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The map label for this gene is hbd [H]

Identifier: 188586491

GI number: 188586491

Start: 1964130

End: 1964975

Strand: Reverse

Name: hbd [H]

Synonym: Nther_1876

Alternate gene names: 188586491

Gene position: 1964975-1964130 (Counterclockwise)

Preceding gene: 188586492

Following gene: 188586488

Centisome position: 62.07

GC content: 35.58

Gene sequence:

>846_bases
ATGAACAAGGCTTTAGTAGTAGGTGCTGGTACTATGGGTTCTGGAATAGCCCAAGTTTTAGCAACAGCTGGTTGTGAAGT
ATTCTTAAATGATGTAAACAAATCTTTTATAGAAAAAGGTTTGGGTAAAATTGAGAAACAATTGGATAAGCAGGTGTCAA
AAGAAAAGATTGATCTGGCTAAAAAAGAGGAAATAATGAGTAATATAAATACTCATGAAGACCTAAACCAATCAATTGAT
GTCGACATAGTTATTGAAGCTGTTTTGGAAGATATTGAAGTTAAGAAAGAAGTATTCAATAAGATCTCTGAAAATTGTCC
TCCTGAGACAATTTTTGCTACTAATACATCTGCCTTAAGTGTTACTGAAATAGCTAACGAAACAGATAGAAAAGAACAAT
TTATAGGTATTCATTTCTTTAATCCAGCTCCGGTAATGCCTTTAGTTGAAATTGTCAGGGCAAAAACAAGTGATGAGGAA
ATAGTTGAAAAAGGATATGAGTTTGCTAAACAAATTGGAAAAGAACCTTTGATTGTCAATGAAGCTCCGGGTTTTGTAGT
GAATCGAATTCTAGTTCCTATGATAAATGAAGCTGCGTTTGCTGTAATGGAAAATGTGGCCAGCGCAGAAGATATTGATA
AAGGGATGAAGCTTGGTGCCAACCACCCCGTTGGCCCCCTTACTTTGGCAGATATGATAGGTCTTGACGTTTGCCTTGCA
GTAATGGAAACGCTATACGATGAATTTGGAGATCCTAAATATAGACCATGTCCATTGTTAAGAAAACTTGTACGAGCTGG
ATATGTGGGTAAAAAATCAGGAAAAGGATTTTTTGATTATTCCTAA

Upstream 100 bases:

>100_bases
GTGTATGTTTTTCAACTGAGGACCAGAAAGAAGGAATGGAAGCATTTTTAGAAAATAGGAAACCAACTTTTAAAGATAAA
TAAGAAGGGAGGAAATTATT

Downstream 100 bases:

>100_bases
TGGAAGTATTAAATTCCCAAATTAGGCAGAACCATTTCTTAAAAATTACTTACAGGATTGGGTTCTATATTCTAACTATA
GGACTCAATCCTTTTATTTT

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MNKALVVGAGTMGSGIAQVLATAGCEVFLNDVNKSFIEKGLGKIEKQLDKQVSKEKIDLAKKEEIMSNINTHEDLNQSID
VDIVIEAVLEDIEVKKEVFNKISENCPPETIFATNTSALSVTEIANETDRKEQFIGIHFFNPAPVMPLVEIVRAKTSDEE
IVEKGYEFAKQIGKEPLIVNEAPGFVVNRILVPMINEAAFAVMENVASAEDIDKGMKLGANHPVGPLTLADMIGLDVCLA
VMETLYDEFGDPKYRPCPLLRKLVRAGYVGKKSGKGFFDYS

Sequences:

>Translated_281_residues
MNKALVVGAGTMGSGIAQVLATAGCEVFLNDVNKSFIEKGLGKIEKQLDKQVSKEKIDLAKKEEIMSNINTHEDLNQSID
VDIVIEAVLEDIEVKKEVFNKISENCPPETIFATNTSALSVTEIANETDRKEQFIGIHFFNPAPVMPLVEIVRAKTSDEE
IVEKGYEFAKQIGKEPLIVNEAPGFVVNRILVPMINEAAFAVMENVASAEDIDKGMKLGANHPVGPLTLADMIGLDVCLA
VMETLYDEFGDPKYRPCPLLRKLVRAGYVGKKSGKGFFDYS
>Mature_281_residues
MNKALVVGAGTMGSGIAQVLATAGCEVFLNDVNKSFIEKGLGKIEKQLDKQVSKEKIDLAKKEEIMSNINTHEDLNQSID
VDIVIEAVLEDIEVKKEVFNKISENCPPETIFATNTSALSVTEIANETDRKEQFIGIHFFNPAPVMPLVEIVRAKTSDEE
IVEKGYEFAKQIGKEPLIVNEAPGFVVNRILVPMINEAAFAVMENVASAEDIDKGMKLGANHPVGPLTLADMIGLDVCLA
VMETLYDEFGDPKYRPCPLLRKLVRAGYVGKKSGKGFFDYS

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=283, Percent_Identity=40.2826855123675, Blast_Score=214, Evalue=6e-56,
Organism=Homo sapiens, GI296179427, Length=301, Percent_Identity=38.2059800664452, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI20127408, Length=276, Percent_Identity=34.7826086956522, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI68989263, Length=296, Percent_Identity=34.4594594594595, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI261878539, Length=296, Percent_Identity=34.4594594594595, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI115430219, Length=230, Percent_Identity=30, Blast_Score=91, Evalue=9e-19,
Organism=Escherichia coli, GI1787661, Length=276, Percent_Identity=39.8550724637681, Blast_Score=219, Evalue=1e-58,
Organism=Escherichia coli, GI1790281, Length=264, Percent_Identity=36.7424242424242, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788682, Length=259, Percent_Identity=33.5907335907336, Blast_Score=160, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17553560, Length=281, Percent_Identity=38.4341637010676, Blast_Score=211, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=37.6306620209059, Blast_Score=207, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17563036, Length=285, Percent_Identity=35.7894736842105, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25144276, Length=282, Percent_Identity=38.2978723404255, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17508951, Length=282, Percent_Identity=38.2978723404255, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17508953, Length=282, Percent_Identity=38.2978723404255, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=36.5248226950355, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71985923, Length=275, Percent_Identity=33.0909090909091, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=31.0714285714286, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI193203623, Length=202, Percent_Identity=26.7326732673267, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115533614, Length=202, Percent_Identity=26.7326732673267, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921000, Length=277, Percent_Identity=34.2960288808664, Blast_Score=167, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24583077, Length=277, Percent_Identity=34.2960288808664, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24583079, Length=277, Percent_Identity=34.2960288808664, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI45549573, Length=236, Percent_Identity=27.5423728813559, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20129993, Length=219, Percent_Identity=25.5707762557078, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30796; Mature: 30796

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKALVVGAGTMGSGIAQVLATAGCEVFLNDVNKSFIEKGLGKIEKQLDKQVSKEKIDLA
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKEEIMSNINTHEDLNQSIDVDIVIEAVLEDIEVKKEVFNKISENCPPETIFATNTSALS
HHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHH
VTEIANETDRKEQFIGIHFFNPAPVMPLVEIVRAKTSDEEIVEKGYEFAKQIGKEPLIVN
HHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEE
EAPGFVVNRILVPMINEAAFAVMENVASAEDIDKGMKLGANHPVGPLTLADMIGLDVCLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
VMETLYDEFGDPKYRPCPLLRKLVRAGYVGKKSGKGFFDYS
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNKALVVGAGTMGSGIAQVLATAGCEVFLNDVNKSFIEKGLGKIEKQLDKQVSKEKIDLA
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKEEIMSNINTHEDLNQSIDVDIVIEAVLEDIEVKKEVFNKISENCPPETIFATNTSALS
HHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHH
VTEIANETDRKEQFIGIHFFNPAPVMPLVEIVRAKTSDEEIVEKGYEFAKQIGKEPLIVN
HHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEE
EAPGFVVNRILVPMINEAAFAVMENVASAEDIDKGMKLGANHPVGPLTLADMIGLDVCLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
VMETLYDEFGDPKYRPCPLLRKLVRAGYVGKKSGKGFFDYS
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]