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The map label for this gene is rnhA [H]

Identifier: 188585798

GI number: 188585798

Start: 1241805

End: 1242263

Strand: Direct

Name: rnhA [H]

Synonym: Nther_1172

Alternate gene names: 188585798

Gene position: 1241805-1242263 (Clockwise)

Preceding gene: 188585797

Following gene: 188585799

Centisome position: 39.23

GC content: 38.56

Gene sequence:

>459_bases
ATGACTAATACAAATGAAGACAAGAAAAGAGTTACGATTTATACCGACGGAGCTTGCAGTGGCAACCCTGGTCCGGGTGG
TTGGGGTGCTATTTTGCTTTTTAATGAACATAAAAAGGAATTATCAGGTTCTGCGGAGAATACTACCAATCAAAGAATGG
AATTATATGCCGCAGTGCAGGCTCTGAAAGCATTGAAGTACCCGTGTAATGTGGAGCTATGTAGTGATAGCGCATATTTA
GTTAATTGTTTTCAACAGGGCTGGTGGAAGAAGTGGCAGCGCAATAATTGGTTAACTAAATCAAAGAAAAAAGTGGATAA
TCAGGATTTATGGAGAGAACTCATTGAATTAAATGATTATCACTCAATTCAATGGATTAAGGTTAAAGGTCACAGCGATG
ATGAACTTAATAATCGAGCTGATCAATTGGCAACGGAAGCAATTCCTGACAAGAGTTAA

Upstream 100 bases:

>100_bases
TGTAAAGATTTGAGTAATATTTTAAAATATTGTTTGTGTAAATTTTTTCTGTAACAAGTTATAATACTTGTTACAGAATT
TTTTTTAGGGAGAGATTTAT

Downstream 100 bases:

>100_bases
ATCTATATATTTATTTACACGGGTGGTGTAAAAATTAAACAAAATTGAGAGTACTTTAAAACTGGTATGTGTGGGTCTGT
TTTTAATATTTTGTATTAAT

Product: RNase HI

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MTNTNEDKKRVTIYTDGACSGNPGPGGWGAILLFNEHKKELSGSAENTTNQRMELYAAVQALKALKYPCNVELCSDSAYL
VNCFQQGWWKKWQRNNWLTKSKKKVDNQDLWRELIELNDYHSIQWIKVKGHSDDELNNRADQLATEAIPDKS

Sequences:

>Translated_152_residues
MTNTNEDKKRVTIYTDGACSGNPGPGGWGAILLFNEHKKELSGSAENTTNQRMELYAAVQALKALKYPCNVELCSDSAYL
VNCFQQGWWKKWQRNNWLTKSKKKVDNQDLWRELIELNDYHSIQWIKVKGHSDDELNNRADQLATEAIPDKS
>Mature_151_residues
TNTNEDKKRVTIYTDGACSGNPGPGGWGAILLFNEHKKELSGSAENTTNQRMELYAAVQALKALKYPCNVELCSDSAYLV
NCFQQGWWKKWQRNNWLTKSKKKVDNQDLWRELIELNDYHSIQWIKVKGHSDDELNNRADQLATEAIPDKS

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=146, Percent_Identity=34.9315068493151, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786408, Length=139, Percent_Identity=47.4820143884892, Blast_Score=123, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 17421; Mature: 17289

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTNEDKKRVTIYTDGACSGNPGPGGWGAILLFNEHKKELSGSAENTTNQRMELYAAVQ
CCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCHHHHCCCCCCCHHHHHHHHHHHH
ALKALKYPCNVELCSDSAYLVNCFQQGWWKKWQRNNWLTKSKKKVDNQDLWRELIELNDY
HHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHCCCC
HSIQWIKVKGHSDDELNNRADQLATEAIPDKS
CCEEEEEEECCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TNTNEDKKRVTIYTDGACSGNPGPGGWGAILLFNEHKKELSGSAENTTNQRMELYAAVQ
CCCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCHHHHCCCCCCCHHHHHHHHHHHH
ALKALKYPCNVELCSDSAYLVNCFQQGWWKKWQRNNWLTKSKKKVDNQDLWRELIELNDY
HHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHCCCC
HSIQWIKVKGHSDDELNNRADQLATEAIPDKS
CCEEEEEEECCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]