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The map label for this gene is uppS

Identifier: 189025829

GI number: 189025829

Start: 656361

End: 657047

Strand: Reverse

Name: uppS

Synonym: TPASS_0603

Alternate gene names: 189025829

Gene position: 657047-656361 (Counterclockwise)

Preceding gene: 189025830

Following gene: 189025828

Centisome position: 57.66

GC content: 52.98

Gene sequence:

>687_bases
GTGCAGCACGTGGCCATCATCATGGATGGAAACGGGAGATGGGCGGAAAGGAGAGGGTTGCGGCGCAGTGCAGGGCACCG
GCGGGGGCTGCAGACAGCGCGAGAGATTGTCGCGGCGCTGTGCGCGATTCGGGTGCCTTTTGTTACTCTGTATGTGTTTT
CTACTGAAAACTGGAAGCGCTCTGCGCATGAAGTGCATTTCTTGATGAATTTAATCAGGTGGTATTTGAAAAAGGAGATG
TCATTCTATGTGGAGCATGCCATTCGCGTAGTGCACCTGGGTTGTGCGCAGACACTTCCGCCTGATGTGCGCAGCCAGAT
AGAGTATGTTGTGGAACGCACTCGGTCTCATCGGGGAACTACTGTTGCGCTTGCTATAAATTATGGGGGAAAAGATGAAA
TTTTACGTGCGGTAAAAAAGGTTTTGTGCAGCACTTCGTGCCCGGATGGTGAGCTTCTCACCGAAGAAGCTTTCGGCGCG
TGCCTTGATGCGCCGCAGTTGCCGAGTGTCGACTTTCTCATCAGAACAGGGGGTCAGCAACGCATGAGTAATTTTTTGCT
TTGGCAAAGCGCGTACGCGGAGTTCTATTTTACCGATATCCTGTGGCCTGACTTTCGGGTAGAAGACATGCTGCGCGCCC
TGGATGAGTATCGCCTGCGCACGCGTACCTTTGGGGGTTTGGAATGA

Upstream 100 bases:

>100_bases
CAGCAGAAGAGGCCTTCCAAAAAGCGACTGACGCTTCTGTCGCAGACGTTGCACGGTACTTGGCCGAGAAGGAAAAGGAT
ATCCTGGAAGGTTGAGTGCC

Downstream 100 bases:

>100_bases
GCGCGGAAATAAAGAGGCTGTTAATCTTTTTTTTCGGCGTTCCAACTATTCTTATGTTGGTATATGCGGCACCGCATGCA
CACTTCCTAGCGTTCCATTT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MQHVAIIMDGNGRWAERRGLRRSAGHRRGLQTAREIVAALCAIRVPFVTLYVFSTENWKRSAHEVHFLMNLIRWYLKKEM
SFYVEHAIRVVHLGCAQTLPPDVRSQIEYVVERTRSHRGTTVALAINYGGKDEILRAVKKVLCSTSCPDGELLTEEAFGA
CLDAPQLPSVDFLIRTGGQQRMSNFLLWQSAYAEFYFTDILWPDFRVEDMLRALDEYRLRTRTFGGLE

Sequences:

>Translated_228_residues
MQHVAIIMDGNGRWAERRGLRRSAGHRRGLQTAREIVAALCAIRVPFVTLYVFSTENWKRSAHEVHFLMNLIRWYLKKEM
SFYVEHAIRVVHLGCAQTLPPDVRSQIEYVVERTRSHRGTTVALAINYGGKDEILRAVKKVLCSTSCPDGELLTEEAFGA
CLDAPQLPSVDFLIRTGGQQRMSNFLLWQSAYAEFYFTDILWPDFRVEDMLRALDEYRLRTRTFGGLE
>Mature_228_residues
MQHVAIIMDGNGRWAERRGLRRSAGHRRGLQTAREIVAALCAIRVPFVTLYVFSTENWKRSAHEVHFLMNLIRWYLKKEM
SFYVEHAIRVVHLGCAQTLPPDVRSQIEYVVERTRSHRGTTVALAINYGGKDEILRAVKKVLCSTSCPDGELLTEEAFGA
CLDAPQLPSVDFLIRTGGQQRMSNFLLWQSAYAEFYFTDILWPDFRVEDMLRALDEYRLRTRTFGGLE

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=30.9417040358744, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=30.9417040358744, Blast_Score=119, Evalue=2e-27,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=41.5584415584416, Blast_Score=177, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=30.5309734513274, Blast_Score=103, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6319474, Length=209, Percent_Identity=30.1435406698565, Blast_Score=105, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323748, Length=217, Percent_Identity=29.9539170506912, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI18857969, Length=206, Percent_Identity=33.495145631068, Blast_Score=118, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_TREPA (O83612)

Other databases:

- EMBL:   AE000520
- PIR:   E71304
- RefSeq:   NP_219041.1
- ProteinModelPortal:   O83612
- SMR:   O83612
- IntAct:   O83612
- GeneID:   2611532
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0603
- NMPDR:   fig|243276.1.peg.600
- TIGR:   TP_0603
- HOGENOM:   HBG627837
- OMA:   FLWRIAY
- ProtClustDB:   PRK14833
- BioCyc:   TPAL243276:TP_0603-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 26271; Mature: 26271

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 9-9

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHVAIIMDGNGRWAERRGLRRSAGHRRGLQTAREIVAALCAIRVPFVTLYVFSTENWKR
CCEEEEEECCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHH
SAHEVHFLMNLIRWYLKKEMSFYVEHAIRVVHLGCAQTLPPDVRSQIEYVVERTRSHRGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
TVALAINYGGKDEILRAVKKVLCSTSCPDGELLTEEAFGACLDAPQLPSVDFLIRTGGQQ
EEEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHEECCCHH
RMSNFLLWQSAYAEFYFTDILWPDFRVEDMLRALDEYRLRTRTFGGLE
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQHVAIIMDGNGRWAERRGLRRSAGHRRGLQTAREIVAALCAIRVPFVTLYVFSTENWKR
CCEEEEEECCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHH
SAHEVHFLMNLIRWYLKKEMSFYVEHAIRVVHLGCAQTLPPDVRSQIEYVVERTRSHRGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
TVALAINYGGKDEILRAVKKVLCSTSCPDGELLTEEAFGACLDAPQLPSVDFLIRTGGQQ
EEEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHEECCCHH
RMSNFLLWQSAYAEFYFTDILWPDFRVEDMLRALDEYRLRTRTFGGLE
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876