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The map label for this gene is ubiB [H]

Identifier: 189183526

GI number: 189183526

Start: 637564

End: 638952

Strand: Direct

Name: ubiB [H]

Synonym: OTT_0619

Alternate gene names: 189183526

Gene position: 637564-638952 (Clockwise)

Preceding gene: 189183525

Following gene: 189183527

Centisome position: 31.74

GC content: 31.1

Gene sequence:

>1389_bases
ATGATTAACTTTATTAAGAATGTAATAGCATTAATAGGAGTTTTGGCAATAGTTAGTAAATACAAAATATTGCAAAATAT
TGATTGTACTAACTTATCTTTTTTATTCAGAAGTATCATTAAACTAATTAACTTTCTTTTTTATCCAATTTGTTTGGTAT
ATAGAAATAATCAGCAATATAGTGATAGATTAACAAACTGCTTAAAAGAACTTGGCCCCGCATATATTAAGTTAGGACAA
ACATTATCTACTAGACCTGACTTAATTGGTAGCAACATGGCTGATTCATTAAAGATATTACAGGATAAATTGCCTCCGTT
TTCAACTCAAGAAGCAAAAAAAATTATTACAGCTTGCCTTAAAATGGAAATAGATCAAGTATTTTCTTTTTTTCCAAAAG
AAGTAGTAGTTGCAGCATCTATTGCTCAAGTATATAAAGCCCAGCTAGTCACTGGAGAAGAAGTGGCAGTAAAGGTGCTA
AGACCTAATGTACAAGCTGAATATCTTGAAAACATAGAAACATTACATTTCATTGCTAAGATTTTATTAAAGTTTTTGCC
TAAAGTTAAGAGGCTGAAATTAGTAGAGGTAATAGATATATTACGAAACTCTATGGTCAGTGAATTGGATATGAGAATTG
AAGCAGCATCATATTCTGAAATGCTAGATAATTTTATATCAGATCGCAATACTTATATACCAAAAGTGTATTGGGAATTT
ACTGCCGAAAAAGTTTTAACTGTTGAGTGGATTCATGGATTGCCAATTCGTGAACGGCAACTAATAATAAATCAAGGAAC
ATCCTTGAAAGATCTATCAGAAAAAGTTGTCTTGATGTTTTTTAATCAGGCTTACAGAGATGGATTTTTTCATGCTGATT
TACATCATGGAAATGTTCTAGTTTTGCCAGACGGCAAGATAGGATTAGTAGATTTTGGTATAATAGGCAGGCTATCTGAA
AAGGATAGAATTGCAGTAGCTGAGATTTTGTACGCTTTTCTGGAACGAGACTATAAGAAAGTTGCTAAAATTCATCTGCA
AGCTGGCTATATACCAGAAAATACCAATTTAGACTTATTTTCCCAATATTGCAGGTCTATAGCTGAACCTATTATTGGAT
TATCACTGAAAAATTTATCTCTTGGTAAATTGCTTGCTCAATTGTTTATGATAACAGAGAATTTTGGCATGGAAACTCAG
CCGCAATTATTACTGTTGCAAAAGACTATGATAGTAGTTGAGGGAATAAGCAGAGATCTAAATCCTGATATTAATATATG
GGAATTAATGAAACCATGGATGAAAAAATGGGCAGCAAAAAATATTAGTATTGAGGCAAGATTATTTAGATCATTGTCTA
GCATTTTAAAACAATTAGTTAATTATTAA

Upstream 100 bases:

>100_bases
AACAAGACTTTTGTCAAATAATTAATAGCGTAGGATTTCAGAACGTTAAGTTTTGCAATTTAACTTTTGGCATTGTTGCA
ATACACTCAGCTCTCAAATT

Downstream 100 bases:

>100_bases
CCTAAGTTCGATATAATAGATTTCTTTCGAAACTAGAGAATGATGTAGAATAGTGTTATAAAGATCTGATTTGAGGTAAT
AATGAAATTTGATCAAATTA

Product: ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MINFIKNVIALIGVLAIVSKYKILQNIDCTNLSFLFRSIIKLINFLFYPICLVYRNNQQYSDRLTNCLKELGPAYIKLGQ
TLSTRPDLIGSNMADSLKILQDKLPPFSTQEAKKIITACLKMEIDQVFSFFPKEVVVAASIAQVYKAQLVTGEEVAVKVL
RPNVQAEYLENIETLHFIAKILLKFLPKVKRLKLVEVIDILRNSMVSELDMRIEAASYSEMLDNFISDRNTYIPKVYWEF
TAEKVLTVEWIHGLPIRERQLIINQGTSLKDLSEKVVLMFFNQAYRDGFFHADLHHGNVLVLPDGKIGLVDFGIIGRLSE
KDRIAVAEILYAFLERDYKKVAKIHLQAGYIPENTNLDLFSQYCRSIAEPIIGLSLKNLSLGKLLAQLFMITENFGMETQ
PQLLLLQKTMIVVEGISRDLNPDINIWELMKPWMKKWAAKNISIEARLFRSLSSILKQLVNY

Sequences:

>Translated_462_residues
MINFIKNVIALIGVLAIVSKYKILQNIDCTNLSFLFRSIIKLINFLFYPICLVYRNNQQYSDRLTNCLKELGPAYIKLGQ
TLSTRPDLIGSNMADSLKILQDKLPPFSTQEAKKIITACLKMEIDQVFSFFPKEVVVAASIAQVYKAQLVTGEEVAVKVL
RPNVQAEYLENIETLHFIAKILLKFLPKVKRLKLVEVIDILRNSMVSELDMRIEAASYSEMLDNFISDRNTYIPKVYWEF
TAEKVLTVEWIHGLPIRERQLIINQGTSLKDLSEKVVLMFFNQAYRDGFFHADLHHGNVLVLPDGKIGLVDFGIIGRLSE
KDRIAVAEILYAFLERDYKKVAKIHLQAGYIPENTNLDLFSQYCRSIAEPIIGLSLKNLSLGKLLAQLFMITENFGMETQ
PQLLLLQKTMIVVEGISRDLNPDINIWELMKPWMKKWAAKNISIEARLFRSLSSILKQLVNY
>Mature_462_residues
MINFIKNVIALIGVLAIVSKYKILQNIDCTNLSFLFRSIIKLINFLFYPICLVYRNNQQYSDRLTNCLKELGPAYIKLGQ
TLSTRPDLIGSNMADSLKILQDKLPPFSTQEAKKIITACLKMEIDQVFSFFPKEVVVAASIAQVYKAQLVTGEEVAVKVL
RPNVQAEYLENIETLHFIAKILLKFLPKVKRLKLVEVIDILRNSMVSELDMRIEAASYSEMLDNFISDRNTYIPKVYWEF
TAEKVLTVEWIHGLPIRERQLIINQGTSLKDLSEKVVLMFFNQAYRDGFFHADLHHGNVLVLPDGKIGLVDFGIIGRLSE
KDRIAVAEILYAFLERDYKKVAKIHLQAGYIPENTNLDLFSQYCRSIAEPIIGLSLKNLSLGKLLAQLFMITENFGMETQ
PQLLLLQKTMIVVEGISRDLNPDINIWELMKPWMKKWAAKNISIEARLFRSLSSILKQLVNY

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=285, Percent_Identity=29.4736842105263, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI40254938, Length=291, Percent_Identity=28.5223367697594, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI217035081, Length=282, Percent_Identity=26.241134751773, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI32261307, Length=349, Percent_Identity=23.7822349570201, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI2367309, Length=393, Percent_Identity=37.9134860050891, Blast_Score=286, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17559152, Length=309, Percent_Identity=28.4789644012945, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6325148, Length=482, Percent_Identity=23.2365145228216, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323282, Length=261, Percent_Identity=26.0536398467433, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321319, Length=295, Percent_Identity=25.0847457627119, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24662575, Length=278, Percent_Identity=30.5755395683453, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI22024280, Length=279, Percent_Identity=27.5985663082437, Blast_Score=115, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 52946; Mature: 52946

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA