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The map label for this gene is hemN [H]

Identifier: 188585806

GI number: 188585806

Start: 1251345

End: 1252550

Strand: Direct

Name: hemN [H]

Synonym: Nther_1180

Alternate gene names: 188585806

Gene position: 1251345-1252550 (Clockwise)

Preceding gene: 188585805

Following gene: 188585807

Centisome position: 39.53

GC content: 34.16

Gene sequence:

>1206_bases
TTGATAAATAAAACGGATTACAAAAAGGGACTGTACATTCATGTCCCTTTTTGTTTATCTAAATGTAAATACTGCGATTT
TAATAGTAGAGAACTTCAATCCCAGGATGAAATAACAAACTACTTAAAAACAATAAAAAAACAGACTAAGACATTTTACA
GAAAACTTGGCCTTAACCAAGAATCATGGGACAGCATATATATTGGTGGAGGAACTCCTTCTTGTTTAACGGAAGAGGCT
TTACACGATTTATTGTCATTCTATATAGAGAACTCCAATACTAGTTTTGACAACGACGGGCAAAGCAGAGAGATTACTGT
GGAAGTGAATCCTAATTCAATCACTAGTGAAAAAGCGACTATTTTAGCTTCGAAAGTTAATCGCATCAGCATAGGCTTAC
AGAGTACTCATTCTAAATATTTAAAAAGGTTAGGAAGAATACACACATGGAATGATTTTATTCGAGCTTATGAACTCTTG
GTATCAAAAGGGATAGACAATATTAATGTTGATTTAATCTATGGCATTCCCGGACAAAGGTTGGAAGATTTAGAACAAGA
TCTGGATCTTCTTACGAATTTAACTCCTTTTCCCCCGAAACATATATCCTTGTATAATCTAACGATAGAAGAAGGAACTC
CGTTAATGGAAGAATATCAAACAGGAGAACTACCTATCCTTGATGAACAGTCTGAAGTGTCTATGTATAACATGGCCAGG
GAAATCCTGCAAGATCGAGGATATAAGCACTACGAACTTTCTAATTTTTCTAAAGAAGGATATCAATGCCGACACAATTT
AATCTACTGGTTAAGACATAACTATTTGGGTTTAGGACCTGGTGCGCACAGCTTGTGGAATAGCAAAAGATTTTATTGTA
CCGAATCCATTACAGACTATTTAAAAGCCAGTCAAGACCAAGACTTGGATGAAAGAACCTTAATTCAAGATTGCTGGGAT
GTATCACGAGAAGAAGCTTTATCGGAAAGGATTTTTTTAGGCTTGCGTTTGTTATCAGGTGTTGATTTGGAAGAAATCTC
TCAAGAGTTTCAATTAGATGTAGAGAAAAAATTTGCTAAACAAATTAAAAAATTAATTGATCAAGGATTTTTAACAAAAA
CAGGTTCTGTTATTAAACTAACCGAAAAGGCATATATGCTGTCAAATTATGTTTTTATGGAGTTCCTACCTCATCTTGAC
AAATAA

Upstream 100 bases:

>100_bases
AAGAGAAAATTATTAGAAAAACAAAAAGAAGGGAAACAGAGAATGAAACAAGTCGGGAAGGTAGATATACCTCAAGAAGC
CTTTATGGCGGTGTTGAGCA

Downstream 100 bases:

>100_bases
CTTGGCTAGTGTTATTTTTTAACTGGATCAATTAGCACTCTTGTTTTAAGAGTGCTAATAACTTTCAGGGGTGATTTGAT
GAGCCTTAATTGGCGTAAGC

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MINKTDYKKGLYIHVPFCLSKCKYCDFNSRELQSQDEITNYLKTIKKQTKTFYRKLGLNQESWDSIYIGGGTPSCLTEEA
LHDLLSFYIENSNTSFDNDGQSREITVEVNPNSITSEKATILASKVNRISIGLQSTHSKYLKRLGRIHTWNDFIRAYELL
VSKGIDNINVDLIYGIPGQRLEDLEQDLDLLTNLTPFPPKHISLYNLTIEEGTPLMEEYQTGELPILDEQSEVSMYNMAR
EILQDRGYKHYELSNFSKEGYQCRHNLIYWLRHNYLGLGPGAHSLWNSKRFYCTESITDYLKASQDQDLDERTLIQDCWD
VSREEALSERIFLGLRLLSGVDLEEISQEFQLDVEKKFAKQIKKLIDQGFLTKTGSVIKLTEKAYMLSNYVFMEFLPHLD
K

Sequences:

>Translated_401_residues
MINKTDYKKGLYIHVPFCLSKCKYCDFNSRELQSQDEITNYLKTIKKQTKTFYRKLGLNQESWDSIYIGGGTPSCLTEEA
LHDLLSFYIENSNTSFDNDGQSREITVEVNPNSITSEKATILASKVNRISIGLQSTHSKYLKRLGRIHTWNDFIRAYELL
VSKGIDNINVDLIYGIPGQRLEDLEQDLDLLTNLTPFPPKHISLYNLTIEEGTPLMEEYQTGELPILDEQSEVSMYNMAR
EILQDRGYKHYELSNFSKEGYQCRHNLIYWLRHNYLGLGPGAHSLWNSKRFYCTESITDYLKASQDQDLDERTLIQDCWD
VSREEALSERIFLGLRLLSGVDLEEISQEFQLDVEKKFAKQIKKLIDQGFLTKTGSVIKLTEKAYMLSNYVFMEFLPHLD
K
>Mature_401_residues
MINKTDYKKGLYIHVPFCLSKCKYCDFNSRELQSQDEITNYLKTIKKQTKTFYRKLGLNQESWDSIYIGGGTPSCLTEEA
LHDLLSFYIENSNTSFDNDGQSREITVEVNPNSITSEKATILASKVNRISIGLQSTHSKYLKRLGRIHTWNDFIRAYELL
VSKGIDNINVDLIYGIPGQRLEDLEQDLDLLTNLTPFPPKHISLYNLTIEEGTPLMEEYQTGELPILDEQSEVSMYNMAR
EILQDRGYKHYELSNFSKEGYQCRHNLIYWLRHNYLGLGPGAHSLWNSKRFYCTESITDYLKASQDQDLDERTLIQDCWD
VSREEALSERIFLGLRLLSGVDLEEISQEFQLDVEKKFAKQIKKLIDQGFLTKTGSVIKLTEKAYMLSNYVFMEFLPHLD
K

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=279, Percent_Identity=34.0501792114695, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1789325, Length=389, Percent_Identity=32.133676092545, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI87082341, Length=408, Percent_Identity=24.0196078431373, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 46571; Mature: 46571

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINKTDYKKGLYIHVPFCLSKCKYCDFNSRELQSQDEITNYLKTIKKQTKTFYRKLGLNQ
CCCCCCCCCCEEEEEHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCC
ESWDSIYIGGGTPSCLTEEALHDLLSFYIENSNTSFDNDGQSREITVEVNPNSITSEKAT
CCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCHHHH
ILASKVNRISIGLQSTHSKYLKRLGRIHTWNDFIRAYELLVSKGIDNINVDLIYGIPGQR
HHHHHHHHEEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHH
LEDLEQDLDLLTNLTPFPPKHISLYNLTIEEGTPLMEEYQTGELPILDEQSEVSMYNMAR
HHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHHCCCCCCCCCCCHHHHHHHHHH
EILQDRGYKHYELSNFSKEGYQCRHNLIYWLRHNYLGLGPGAHSLWNSKRFYCTESITDY
HHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHCCEECCCCHHHHHCCCCEEEHHHHHHH
LKASQDQDLDERTLIQDCWDVSREEALSERIFLGLRLLSGVDLEEISQEFQLDVEKKFAK
HHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHH
QIKKLIDQGFLTKTGSVIKLTEKAYMLSNYVFMEFLPHLDK
HHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MINKTDYKKGLYIHVPFCLSKCKYCDFNSRELQSQDEITNYLKTIKKQTKTFYRKLGLNQ
CCCCCCCCCCEEEEEHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCC
ESWDSIYIGGGTPSCLTEEALHDLLSFYIENSNTSFDNDGQSREITVEVNPNSITSEKAT
CCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCHHHH
ILASKVNRISIGLQSTHSKYLKRLGRIHTWNDFIRAYELLVSKGIDNINVDLIYGIPGQR
HHHHHHHHEEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHH
LEDLEQDLDLLTNLTPFPPKHISLYNLTIEEGTPLMEEYQTGELPILDEQSEVSMYNMAR
HHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHHCCCCCCCCCCCHHHHHHHHHH
EILQDRGYKHYELSNFSKEGYQCRHNLIYWLRHNYLGLGPGAHSLWNSKRFYCTESITDY
HHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHCCEECCCCHHHHHCCCCEEEHHHHHHH
LKASQDQDLDERTLIQDCWDVSREEALSERIFLGLRLLSGVDLEEISQEFQLDVEKKFAK
HHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHH
QIKKLIDQGFLTKTGSVIKLTEKAYMLSNYVFMEFLPHLDK
HHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]