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The map label for this gene is ispH [H]

Identifier: 188586255

GI number: 188586255

Start: 1718111

End: 1720228

Strand: Reverse

Name: ispH [H]

Synonym: Nther_1638

Alternate gene names: 188586255

Gene position: 1720228-1718111 (Counterclockwise)

Preceding gene: 188586256

Following gene: 188586254

Centisome position: 54.34

GC content: 35.22

Gene sequence:

>2118_bases
TTGGAAATATTGGTTGCAAAAGGTGCTGGTTTCTGTAGCGGTGTTAATAGAGCCTTAGATAAGACAATCCAAGCTGTACA
AACTGATACATCACGGGACATTCAAGTTTTTACCCTTGGCCCCATTGTACATAATAAAGAGGTTATACAAAACTTAACAG
AAAAAGGAATAGGTATTATCGAAAATTTAACCCAGCTCCAATCGAAGAAATGTTTAAGTGAAGAAACTAATAATTATGTC
GTTATTAGAAGTCATGGAGTTGGACCGGAAACTTTTAAGATGCTGAATAATTTAAGTAATACGGATGTGATTGACGCTAC
TTGTCCTTTTGTTAGGAAGGTACAACAGAAAGCAAGTAAATTATATCAAGATGGGTATCAAATTTTCATAGTAGGTGATC
CTAATCATCCGGAAGTGAAAGGAATTAAAGAATGGACTGATAATAATGCCATTGTGATTGAAAAACCTGAACAAGTTAAT
GATATAGAAATATCTAATAAAACTGCTGTAGTTGCTCAAACTACATTAAGAGAAGAAAAATTTAATGAAATTGTGGAAAA
AATACTTGATAGAAACCCAAATACAATAGTTCATAACACTATATGTGATGCCACTCAAAAACGACAAACTGCCACTAAAG
AGTTAGCAGGGCAAGTGGATGTCATGATTGTCGTTGGAGGATATAACAGCTCAAATACCAAAAAACTAAAAGAGTTAGCT
GTCAAGGAAGGTGTACCTACTTATCATATTGAGACAGCTAAGGAACTAAAAACAGATTGGTTTTTGGGCTGTAAAAAGAT
AGGTGTGACGGCAGGGGCCTCGACACCTGATTGGACTATAAAGGAGGTAGTTGGTAAAATGAGAGAATTTGAAGAGCAAA
ATGAAAACCTTAATACTAATTCAGATGAGTCAACTCAAGAAAGCCAAGATGAATTAATGAAAGCAACAGAAGATTCGGCT
GACAAACTTGACAGGGGACAAGTCGTTAAAGGAAAGGTAGTTAAAGTAACAGAAGATGAAGCAATGATTGATGTAGGTTA
TAAATTTGAAGGCTCAGTACCAGTTAACGAAATGCCAATAAAGGAAGGAGAATCTCTAGAGGATTTACTTTCTGAGGGAG
ACGAAATTGATGTTAAAGTGGTGAAAGTTGATGACGAAGAAGGACAATTAATACTTTCTAAAAAATGGGCTGACAAAGAT
AAACAATGGGAGCAATTGGAACAGCTTATGGAAAATGATGAAGAAATCAAAGCACAAGTGACAGAGGAAGTCAAAGGTGG
TTTGGTCGTTGATTTAGGTCAATTACAAGGGTTTATACCAGCCTCCCACGTAGACATACATTATGTACCCGATTTAAGCA
AGTATGTGGGAGAAGAATTGAGACTGAAACCCATAGAATTGGATCGTTCTAGAAATAAGATAGTACTAAGCCAGAAAAAT
ATTTTAGAACAGGAACAGGAAGAAAAGAAAAATAAAACCATGGAAACTATTACAGAAGGTGATATCGTCGACGGAACCGT
TAAAAGGTTAACCGATTTTGGAGCCTTCATCGATATCGGTGGAATTGATGGTTTATGTCATATTTCTCAAATTTCACATA
GTAGAATTGACCATCCTGAAAGTGAATTAGAAACTGGGGAAAATGTTAAGGTAAAAGTATTAAGCTTAGATCCTGAAAAT
GAACGTATATCATTAAGTATTAAAGAAGCACAGCCTGATCCCTTTGAAACTTTTATGAAACAGTATAAATCTGGAGATAT
CGTTCAAGGCAAGGTTGTTAGAACTGTTAATTTTGGTGCATTTATTGAAATCACACCAGGTGTTGAAGGACTTTGTCATA
TTTCTCAATTATCCGATGATCATGTTGCTAAAACCCAAGATGTAGTTAATGAGGGTGATCAAGTTACCGTCAAAATATTA
AGTATAGATGATCAGCAGAAAAAGGTTAGTTTAAGTATCAAAGAAGCTCAGGGAAAAAGCAAAAAAGAACAAGAACAAGA
AGAGTTTGCAAAATATCAGGATAGTCAAGAGGAAGAAGAAGGTGTGAAATTAGGAGATATGTTTGGTGATGTACTAGAGG
AAATAAAGGAAGATGATAAGGATGATAAATCGAAGTGA

Upstream 100 bases:

>100_bases
AGTCAGTATATAATGGACACAATTAACAGTGAATTAAATTAGATAATTGACAAAAATAATTTAGATTAAGACAATTATCT
AGAAGTTGAGGTGGGGATTA

Downstream 100 bases:

>100_bases
TAGGAAATCAGATCATTTACATCTAGCAATTAACCAATATGATACTCAAAATATTCTAGAAGACATAAAGTTACTTCATA
ATTGTTTACCTGAATGTAAT

Product: hydroxymethylbutenyl pyrophosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 705; Mature: 705

Protein sequence:

>705_residues
MEILVAKGAGFCSGVNRALDKTIQAVQTDTSRDIQVFTLGPIVHNKEVIQNLTEKGIGIIENLTQLQSKKCLSEETNNYV
VIRSHGVGPETFKMLNNLSNTDVIDATCPFVRKVQQKASKLYQDGYQIFIVGDPNHPEVKGIKEWTDNNAIVIEKPEQVN
DIEISNKTAVVAQTTLREEKFNEIVEKILDRNPNTIVHNTICDATQKRQTATKELAGQVDVMIVVGGYNSSNTKKLKELA
VKEGVPTYHIETAKELKTDWFLGCKKIGVTAGASTPDWTIKEVVGKMREFEEQNENLNTNSDESTQESQDELMKATEDSA
DKLDRGQVVKGKVVKVTEDEAMIDVGYKFEGSVPVNEMPIKEGESLEDLLSEGDEIDVKVVKVDDEEGQLILSKKWADKD
KQWEQLEQLMENDEEIKAQVTEEVKGGLVVDLGQLQGFIPASHVDIHYVPDLSKYVGEELRLKPIELDRSRNKIVLSQKN
ILEQEQEEKKNKTMETITEGDIVDGTVKRLTDFGAFIDIGGIDGLCHISQISHSRIDHPESELETGENVKVKVLSLDPEN
ERISLSIKEAQPDPFETFMKQYKSGDIVQGKVVRTVNFGAFIEITPGVEGLCHISQLSDDHVAKTQDVVNEGDQVTVKIL
SIDDQQKKVSLSIKEAQGKSKKEQEQEEFAKYQDSQEEEEGVKLGDMFGDVLEEIKEDDKDDKSK

Sequences:

>Translated_705_residues
MEILVAKGAGFCSGVNRALDKTIQAVQTDTSRDIQVFTLGPIVHNKEVIQNLTEKGIGIIENLTQLQSKKCLSEETNNYV
VIRSHGVGPETFKMLNNLSNTDVIDATCPFVRKVQQKASKLYQDGYQIFIVGDPNHPEVKGIKEWTDNNAIVIEKPEQVN
DIEISNKTAVVAQTTLREEKFNEIVEKILDRNPNTIVHNTICDATQKRQTATKELAGQVDVMIVVGGYNSSNTKKLKELA
VKEGVPTYHIETAKELKTDWFLGCKKIGVTAGASTPDWTIKEVVGKMREFEEQNENLNTNSDESTQESQDELMKATEDSA
DKLDRGQVVKGKVVKVTEDEAMIDVGYKFEGSVPVNEMPIKEGESLEDLLSEGDEIDVKVVKVDDEEGQLILSKKWADKD
KQWEQLEQLMENDEEIKAQVTEEVKGGLVVDLGQLQGFIPASHVDIHYVPDLSKYVGEELRLKPIELDRSRNKIVLSQKN
ILEQEQEEKKNKTMETITEGDIVDGTVKRLTDFGAFIDIGGIDGLCHISQISHSRIDHPESELETGENVKVKVLSLDPEN
ERISLSIKEAQPDPFETFMKQYKSGDIVQGKVVRTVNFGAFIEITPGVEGLCHISQLSDDHVAKTQDVVNEGDQVTVKIL
SIDDQQKKVSLSIKEAQGKSKKEQEQEEFAKYQDSQEEEEGVKLGDMFGDVLEEIKEDDKDDKSK
>Mature_705_residues
MEILVAKGAGFCSGVNRALDKTIQAVQTDTSRDIQVFTLGPIVHNKEVIQNLTEKGIGIIENLTQLQSKKCLSEETNNYV
VIRSHGVGPETFKMLNNLSNTDVIDATCPFVRKVQQKASKLYQDGYQIFIVGDPNHPEVKGIKEWTDNNAIVIEKPEQVN
DIEISNKTAVVAQTTLREEKFNEIVEKILDRNPNTIVHNTICDATQKRQTATKELAGQVDVMIVVGGYNSSNTKKLKELA
VKEGVPTYHIETAKELKTDWFLGCKKIGVTAGASTPDWTIKEVVGKMREFEEQNENLNTNSDESTQESQDELMKATEDSA
DKLDRGQVVKGKVVKVTEDEAMIDVGYKFEGSVPVNEMPIKEGESLEDLLSEGDEIDVKVVKVDDEEGQLILSKKWADKD
KQWEQLEQLMENDEEIKAQVTEEVKGGLVVDLGQLQGFIPASHVDIHYVPDLSKYVGEELRLKPIELDRSRNKIVLSQKN
ILEQEQEEKKNKTMETITEGDIVDGTVKRLTDFGAFIDIGGIDGLCHISQISHSRIDHPESELETGENVKVKVLSLDPEN
ERISLSIKEAQPDPFETFMKQYKSGDIVQGKVVRTVNFGAFIEITPGVEGLCHISQLSDDHVAKTQDVVNEGDQVTVKIL
SIDDQQKKVSLSIKEAQGKSKKEQEQEEFAKYQDSQEEEEGVKLGDMFGDVLEEIKEDDKDDKSK

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0539

COG function: function code J; Ribosomal protein S1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 S1 motif domains [H]

Homologues:

Organism=Homo sapiens, GI70980549, Length=352, Percent_Identity=23.0113636363636, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI1787140, Length=360, Percent_Identity=34.4444444444444, Blast_Score=226, Evalue=4e-60,
Organism=Escherichia coli, GI1786212, Length=297, Percent_Identity=30.976430976431, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI145693187, Length=77, Percent_Identity=48.0519480519481, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI87082262, Length=77, Percent_Identity=42.8571428571429, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323885, Length=172, Percent_Identity=29.0697674418605, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: 16,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR000110
- InterPro:   IPR022967 [H]

Pfam domain/function: PF02401 LYTB; PF00575 S1 [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 78863; Mature: 78863

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILVAKGAGFCSGVNRALDKTIQAVQTDTSRDIQVFTLGPIVHNKEVIQNLTEKGIGII
CEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHH
ENLTQLQSKKCLSEETNNYVVIRSHGVGPETFKMLNNLSNTDVIDATCPFVRKVQQKASK
HHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHH
LYQDGYQIFIVGDPNHPEVKGIKEWTDNNAIVIEKPEQVNDIEISNKTAVVAQTTLREEK
HHHCCCEEEEEECCCCCCCCCHHHHCCCCEEEEECCCCCCCEEECCCEEEEEHHHHHHHH
FNEIVEKILDRNPNTIVHNTICDATQKRQTATKELAGQVDVMIVVGGYNSSNTKKLKELA
HHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHH
VKEGVPTYHIETAKELKTDWFLGCKKIGVTAGASTPDWTIKEVVGKMREFEEQNENLNTN
HHCCCCCEEECCHHHHHHHHHHHHHHHCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
SDESTQESQDELMKATEDSADKLDRGQVVKGKVVKVTEDEAMIDVGYKFEGSVPVNEMPI
CCCCHHHHHHHHHHHHCCCHHHCCCCCEECCEEEEEECCCEEEEECEEEECCCCCCCCCC
KEGESLEDLLSEGDEIDVKVVKVDDEEGQLILSKKWADKDKQWEQLEQLMENDEEIKAQV
CCCCCHHHHHCCCCCEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHHHHH
TEEVKGGLVVDLGQLQGFIPASHVDIHYVPDLSKYVGEELRLKPIELDRSRNKIVLSQKN
HHHHCCCEEEEHHHHCCCCCCCCEEEEECCCHHHHCCCHHEEECEEECCCCCEEEEEHHH
ILEQEQEEKKNKTMETITEGDIVDGTVKRLTDFGAFIDIGGIDGLCHISQISHSRIDHPE
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCCH
SELETGENVKVKVLSLDPENERISLSIKEAQPDPFETFMKQYKSGDIVQGKVVRTVNFGA
HHHCCCCCEEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEECEEEEEEECCE
FIEITPGVEGLCHISQLSDDHVAKTQDVVNEGDQVTVKILSIDDQQKKVSLSIKEAQGKS
EEEECCCCCHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEEHHCCCC
KKEQEQEEFAKYQDSQEEEEGVKLGDMFGDVLEEIKEDDKDDKSK
HHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEILVAKGAGFCSGVNRALDKTIQAVQTDTSRDIQVFTLGPIVHNKEVIQNLTEKGIGII
CEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHH
ENLTQLQSKKCLSEETNNYVVIRSHGVGPETFKMLNNLSNTDVIDATCPFVRKVQQKASK
HHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHH
LYQDGYQIFIVGDPNHPEVKGIKEWTDNNAIVIEKPEQVNDIEISNKTAVVAQTTLREEK
HHHCCCEEEEEECCCCCCCCCHHHHCCCCEEEEECCCCCCCEEECCCEEEEEHHHHHHHH
FNEIVEKILDRNPNTIVHNTICDATQKRQTATKELAGQVDVMIVVGGYNSSNTKKLKELA
HHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHH
VKEGVPTYHIETAKELKTDWFLGCKKIGVTAGASTPDWTIKEVVGKMREFEEQNENLNTN
HHCCCCCEEECCHHHHHHHHHHHHHHHCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
SDESTQESQDELMKATEDSADKLDRGQVVKGKVVKVTEDEAMIDVGYKFEGSVPVNEMPI
CCCCHHHHHHHHHHHHCCCHHHCCCCCEECCEEEEEECCCEEEEECEEEECCCCCCCCCC
KEGESLEDLLSEGDEIDVKVVKVDDEEGQLILSKKWADKDKQWEQLEQLMENDEEIKAQV
CCCCCHHHHHCCCCCEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHHHHH
TEEVKGGLVVDLGQLQGFIPASHVDIHYVPDLSKYVGEELRLKPIELDRSRNKIVLSQKN
HHHHCCCEEEEHHHHCCCCCCCCEEEEECCCHHHHCCCHHEEECEEECCCCCEEEEEHHH
ILEQEQEEKKNKTMETITEGDIVDGTVKRLTDFGAFIDIGGIDGLCHISQISHSRIDHPE
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCCH
SELETGENVKVKVLSLDPENERISLSIKEAQPDPFETFMKQYKSGDIVQGKVVRTVNFGA
HHHCCCCCEEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEECEEEEEEECCE
FIEITPGVEGLCHISQLSDDHVAKTQDVVNEGDQVTVKILSIDDQQKKVSLSIKEAQGKS
EEEECCCCCHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEEHHCCCC
KKEQEQEEFAKYQDSQEEEEGVKLGDMFGDVLEEIKEDDKDDKSK
HHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]