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The map label for this gene is pyrH [H]

Identifier: 189184778

GI number: 189184778

Start: 1910405

End: 1911157

Strand: Reverse

Name: pyrH [H]

Synonym: OTT_1871

Alternate gene names: 189184778

Gene position: 1911157-1910405 (Counterclockwise)

Preceding gene: 189184779

Following gene: 189184777

Centisome position: 95.13

GC content: 32.27

Gene sequence:

>753_bases
ATGAACAACTTAAGGTATAATAGATTGCTTATCAAGCTTAGCGGAGCAGCATTAAAAGGAGATAGCAATACTGATAATTT
TGATATTAAAAAGCTGAAATACATAGCTCAAGAAATATTAGCTATCAAAAATATGGGAATAGAGGTTGCTCTTGTAACTG
GAGGTGGAAATATTTTTAGAGGAAATAGTGCAGAGTATTGGAAGATAGAACGTGCTGAAGCTGATAACGTTGGAATGCTT
GGCACTATTATAAATGCTTTGATGCTAAAGGCAGCATTAGAAAAGGAATCTAATTATAAAGTTAGAGTTATGAGCGCAAT
CAAAATCGAAGCAGTTGCTGAACCATTTATTAGATCTAGAGCTTTAAGTCACCTAGACAAAGGATATTTAATCATTTTAG
CTGCTGGCATAGGACAACCATTTATTACAACTGACTATACTGCTGCACAACGAGCATTAGAGTTAAGATGTGATGCCATG
CTTGTTGCAAAGCATGGAGTAAATGGAGTTTTTGATTCCAATCCTAAAGAGGATAATAATGCAAGACAATATTGCACTTT
AGCATATGACGACTTTTTAATTAATCAACTAAATATTATGGATCATTCAGCTGTGTTATTAGCAAAGCAGCATAATTTAC
CAATTCATATTTTTAACTTTGATCAAAAGCTAGCAGCAAAGGATATATGTTTAGGTAAAAATATTGGTACTTATATTTCT
TCAAATACAAAAATGCAATTTTCAAATGAATAA

Upstream 100 bases:

>100_bases
ATAGCTAAACTCTTGATAAAAGCTTAAATTTCATCTTTAGTATGTATTGAATGAATTTCTCAAAAAAATAAATAGAGTTA
TAATCTATGGGAATGTAACT

Downstream 100 bases:

>100_bases
CAATGGTTCCATTGAGAAAAATTATAGCTGAAAATAATGTATCAATAACATGAATCATCATCAGTCAAGTATGCCAAATA
CTTTATTTAAGTTACTTGCG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MNNLRYNRLLIKLSGAALKGDSNTDNFDIKKLKYIAQEILAIKNMGIEVALVTGGGNIFRGNSAEYWKIERAEADNVGML
GTIINALMLKAALEKESNYKVRVMSAIKIEAVAEPFIRSRALSHLDKGYLIILAAGIGQPFITTDYTAAQRALELRCDAM
LVAKHGVNGVFDSNPKEDNNARQYCTLAYDDFLINQLNIMDHSAVLLAKQHNLPIHIFNFDQKLAAKDICLGKNIGTYIS
SNTKMQFSNE

Sequences:

>Translated_250_residues
MNNLRYNRLLIKLSGAALKGDSNTDNFDIKKLKYIAQEILAIKNMGIEVALVTGGGNIFRGNSAEYWKIERAEADNVGML
GTIINALMLKAALEKESNYKVRVMSAIKIEAVAEPFIRSRALSHLDKGYLIILAAGIGQPFITTDYTAAQRALELRCDAM
LVAKHGVNGVFDSNPKEDNNARQYCTLAYDDFLINQLNIMDHSAVLLAKQHNLPIHIFNFDQKLAAKDICLGKNIGTYIS
SNTKMQFSNE
>Mature_250_residues
MNNLRYNRLLIKLSGAALKGDSNTDNFDIKKLKYIAQEILAIKNMGIEVALVTGGGNIFRGNSAEYWKIERAEADNVGML
GTIINALMLKAALEKESNYKVRVMSAIKIEAVAEPFIRSRALSHLDKGYLIILAAGIGQPFITTDYTAAQRALELRCDAM
LVAKHGVNGVFDSNPKEDNNARQYCTLAYDDFLINQLNIMDHSAVLLAKQHNLPIHIFNFDQKLAAKDICLGKNIGTYIS
SNTKMQFSNE

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=237, Percent_Identity=38.8185654008439, Blast_Score=165, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 27744; Mature: 27744

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLRYNRLLIKLSGAALKGDSNTDNFDIKKLKYIAQEILAIKNMGIEVALVTGGGNIFR
CCCCEEEEEEEEEECCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEE
GNSAEYWKIERAEADNVGMLGTIINALMLKAALEKESNYKVRVMSAIKIEAVAEPFIRSR
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHH
ALSHLDKGYLIILAAGIGQPFITTDYTAAQRALELRCDAMLVAKHGVNGVFDSNPKEDNN
HHHHCCCCEEEEEEECCCCCCEECCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCC
ARQYCTLAYDDFLINQLNIMDHSAVLLAKQHNLPIHIFNFDQKLAAKDICLGKNIGTYIS
CCEEEEEEEHHHHHHHHEECCCCEEEEEECCCCEEEEEECCHHHHHHHHHCCCCCCCEEC
SNTKMQFSNE
CCCEEEECCC
>Mature Secondary Structure
MNNLRYNRLLIKLSGAALKGDSNTDNFDIKKLKYIAQEILAIKNMGIEVALVTGGGNIFR
CCCCEEEEEEEEEECCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEE
GNSAEYWKIERAEADNVGMLGTIINALMLKAALEKESNYKVRVMSAIKIEAVAEPFIRSR
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHH
ALSHLDKGYLIILAAGIGQPFITTDYTAAQRALELRCDAMLVAKHGVNGVFDSNPKEDNN
HHHHCCCCEEEEEEECCCCCCEECCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCC
ARQYCTLAYDDFLINQLNIMDHSAVLLAKQHNLPIHIFNFDQKLAAKDICLGKNIGTYIS
CCEEEEEEEHHHHHHHHEECCCCEEEEEECCCCEEEEEECCHHHHHHHHHCCCCCCCEEC
SNTKMQFSNE
CCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA