCATAAGACTTGGTACATTATTCATTT
TTGTTGGTCTCTCAATCAAAATGGCACTGTTTCCACTCAGCAGATGGCTGGTTAACGCATATAGTGAAGCACCTAGCTTC
ATTAGCATATTTTTTTCAGGTACAGTAACCAAAGTGATGATATATGTTTTTATTAGAATCTTTTACACTGTTTTTCAGCA
AAATTTTTTCTTACCACTAAGCAACGTGATGATCATCCTTGCGCTTTGTGCTGTTGTATTTGGATCAATATCTGCAATGA
TCGAAAAAGATATAAAAAGACTGTTTGCTCACTCCAGTATCAGTCAGATTGGCTATATAATTTTAATGCTGGGTTTAAAT
TCAAAAGCAGGTTTGTTTTCAGTAGTTCTTCACATAGTAAATCATAGCATGATAAAAACGTCTTTATTCATGACTGCAGG
GTGTATTTCTTATAAGTTTGGTATGACAAAAATAGAAAATTTATCAGGACTAAAAAAGTCAATGCCCTATACAACACTTG
CATTTACTCTACTTAGTTTCGCATTAATCGGTGTACCTTTGACAAATGGCTTTGTAAGTAAGTGGTATATGATGAAAGCA
ATTATCGAATCTCATGCATGGATTTCCCTTGCAGTTTTTGCTGCTGGCTCTTTTCTTGCACTAATATATATGTGGAGAAT
GGTTGAGAAAATATATTTTGAAAACAGTACAGCATCAAACGCTGGAATGACACTTAATGAGGTACCATTGCTTATGCTCT
TTTGTCTATTATTTATGGCAATTTTAACGGTAATAACTGGGATATATAGTAGTCCAATTCGGTTGGTAATTAATAAATTT
GCTTTTTGA

Upstream 100 bases:

>100_bases
TAAGTTTGTTACTGCATTATAAATTTTAGATAACATAAAGGTATTAAAACAAAAAGTATTATATATACTAATACTTTAAC
GATGTATTAACAACAGTTTA

Downstream 100 bases:

>100_bases
TTTTCTTATGTTTTATTGTATCTCAAAGTCTGTAAAGTTTTTGCTGTGGATAAGCTGAAGAAGATTCACTTATTATTAGT
CATTAACGTAATAGCTCTGT

Product: putative monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MQLPILQVIIPIIASMFCFLTRKHKVSWFISFFTTAATFFISLMLLVKTYNGEIITYYLGDWAPPYGIELRIDILNSLIL
TLVNFIALISVLYSFHINEKEISKNKIIGFYSLFLLCLSGLLGILVTNDIFNLYVFLEISSLSSYVLVSMGRDKKALVAA
FEYLISGTVGATFYLFGIGLLYSMTGTLNMSDMAERIVPLYDNNIIRLGTLFIFVGLSIKMALFPLSRWLVNAYSEAPSF
ISIFFSGTVTKVMIYVFIRIFYTVFQQNFFLPLSNVMIILALCAVVFGSISAMIEKDIKRLFAHSSISQIGYIILMLGLN
SKAGLFSVVLHIVNHSMIKTSLFMTAGCISYKFGMTKIENLSGLKKSMPYTTLAFTLLSFALIGVPLTNGFVSKWYMMKA
IIESHAWISLAVFAAGSFLALIYMWRMVEKIYFENSTASNAGMTLNEVPLLMLFCLLFMAILTVITGIYSSPIRLVINKF
AF

Sequences:

>Translated_482_residues
MQLPILQVIIPIIASMFCFLTRKHKVSWFISFFTTAATFFISLMLLVKTYNGEIITYYLGDWAPPYGIELRIDILNSLIL
TLVNFIALISVLYSFHINEKEISKNKIIGFYSLFLLCLSGLLGILVTNDIFNLYVFLEISSLSSYVLVSMGRDKKALVAA
FEYLISGTVGATFYLFGIGLLYSMTGTLNMSDMAERIVPLYDNNIIRLGTLFIFVGLSIKMALFPLSRWLVNAYSEAPSF
ISIFFSGTVTKVMIYVFIRIFYTVFQQNFFLPLSNVMIILALCAVVFGSISAMIEKDIKRLFAHSSISQIGYIILMLGLN
SKAGLFSVVLHIVNHSMIKTSLFMTAGCISYKFGMTKIENLSGLKKSMPYTTLAFTLLSFALIGVPLTNGFVSKWYMMKA
IIESHAWISLAVFAAGSFLALIYMWRMVEKIYFENSTASNAGMTLNEVPLLMLFCLLFMAILTVITGIYSSPIRLVINKF
AF
>Mature_482_residues
MQLPILQVIIPIIASMFCFLTRKHKVSWFISFFTTAATFFISLMLLVKTYNGEIITYYLGDWAPPYGIELRIDILNSLIL
TLVNFIALISVLYSFHINEKEISKNKIIGFYSLFLLCLSGLLGILVTNDIFNLYVFLEISSLSSYVLVSMGRDKKALVAA
FEYLISGTVGATFYLFGIGLLYSMTGTLNMSDMAERIVPLYDNNIIRLGTLFIFVGLSIKMALFPLSRWLVNAYSEAPSF
ISIFFSGTVTKVMIYVFIRIFYTVFQQNFFLPLSNVMIILALCAVVFGSISAMIEKDIKRLFAHSSISQIGYIILMLGLN
SKAGLFSVVLHIVNHSMIKTSLFMTAGCISYKFGMTKIENLSGLKKSMPYTTLAFTLLSFALIGVPLTNGFVSKWYMMKA
IIESHAWISLAVFAAGSFLALIYMWRMVEKIYFENSTASNAGMTLNEVPLLMLFCLLFMAILTVITGIYSSPIRLVINKF
AF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=330, Percent_Identity=26.0606060606061, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1788831, Length=403, Percent_Identity=29.7766749379653, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1788827, Length=438, Percent_Identity=27.1689497716895, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1788829, Length=414, Percent_Identity=27.2946859903382, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788613, Length=499, Percent_Identity=25.8517034068136, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI145693160, Length=421, Percent_Identity=24.9406175771971, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788614, Length=423, Percent_Identity=26.241134751773, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI2367154, Length=426, Percent_Identity=24.6478873239437, Blast_Score=93, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54158; Mature: 54158

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLPILQVIIPIIASMFCFLTRKHKVSWFISFFTTAATFFISLMLLVKTYNGEIITYYLG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
DWAPPYGIELRIDILNSLILTLVNFIALISVLYSFHINEKEISKNKIIGFYSLFLLCLSG
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LLGILVTNDIFNLYVFLEISSLSSYVLVSMGRDKKALVAAFEYLISGTVGATFYLFGIGL
HHHHHHHHHHHHEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHCHHHHHHHHHHHHH
LYSMTGTLNMSDMAERIVPLYDNNIIRLGTLFIFVGLSIKMALFPLSRWLVNAYSEAPSF
HHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ISIFFSGTVTKVMIYVFIRIFYTVFQQNFFLPLSNVMIILALCAVVFGSISAMIEKDIKR
EEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFAHSSISQIGYIILMLGLNSKAGLFSVVLHIVNHSMIKTSLFMTAGCISYKFGMTKIEN
HHHHCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LSGLKKSMPYTTLAFTLLSFALIGVPLTNGFVSKWYMMKAIIESHAWISLAVFAAGSFLA
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LIYMWRMVEKIYFENSTASNAGMTLNEVPLLMLFCLLFMAILTVITGIYSSPIRLVINKF
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AF
CC
>Mature Secondary Structure
MQLPILQVIIPIIASMFCFLTRKHKVSWFISFFTTAATFFISLMLLVKTYNGEIITYYLG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
DWAPPYGIELRIDILNSLILTLVNFIALISVLYSFHINEKEISKNKIIGFYSLFLLCLSG
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LLGILVTNDIFNLYVFLEISSLSSYVLVSMGRDKKALVAAFEYLISGTVGATFYLFGIGL
HHHHHHHHHHHHEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHCHHHHHHHHHHHHH
LYSMTGTLNMSDMAERIVPLYDNNIIRLGTLFIFVGLSIKMALFPLSRWLVNAYSEAPSF
HHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ISIFFSGTVTKVMIYVFIRIFYTVFQQNFFLPLSNVMIILALCAVVFGSISAMIEKDIKR
EEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFAHSSISQIGYIILMLGLNSKAGLFSVVLHIVNHSMIKTSLFMTAGCISYKFGMTKIEN
HHHHCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LSGLKKSMPYTTLAFTLLSFALIGVPLTNGFVSKWYMMKAIIESHAWISLAVFAAGSFLA
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LIYMWRMVEKIYFENSTASNAGMTLNEVPLLMLFCLLFMAILTVITGIYSSPIRLVINKF
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AF
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA