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The map label for this gene is hemC [H]

Identifier: 190570895

GI number: 190570895

Start: 510804

End: 511682

Strand: Reverse

Name: hemC [H]

Synonym: WPa_0474

Alternate gene names: 190570895

Gene position: 511682-510804 (Counterclockwise)

Preceding gene: 190570898

Following gene: 190570894

Centisome position: 34.52

GC content: 36.29

Gene sequence:

>879_bases
ATGCTAGTTAAAATAGGTACGAGAGGAAGCGACCTTGCGCTCATCCAAGCTTTGGAAGCAAAACAAAGATTATTAGAGTC
TTTTCCTAATCTATCCGTTGAGATCATTAAAATCAAAACTTCTGGTGATAAATATGCTAATGTAACCCTTGCTGAAATAG
GAGGTAAAGGACTGTTCCTCAGGGAGATTGAGGCTGAATTACTCAAAAATAATATAGATATGGCGGTTCATTCGCTAAAA
GATGTACCTGCGTTTTTCTCGAAGGACTTAACAATTCCTTGTGTTTTAGAGAGGCTAAGTCCATGTGATGTATTTATTTC
TCATAAATATAAGAGCCTAAAAACTTTGCCACAGCAGGCTACAATTGCAACTTCTTCAATAAGAAGAAAAGTTCAGCTGT
TAAATCTCAGGCCAGACTTAAATGTAGTGCCACTGCGTGGAAATGTGACAACTAGACTGCAAAATCAGAATTTTGATGGA
ATGATTTTAGCTGAAGCAGGGCTGATAAGATTAAAAAAATATCACTTAATTACAGAGGTATTGCCACCAAAAGTCATGTT
AAGCGCAGTAGGGCAGGGGACAATTTGCATTCAATGCCGAAAGAATGATATAAAAGTTATCGATCTTTTAGAGAAAATTA
ATAATAATATGTCTTTTATAAGGGCAAAATCAGAGCGCAGTTTCATGAAGACAGTAAATGGTTCATGCTTTACACCGCTT
GCAGCTTTAGCAGAATATGTGAGTGAAAACATGCTACATCTTTATTGTATGTTAGCGGGCGAGAGAGTTATATACTTTAC
TGAACGCACTTCGTTTGTAGAAGATGCAGAAAAAATGGGTATGGATGCAGGATTAGAGTTAAAATCAAAATGCTTATAA

Upstream 100 bases:

>100_bases
AATGTTCGTGATACTAAGGGCTAATTGTAAAATGTTCAATAACTAAATTGGAGATAATAAAAAATGGGCATAGAATATAG
ACATATAATATGAAGGATAT

Downstream 100 bases:

>100_bases
GCTTACCTAAAGTATGTGGAATCTACCGTTATAATGTTTCAATGTCTAAAATGACTTGGTTAAATGTTGGTGGCCAAGCT
GATGTACTATTTAAGCCACG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MLVKIGTRGSDLALIQALEAKQRLLESFPNLSVEIIKIKTSGDKYANVTLAEIGGKGLFLREIEAELLKNNIDMAVHSLK
DVPAFFSKDLTIPCVLERLSPCDVFISHKYKSLKTLPQQATIATSSIRRKVQLLNLRPDLNVVPLRGNVTTRLQNQNFDG
MILAEAGLIRLKKYHLITEVLPPKVMLSAVGQGTICIQCRKNDIKVIDLLEKINNNMSFIRAKSERSFMKTVNGSCFTPL
AALAEYVSENMLHLYCMLAGERVIYFTERTSFVEDAEKMGMDAGLELKSKCL

Sequences:

>Translated_292_residues
MLVKIGTRGSDLALIQALEAKQRLLESFPNLSVEIIKIKTSGDKYANVTLAEIGGKGLFLREIEAELLKNNIDMAVHSLK
DVPAFFSKDLTIPCVLERLSPCDVFISHKYKSLKTLPQQATIATSSIRRKVQLLNLRPDLNVVPLRGNVTTRLQNQNFDG
MILAEAGLIRLKKYHLITEVLPPKVMLSAVGQGTICIQCRKNDIKVIDLLEKINNNMSFIRAKSERSFMKTVNGSCFTPL
AALAEYVSENMLHLYCMLAGERVIYFTERTSFVEDAEKMGMDAGLELKSKCL
>Mature_292_residues
MLVKIGTRGSDLALIQALEAKQRLLESFPNLSVEIIKIKTSGDKYANVTLAEIGGKGLFLREIEAELLKNNIDMAVHSLK
DVPAFFSKDLTIPCVLERLSPCDVFISHKYKSLKTLPQQATIATSSIRRKVQLLNLRPDLNVVPLRGNVTTRLQNQNFDG
MILAEAGLIRLKKYHLITEVLPPKVMLSAVGQGTICIQCRKNDIKVIDLLEKINNNMSFIRAKSERSFMKTVNGSCFTPL
AALAEYVSENMLHLYCMLAGERVIYFTERTSFVEDAEKMGMDAGLELKSKCL

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=247, Percent_Identity=37.246963562753, Blast_Score=177, Evalue=8e-45,
Organism=Homo sapiens, GI20149500, Length=247, Percent_Identity=37.246963562753, Blast_Score=177, Evalue=9e-45,
Organism=Escherichia coli, GI48994974, Length=292, Percent_Identity=41.0958904109589, Blast_Score=218, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6319996, Length=289, Percent_Identity=32.5259515570934, Blast_Score=151, Evalue=1e-37,
Organism=Drosophila melanogaster, GI20130425, Length=256, Percent_Identity=38.28125, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 32636; Mature: 32636

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVKIGTRGSDLALIQALEAKQRLLESFPNLSVEIIKIKTSGDKYANVTLAEIGGKGLFL
CEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCEEEEEEEEECCCEEEH
REIEAELLKNNIDMAVHSLKDVPAFFSKDLTIPCVLERLSPCDVFISHKYKSLKTLPQQA
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHCCHHHHHCCCCHH
TIATSSIRRKVQLLNLRPDLNVVPLRGNVTTRLQNQNFDGMILAEAGLIRLKKYHLITEV
HHHHHHHHHHHHEEECCCCCEEEEECCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHH
LPPKVMLSAVGQGTICIQCRKNDIKVIDLLEKINNNMSFIRAKSERSFMKTVNGSCFTPL
CCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCCHH
AALAEYVSENMLHLYCMLAGERVIYFTERTSFVEDAEKMGMDAGLELKSKCL
HHHHHHHHHHHHEEEEEECCCEEEEEECCCHHHHHHHHCCCCCCCCHHCCCC
>Mature Secondary Structure
MLVKIGTRGSDLALIQALEAKQRLLESFPNLSVEIIKIKTSGDKYANVTLAEIGGKGLFL
CEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCEEEEEEEEECCCEEEH
REIEAELLKNNIDMAVHSLKDVPAFFSKDLTIPCVLERLSPCDVFISHKYKSLKTLPQQA
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHCCHHHHHCCCCHH
TIATSSIRRKVQLLNLRPDLNVVPLRGNVTTRLQNQNFDGMILAEAGLIRLKKYHLITEV
HHHHHHHHHHHHEEECCCCCEEEEECCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHH
LPPKVMLSAVGQGTICIQCRKNDIKVIDLLEKINNNMSFIRAKSERSFMKTVNGSCFTPL
CCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCCHH
AALAEYVSENMLHLYCMLAGERVIYFTERTSFVEDAEKMGMDAGLELKSKCL
HHHHHHHHHHHHEEEEEECCCEEEEEECCCHHHHHHHHCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA