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The map label for this gene is ubiE [H]

Identifier: 189183525

GI number: 189183525

Start: 636794

End: 637567

Strand: Direct

Name: ubiE [H]

Synonym: OTT_0618

Alternate gene names: 189183525

Gene position: 636794-637567 (Clockwise)

Preceding gene: 189183520

Following gene: 189183526

Centisome position: 31.7

GC content: 28.04

Gene sequence:

>774_bases
ATGACGAAGAATTATAATCATAATAATGGTAATAAATCTACTTTTGGATTTCAACTTGTTGATAGTGATAAAAAGAATCA
ATTGGTTGCCAAAGTGTTTGATTCTGTTACTCAGCATTATGATTTAATGAATAATATACTTAGTTTAGGTGTTCATTATT
TTTGGAAACAAAAATTTTGTAATAGATTTTTCGATTTTAATGGTTCATTGATTGATGTTGCTTCAGGAACTGGTGATATA
GCTTTAACATTTTATCGTAAAGCGAAGAAATGTTATGCTATTCCTAATGTTACTATTTGTGATATAAACTATAATATGTT
ACAAAAGTGTCGAGAGAAGGCTGTAGATAGTAACTTATTAGAAAATATACATTATATTAATTGTAATGCAGAAAATTTAC
CTTTTGCAGATAATAGTTTTGATAATTTTTCAATTGCTTTTGGAATTCGTAATGTTACCAACATTAAAGCTTCATTACAA
GAAGCTTACCGAGTTTTAAAGCCAGGTGGCCAGTTTTTATGTTTAGAGTTTTCTAAAGTAGAAAATCGATATGTAAGCAA
ACTGTATGACTTATATTCATTTAACTTAATACCTTTAATAGGTAAAATAGTGGCCAATAATCAACAAGCCTATCAATACT
TAGTAGAAAGTATTAGAACATTTCCTGAGCAACAAGACTTTTGTCAAATAATTAATAGCGTAGGATTTCAGAACGTTAAG
TTTTGCAATTTAACTTTTGGCATTGTTGCAATACACTCAGCTCTCAAATTATGA

Upstream 100 bases:

>100_bases
CTTCCTGACTTCATGTAACAATGGCATATTTTTTTAGTTTGATTTTTATGATGTTTAGTTATTATATTATTTGTTTTGAT
CATATTTAGAAAATAATTCA

Downstream 100 bases:

>100_bases
TTAACTTTATTAAGAATGTAATAGCATTAATAGGAGTTTTGGCAATAGTTAGTAAATACAAAATATTGCAAAATATTGAT
TGTACTAACTTATCTTTTTT

Product: ubiquinone/menaquinone biosynthesis methlytransferase UbiE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MTKNYNHNNGNKSTFGFQLVDSDKKNQLVAKVFDSVTQHYDLMNNILSLGVHYFWKQKFCNRFFDFNGSLIDVASGTGDI
ALTFYRKAKKCYAIPNVTICDINYNMLQKCREKAVDSNLLENIHYINCNAENLPFADNSFDNFSIAFGIRNVTNIKASLQ
EAYRVLKPGGQFLCLEFSKVENRYVSKLYDLYSFNLIPLIGKIVANNQQAYQYLVESIRTFPEQQDFCQIINSVGFQNVK
FCNLTFGIVAIHSALKL

Sequences:

>Translated_257_residues
MTKNYNHNNGNKSTFGFQLVDSDKKNQLVAKVFDSVTQHYDLMNNILSLGVHYFWKQKFCNRFFDFNGSLIDVASGTGDI
ALTFYRKAKKCYAIPNVTICDINYNMLQKCREKAVDSNLLENIHYINCNAENLPFADNSFDNFSIAFGIRNVTNIKASLQ
EAYRVLKPGGQFLCLEFSKVENRYVSKLYDLYSFNLIPLIGKIVANNQQAYQYLVESIRTFPEQQDFCQIINSVGFQNVK
FCNLTFGIVAIHSALKL
>Mature_256_residues
TKNYNHNNGNKSTFGFQLVDSDKKNQLVAKVFDSVTQHYDLMNNILSLGVHYFWKQKFCNRFFDFNGSLIDVASGTGDIA
LTFYRKAKKCYAIPNVTICDINYNMLQKCREKAVDSNLLENIHYINCNAENLPFADNSFDNFSIAFGIRNVTNIKASLQE
AYRVLKPGGQFLCLEFSKVENRYVSKLYDLYSFNLIPLIGKIVANNQQAYQYLVESIRTFPEQQDFCQIINSVGFQNVKF
CNLTFGIVAIHSALKL

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=277, Percent_Identity=43.3212996389892, Blast_Score=243, Evalue=9e-65,
Organism=Escherichia coli, GI48994983, Length=248, Percent_Identity=43.9516129032258, Blast_Score=216, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI17557039, Length=258, Percent_Identity=43.0232558139535, Blast_Score=223, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323526, Length=256, Percent_Identity=39.84375, Blast_Score=187, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24641702, Length=254, Percent_Identity=46.4566929133858, Blast_Score=232, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 29459; Mature: 29328

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNYNHNNGNKSTFGFQLVDSDKKNQLVAKVFDSVTQHYDLMNNILSLGVHYFWKQKFC
CCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRFFDFNGSLIDVASGTGDIALTFYRKAKKCYAIPNVTICDINYNMLQKCREKAVDSNLL
HHHHCCCCCEEEECCCCCCEEEHEEHHHHHHEECCCCEEEECCHHHHHHHHHHHHHHHHH
ENIHYINCNAENLPFADNSFDNFSIAFGIRNVTNIKASLQEAYRVLKPGGQFLCLEFSKV
HCEEEEECCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHH
ENRYVSKLYDLYSFNLIPLIGKIVANNQQAYQYLVESIRTFPEQQDFCQIINSVGFQNVK
HHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
FCNLTFGIVAIHSALKL
EEHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKNYNHNNGNKSTFGFQLVDSDKKNQLVAKVFDSVTQHYDLMNNILSLGVHYFWKQKFC
CCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRFFDFNGSLIDVASGTGDIALTFYRKAKKCYAIPNVTICDINYNMLQKCREKAVDSNLL
HHHHCCCCCEEEECCCCCCEEEHEEHHHHHHEECCCCEEEECCHHHHHHHHHHHHHHHHH
ENIHYINCNAENLPFADNSFDNFSIAFGIRNVTNIKASLQEAYRVLKPGGQFLCLEFSKV
HCEEEEECCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHH
ENRYVSKLYDLYSFNLIPLIGKIVANNQQAYQYLVESIRTFPEQQDFCQIINSVGFQNVK
HHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
FCNLTFGIVAIHSALKL
EEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA