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The map label for this gene is mutL [H]

Identifier: 190570725

GI number: 190570725

Start: 282022

End: 283830

Strand: Reverse

Name: mutL [H]

Synonym: WPa_0278

Alternate gene names: 190570725

Gene position: 283830-282022 (Counterclockwise)

Preceding gene: 190570726

Following gene: 190570724

Centisome position: 19.15

GC content: 35.82

Gene sequence:

>1809_bases
ATGGCAATAATTCTTTTAGATACAAAAACAATAAATCGTATAGCAGCAGGTGAAGTAATCGAAAGGCCAGCAAGTGTAGT
AAAGGAATTAGTAGAAAATGCAATAGATGCTGGAAGTTCAGAAATAGAGATCAAAATAGAAAGTGGTGGGCGTAACCTTA
TCACTGTGACAGATAATGGAAATGGAATAGAAAAGGAAGATTTGGAACTTGCGTTTATGCGCCACGCTACTTCAAAATTA
AGCGATGGTGAATTAATAGAGATCAGACATCTTGGCTTTAGAGGAGAGGCTCTGCCTTCAATTGCAGCAGTAAGCAGAAT
GAAATTATCATCCAAGGCAAGTGGAGCAAAGGAAGCATGGTCTATAAGATATGAGGGAGGAGAAAAAGTAAGAGAGATTA
CCCCTTGTTCTTTGTTGCAAGGTACATATATTGAAGTTCGTGACTTATTTTTTGCTACACCAAATAGACTAAAGTTTCTA
AAAACCGAAAGGGCAGAAACACAAAGTATTGTTGATATTGTGAATAACTTAGCGATGATTAATTATAGTATTGGGTTTAC
TCTCACTTCTGGTAATAAAAAGCTCTTAAAATATGTTAAGCAAACTTCGCTGTTCAACAGATTATGTGAAATAGAAAAAG
AATTTCAAAGCAATTCACTGGAAGTTAAAGAGGAAGAAGAAGGCATCAAACTTAAGGGACACATCTGTAAACCTAATGTC
AATCGTGGCAACTCAACTCAGATTTATACGTTTGTTAATGGAAGGCCAATGAAAGACAATCTACTTGTTGGTGCAATTAG
GTATGCGTATCACGATTTTATTCCAAACAATAGGTATCCTTTTGCAGTGTTGCATTTAGAAGTACCATATGACCAAGTAG
ATGTAAATGTGCATCCAAATAAATCGGAAGTAAGATTTCAGAATAAAAGGCTAATATATGAAATAGTGAGAAGAGGGATA
ATAAAAACACTATCAACGAGATTTGCAGCGGGTGATCAAGGTATTGAAGAGGAGCTAATTTTTAATGATAGTAAAAGCCA
AGAGCAGATTGATAGTCAAGAGAAAAAAGATCAAAAAGAGTTTTATGAAAAGAGACCAAGTCTTTTAGAAAATCGTCTAA
TGAAAGAGTTCAATGCACCAGATGAAAGAAGGCAAAGCTTACCAGAAACTTTTAAGTATGGAGAATCCCCACCCCAAAAG
GGAACGATGGTTTTAGAAAGGAAGCAAATTGATTTAATAGCGGATCATCCTCTAGGATATGCACGCTGTCAGGTCTACAA
TACTTACATTATTGCTGAGGCTAAAGGAAAATTAATTATAGTAGACCAGCACGCAGCTCATGAGAGATTGATATACGAGT
GCTTAACAAGCATAAAAAGACAAAAATTTCTTCTTCCTGAAACAGTTGAGATTAAAAACCAAGCAGGAATGGAGATGGTT
GGAATGTATAAAGATAGGCTCTTTGAAATGGGTTTTGGTATTGAAATAGAATCAGAAGATAAAGTAAGGGTGAAAGAAAT
ACCTGCAATTTTAGGAACAATAAATGTGAAAGAGATGGTGATGAATATAGTTGATAGATTAATGGAGATAGGAGATACGC
TACCTATAGAAGAAAAAGTGAACAAGATACTAGCTACCATTGCGTGCCATGGGTCAATTAGAGCTGGAAGGGCAATGAAG
TTGGAGGAGATGAATGAGTTGATGAGACAAATGGAGGAAACACCTTATGCTGGGCAATGCAATCACGGAAGACCAACGTA
TATAGAAATGAAACTAAGTGATATAGAAAAATTGTTTGAAAGGAGATGA

Upstream 100 bases:

>100_bases
CTAGAAAGGAATCTAAAAATCTAAAATATAGAGATTGTGAGGTCAAGAAATCACCAAAAAATAGAGGGAACTCTAAGTTT
CATAGATTGGGTGGAGTATT

Downstream 100 bases:

