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The map label for this gene is glmU [H]

Identifier: 188584702

GI number: 188584702

Start: 74232

End: 75638

Strand: Direct

Name: glmU [H]

Synonym: Nther_0060

Alternate gene names: 188584702

Gene position: 74232-75638 (Clockwise)

Preceding gene: 188584701

Following gene: 188584703

Centisome position: 2.34

GC content: 36.46

Gene sequence:

>1407_bases
GTGATTAGCTTGAATGATGCTAATACTACTGCTGTTATTTTAGCTGCTGGCAAGGGTACCAGAATGAAGTCAAAAATTCC
AAAAGTATTACATGAAGTTTGTAATAAACCACTATTGTGGCATATTTTAACAGCTGCTCAATCTGTTACGGATAAGCAGA
CAGTGGTGACTGGCTATGGTAGAGAAAAAGTAGAAAACTTTCTTAAAGAAAAATTTGATGATAAAAACTTAACAACTACA
ATTCAGGAACGTCAGATGGGTACTGGGCATGCAGTTGTATGTGCAAAAAATCAATTAAATAGTCCACACACTATGGTGTT
GTTAGGGGATACACCATTGATTACAGATCAAGAGCTGTCAGGACTGAAAAAATACCATGTTGATAATGCATCTGCAGCTA
CAATACTTACCATTACCGAGAATGATCCTCATGGCTATGGTAGGATTATTAGAGATAAAGACGGTTTTGTTAAAAAAATA
GTTGAAGAAGCCGATGCCACACCGCAAGAGAAAGATATTAATGAAATTAATACAGGACTCATGATATTTGAGACTGAAAA
ACTTTTGTTTGCTTTAGATAAATTGGACTCAGAAAATAATCAAGGTGAATATTACTTAACTGATGTTATCAATATTTTGT
ATCAAACAGGCGAATGTGTTTTAGGATATCAAATAGAAAAAACATATCGGGCATTGGGTGTTAATGACAGAGCAGAACTG
GCTAGAGCCGAAAAAATAAAACGCCAGGAGATAAACAACGAGTTTATGTATTGTGGAGTGACTATAAAAGATCCAGAAAG
CACATATATAGATCCTGAGATTTCTATTGGATATGATACAGTTATTTACCCTAATACTTATCTTACTGGGGACACCCGTA
TAGGGACGAACTGTGAAATTGGTCCAGAGGTACAAATTTCAGATTCCTTTATCGGTGATGGCTGTAAAGTAAAAAAATCA
CAGATTACGGATAGTATATTAGAAGATGAGGTATCTATAGGTCCCTATGCTCAAATTCGTCCAGGTACAACAATTGGATC
AAAAGCTAAAATAGGTAACTTTGTTGAAGTCAAAAATTCAAGTATCGGTGAAAACACTAAAGCTAATCATCTGGCCTATA
TTGGCGATGCAGATATAGGATCAAATGTTAATATGGGGGCCGGCAGTGTTATAGTGAATTATGATGGACAGATCAAACAC
AGAACAGTTATAGAGGATGGAGCTTTTGTTGGTTGTAATAGTAATCTAGTAGCTCCCGTTACGATAAAAACGAATGCTTT
CGTTGCTGCCGGGAGTACTGTAACAGAAAACATCCCTGAAGATAGCTTGGGGATTGCTCGATGCAGACAAACAAACAAAG
AAGATTGGGTTACTAAAAAAATGGGCAGGGGGTATAGTGATGGCTAA

Upstream 100 bases:

>100_bases
CCGGTATAATTATGTCCAAAAAAGGAGCTAATATGCTCCTTTTTTGGTGTTAACCTTTAACTGTGATATAATATTTTCGA
ACTTAAATTGGATGACTGGG

Downstream 100 bases:

>100_bases
TGATGAAAAGCGACTTAATACTAAAAACTTAAAGATTTTTTCAGGAAATGCTAATCTAAATCTATCCCAAGAAATAACAG
AATATTTGGGAGTAGACATG

Product: glucosamine-1-phosphate N-acetyltransferase, UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MISLNDANTTAVILAAGKGTRMKSKIPKVLHEVCNKPLLWHILTAAQSVTDKQTVVTGYGREKVENFLKEKFDDKNLTTT
IQERQMGTGHAVVCAKNQLNSPHTMVLLGDTPLITDQELSGLKKYHVDNASAATILTITENDPHGYGRIIRDKDGFVKKI
VEEADATPQEKDINEINTGLMIFETEKLLFALDKLDSENNQGEYYLTDVINILYQTGECVLGYQIEKTYRALGVNDRAEL
ARAEKIKRQEINNEFMYCGVTIKDPESTYIDPEISIGYDTVIYPNTYLTGDTRIGTNCEIGPEVQISDSFIGDGCKVKKS
QITDSILEDEVSIGPYAQIRPGTTIGSKAKIGNFVEVKNSSIGENTKANHLAYIGDADIGSNVNMGAGSVIVNYDGQIKH
RTVIEDGAFVGCNSNLVAPVTIKTNAFVAAGSTVTENIPEDSLGIARCRQTNKEDWVTKKMGRGYSDG

Sequences:

>Translated_468_residues
MISLNDANTTAVILAAGKGTRMKSKIPKVLHEVCNKPLLWHILTAAQSVTDKQTVVTGYGREKVENFLKEKFDDKNLTTT
IQERQMGTGHAVVCAKNQLNSPHTMVLLGDTPLITDQELSGLKKYHVDNASAATILTITENDPHGYGRIIRDKDGFVKKI
VEEADATPQEKDINEINTGLMIFETEKLLFALDKLDSENNQGEYYLTDVINILYQTGECVLGYQIEKTYRALGVNDRAEL
ARAEKIKRQEINNEFMYCGVTIKDPESTYIDPEISIGYDTVIYPNTYLTGDTRIGTNCEIGPEVQISDSFIGDGCKVKKS
QITDSILEDEVSIGPYAQIRPGTTIGSKAKIGNFVEVKNSSIGENTKANHLAYIGDADIGSNVNMGAGSVIVNYDGQIKH
RTVIEDGAFVGCNSNLVAPVTIKTNAFVAAGSTVTENIPEDSLGIARCRQTNKEDWVTKKMGRGYSDG
>Mature_468_residues
MISLNDANTTAVILAAGKGTRMKSKIPKVLHEVCNKPLLWHILTAAQSVTDKQTVVTGYGREKVENFLKEKFDDKNLTTT
IQERQMGTGHAVVCAKNQLNSPHTMVLLGDTPLITDQELSGLKKYHVDNASAATILTITENDPHGYGRIIRDKDGFVKKI
VEEADATPQEKDINEINTGLMIFETEKLLFALDKLDSENNQGEYYLTDVINILYQTGECVLGYQIEKTYRALGVNDRAEL
ARAEKIKRQEINNEFMYCGVTIKDPESTYIDPEISIGYDTVIYPNTYLTGDTRIGTNCEIGPEVQISDSFIGDGCKVKKS
QITDSILEDEVSIGPYAQIRPGTTIGSKAKIGNFVEVKNSSIGENTKANHLAYIGDADIGSNVNMGAGSVIVNYDGQIKH
RTVIEDGAFVGCNSNLVAPVTIKTNAFVAAGSTVTENIPEDSLGIARCRQTNKEDWVTKKMGRGYSDG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=456, Percent_Identity=39.6929824561403, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI133931050, Length=381, Percent_Identity=25.1968503937008, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355443, Length=387, Percent_Identity=23.5142118863049, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644084, Length=387, Percent_Identity=23.5142118863049, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 51308; Mature: 51308

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISLNDANTTAVILAAGKGTRMKSKIPKVLHEVCNKPLLWHILTAAQSVTDKQTVVTGYG
CEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCEEEECCC
REKVENFLKEKFDDKNLTTTIQERQMGTGHAVVCAKNQLNSPHTMVLLGDTPLITDQELS
HHHHHHHHHHHCCCCCCEEHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHHH
GLKKYHVDNASAATILTITENDPHGYGRIIRDKDGFVKKIVEEADATPQEKDINEINTGL
HHHHCCCCCCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCHHHHCCCE
MIFETEKLLFALDKLDSENNQGEYYLTDVINILYQTGECVLGYQIEKTYRALGVNDRAEL
EEEECHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCEEEEEEEHHHHHHCCCCCHHHH
ARAEKIKRQEINNEFMYCGVTIKDPESTYIDPEISIGYDTVIYPNTYLTGDTRIGTNCEI
HHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEECCEEEEECCCEEECCCCEECCCCCC
GPEVQISDSFIGDGCKVKKSQITDSILEDEVSIGPYAQIRPGTTIGSKAKIGNFVEVKNS
CCCEEECCCCCCCCCEEEHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCEEEECCC
SIGENTKANHLAYIGDADIGSNVNMGAGSVIVNYDGQIKHRTVIEDGAFVGCNSNLVAPV
CCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCEEECCCCEEEEE
TIKTNAFVAAGSTVTENIPEDSLGIARCRQTNKEDWVTKKMGRGYSDG
EEECCEEEEECCHHHCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MISLNDANTTAVILAAGKGTRMKSKIPKVLHEVCNKPLLWHILTAAQSVTDKQTVVTGYG
CEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCEEEECCC
REKVENFLKEKFDDKNLTTTIQERQMGTGHAVVCAKNQLNSPHTMVLLGDTPLITDQELS
HHHHHHHHHHHCCCCCCEEHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHHH
GLKKYHVDNASAATILTITENDPHGYGRIIRDKDGFVKKIVEEADATPQEKDINEINTGL
HHHHCCCCCCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCHHHHCCCE
MIFETEKLLFALDKLDSENNQGEYYLTDVINILYQTGECVLGYQIEKTYRALGVNDRAEL
EEEECHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCEEEEEEEHHHHHHCCCCCHHHH
ARAEKIKRQEINNEFMYCGVTIKDPESTYIDPEISIGYDTVIYPNTYLTGDTRIGTNCEI
HHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEECCEEEEECCCEEECCCCEECCCCCC
GPEVQISDSFIGDGCKVKKSQITDSILEDEVSIGPYAQIRPGTTIGSKAKIGNFVEVKNS
CCCEEECCCCCCCCCEEEHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCEEEECCC
SIGENTKANHLAYIGDADIGSNVNMGAGSVIVNYDGQIKHRTVIEDGAFVGCNSNLVAPV
CCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCEEECCCCEEEEE
TIKTNAFVAAGSTVTENIPEDSLGIARCRQTNKEDWVTKKMGRGYSDG
EEECCEEEEECCHHHCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]