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The map label for this gene is guaB [H]

Identifier: 190570948

GI number: 190570948

Start: 569717

End: 571204

Strand: Reverse

Name: guaB [H]

Synonym: WPa_0530

Alternate gene names: 190570948

Gene position: 571204-569717 (Counterclockwise)

Preceding gene: 190570949

Following gene: 190570945

Centisome position: 38.53

GC content: 38.04

Gene sequence:

>1488_bases
ATGAAAAAAATGGAAGCTTGTTATTCGTTTGACGATGTACTTCTCTTACCGGCCTATTCTGATGTATTGCCTCGTGATGC
AGACACAAGAACTTATCTAACAAATAATATAGAACTAAATATCCCTCTCATATCCTCTGCAATGGACACTGTCACTGAAT
CAGGCTTTGCAATAGCTATTGCCCAACATGGTGGAATAGGTTGCATACATAAGAATTTATCAATAGATGAACAAGTGTTA
GAAGTAAGAAGGGTGAAAAAATATGAAAGCTGGATCGTGTATAACCCAATTACAATTTCCCCAGATAAAACAGTTGCAGA
AGCAGTTTCATTAATGAGAGAGTATAATTATTCCGGCATTCCTGTAGTTGATCAACGCAAGTTAGTGGGAATTTTAACTA
ATCGAGATGTGAGGTTTATTGAAGACCAGAACATGAATATAAAAGTTTCCGAGGTAATGACAAAAGATAAGTTAGTAACA
GTTCGAGAGCAGGCAGTAAATAGCGCCTCAGCAATGAAATTGTTGCATGCAAATAGAATAGAGAAGCTTTTGGTTGTTGA
TGAAAATTCTTGTTGCATAGGTCTAATCACAGTTAAAGACATCGAAAAATACAATAGATATCCAAATTCATGTAAAGACA
GTAAAGGTCGACTCAGAGTTGCCGCTGCAATTGGTACTGGTAAAAAAGACGGTATAGAAAGATGTGAAGCTTTGGTCGAA
GAAGAAGTTGATGTGGTTATTGTAGATACCGCTCACGGTCATTCCGAGAACGTTATCAGCACTATTAAGGAAATAAAAAA
GATGTATCCGAATACGCAATTAATCGGCGGAAATATTACAACAAAGGAGGCTGCTGAAGCGTTGATTGATGCTGGTGTTG
ATGCAGTGAAAGTTGGAATAGGGCCAGGATCAATTTGTACTACCAGAATAGTTACAGGCGTTGGTATGCCACAATTCTCT
GCGATCAAGAATATTGCAGAGGTTTGTAAAACAAAAAACGTCAGACTAATTGCTGATGGTGGAATAAAATATTCGGGAGA
TGTTGCAAAAGCTATTGCAGCTGGTGCTGATACTGTGATGATAGGTTCAATCTTTGCTGGTACTGAGGAAAGCCCAGGTG
AGATTATCATGTATAAGGGTAGAGCATATAAGGAATATCGAGGAATGGGATCTATTAGTGCAATGAAACGAGGGTCAGCT
AGCCGTTATTTTCAAGATTCAAAACTTGATTTAGTCCCACAAGGAGTAGAAGCAAGAGTTCCTTTTAAAGGTCCAGCTTC
AGGAGTGATCTGTCAGTTAATTGGTGGGTTGCAAGCTGCAATGGGTTACACTGGCAACCGTAATATAGAAGAGATGAAAA
AAAACTGCAAATTTGTCACTATTACTTCATCAGGGTTAAGAGAAAGTCATGCTCATGATATAATCATTACACAGGAAGCT
CCAAATTACGCTTACCAAGCATCTAATTTATCATCTGATTCAGAGTAA

Upstream 100 bases:

>100_bases
TTCTATCCTATTTTGATCTAAAAATAGCTGGAGCCAGGCTAATTTTGCAAAAGCTCTATTGCAATTTCATTAATTGGCGT
ATAAGCTTTAAATAAAGCAT

Downstream 100 bases:

>100_bases
ATACAATCCCCTTTTGAGTGGGTCATTTCAACACTGGTACACAATTGATATTAATATTAAGAGTCAAAAAGATGTCATCT
AAGTGGCTGACACTGGAAAA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MKKMEACYSFDDVLLLPAYSDVLPRDADTRTYLTNNIELNIPLISSAMDTVTESGFAIAIAQHGGIGCIHKNLSIDEQVL
EVRRVKKYESWIVYNPITISPDKTVAEAVSLMREYNYSGIPVVDQRKLVGILTNRDVRFIEDQNMNIKVSEVMTKDKLVT
VREQAVNSASAMKLLHANRIEKLLVVDENSCCIGLITVKDIEKYNRYPNSCKDSKGRLRVAAAIGTGKKDGIERCEALVE
EEVDVVIVDTAHGHSENVISTIKEIKKMYPNTQLIGGNITTKEAAEALIDAGVDAVKVGIGPGSICTTRIVTGVGMPQFS
AIKNIAEVCKTKNVRLIADGGIKYSGDVAKAIAAGADTVMIGSIFAGTEESPGEIIMYKGRAYKEYRGMGSISAMKRGSA
SRYFQDSKLDLVPQGVEARVPFKGPASGVICQLIGGLQAAMGYTGNRNIEEMKKNCKFVTITSSGLRESHAHDIIITQEA
PNYAYQASNLSSDSE

Sequences:

>Translated_495_residues
MKKMEACYSFDDVLLLPAYSDVLPRDADTRTYLTNNIELNIPLISSAMDTVTESGFAIAIAQHGGIGCIHKNLSIDEQVL
EVRRVKKYESWIVYNPITISPDKTVAEAVSLMREYNYSGIPVVDQRKLVGILTNRDVRFIEDQNMNIKVSEVMTKDKLVT
VREQAVNSASAMKLLHANRIEKLLVVDENSCCIGLITVKDIEKYNRYPNSCKDSKGRLRVAAAIGTGKKDGIERCEALVE
EEVDVVIVDTAHGHSENVISTIKEIKKMYPNTQLIGGNITTKEAAEALIDAGVDAVKVGIGPGSICTTRIVTGVGMPQFS
AIKNIAEVCKTKNVRLIADGGIKYSGDVAKAIAAGADTVMIGSIFAGTEESPGEIIMYKGRAYKEYRGMGSISAMKRGSA
SRYFQDSKLDLVPQGVEARVPFKGPASGVICQLIGGLQAAMGYTGNRNIEEMKKNCKFVTITSSGLRESHAHDIIITQEA
PNYAYQASNLSSDSE
>Mature_495_residues
MKKMEACYSFDDVLLLPAYSDVLPRDADTRTYLTNNIELNIPLISSAMDTVTESGFAIAIAQHGGIGCIHKNLSIDEQVL
EVRRVKKYESWIVYNPITISPDKTVAEAVSLMREYNYSGIPVVDQRKLVGILTNRDVRFIEDQNMNIKVSEVMTKDKLVT
VREQAVNSASAMKLLHANRIEKLLVVDENSCCIGLITVKDIEKYNRYPNSCKDSKGRLRVAAAIGTGKKDGIERCEALVE
EEVDVVIVDTAHGHSENVISTIKEIKKMYPNTQLIGGNITTKEAAEALIDAGVDAVKVGIGPGSICTTRIVTGVGMPQFS
AIKNIAEVCKTKNVRLIADGGIKYSGDVAKAIAAGADTVMIGSIFAGTEESPGEIIMYKGRAYKEYRGMGSISAMKRGSA
SRYFQDSKLDLVPQGVEARVPFKGPASGVICQLIGGLQAAMGYTGNRNIEEMKKNCKFVTITSSGLRESHAHDIIITQEA
PNYAYQASNLSSDSE

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=477, Percent_Identity=39.2033542976939, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI217035146, Length=477, Percent_Identity=38.3647798742138, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI34328928, Length=477, Percent_Identity=38.3647798742138, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI34328930, Length=477, Percent_Identity=38.3647798742138, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI156616279, Length=477, Percent_Identity=38.3647798742138, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI217035152, Length=483, Percent_Identity=38.0952380952381, Blast_Score=318, Evalue=6e-87,
Organism=Homo sapiens, GI217035148, Length=477, Percent_Identity=37.5262054507338, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI217035150, Length=477, Percent_Identity=35.6394129979036, Blast_Score=285, Evalue=9e-77,
Organism=Homo sapiens, GI50541956, Length=248, Percent_Identity=39.1129032258064, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI50541954, Length=248, Percent_Identity=39.1129032258064, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI50541952, Length=248, Percent_Identity=39.1129032258064, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI50541948, Length=248, Percent_Identity=39.1129032258064, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI156104880, Length=247, Percent_Identity=36.4372469635627, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1788855, Length=481, Percent_Identity=54.6777546777547, Blast_Score=480, Evalue=1e-136,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=38.0090497737557, Blast_Score=162, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71994385, Length=481, Percent_Identity=34.7193347193347, Blast_Score=264, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI71994389, Length=430, Percent_Identity=35.3488372093023, Blast_Score=250, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI17560440, Length=242, Percent_Identity=37.1900826446281, Blast_Score=177, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=39.1393442622951, Blast_Score=323, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6323464, Length=488, Percent_Identity=39.344262295082, Blast_Score=315, Evalue=8e-87,
Organism=Saccharomyces cerevisiae, GI6323585, Length=482, Percent_Identity=38.3817427385892, Blast_Score=314, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6319352, Length=346, Percent_Identity=39.5953757225434, Blast_Score=240, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=43.1034482758621, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=38.7966804979253, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=38.7966804979253, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=39.0519187358916, Blast_Score=282, Evalue=5e-76,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53866; Mature: 53866

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKMEACYSFDDVLLLPAYSDVLPRDADTRTYLTNNIELNIPLISSAMDTVTESGFAIAI
CCCHHHHCCCCCEEEECCHHHHCCCCCCCCEEEECCEEEEECCHHHHHHHHHCCCEEEEE
AQHGGIGCIHKNLSIDEQVLEVRRVKKYESWIVYNPITISPDKTVAEAVSLMREYNYSGI
ECCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEECCEEECCCHHHHHHHHHHHHCCCCCC
PVVDQRKLVGILTNRDVRFIEDQNMNIKVSEVMTKDKLVTVREQAVNSASAMKLLHANRI
CEECCCCEEEEEECCCEEEEECCCCCEEHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCC
EKLLVVDENSCCIGLITVKDIEKYNRYPNSCKDSKGRLRVAAAIGTGKKDGIERCEALVE
EEEEEEECCCCEEEEEEHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
EEVDVVIVDTAHGHSENVISTIKEIKKMYPNTQLIGGNITTKEAAEALIDAGVDAVKVGI
CCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCEEEEEC
GPGSICTTRIVTGVGMPQFSAIKNIAEVCKTKNVRLIADGGIKYSGDVAKAIAAGADTVM
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCEEECCHHHHHHHCCCCEEE
IGSIFAGTEESPGEIIMYKGRAYKEYRGMGSISAMKRGSASRYFQDSKLDLVPQGVEARV
EEEEECCCCCCCCCEEEECCCCHHHHCCCCCHHHHHCCCCHHCCCCCCCCCCCCCCCEEC
PFKGPASGVICQLIGGLQAAMGYTGNRNIEEMKKNCKFVTITSSGLRESHAHDIIITQEA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEEEECCCCCCCCCCEEEEEECC
PNYAYQASNLSSDSE
CCCEEECCCCCCCCC
>Mature Secondary Structure
MKKMEACYSFDDVLLLPAYSDVLPRDADTRTYLTNNIELNIPLISSAMDTVTESGFAIAI
CCCHHHHCCCCCEEEECCHHHHCCCCCCCCEEEECCEEEEECCHHHHHHHHHCCCEEEEE
AQHGGIGCIHKNLSIDEQVLEVRRVKKYESWIVYNPITISPDKTVAEAVSLMREYNYSGI
ECCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEECCEEECCCHHHHHHHHHHHHCCCCCC
PVVDQRKLVGILTNRDVRFIEDQNMNIKVSEVMTKDKLVTVREQAVNSASAMKLLHANRI
CEECCCCEEEEEECCCEEEEECCCCCEEHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCC
EKLLVVDENSCCIGLITVKDIEKYNRYPNSCKDSKGRLRVAAAIGTGKKDGIERCEALVE
EEEEEEECCCCEEEEEEHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
EEVDVVIVDTAHGHSENVISTIKEIKKMYPNTQLIGGNITTKEAAEALIDAGVDAVKVGI
CCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCEEEEEC
GPGSICTTRIVTGVGMPQFSAIKNIAEVCKTKNVRLIADGGIKYSGDVAKAIAAGADTVM
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCEEECCHHHHHHHCCCCEEE
IGSIFAGTEESPGEIIMYKGRAYKEYRGMGSISAMKRGSASRYFQDSKLDLVPQGVEARV
EEEEECCCCCCCCCEEEECCCCHHHHCCCCCHHHHHCCCCHHCCCCCCCCCCCCCCCEEC
PFKGPASGVICQLIGGLQAAMGYTGNRNIEEMKKNCKFVTITSSGLRESHAHDIIITQEA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEEEECCCCCCCCCCEEEEEECC
PNYAYQASNLSSDSE
CCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]