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The map label for this gene is ndk

Identifier: 189184808

GI number: 189184808

Start: 1938003

End: 1938428

Strand: Reverse

Name: ndk

Synonym: OTT_1901

Alternate gene names: 189184808

Gene position: 1938428-1938003 (Counterclockwise)

Preceding gene: 189184819

Following gene: 189184806

Centisome position: 96.49

GC content: 30.28

Gene sequence:

>426_bases
ATGAACATGGAATACACTCTTTCAATTTTAAAACCAGATGTGATTAAAAGAAACATCATTGGAAAAGTTAATACCTACAT
AGAAAATTCTGGACTAAAAATTATAGCTCAAAAAACTCTTTTGCTTACTAAAGTACAAGCAGAAAATTTTTACATAATAC
ATAAGGATAGAGCATATTATCAAAGTTTAGTGCAAAATATGACGTCTGGTCCAGTAGTAGTACAAGTATTATATGGCCTA
AATGCTGTAAAAAAATACAGAGAAATCATAGGGGCTACTAATCCATGCGATGCTAAAAAAGGAACAATCAGAGGAGACAT
CGCAAAAAGTATCGATGAAAATACAGTTCATGGGTCTGATAGCTTAGAAAATGCTGATATAGAAATAAAATTTTTCTTTG
CCTTGATTGAATATGCATATCTTTAA

Upstream 100 bases:

>100_bases
CATAAGATGTTATTTAAATAAATAATTACTAGAAATTAAACACTCAAAAATATATACTACTAACACTCTTACTATTATTA
TATTAGTTAAATTAAAGTTT

Downstream 100 bases:

>100_bases
AATTAAATGCTTTTGTTATTGTTATGTTGATAATTAATATAGTAGTTTAGCCTAAGTTAAACGTAAAAATGTGATATGGC
TAAATAAAAAAATATCAATA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MNMEYTLSILKPDVIKRNIIGKVNTYIENSGLKIIAQKTLLLTKVQAENFYIIHKDRAYYQSLVQNMTSGPVVVQVLYGL
NAVKKYREIIGATNPCDAKKGTIRGDIAKSIDENTVHGSDSLENADIEIKFFFALIEYAYL

Sequences:

>Translated_141_residues
MNMEYTLSILKPDVIKRNIIGKVNTYIENSGLKIIAQKTLLLTKVQAENFYIIHKDRAYYQSLVQNMTSGPVVVQVLYGL
NAVKKYREIIGATNPCDAKKGTIRGDIAKSIDENTVHGSDSLENADIEIKFFFALIEYAYL
>Mature_141_residues
MNMEYTLSILKPDVIKRNIIGKVNTYIENSGLKIIAQKTLLLTKVQAENFYIIHKDRAYYQSLVQNMTSGPVVVQVLYGL
NAVKKYREIIGATNPCDAKKGTIRGDIAKSIDENTVHGSDSLENADIEIKFFFALIEYAYL

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392227, Length=140, Percent_Identity=40.7142857142857, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI66392205, Length=140, Percent_Identity=40.7142857142857, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI4505409, Length=140, Percent_Identity=40.7142857142857, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI66392192, Length=140, Percent_Identity=40.7142857142857, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI66392203, Length=140, Percent_Identity=40.7142857142857, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI38045913, Length=140, Percent_Identity=39.2857142857143, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI4557797, Length=140, Percent_Identity=39.2857142857143, Blast_Score=113, Evalue=4e-26,
Organism=Homo sapiens, GI37693993, Length=130, Percent_Identity=40.7692307692308, Blast_Score=112, Evalue=8e-26,
Organism=Homo sapiens, GI4826862, Length=140, Percent_Identity=37.1428571428571, Blast_Score=99, Evalue=8e-22,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI7019465, Length=136, Percent_Identity=30.8823529411765, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI37574614, Length=136, Percent_Identity=30.8823529411765, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=29.6296296296296, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI148839372, Length=139, Percent_Identity=29.4964028776978, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788866, Length=134, Percent_Identity=47.7611940298507, Blast_Score=139, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17506807, Length=132, Percent_Identity=40.1515151515151, Blast_Score=112, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6322783, Length=130, Percent_Identity=34.6153846153846, Blast_Score=95, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45549037, Length=132, Percent_Identity=41.6666666666667, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI18860097, Length=140, Percent_Identity=30.7142857142857, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_ORITB (A5CF69)

Other databases:

- EMBL:   AM494475
- RefSeq:   YP_001249102.1
- ProteinModelPortal:   A5CF69
- SMR:   A5CF69
- STRING:   A5CF69
- GeneID:   5218244
- GenomeReviews:   AM494475_GR
- KEGG:   ots:OTBS_1862
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   OTSU357244:OTBS_1862-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15908; Mature: 15908

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMEYTLSILKPDVIKRNIIGKVNTYIENSGLKIIAQKTLLLTKVQAENFYIIHKDRAYY
CCCEEEEEECCCHHHHHHHHHHHHHEEECCCEEEEEEHHEEEEEEECCCEEEEECCHHHH
QSLVQNMTSGPVVVQVLYGLNAVKKYREIIGATNPCDAKKGTIRGDIAKSIDENTVHGSD
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCC
SLENADIEIKFFFALIEYAYL
CCCCCCEEEHHHHHHHHHHCC
>Mature Secondary Structure
MNMEYTLSILKPDVIKRNIIGKVNTYIENSGLKIIAQKTLLLTKVQAENFYIIHKDRAYY
CCCEEEEEECCCHHHHHHHHHHHHHEEECCCEEEEEEHHEEEEEEECCCEEEEECCHHHH
QSLVQNMTSGPVVVQVLYGLNAVKKYREIIGATNPCDAKKGTIRGDIAKSIDENTVHGSD
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCC
SLENADIEIKFFFALIEYAYL
CCCCCCEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA