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The map label for this gene is frr

Identifier: 189025830

GI number: 189025830

Start: 657053

End: 657604

Strand: Reverse

Name: frr

Synonym: TPASS_0604

Alternate gene names: 189025830

Gene position: 657604-657053 (Counterclockwise)

Preceding gene: 189025831

Following gene: 189025829

Centisome position: 57.71

GC content: 52.9

Gene sequence:

>552_bases
ATGGGTATCGCTGAGTGCTATGAGCAGAAGATGAAGAAGTCCCTCTCAGCGCTGCAGGAGGGTTTTAACACGCTGCGTAC
TGAACGTGCGACTGCACATTTGCTTGATCAGATTACTGTCGACTACTATCAGCAACCAACCGCGCTTAGTCAGGTGGCTA
CCGTTTCGGTACCCGAGGCGCGTTTGATCATTATCCAGCCTTGGGATAAAACGCTCCTTGCGGATATCGAGCGTGCAATT
TTAAAGTCAAAATTGTCGCTCAATCCCTCCAACGACGGCAAGGTTATTCGTCTAGTGATTCCTCCACTTACCCAGGAGCG
AAGGAAGGAGCTTGTCAGGCAGGCGCGCGCGTTAGCCGAGCAGGCGCGCGTTGCTATTCGCAATATTCGCCGTGAGGGAA
TCGAGGAAGCAAAGCGCGGGCATAAGGAGGGACTGCTAAGCGAGGATGCACTGAAAGCAGCAGAAGAGGCCTTCCAAAAA
GCGACTGACGCTTCTGTCGCAGACGTTGCACGGTACTTGGCCGAGAAGGAAAAGGATATCCTGGAAGGTTGA

Upstream 100 bases:

>100_bases
GGAAGCACGGATAGATCCTGCCACCCTGCAGGATGGGGAGCAAGCAGGCGTGGGGGAGCTCGTGCTTCTCTCTTGCCGCA
CTGTGTTGTGAGGGGAAAAG

Downstream 100 bases:

>100_bases
GTGCCGTGCAGCACGTGGCCATCATCATGGATGGAAACGGGAGATGGGCGGAAAGGAGAGGGTTGCGGCGCAGTGCAGGG
CACCGGCGGGGGCTGCAGAC

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MGIAECYEQKMKKSLSALQEGFNTLRTERATAHLLDQITVDYYQQPTALSQVATVSVPEARLIIIQPWDKTLLADIERAI
LKSKLSLNPSNDGKVIRLVIPPLTQERRKELVRQARALAEQARVAIRNIRREGIEEAKRGHKEGLLSEDALKAAEEAFQK
ATDASVADVARYLAEKEKDILEG

Sequences:

>Translated_183_residues
MGIAECYEQKMKKSLSALQEGFNTLRTERATAHLLDQITVDYYQQPTALSQVATVSVPEARLIIIQPWDKTLLADIERAI
LKSKLSLNPSNDGKVIRLVIPPLTQERRKELVRQARALAEQARVAIRNIRREGIEEAKRGHKEGLLSEDALKAAEEAFQK
ATDASVADVARYLAEKEKDILEG
>Mature_182_residues
GIAECYEQKMKKSLSALQEGFNTLRTERATAHLLDQITVDYYQQPTALSQVATVSVPEARLIIIQPWDKTLLADIERAIL
KSKLSLNPSNDGKVIRLVIPPLTQERRKELVRQARALAEQARVAIRNIRREGIEEAKRGHKEGLLSEDALKAAEEAFQKA
TDASVADVARYLAEKEKDILEG

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family

Homologues:

Organism=Homo sapiens, GI20270317, Length=176, Percent_Identity=30.1136363636364, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI291042689, Length=149, Percent_Identity=30.8724832214765, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786368, Length=175, Percent_Identity=40.5714285714286, Blast_Score=137, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24661488, Length=174, Percent_Identity=29.8850574712644, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): RRF_TREPA (O83613)

Other databases:

- EMBL:   AE000520
- PIR:   F71304
- RefSeq:   NP_219042.1
- ProteinModelPortal:   O83613
- SMR:   O83613
- IntAct:   O83613
- GeneID:   2611533
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0604
- NMPDR:   fig|243276.1.peg.601
- TIGR:   TP_0604
- HOGENOM:   HBG533975
- OMA:   YYGAETP
- ProtClustDB:   PRK00083
- BioCyc:   TPAL243276:TP_0604-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00040
- InterPro:   IPR002661
- InterPro:   IPR015998
- PANTHER:   PTHR20982
- TIGRFAMs:   TIGR00496

Pfam domain/function: PF01765 RRF; SSF55194 Ribosome_recyc_fac

EC number: NA

Molecular weight: Translated: 20504; Mature: 20373

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIAECYEQKMKKSLSALQEGFNTLRTERATAHLLDQITVDYYQQPTALSQVATVSVPEA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCC
RLIIIQPWDKTLLADIERAILKSKLSLNPSNDGKVIRLVIPPLTQERRKELVRQARALAE
EEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
QARVAIRNIRREGIEEAKRGHKEGLLSEDALKAAEEAFQKATDASVADVARYLAEKEKDI
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LEG
CCC
>Mature Secondary Structure 
GIAECYEQKMKKSLSALQEGFNTLRTERATAHLLDQITVDYYQQPTALSQVATVSVPEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCC
RLIIIQPWDKTLLADIERAILKSKLSLNPSNDGKVIRLVIPPLTQERRKELVRQARALAE
EEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
QARVAIRNIRREGIEEAKRGHKEGLLSEDALKAAEEAFQKATDASVADVARYLAEKEKDI
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LEG
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876