>100_bases
GTTCAGTTTGTCAAAAAGGTTCCCAATTAAGTATAAGTAACGGCTCTTCTGATTATGAGTATAAAATGTGAAAAAAGAGA
ATAAATGCTCTAATTTTTTA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 601

Protein sequence:

>602_residues
MAIILLDTKTINRIAAGEVIERPASVVKELVENAIDAGSSEIEIKIESGGRNLITVTDNGNGIEKEDLELAFMRHATSKL
SDGELIEIRHLGFRGEALPSIAAVSRMKLSSKASGAKEAWSIRYEGGEKVREITPCSLLQGTYIEVRDLFFATPNRLKFL
KTERAETQSIVDIVNNLAMINYSIGFTLTSGNKKLLKYVKQTSLFNRLCEIEKEFQSNSLEVKEEEEGIKLKGHICKPNV
NRGNSTQIYTFVNGRPMKDNLLVGAIRYAYHDFIPNNRYPFAVLHLEVPYDQVDVNVHPNKSEVRFQNKRLIYEIVRRGI
IKTLSTRFAAGDQGIEEELIFNDSKSQEQIDSQEKKDQKEFYEKRPSLLENRLMKEFNAPDERRQSLPETFKYGESPPQK
GTMVLERKQIDLIADHPLGYARCQVYNTYIIAEAKGKLIIVDQHAAHERLIYECLTSIKRQKFLLPETVEIKNQAGMEMV
GMYKDRLFEMGFGIEIESEDKVRVKEIPAILGTINVKEMVMNIVDRLMEIGDTLPIEEKVNKILATIACHGSIRAGRAMK
LEEMNELMRQMEETPYAGQCNHGRPTYIEMKLSDIEKLFERR

Sequences:

>Translated_602_residues
MAIILLDTKTINRIAAGEVIERPASVVKELVENAIDAGSSEIEIKIESGGRNLITVTDNGNGIEKEDLELAFMRHATSKL
SDGELIEIRHLGFRGEALPSIAAVSRMKLSSKASGAKEAWSIRYEGGEKVREITPCSLLQGTYIEVRDLFFATPNRLKFL
KTERAETQSIVDIVNNLAMINYSIGFTLTSGNKKLLKYVKQTSLFNRLCEIEKEFQSNSLEVKEEEEGIKLKGHICKPNV
NRGNSTQIYTFVNGRPMKDNLLVGAIRYAYHDFIPNNRYPFAVLHLEVPYDQVDVNVHPNKSEVRFQNKRLIYEIVRRGI
IKTLSTRFAAGDQGIEEELIFNDSKSQEQIDSQEKKDQKEFYEKRPSLLENRLMKEFNAPDERRQSLPETFKYGESPPQK
GTMVLERKQIDLIADHPLGYARCQVYNTYIIAEAKGKLIIVDQHAAHERLIYECLTSIKRQKFLLPETVEIKNQAGMEMV
GMYKDRLFEMGFGIEIESEDKVRVKEIPAILGTINVKEMVMNIVDRLMEIGDTLPIEEKVNKILATIACHGSIRAGRAMK
LEEMNELMRQMEETPYAGQCNHGRPTYIEMKLSDIEKLFERR
>Mature_601_residues
AIILLDTKTINRIAAGEVIERPASVVKELVENAIDAGSSEIEIKIESGGRNLITVTDNGNGIEKEDLELAFMRHATSKLS
DGELIEIRHLGFRGEALPSIAAVSRMKLSSKASGAKEAWSIRYEGGEKVREITPCSLLQGTYIEVRDLFFATPNRLKFLK
TERAETQSIVDIVNNLAMINYSIGFTLTSGNKKLLKYVKQTSLFNRLCEIEKEFQSNSLEVKEEEEGIKLKGHICKPNVN
RGNSTQIYTFVNGRPMKDNLLVGAIRYAYHDFIPNNRYPFAVLHLEVPYDQVDVNVHPNKSEVRFQNKRLIYEIVRRGII
KTLSTRFAAGDQGIEEELIFNDSKSQEQIDSQEKKDQKEFYEKRPSLLENRLMKEFNAPDERRQSLPETFKYGESPPQKG
TMVLERKQIDLIADHPLGYARCQVYNTYIIAEAKGKLIIVDQHAAHERLIYECLTSIKRQKFLLPETVEIKNQAGMEMVG
MYKDRLFEMGFGIEIESEDKVRVKEIPAILGTINVKEMVMNIVDRLMEIGDTLPIEEKVNKILATIACHGSIRAGRAMKL
EEMNELMRQMEETPYAGQCNHGRPTYIEMKLSDIEKLFERR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=322, Percent_Identity=36.9565217391304, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4505913, Length=353, Percent_Identity=28.0453257790368, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI310128478, Length=353, Percent_Identity=28.0453257790368, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI4505911, Length=330, Percent_Identity=29.0909090909091, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI189458898, Length=333, Percent_Identity=28.8288288288288, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI189458896, Length=313, Percent_Identity=27.7955271565495, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI310128480, Length=305, Percent_Identity=26.2295081967213, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI263191589, Length=231, Percent_Identity=31.1688311688312, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI91992162, Length=355, Percent_Identity=25.0704225352113, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI91992160, Length=355, Percent_Identity=25.0704225352113, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1790612, Length=351, Percent_Identity=40.1709401709402, Blast_Score=248, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI71991825, Length=317, Percent_Identity=32.4921135646688, Blast_Score=161, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17562796, Length=347, Percent_Identity=26.2247838616715, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=322, Percent_Identity=35.4037267080745, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324247, Length=412, Percent_Identity=26.4563106796117, Blast_Score=128, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6325093, Length=172, Percent_Identity=27.906976744186, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323063, Length=196, Percent_Identity=27.5510204081633, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17136968, Length=320, Percent_Identity=33.125, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI17136970, Length=350, Percent_Identity=24.2857142857143, Blast_Score=110, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 68708; Mature: 68577

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIILLDTKTINRIAAGEVIERPASVVKELVENAIDAGSSEIEIKIESGGRNLITVTDNG
CEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCC
NGIEKEDLELAFMRHATSKLSDGELIEIRHLGFRGEALPSIAAVSRMKLSSKASGAKEAW
CCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHE
SIRYEGGEKVREITPCSLLQGTYIEVRDLFFATPNRLKFLKTERAETQSIVDIVNNLAMI
EEEECCCCHHHHCCCHHHHCCCHHEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEE
NYSIGFTLTSGNKKLLKYVKQTSLFNRLCEIEKEFQSNSLEVKEEEEGIKLKGHICKPNV
EEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEEEECCCC
NRGNSTQIYTFVNGRPMKDNLLVGAIRYAYHDFIPNNRYPFAVLHLEVPYDQVDVNVHPN
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEECCC
KSEVRFQNKRLIYEIVRRGIIKTLSTRFAAGDQGIEEELIFNDSKSQEQIDSQEKKDQKE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEECCCCCHHHHHHHHHHHHHH
FYEKRPSLLENRLMKEFNAPDERRQSLPETFKYGESPPQKGTMVLERKQIDLIADHPLGY
HHHHCHHHHHHHHHHHCCCCHHHHHCCCHHHHCCCCCCCCCCEEEEECCEEEEECCCCCC
ARCQVYNTYIIAEAKGKLIIVDQHAAHERLIYECLTSIKRQKFLLPETVEIKNQAGMEMV
EEEEEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHH
GMYKDRLFEMGFGIEIESEDKVRVKEIPAILGTINVKEMVMNIVDRLMEIGDTLPIEEKV
HHHHHHHHHCCCCEEECCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHH
NKILATIACHGSIRAGRAMKLEEMNELMRQMEETPYAGQCNHGRPTYIEMKLSDIEKLFE
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHH
RR
CC
>Mature Secondary Structure 
AIILLDTKTINRIAAGEVIERPASVVKELVENAIDAGSSEIEIKIESGGRNLITVTDNG
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCC
NGIEKEDLELAFMRHATSKLSDGELIEIRHLGFRGEALPSIAAVSRMKLSSKASGAKEAW
CCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHE
SIRYEGGEKVREITPCSLLQGTYIEVRDLFFATPNRLKFLKTERAETQSIVDIVNNLAMI
EEEECCCCHHHHCCCHHHHCCCHHEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEE
NYSIGFTLTSGNKKLLKYVKQTSLFNRLCEIEKEFQSNSLEVKEEEEGIKLKGHICKPNV
EEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEEEECCCC
NRGNSTQIYTFVNGRPMKDNLLVGAIRYAYHDFIPNNRYPFAVLHLEVPYDQVDVNVHPN
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEECCC
KSEVRFQNKRLIYEIVRRGIIKTLSTRFAAGDQGIEEELIFNDSKSQEQIDSQEKKDQKE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEECCCCCHHHHHHHHHHHHHH
FYEKRPSLLENRLMKEFNAPDERRQSLPETFKYGESPPQKGTMVLERKQIDLIADHPLGY
HHHHCHHHHHHHHHHHCCCCHHHHHCCCHHHHCCCCCCCCCCEEEEECCEEEEECCCCCC
ARCQVYNTYIIAEAKGKLIIVDQHAAHERLIYECLTSIKRQKFLLPETVEIKNQAGMEMV
EEEEEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHH
GMYKDRLFEMGFGIEIESEDKVRVKEIPAILGTINVKEMVMNIVDRLMEIGDTLPIEEKV
HHHHHHHHHCCCCEEECCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHH
NKILATIACHGSIRAGRAMKLEEMNELMRQMEETPYAGQCNHGRPTYIEMKLSDIEKLFE
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHH
RR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA