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The map label for this gene is moeZ [H]

Identifier: 188585719

GI number: 188585719

Start: 1153698

End: 1154552

Strand: Direct

Name: moeZ [H]

Synonym: Nther_1092

Alternate gene names: 188585719

Gene position: 1153698-1154552 (Clockwise)

Preceding gene: 188585718

Following gene: 188585720

Centisome position: 36.45

GC content: 38.6

Gene sequence:

>855_bases
TTGCTTGAAACTATCACAGAAAAGTGGGGTGAACTGATGAACTTTAATGAAGCACAACTAGAACGTTATTCCAGACAAAT
CATTTTATCCGAGGTGGGTGTCGAGGGACAGCAGAAATTGCTAGACTCAAAAGTGTTAATCATTGGCACTGGAGGCCTTG
GGGCGCCTGCAGCCATGTATTTAGCTGCTCTGGGAATTGGTACAATTGGTTTGGTAGATGGTGATAAAGTCGAACTTTCA
AATTTACAACGTCAAATTATTCATCAAACTAAAGATATAGGTAAACTTAAAGCGGAATCAGGAAAGGAAACAATACTACA
CATGAATCCAGATGTAGAAGTTATTCCGCATAATACCTGGATTAATTCACAAAATATCCAGGATATAATTGAAGACTATG
ATTTCGTTATTGATGGCACAGACAATTTTGCAGCCAAATTTTTAATTAACGATGCATGTGTAATGTCGGAAAAACCTTTT
TGTCATGCGGGTATAATTCGATTCCAGGGTCAAGTGATGACTTATGTTCCAAATGGTAATGGGGTTACTCCTTGTTATAG
ATGTGTTTTTAATGAGCCCCCGCCTGACGGGGTGGTTCCTTCTTGCCAGGAAGCTGGTGTCCTTGGACTTCTAGGGGGAG
TGATTGGTGGCTTACAAGCTACAGAAGCGGTTAAATACTTATTAGGAATAGGAGACAATTTGACAGGTGAATTATTAGTT
TATGATGCTTTAAAAATGGATTTTAGAAAAATTGAATTACATTCAGACAGGGATTGTAAAATTTGCGGAACTAACCCAGA
AATCAAAGACTTGGTTGACTACACGGGTCCTAAATGTAACCTACAAACAAAGTGA

Upstream 100 bases:

>100_bases
AAACAATTACCATCAGGGGCAAGAGTAGTGACAGTTTTCCCTGACACGGGAGAGCGTTACTTGAGCATGGCTCCTTATTT
TAACTTATAGAAAAAATTAC

Downstream 100 bases:

>100_bases
TTAAAGGGTGTTTATATGAAAATATGGATTTTACAGACAGAATATCAGAAAATGTTAGAACATGCTAAAAAAGAGTTTCC
CCTTGAATGTTGTGGCCTCA

Product: UBA/THIF-type NAD/FAD binding protein

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MLETITEKWGELMNFNEAQLERYSRQIILSEVGVEGQQKLLDSKVLIIGTGGLGAPAAMYLAALGIGTIGLVDGDKVELS
NLQRQIIHQTKDIGKLKAESGKETILHMNPDVEVIPHNTWINSQNIQDIIEDYDFVIDGTDNFAAKFLINDACVMSEKPF
CHAGIIRFQGQVMTYVPNGNGVTPCYRCVFNEPPPDGVVPSCQEAGVLGLLGGVIGGLQATEAVKYLLGIGDNLTGELLV
YDALKMDFRKIELHSDRDCKICGTNPEIKDLVDYTGPKCNLQTK

Sequences:

>Translated_284_residues
MLETITEKWGELMNFNEAQLERYSRQIILSEVGVEGQQKLLDSKVLIIGTGGLGAPAAMYLAALGIGTIGLVDGDKVELS
NLQRQIIHQTKDIGKLKAESGKETILHMNPDVEVIPHNTWINSQNIQDIIEDYDFVIDGTDNFAAKFLINDACVMSEKPF
CHAGIIRFQGQVMTYVPNGNGVTPCYRCVFNEPPPDGVVPSCQEAGVLGLLGGVIGGLQATEAVKYLLGIGDNLTGELLV
YDALKMDFRKIELHSDRDCKICGTNPEIKDLVDYTGPKCNLQTK
>Mature_284_residues
MLETITEKWGELMNFNEAQLERYSRQIILSEVGVEGQQKLLDSKVLIIGTGGLGAPAAMYLAALGIGTIGLVDGDKVELS
NLQRQIIHQTKDIGKLKAESGKETILHMNPDVEVIPHNTWINSQNIQDIIEDYDFVIDGTDNFAAKFLINDACVMSEKPF
CHAGIIRFQGQVMTYVPNGNGVTPCYRCVFNEPPPDGVVPSCQEAGVLGLLGGVIGGLQATEAVKYLLGIGDNLTGELLV
YDALKMDFRKIELHSDRDCKICGTNPEIKDLVDYTGPKCNLQTK

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=254, Percent_Identity=43.7007874015748, Blast_Score=211, Evalue=4e-55,
Organism=Homo sapiens, GI4885649, Length=160, Percent_Identity=31.25, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI23510338, Length=190, Percent_Identity=27.8947368421053, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI23510340, Length=190, Percent_Identity=27.8947368421053, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI38045942, Length=193, Percent_Identity=31.6062176165803, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI38045944, Length=190, Percent_Identity=31.5789473684211, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI13376212, Length=267, Percent_Identity=29.2134831460674, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI38327032, Length=255, Percent_Identity=28.6274509803922, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI38045948, Length=166, Percent_Identity=28.3132530120482, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1787048, Length=252, Percent_Identity=37.6984126984127, Blast_Score=194, Evalue=7e-51,
Organism=Escherichia coli, GI87082356, Length=251, Percent_Identity=42.2310756972112, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1789177, Length=133, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17540406, Length=254, Percent_Identity=42.5196850393701, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI193203301, Length=169, Percent_Identity=28.4023668639053, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17508819, Length=260, Percent_Identity=27.6923076923077, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71984476, Length=213, Percent_Identity=26.7605633802817, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321903, Length=255, Percent_Identity=38.8235294117647, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6322639, Length=195, Percent_Identity=30.7692307692308, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320598, Length=178, Percent_Identity=28.0898876404494, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6325323, Length=183, Percent_Identity=30.6010928961749, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24582879, Length=256, Percent_Identity=46.484375, Blast_Score=235, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24660640, Length=154, Percent_Identity=31.1688311688312, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573937, Length=189, Percent_Identity=30.1587301587302, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI20129973, Length=177, Percent_Identity=31.0734463276836, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641311, Length=261, Percent_Identity=29.8850574712644, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 31057; Mature: 31057

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLETITEKWGELMNFNEAQLERYSRQIILSEVGVEGQQKLLDSKVLIIGTGGLGAPAAMY
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCCCHHHHHH
LAALGIGTIGLVDGDKVELSNLQRQIIHQTKDIGKLKAESGKETILHMNPDVEVIPHNTW
HHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCCCC
INSQNIQDIIEDYDFVIDGTDNFAAKFLINDACVMSEKPFCHAGIIRFQGQVMTYVPNGN
CCCCHHHHHHHCCCEEEECCCCCEEHHEECCHHHCCCCCCHHHCEEEECCEEEEEECCCC
GVTPCYRCVFNEPPPDGVVPSCQEAGVLGLLGGVIGGLQATEAVKYLLGIGDNLTGELLV
CCCHHHHEECCCCCCCCCCCCHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEE
YDALKMDFRKIELHSDRDCKICGTNPEIKDLVDYTGPKCNLQTK
EHHHHCCCEEEEECCCCCCEEECCCCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLETITEKWGELMNFNEAQLERYSRQIILSEVGVEGQQKLLDSKVLIIGTGGLGAPAAMY
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCCCHHHHHH
LAALGIGTIGLVDGDKVELSNLQRQIIHQTKDIGKLKAESGKETILHMNPDVEVIPHNTW
HHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCCCC
INSQNIQDIIEDYDFVIDGTDNFAAKFLINDACVMSEKPFCHAGIIRFQGQVMTYVPNGN
CCCCHHHHHHHCCCEEEECCCCCEEHHEECCHHHCCCCCCHHHCEEEECCEEEEEECCCC
GVTPCYRCVFNEPPPDGVVPSCQEAGVLGLLGGVIGGLQATEAVKYLLGIGDNLTGELLV
CCCHHHHEECCCCCCCCCCCCHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEE
YDALKMDFRKIELHSDRDCKICGTNPEIKDLVDYTGPKCNLQTK
EHHHHCCCEEEEECCCCCCEEECCCCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]