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The map label for this gene is adiC [H]

Identifier: 190571125

GI number: 190571125

Start: 788281

End: 789555

Strand: Reverse

Name: adiC [H]

Synonym: WPa_0723

Alternate gene names: 190571125

Gene position: 789555-788281 (Counterclockwise)

Preceding gene: 190571128

Following gene: 190571124

Centisome position: 53.26

GC content: 36.31

Gene sequence:

>1275_bases
GTGTCAAATAAAATAGGCTTTTTTGCTATTTTTGCCTTGGTGATTAGTAGCCAAATTGGCTCTGGAATTTTTATGCTCCC
AATCAGCCTTGCACCATACGGCGCTTATAGCCTCATAAGCTGGGTTATATCAGGATTTGGTGCTATATCTCTTGCTTTAG
TTTTTGCTTCACTCTGCGCAAAATTTCCAGAAACGGGTGGTCCTCATATTTATGTGAAACATGCCTTTGGCTCTACAGCA
GCTTTTTTTGTTGGCTGGACATATTGGGTAAGCTCGTGGGTAAGCTCAACAGCTGTGACAATTGCAAGTATCGGTTATTT
AGCCCCGCTTTTTCATAATGATATACAAGATATACGTTTGCTTTTAGAAATAACATTAATTTTAGCTATCATGCTAATAA
ACTTAAGAGGGGTAACTACTGCTGGGCATGTTGAGCTTCTTCTGACCATTGTTAAAATTATCGCACTTCTTGCAATACCC
ATAGCAGGATTATTTTTCTTTGATAGAAATAATTTTGTTGTAAGTGAGGAAGTATCAAACTTTACGATGTCTCAAGTCCT
TGCGCGCTCTACACTCCTTACTCTATGGTGTTTTATTGGACTTGAATCAGCAACGGCACCTGCAGGATCTGTCAATAATC
CCTCTAAAACAATACCAAGGGCTATAGTGCTTGGAACAGTCTGTGTTGCTGTGATATATTTCATCAATAGTCTTTCAATT
ATGGGATTGATAAGTGGTAATGAACTAGCTAGTTCAAAAGCACCATATGTTGATGCGATAAAAATTATGCTTCCAGGTAA
TTGGCATTTAATTGTTTCTGTTGTTGCCTTTATCGTTTCTGTAAGTAATTTAAATGCTTGGTTTTTAGCTGATGGACAGG
TCACCTTAGGCCTTGCAAAAGACAAGTTAATGCCGCAATTTTTTGGCAAAAAAAATAAGCATGATGCTCCATTATGGGGA
ATAATACTCAGTACTTTGGGGGTGTTAGTTTTACTTATCCTAACGTCAAACAAAAGTTTTGCTGAGCAAGTAACTTCAAT
AATTGATATCTCTGTGGTGTCATTTTTGTTTATCTACTTAGCATGTAGCCTTGCTTTTCTCAAAGTTAATATACAAGACA
AAAGCTACTGCAAATTTTTAATTGGAGGTGTGGCTGTATCTTTTTGCTGTTGGGTAATATACGAGACTTCTATAAAAACA
TTGTTAATATCAAGTCTATTCCCTTTAAGCGGAACACTTATTTATCTACTTTGGTATCATAAACTAAAAACTTAA

Upstream 100 bases:

>100_bases
ATATGCTTAAATTAAAAAAATGCAAATTTTGTAAAGACCAATTGAAATTTCTGAGCTTCAACTATATTGTTAATTATTCA
GATAAAAATTAAACATTGTC

Downstream 100 bases:

>100_bases
CTTAAATTTTTTATTTGCTAAAATTCTTAAGCTATACTACTGGCTTACATTAATAGAATTAAGAGGTATTGTGTCAAATA
AAATAGGTTTTTGGGCTGTT

Product: amino acid permease family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSNKIGFFAIFALVISSQIGSGIFMLPISLAPYGAYSLISWVISGFGAISLALVFASLCAKFPETGGPHIYVKHAFGSTA
AFFVGWTYWVSSWVSSTAVTIASIGYLAPLFHNDIQDIRLLLEITLILAIMLINLRGVTTAGHVELLLTIVKIIALLAIP
IAGLFFFDRNNFVVSEEVSNFTMSQVLARSTLLTLWCFIGLESATAPAGSVNNPSKTIPRAIVLGTVCVAVIYFINSLSI
MGLISGNELASSKAPYVDAIKIMLPGNWHLIVSVVAFIVSVSNLNAWFLADGQVTLGLAKDKLMPQFFGKKNKHDAPLWG
IILSTLGVLVLLILTSNKSFAEQVTSIIDISVVSFLFIYLACSLAFLKVNIQDKSYCKFLIGGVAVSFCCWVIYETSIKT
LLISSLFPLSGTLIYLLWYHKLKT

Sequences:

>Translated_424_residues
MSNKIGFFAIFALVISSQIGSGIFMLPISLAPYGAYSLISWVISGFGAISLALVFASLCAKFPETGGPHIYVKHAFGSTA
AFFVGWTYWVSSWVSSTAVTIASIGYLAPLFHNDIQDIRLLLEITLILAIMLINLRGVTTAGHVELLLTIVKIIALLAIP
IAGLFFFDRNNFVVSEEVSNFTMSQVLARSTLLTLWCFIGLESATAPAGSVNNPSKTIPRAIVLGTVCVAVIYFINSLSI
MGLISGNELASSKAPYVDAIKIMLPGNWHLIVSVVAFIVSVSNLNAWFLADGQVTLGLAKDKLMPQFFGKKNKHDAPLWG
IILSTLGVLVLLILTSNKSFAEQVTSIIDISVVSFLFIYLACSLAFLKVNIQDKSYCKFLIGGVAVSFCCWVIYETSIKT
LLISSLFPLSGTLIYLLWYHKLKT
>Mature_423_residues
SNKIGFFAIFALVISSQIGSGIFMLPISLAPYGAYSLISWVISGFGAISLALVFASLCAKFPETGGPHIYVKHAFGSTAA
FFVGWTYWVSSWVSSTAVTIASIGYLAPLFHNDIQDIRLLLEITLILAIMLINLRGVTTAGHVELLLTIVKIIALLAIPI
AGLFFFDRNNFVVSEEVSNFTMSQVLARSTLLTLWCFIGLESATAPAGSVNNPSKTIPRAIVLGTVCVAVIYFINSLSIM
GLISGNELASSKAPYVDAIKIMLPGNWHLIVSVVAFIVSVSNLNAWFLADGQVTLGLAKDKLMPQFFGKKNKHDAPLWGI
ILSTLGVLVLLILTSNKSFAEQVTSIIDISVVSFLFIYLACSLAFLKVNIQDKSYCKFLIGGVAVSFCCWVIYETSIKTL
LISSLFPLSGTLIYLLWYHKLKT

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI71999149, Length=335, Percent_Identity=24.1791044776119, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI187423910, Length=297, Percent_Identity=23.5690235690236, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI7657591, Length=297, Percent_Identity=23.5690235690236, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI186910308, Length=305, Percent_Identity=25.2459016393443, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI186910306, Length=305, Percent_Identity=25.2459016393443, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI186910304, Length=305, Percent_Identity=25.2459016393443, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI2367353, Length=428, Percent_Identity=27.1028037383178, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI1786908, Length=361, Percent_Identity=29.3628808864266, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1790575, Length=438, Percent_Identity=27.8538812785388, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1787890, Length=448, Percent_Identity=26.1160714285714, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI87082250, Length=348, Percent_Identity=28.735632183908, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790653, Length=405, Percent_Identity=23.4567901234568, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789017, Length=371, Percent_Identity=23.4501347708895, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081708, Length=354, Percent_Identity=22.5988700564972, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786302, Length=383, Percent_Identity=22.1932114882507, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71993915, Length=356, Percent_Identity=22.752808988764, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=453, Percent_Identity=26.4900662251656, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI32566699, Length=291, Percent_Identity=24.7422680412371, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71995382, Length=338, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI221331183, Length=269, Percent_Identity=29.7397769516729, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17647653, Length=269, Percent_Identity=29.7397769516729, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24664379, Length=269, Percent_Identity=29.7397769516729, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24651635, Length=251, Percent_Identity=26.6932270916335, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24651633, Length=251, Percent_Identity=26.6932270916335, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI221512776, Length=411, Percent_Identity=21.1678832116788, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666159, Length=411, Percent_Identity=21.1678832116788, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46038; Mature: 45907

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKIGFFAIFALVISSQIGSGIFMLPISLAPYGAYSLISWVISGFGAISLALVFASLCA
CCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KFPETGGPHIYVKHAFGSTAAFFVGWTYWVSSWVSSTAVTIASIGYLAPLFHNDIQDIRL
HCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LLEITLILAIMLINLRGVTTAGHVELLLTIVKIIALLAIPIAGLFFFDRNNFVVSEEVSN
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEHHHHH
FTMSQVLARSTLLTLWCFIGLESATAPAGSVNNPSKTIPRAIVLGTVCVAVIYFINSLSI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MGLISGNELASSKAPYVDAIKIMLPGNWHLIVSVVAFIVSVSNLNAWFLADGQVTLGLAK
EEEECCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEHH
DKLMPQFFGKKNKHDAPLWGIILSTLGVLVLLILTSNKSFAEQVTSIIDISVVSFLFIYL
HHHCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ACSLAFLKVNIQDKSYCKFLIGGVAVSFCCWVIYETSIKTLLISSLFPLSGTLIYLLWYH
HHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
KLKT
HHCC
>Mature Secondary Structure 
SNKIGFFAIFALVISSQIGSGIFMLPISLAPYGAYSLISWVISGFGAISLALVFASLCA
CCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KFPETGGPHIYVKHAFGSTAAFFVGWTYWVSSWVSSTAVTIASIGYLAPLFHNDIQDIRL
HCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LLEITLILAIMLINLRGVTTAGHVELLLTIVKIIALLAIPIAGLFFFDRNNFVVSEEVSN
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEHHHHH
FTMSQVLARSTLLTLWCFIGLESATAPAGSVNNPSKTIPRAIVLGTVCVAVIYFINSLSI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MGLISGNELASSKAPYVDAIKIMLPGNWHLIVSVVAFIVSVSNLNAWFLADGQVTLGLAK
EEEECCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEHH
DKLMPQFFGKKNKHDAPLWGIILSTLGVLVLLILTSNKSFAEQVTSIIDISVVSFLFIYL
HHHCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ACSLAFLKVNIQDKSYCKFLIGGVAVSFCCWVIYETSIKTLLISSLFPLSGTLIYLLWYH
HHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
KLKT
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]