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The map label for this gene is cysK [H]

Identifier: 188585718

GI number: 188585718

Start: 1152776

End: 1153687

Strand: Direct

Name: cysK [H]

Synonym: Nther_1091

Alternate gene names: 188585718

Gene position: 1152776-1153687 (Clockwise)

Preceding gene: 188585714

Following gene: 188585719

Centisome position: 36.42

GC content: 38.6

Gene sequence:

>912_bases
ATGAGTGCTTTAAAATTAATAGGTAATACACCTTTGATTAGAATGAGCCGGAATATAGTGGGCACTGAAGCTGAGGTTTT
TGCAAAACTAGAAATGTTTAATCCAGGAGGTAGCGTAAAAGATAGAATTGCATTAAGTATGATTAACTCGGCCGAACAAA
ACGGGCATTTATCACAGGGAGGAACAATTCTAGAACCGACCAGTGGAAACACTGGGATCGGATTAGCTATTGTAGCTGCT
GTTAAAGGATATCAATTAATTTTGACTATGCCAGAGAGTATGAGTGAAGAAAGACGGGCATTATTAAAATCTTATGGAGC
AGAGCTTGTACTGACGCTAGCAGATAAAGGTATGGGAGGAGCTGTTGAGAAAGCTAATCAAATTAAAAGGGAAAATCCGG
ATTACTTTATCCCTCAACAATTTAATAACATCAGTAATCCAGAAATACACAAACAAACTACTGCCAGGGAAATTATTTCA
GAATTAGATTCAGATATAGATGGATTAGTACTCGGTGTTGGTACTGGCGGAACAATTACAGGTGTAGGTGAAGTTTTAAA
ACACAAAAATCCTAATTTAAAAATCTTTGCAGTTGAACCAAAGGAATCACCGGTACTGTCTGGAGGGAATCCAGGTCCTC
ATAAAATTCAAGGGCTAGGGGCAGGTTTTGTACCTCAAGTATTAAAGACAGAATTGATTGATGAAGTAATTCAGGTTGAT
AGTTCTGAAGCCTATGATATGAGCAATCAATTGGCAAAACAGGAAGGTTTACTGGCCGGAATATCTAGTGGTGCTGCATT
GAAAGGGGTATTAAAGGCTTTAAAACAATTACCATCAGGGGCAAGAGTAGTGACAGTTTTCCCTGACACGGGAGAGCGTT
ACTTGAGCATGGCTCCTTATTTTAACTTATAG

Upstream 100 bases:

>100_bases
AACTACTTGACAGTGAAGCAAAAAAAGTTTAGAGTTATAAATAACTTGAACAACTAAAAACCTAAAGGTTTATAGGGGAA
TAAAAAGGAGAGGATTAAAT

Downstream 100 bases:

>100_bases
AAAAAATTACTTGCTTGAAACTATCACAGAAAAGTGGGGTGAACTGATGAACTTTAATGAAGCACAACTAGAACGTTATT
CCAGACAAATCATTTTATCC

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSALKLIGNTPLIRMSRNIVGTEAEVFAKLEMFNPGGSVKDRIALSMINSAEQNGHLSQGGTILEPTSGNTGIGLAIVAA
VKGYQLILTMPESMSEERRALLKSYGAELVLTLADKGMGGAVEKANQIKRENPDYFIPQQFNNISNPEIHKQTTAREIIS
ELDSDIDGLVLGVGTGGTITGVGEVLKHKNPNLKIFAVEPKESPVLSGGNPGPHKIQGLGAGFVPQVLKTELIDEVIQVD
SSEAYDMSNQLAKQEGLLAGISSGAALKGVLKALKQLPSGARVVTVFPDTGERYLSMAPYFNL

Sequences:

>Translated_303_residues
MSALKLIGNTPLIRMSRNIVGTEAEVFAKLEMFNPGGSVKDRIALSMINSAEQNGHLSQGGTILEPTSGNTGIGLAIVAA
VKGYQLILTMPESMSEERRALLKSYGAELVLTLADKGMGGAVEKANQIKRENPDYFIPQQFNNISNPEIHKQTTAREIIS
ELDSDIDGLVLGVGTGGTITGVGEVLKHKNPNLKIFAVEPKESPVLSGGNPGPHKIQGLGAGFVPQVLKTELIDEVIQVD
SSEAYDMSNQLAKQEGLLAGISSGAALKGVLKALKQLPSGARVVTVFPDTGERYLSMAPYFNL
>Mature_302_residues
SALKLIGNTPLIRMSRNIVGTEAEVFAKLEMFNPGGSVKDRIALSMINSAEQNGHLSQGGTILEPTSGNTGIGLAIVAAV
KGYQLILTMPESMSEERRALLKSYGAELVLTLADKGMGGAVEKANQIKRENPDYFIPQQFNNISNPEIHKQTTAREIISE
LDSDIDGLVLGVGTGGTITGVGEVLKHKNPNLKIFAVEPKESPVLSGGNPGPHKIQGLGAGFVPQVLKTELIDEVIQVDS
SEAYDMSNQLAKQEGLLAGISSGAALKGVLKALKQLPSGARVVTVFPDTGERYLSMAPYFNL

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=303, Percent_Identity=42.2442244224422, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI295821200, Length=303, Percent_Identity=42.2442244224422, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI4557415, Length=303, Percent_Identity=42.2442244224422, Blast_Score=238, Evalue=6e-63,
Organism=Escherichia coli, GI1788754, Length=307, Percent_Identity=48.8599348534202, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI2367138, Length=301, Percent_Identity=40.1993355481728, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI115535073, Length=304, Percent_Identity=50.6578947368421, Blast_Score=270, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17535051, Length=301, Percent_Identity=46.1794019933555, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17562970, Length=300, Percent_Identity=43.6666666666667, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI32566674, Length=292, Percent_Identity=44.8630136986301, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17561720, Length=301, Percent_Identity=43.5215946843854, Blast_Score=207, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17534315, Length=311, Percent_Identity=38.5852090032154, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI25147552, Length=309, Percent_Identity=36.8932038834951, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32566672, Length=215, Percent_Identity=40.9302325581395, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=40.3361344537815, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=38.8535031847134, Blast_Score=216, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6321449, Length=323, Percent_Identity=33.1269349845201, Blast_Score=139, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24643623, Length=304, Percent_Identity=39.4736842105263, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI20129101, Length=304, Percent_Identity=39.4736842105263, Blast_Score=209, Evalue=1e-54,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32165; Mature: 32034

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALKLIGNTPLIRMSRNIVGTEAEVFAKLEMFNPGGSVKDRIALSMINSAEQNGHLSQG
CCCCEECCCCCEEEECCCCCCCCHHHEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCC
GTILEPTSGNTGIGLAIVAAVKGYQLILTMPESMSEERRALLKSYGAELVLTLADKGMGG
CEEECCCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCC
AVEKANQIKRENPDYFIPQQFNNISNPEIHKQTTAREIISELDSDIDGLVLGVGTGGTIT
HHHHHHHHHHCCCCEECCHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHH
GVGEVLKHKNPNLKIFAVEPKESPVLSGGNPGPHKIQGLGAGFVPQVLKTELIDEVIQVD
HHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCC
SSEAYDMSNQLAKQEGLLAGISSGAALKGVLKALKQLPSGARVVTVFPDTGERYLSMAPY
CCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHEECCCC
FNL
CCC
>Mature Secondary Structure 
SALKLIGNTPLIRMSRNIVGTEAEVFAKLEMFNPGGSVKDRIALSMINSAEQNGHLSQG
CCCEECCCCCEEEECCCCCCCCHHHEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCC
GTILEPTSGNTGIGLAIVAAVKGYQLILTMPESMSEERRALLKSYGAELVLTLADKGMGG
CEEECCCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCC
AVEKANQIKRENPDYFIPQQFNNISNPEIHKQTTAREIISELDSDIDGLVLGVGTGGTIT
HHHHHHHHHHCCCCEECCHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHH
GVGEVLKHKNPNLKIFAVEPKESPVLSGGNPGPHKIQGLGAGFVPQVLKTELIDEVIQVD
HHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCC
SSEAYDMSNQLAKQEGLLAGISSGAALKGVLKALKQLPSGARVVTVFPDTGERYLSMAPY
CCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHEECCCC
FNL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA