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The map label for this gene is mdh [H]

Identifier: 188586448

GI number: 188586448

Start: 1907680

End: 1908828

Strand: Reverse

Name: mdh [H]

Synonym: Nther_1833

Alternate gene names: 188586448

Gene position: 1908828-1907680 (Counterclockwise)

Preceding gene: 188586449

Following gene: 188586447

Centisome position: 60.3

GC content: 40.03

Gene sequence:

>1149_bases
GTGATTTTTAACTTATTACCCAGACCTCCAGTTATTTTTGGGAATGGAGCGTCTTATCGAACAGGGATGAAAGTTAAAGA
ACTAGGCTGTGATAAAGTTCTGTTAGTTTTTGATCAAGGCATAAAAAATGCAGGTATTGCAGATAAAATCCATGATAATT
TATCAAAAGCTGGTATTCAGGTGATTACCTTTGATGGAGTTGTATCAGACCCTTCCGATGATGTGGTGGAAGAGGGGGCA
AAACTAGCACGTGAAAACAAGGTTCAAGGAGTGATCGGTTTAGGTGGTGGGAGTAGTTTAGACGCAGCCAAAGCTATCAA
TATTTTATTGACCAATTCATCTCCTGTTTCTCAGTATTACGGTATAAATCCACCCATGAATAAAGTGAAGCCTCTAGTAC
TAATACCGACAACAGCGGGAACAGGCTCGGAAATGACCACAGTATCTATGGTTAGTGATACTGAAAAGAACCTCAAGATG
AATATTTTATCTCCTAACTGCCTTCCTACAACTGCAATTGTGGATCCGGAACTTACTTTGAGATTACCTTCCCAGGTAAC
TGCTGAGACGGGAATCGATACTTTATCCCATGCCGTGGAATCATATCTATCTAATCAATCTAATTACATGACAGATTTGT
TAAACGAGCAATCAATAAAATTAACCTTTGATAATTTACCTCAGGCCGTAAAAGATGAAAATGATTTGACTGCACGAGAA
AACATGAGTTTTTCGTCAATGATAGCCGGGATAGCATTTAGTAATTCCATGGTTCATCTAGGTCATGCCATAGCTCATGC
CCTTGGAACCGCTGCTAAACTTTCCCATGGTCTTGGCTGTGCCCTGGCTCTACCACTGACTATTGAATATTTAAGCCAAG
AAGTACCTGAAAGAGTAAAGAAAATCGGTGATATTATGGGGTTAGAGTTAGACGAAGGACTTTCTTCTGAAGATCTCGGT
CAAAATGTTGGTGATAATATTAGATATTTCATTAGGGACCTGGGTTTACCGGGAACTATAGTGGAAGCTGGACTAGATGA
AGAGACTCTCAAGCAAGTTGCCAAGTTGACAGCTATAGACAATAGTCAGATTTTTGCTCCCAAATCAGCGAGTTCTCAAG
AGGTGATGGAGTTATTTGGTAAGCCCTAG

Upstream 100 bases:

>100_bases
ATGAAAATAAACATCTAAATATTTAGGAAACTTTAAACATAGTTTTAAAATATACCTAAAAATTACAGAAATATCAAAAA
ATTAAAGGGAGGGAGTGCAT

Downstream 100 bases:

>100_bases
TGTTATTTAGCCCAAGTGAGTATTTTGTAAAGCCTTCTAAGACTTAAGATGAATACAAATATTAAGGGTGCCTATAGGAG
GGGAGTTTTTATGAATCAAG

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MIFNLLPRPPVIFGNGASYRTGMKVKELGCDKVLLVFDQGIKNAGIADKIHDNLSKAGIQVITFDGVVSDPSDDVVEEGA
KLARENKVQGVIGLGGGSSLDAAKAINILLTNSSPVSQYYGINPPMNKVKPLVLIPTTAGTGSEMTTVSMVSDTEKNLKM
NILSPNCLPTTAIVDPELTLRLPSQVTAETGIDTLSHAVESYLSNQSNYMTDLLNEQSIKLTFDNLPQAVKDENDLTARE
NMSFSSMIAGIAFSNSMVHLGHAIAHALGTAAKLSHGLGCALALPLTIEYLSQEVPERVKKIGDIMGLELDEGLSSEDLG
QNVGDNIRYFIRDLGLPGTIVEAGLDEETLKQVAKLTAIDNSQIFAPKSASSQEVMELFGKP

Sequences:

>Translated_382_residues
MIFNLLPRPPVIFGNGASYRTGMKVKELGCDKVLLVFDQGIKNAGIADKIHDNLSKAGIQVITFDGVVSDPSDDVVEEGA
KLARENKVQGVIGLGGGSSLDAAKAINILLTNSSPVSQYYGINPPMNKVKPLVLIPTTAGTGSEMTTVSMVSDTEKNLKM
NILSPNCLPTTAIVDPELTLRLPSQVTAETGIDTLSHAVESYLSNQSNYMTDLLNEQSIKLTFDNLPQAVKDENDLTARE
NMSFSSMIAGIAFSNSMVHLGHAIAHALGTAAKLSHGLGCALALPLTIEYLSQEVPERVKKIGDIMGLELDEGLSSEDLG
QNVGDNIRYFIRDLGLPGTIVEAGLDEETLKQVAKLTAIDNSQIFAPKSASSQEVMELFGKP
>Mature_382_residues
MIFNLLPRPPVIFGNGASYRTGMKVKELGCDKVLLVFDQGIKNAGIADKIHDNLSKAGIQVITFDGVVSDPSDDVVEEGA
KLARENKVQGVIGLGGGSSLDAAKAINILLTNSSPVSQYYGINPPMNKVKPLVLIPTTAGTGSEMTTVSMVSDTEKNLKM
NILSPNCLPTTAIVDPELTLRLPSQVTAETGIDTLSHAVESYLSNQSNYMTDLLNEQSIKLTFDNLPQAVKDENDLTARE
NMSFSSMIAGIAFSNSMVHLGHAIAHALGTAAKLSHGLGCALALPLTIEYLSQEVPERVKKIGDIMGLELDEGLSSEDLG
QNVGDNIRYFIRDLGLPGTIVEAGLDEETLKQVAKLTAIDNSQIFAPKSASSQEVMELFGKP

Specific function: Fucose metabolism; fourth step. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=410, Percent_Identity=28.0487804878049, Blast_Score=152, Evalue=4e-37,
Organism=Escherichia coli, GI1789163, Length=369, Percent_Identity=30.8943089430894, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI48994951, Length=355, Percent_Identity=29.5774647887324, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI87082107, Length=373, Percent_Identity=32.7077747989276, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI1787493, Length=385, Percent_Identity=29.0909090909091, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1789386, Length=366, Percent_Identity=25.4098360655738, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17537053, Length=412, Percent_Identity=26.6990291262136, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6321181, Length=374, Percent_Identity=33.1550802139037, Blast_Score=200, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24657991, Length=412, Percent_Identity=26.6990291262136, Blast_Score=144, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 40756; Mature: 40756

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFNLLPRPPVIFGNGASYRTGMKVKELGCDKVLLVFDQGIKNAGIADKIHDNLSKAGIQ
CCCCCCCCCCEEECCCCCCCCCCCHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCEE
VITFDGVVSDPSDDVVEEGAKLARENKVQGVIGLGGGSSLDAAKAINILLTNSSPVSQYY
EEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHEEEEEEECCCCHHHHC
GINPPMNKVKPLVLIPTTAGTGSEMTTVSMVSDTEKNLKMNILSPNCLPTTAIVDPELTL
CCCCCHHHCCCEEEEECCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCEEEECCCEEE
RLPSQVTAETGIDTLSHAVESYLSNQSNYMTDLLNEQSIKLTFDNLPQAVKDENDLTARE
ECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEHHHCCHHHCCCCCCCHHH
NMSFSSMIAGIAFSNSMVHLGHAIAHALGTAAKLSHGLGCALALPLTIEYLSQEVPERVK
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHH
KIGDIMGLELDEGLSSEDLGQNVGDNIRYFIRDLGLPGTIVEAGLDEETLKQVAKLTAID
HHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHCC
NSQIFAPKSASSQEVMELFGKP
CCEEECCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MIFNLLPRPPVIFGNGASYRTGMKVKELGCDKVLLVFDQGIKNAGIADKIHDNLSKAGIQ
CCCCCCCCCCEEECCCCCCCCCCCHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCEE
VITFDGVVSDPSDDVVEEGAKLARENKVQGVIGLGGGSSLDAAKAINILLTNSSPVSQYY
EEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHEEEEEEECCCCHHHHC
GINPPMNKVKPLVLIPTTAGTGSEMTTVSMVSDTEKNLKMNILSPNCLPTTAIVDPELTL
CCCCCHHHCCCEEEEECCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCEEEECCCEEE
RLPSQVTAETGIDTLSHAVESYLSNQSNYMTDLLNEQSIKLTFDNLPQAVKDENDLTARE
ECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEHHHCCHHHCCCCCCCHHH
NMSFSSMIAGIAFSNSMVHLGHAIAHALGTAAKLSHGLGCALALPLTIEYLSQEVPERVK
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHH
KIGDIMGLELDEGLSSEDLGQNVGDNIRYFIRDLGLPGTIVEAGLDEETLKQVAKLTAID
HHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHCC
NSQIFAPKSASSQEVMELFGKP
CCEEECCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]