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The map label for this gene is adiC [H]

Identifier: 190571124

GI number: 190571124

Start: 786924

End: 788210

Strand: Reverse

Name: adiC [H]

Synonym: WPa_0722

Alternate gene names: 190571124

Gene position: 788210-786924 (Counterclockwise)

Preceding gene: 190571125

Following gene: 190571122

Centisome position: 53.17

GC content: 37.3

Gene sequence:

>1287_bases
GTGTCAAATAAAATAGGTTTTTGGGCTGTTTTTGCTTTAGTCATTAGTAGTCAGATCGGCTCTGGGGTTTTTATGCTTCC
AATTAGCCTTGCTCCATATGGCGCTTATAGCCTTATAAGTTGGATGATATCAGGAGCTGGTGCTGTGTCTCTTGCGCTAG
TTTTTGCTACGCTATGTGCAAAGTTTCCAGAAACAGGAGGTCCTCACGTTTATGTGAAACATACTTTTGGTTCTACCGCA
GCGTTCTTTGTTGGTTGGACATATTGGGTAATCTCATGGGTTAGTACAACAGCTTTAATAGTTGTGGGTGTTGGCTATCT
TACACCATTTTTCCATGAAGATATCAAAAGTATGCGTTTATTTTTAGAGCTGTTGTTATTTACAATCATTACATTAATAA
ATTTAAGGGGAATAGCTACTGCAGGGCACGTTGAGTTTCTGCTCACGGTTGTGAAGGTTGCTGTATTGCTTGCAATACCT
GTAGCAGCGTTGTTTTTTTTCGATAGAAATAATTTTATCATAAGTGAAGAAATATTAAGTCTTACAACATCGCAAATTCT
TGCCCGCTCTACACTCCTTACTTTATGGTGTTTTATTGGACTTGAATTGGCAACAGCACCTGCAGGGTCAGTTGATAATC
CAGCTAAAACTATACCAAAAGCTGTGGTGCTTGGCACAGTTTGTGTTGCTGTTATATATTTTATCAACAATTTTGCAATT
ATGGGATTGATCAATGGCAACAATTTAGCAAGTTCAAGAGCACCATATGTTGATGCGATAAAAATTATGTTTTCTGGTAA
TTGGCATTTAATTGTTTCTATAGTTGCATTCATTTTTTGTGTTGGCAGTCTAAACGCTTGGGTTTTATCTAGTGGACAAG
TTGCTTTTGGTCTTGCAGAAGATAGACTAATGCCAAAATTCTTTGCTAAAAGGAACAAGCATGGCTCTCCTTTTTGGGGA
ATAACAGTTAGTTCAATTGGAACTGCAATTTTACTAATTCTCACTTCAAACAACAATTTTGCCCAGCAGATTACGTCGAT
TATTGACTTTTCTGTAATTTCATTTTTGTTCGTTTATCTTGCGTGCTGTTTTGCCTTTCTAAAGGTTATTATACAGGAGA
GGAGTTGTTATAAGCTTTTAATTGGTAGCATAGCAACAACCTTTTGTTGTTGGGTGATATTAGAAACCCCTGTAGGTACT
CTGCTGATTTCGAGCCTGTTCACTGCAAGTGGCATACCCATTTATTTATTTTGGTACTGCAAAACTTCTGTGCAACAAAT
TCAGTAG

Upstream 100 bases:

>100_bases
CTACTTTGGTATCATAAACTAAAAACTTAACTTAAATTTTTTATTTGCTAAAATTCTTAAGCTATACTACTGGCTTACAT
TAATAGAATTAAGAGGTATT

Downstream 100 bases:

>100_bases
TGAGAGATACACTTTAAATGGTTAATATTTATGGGCCAAGATTTTTTTTCTCTTTATCTACTTGTTCAATATTACCATTC
TCAAGTTTGCTACCTACTTC

Product: amino acid permease family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSNKIGFWAVFALVISSQIGSGVFMLPISLAPYGAYSLISWMISGAGAVSLALVFATLCAKFPETGGPHVYVKHTFGSTA
AFFVGWTYWVISWVSTTALIVVGVGYLTPFFHEDIKSMRLFLELLLFTIITLINLRGIATAGHVEFLLTVVKVAVLLAIP
VAALFFFDRNNFIISEEILSLTTSQILARSTLLTLWCFIGLELATAPAGSVDNPAKTIPKAVVLGTVCVAVIYFINNFAI
MGLINGNNLASSRAPYVDAIKIMFSGNWHLIVSIVAFIFCVGSLNAWVLSSGQVAFGLAEDRLMPKFFAKRNKHGSPFWG
ITVSSIGTAILLILTSNNNFAQQITSIIDFSVISFLFVYLACCFAFLKVIIQERSCYKLLIGSIATTFCCWVILETPVGT
LLISSLFTASGIPIYLFWYCKTSVQQIQ

Sequences:

>Translated_428_residues
MSNKIGFWAVFALVISSQIGSGVFMLPISLAPYGAYSLISWMISGAGAVSLALVFATLCAKFPETGGPHVYVKHTFGSTA
AFFVGWTYWVISWVSTTALIVVGVGYLTPFFHEDIKSMRLFLELLLFTIITLINLRGIATAGHVEFLLTVVKVAVLLAIP
VAALFFFDRNNFIISEEILSLTTSQILARSTLLTLWCFIGLELATAPAGSVDNPAKTIPKAVVLGTVCVAVIYFINNFAI
MGLINGNNLASSRAPYVDAIKIMFSGNWHLIVSIVAFIFCVGSLNAWVLSSGQVAFGLAEDRLMPKFFAKRNKHGSPFWG
ITVSSIGTAILLILTSNNNFAQQITSIIDFSVISFLFVYLACCFAFLKVIIQERSCYKLLIGSIATTFCCWVILETPVGT
LLISSLFTASGIPIYLFWYCKTSVQQIQ
>Mature_427_residues
SNKIGFWAVFALVISSQIGSGVFMLPISLAPYGAYSLISWMISGAGAVSLALVFATLCAKFPETGGPHVYVKHTFGSTAA
FFVGWTYWVISWVSTTALIVVGVGYLTPFFHEDIKSMRLFLELLLFTIITLINLRGIATAGHVEFLLTVVKVAVLLAIPV
AALFFFDRNNFIISEEILSLTTSQILARSTLLTLWCFIGLELATAPAGSVDNPAKTIPKAVVLGTVCVAVIYFINNFAIM
GLINGNNLASSRAPYVDAIKIMFSGNWHLIVSIVAFIFCVGSLNAWVLSSGQVAFGLAEDRLMPKFFAKRNKHGSPFWGI
TVSSIGTAILLILTSNNNFAQQITSIIDFSVISFLFVYLACCFAFLKVIIQERSCYKLLIGSIATTFCCWVILETPVGTL
LISSLFTASGIPIYLFWYCKTSVQQIQ

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI71999149, Length=366, Percent_Identity=24.5901639344262, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI7657683, Length=338, Percent_Identity=24.8520710059172, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI186910308, Length=311, Percent_Identity=24.4372990353698, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI186910306, Length=311, Percent_Identity=24.4372990353698, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI186910304, Length=311, Percent_Identity=24.4372990353698, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI2367353, Length=400, Percent_Identity=31, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1786908, Length=374, Percent_Identity=27.807486631016, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1790575, Length=406, Percent_Identity=27.3399014778325, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1787890, Length=435, Percent_Identity=26.6666666666667, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082250, Length=461, Percent_Identity=25.5965292841649, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790653, Length=415, Percent_Identity=23.3734939759036, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87081708, Length=334, Percent_Identity=23.3532934131737, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786302, Length=370, Percent_Identity=23.7837837837838, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789017, Length=378, Percent_Identity=22.7513227513227, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790584, Length=391, Percent_Identity=21.7391304347826, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786789, Length=375, Percent_Identity=22.1333333333333, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1786602, Length=341, Percent_Identity=24.0469208211144, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=319, Percent_Identity=23.8244514106583, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71993915, Length=355, Percent_Identity=21.6901408450704, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32566699, Length=282, Percent_Identity=22.3404255319149, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221512776, Length=410, Percent_Identity=22.1951219512195, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24666159, Length=410, Percent_Identity=22.1951219512195, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221331183, Length=316, Percent_Identity=25, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17647653, Length=316, Percent_Identity=25, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24664379, Length=316, Percent_Identity=25, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45550968, Length=337, Percent_Identity=23.7388724035608, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921172, Length=337, Percent_Identity=23.7388724035608, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24651635, Length=305, Percent_Identity=24.2622950819672, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24651633, Length=305, Percent_Identity=24.2622950819672, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46666; Mature: 46535

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKIGFWAVFALVISSQIGSGVFMLPISLAPYGAYSLISWMISGAGAVSLALVFATLCA
CCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
KFPETGGPHVYVKHTFGSTAAFFVGWTYWVISWVSTTALIVVGVGYLTPFFHEDIKSMRL
HCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLELLLFTIITLINLRGIATAGHVEFLLTVVKVAVLLAIPVAALFFFDRNNFIISEEILS
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHH
LTTSQILARSTLLTLWCFIGLELATAPAGSVDNPAKTIPKAVVLGTVCVAVIYFINNFAI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEE
MGLINGNNLASSRAPYVDAIKIMFSGNWHLIVSIVAFIFCVGSLNAWVLSSGQVAFGLAE
EEEEECCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCCEEEECHH
DRLMPKFFAKRNKHGSPFWGITVSSIGTAILLILTSNNNFAQQITSIIDFSVISFLFVYL
HHHHHHHHHHCCCCCCCEECEEHHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
ACCFAFLKVIIQERSCYKLLIGSIATTFCCWVILETPVGTLLISSLFTASGIPIYLFWYC
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEE
KTSVQQIQ
HHHHHHCC
>Mature Secondary Structure 
SNKIGFWAVFALVISSQIGSGVFMLPISLAPYGAYSLISWMISGAGAVSLALVFATLCA
CCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
KFPETGGPHVYVKHTFGSTAAFFVGWTYWVISWVSTTALIVVGVGYLTPFFHEDIKSMRL
HCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLELLLFTIITLINLRGIATAGHVEFLLTVVKVAVLLAIPVAALFFFDRNNFIISEEILS
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHH
LTTSQILARSTLLTLWCFIGLELATAPAGSVDNPAKTIPKAVVLGTVCVAVIYFINNFAI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEE
MGLINGNNLASSRAPYVDAIKIMFSGNWHLIVSIVAFIFCVGSLNAWVLSSGQVAFGLAE
EEEEECCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCCEEEECHH
DRLMPKFFAKRNKHGSPFWGITVSSIGTAILLILTSNNNFAQQITSIIDFSVISFLFVYL
HHHHHHHHHHCCCCCCCEECEEHHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
ACCFAFLKVIIQERSCYKLLIGSIATTFCCWVILETPVGTLLISSLFTASGIPIYLFWYC
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEE
KTSVQQIQ
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]