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The map label for this gene is hisD1 [H]

Identifier: 188586512

GI number: 188586512

Start: 1991309

End: 1992595

Strand: Reverse

Name: hisD1 [H]

Synonym: Nther_1898

Alternate gene names: 188586512

Gene position: 1992595-1991309 (Counterclockwise)

Preceding gene: 188586513

Following gene: 188586511

Centisome position: 62.95

GC content: 39.08

Gene sequence:

>1287_bases
ATGTATAAATTAAAAGAAGCTAAACTAGCTAGCCAAAAGGCAAAATTTGAAGATGTGGAAACTAGAAACACAGTGACCAA
GATAATAGATCAAGTAAGGACAAATGGAGATAAAGCACTATTTGAACTGACTCAATCTTTGGATAATTGCTCTCTATCCA
AATTGGAAGTTAGCCAAGAATATATGAAACAATGTTACGACAATTTAACGGATAAAACTAAAGAAGCGCTTAATTTTGCT
AAAGACCAGATTGAATTTTTTGCAAGTCAGCAACTTGCAGGATTTAAAGAAATAGAATGTGAAAATATCCCTGGAGTAAA
ACTTGGTTACAAGATCAAACCGATTTCATCATGCGGTTGTTATGTACCTGCTGGTAGATATCCCTTACCTTCATCTGCTT
TGATGTCTATAGTACCTGCCAGGGTAGCGGGAGTTGAGAGAATTGTGGCTATTGCTCCACCTGTCAGGAAATATGGTGGA
ATCCACCCGGAATTACTGGCAGCTATGTATCTAGCAGGGGTAGATGAGGTTTATATTGTAGGCGGTGCTCATGGAATTGC
TGCTTTGGCATTGGGCACTGAGACAATATCTAAGGTTGATTTTATTGTGGGACCAGGAAATAAATACGTGACTGAAGCTA
AGCGACAATTGAATGGTATTGTTGGAATAGATCAATTGGCTGGCCCAAGTGAAGTGTTGATAATTGCCGATAATACTGCC
TCTTCAACTAATGTTGCTGCAGATTTATTGGCACAAGCGGAACACGACCCCGATGCCGTTTGTGTACTAGTGACCACTTC
AGAACAACTAGCTAAAGAAGTGAATCAGGAAATTCATCGCCAGCTAGATGAATTGTTAACCTGGGAAACAGCAGCTAAAA
GTTGGGAAGATTACGGAGAAATCATACTAGTGGATAATCTCGACCAAGCTATTGAAATTTCTGATCAGATGGCACCGGAA
CATTTACAATTGATGACCGATAATAACTCAAATATTATGGAGATGGTTAATCACTATGGTTCCTTATTTGTTGGAGAATG
GGCCTCGGTAGCTTTTGGAGATTATGTATCCGGTACAAACCATATTTTGCCAACGGGTAATAGTGCCAGGTTTTCAAGTG
GGTTATCTGTAGGGAAGTTCTTAAAGATGTCTTCATATCAAGTTTTAACAGAAACGGGTGCTCATGAATTATCAGATAAA
TGTATGCACTTAGCTGAGTTAGAGGGACTTGAAGCACATAAAAAGTCAGCTGAGTTACGAGCTGACAACAATAACCCAAA
GGATTAA

Upstream 100 bases:

>100_bases
ACCTTGTGTAGTTACTTGGGAAATGAAAGATGGTAATCCGGATTTTCTAAAATGGATTGATGATGAAGTGAATCAATGCT
AAAACAAAATGGGGGATACT

Downstream 100 bases:

>100_bases
TTAGTTAAGTGATATCTTTAAGTAATTTTTGTATCTTATAAGCAATATTGAGTATTATCAGTAAGGGTCAGATATAGACC
CTTACTTTTTATTTGTTGAT

Product: Histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 1 [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MYKLKEAKLASQKAKFEDVETRNTVTKIIDQVRTNGDKALFELTQSLDNCSLSKLEVSQEYMKQCYDNLTDKTKEALNFA
KDQIEFFASQQLAGFKEIECENIPGVKLGYKIKPISSCGCYVPAGRYPLPSSALMSIVPARVAGVERIVAIAPPVRKYGG
IHPELLAAMYLAGVDEVYIVGGAHGIAALALGTETISKVDFIVGPGNKYVTEAKRQLNGIVGIDQLAGPSEVLIIADNTA
SSTNVAADLLAQAEHDPDAVCVLVTTSEQLAKEVNQEIHRQLDELLTWETAAKSWEDYGEIILVDNLDQAIEISDQMAPE
HLQLMTDNNSNIMEMVNHYGSLFVGEWASVAFGDYVSGTNHILPTGNSARFSSGLSVGKFLKMSSYQVLTETGAHELSDK
CMHLAELEGLEAHKKSAELRADNNNPKD

Sequences:

>Translated_428_residues
MYKLKEAKLASQKAKFEDVETRNTVTKIIDQVRTNGDKALFELTQSLDNCSLSKLEVSQEYMKQCYDNLTDKTKEALNFA
KDQIEFFASQQLAGFKEIECENIPGVKLGYKIKPISSCGCYVPAGRYPLPSSALMSIVPARVAGVERIVAIAPPVRKYGG
IHPELLAAMYLAGVDEVYIVGGAHGIAALALGTETISKVDFIVGPGNKYVTEAKRQLNGIVGIDQLAGPSEVLIIADNTA
SSTNVAADLLAQAEHDPDAVCVLVTTSEQLAKEVNQEIHRQLDELLTWETAAKSWEDYGEIILVDNLDQAIEISDQMAPE
HLQLMTDNNSNIMEMVNHYGSLFVGEWASVAFGDYVSGTNHILPTGNSARFSSGLSVGKFLKMSSYQVLTETGAHELSDK
CMHLAELEGLEAHKKSAELRADNNNPKD
>Mature_428_residues
MYKLKEAKLASQKAKFEDVETRNTVTKIIDQVRTNGDKALFELTQSLDNCSLSKLEVSQEYMKQCYDNLTDKTKEALNFA
KDQIEFFASQQLAGFKEIECENIPGVKLGYKIKPISSCGCYVPAGRYPLPSSALMSIVPARVAGVERIVAIAPPVRKYGG
IHPELLAAMYLAGVDEVYIVGGAHGIAALALGTETISKVDFIVGPGNKYVTEAKRQLNGIVGIDQLAGPSEVLIIADNTA
SSTNVAADLLAQAEHDPDAVCVLVTTSEQLAKEVNQEIHRQLDELLTWETAAKSWEDYGEIILVDNLDQAIEISDQMAPE
HLQLMTDNNSNIMEMVNHYGSLFVGEWASVAFGDYVSGTNHILPTGNSARFSSGLSVGKFLKMSSYQVLTETGAHELSDK
CMHLAELEGLEAHKKSAELRADNNNPKD

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=404, Percent_Identity=40.8415841584158, Blast_Score=295, Evalue=5e-81,
Organism=Saccharomyces cerevisiae, GI6319819, Length=407, Percent_Identity=38.0835380835381, Blast_Score=267, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46691; Mature: 46691

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKLKEAKLASQKAKFEDVETRNTVTKIIDQVRTNGDKALFELTQSLDNCSLSKLEVSQE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHH
YMKQCYDNLTDKTKEALNFAKDQIEFFASQQLAGFKEIECENIPGVKLGYKIKPISSCGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCEECEEECCCCCCCC
YVPAGRYPLPSSALMSIVPARVAGVERIVAIAPPVRKYGGIHPELLAAMYLAGVDEVYIV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCHHHHCCCCHHHHHHHHHHCCCEEEEE
GGAHGIAALALGTETISKVDFIVGPGNKYVTEAKRQLNGIVGIDQLAGPSEVLIIADNTA
ECCHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCCHHHCCCCCCEEEEECCCC
SSTNVAADLLAQAEHDPDAVCVLVTTSEQLAKEVNQEIHRQLDELLTWETAAKSWEDYGE
CCHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCC
IILVDNLDQAIEISDQMAPEHLQLMTDNNSNIMEMVNHYGSLFVGEWASVAFGDYVSGTN
EEEEECCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCEEHHCHHHHHHHHHCCCCC
HILPTGNSARFSSGLSVGKFLKMSSYQVLTETGAHELSDKCMHLAELEGLEAHKKSAELR
CEEECCCCCHHHCCCCHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHCCCEE
ADNNNPKD
CCCCCCCC
>Mature Secondary Structure
MYKLKEAKLASQKAKFEDVETRNTVTKIIDQVRTNGDKALFELTQSLDNCSLSKLEVSQE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHH
YMKQCYDNLTDKTKEALNFAKDQIEFFASQQLAGFKEIECENIPGVKLGYKIKPISSCGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCEECEEECCCCCCCC
YVPAGRYPLPSSALMSIVPARVAGVERIVAIAPPVRKYGGIHPELLAAMYLAGVDEVYIV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCHHHHCCCCHHHHHHHHHHCCCEEEEE
GGAHGIAALALGTETISKVDFIVGPGNKYVTEAKRQLNGIVGIDQLAGPSEVLIIADNTA
ECCHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCCHHHCCCCCCEEEEECCCC
SSTNVAADLLAQAEHDPDAVCVLVTTSEQLAKEVNQEIHRQLDELLTWETAAKSWEDYGE
CCHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCC
IILVDNLDQAIEISDQMAPEHLQLMTDNNSNIMEMVNHYGSLFVGEWASVAFGDYVSGTN
EEEEECCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCEEHHCHHHHHHHHHCCCCC
HILPTGNSARFSSGLSVGKFLKMSSYQVLTETGAHELSDKCMHLAELEGLEAHKKSAELR
CEEECCCCCHHHCCCCHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHCCCEE
ADNNNPKD
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA