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The map label for this gene is dnaX [H]

Identifier: 188584657

GI number: 188584657

Start: 26074

End: 27843

Strand: Direct

Name: dnaX [H]

Synonym: Nther_0015

Alternate gene names: 188584657

Gene position: 26074-27843 (Clockwise)

Preceding gene: 188584656

Following gene: 188584658

Centisome position: 0.82

GC content: 34.75

Gene sequence:

>1770_bases
ATGGATTATCAAGCCCTCTATCGTCAATGGCGTCCAAAATATTTTAGAGATTTGGTAGGACAGGAGCATGTGGTTACTAC
TCTTAAAAACGCTATTAGTCAGAGTCGTATATCCCATGCCTATTTATTTTCTGGTCCACGAGGAACAGGAAAAACTAGTG
TTGCAAAAGTATTCGCCAAGGCTTTAAACTGCGATCACAGTCAGGATAACGAGCCTTGTGGCCAGTGCTCAAGATGTATT
GAACACGATCGAGGGACTTTTATGGACATTTTGGAAATTGATGCAGCATCTAATAGGGGAATTGATGAAATCAGAGAAAT
TAGAGATCATGTTGCTTACTCACCCTCTGAAGGAAACTATAAAGTCTATATTGTCGATGAGGTCCATATGTTAACTACTG
AAGCCTTTAATGCCCTACTAAAAACCTTAGAAGAACCACCAGATTATGTTATTTTTATTTTAGCTACTACTGAACCACAT
AAACTTCCCATGACAGTGTTGTCAAGATGTCAAAGATTTGATTTTTACAGGCTTTCTACATCTAAAATTGAAAAACAATT
GCAAAATGTTATAGATAGTAAAAATTTATCAGCTACTAAAGAGAGTCTTTCAATAATTGCTAAAAAATCTGATGGCGGTA
TGAGAGATGCCCTGAGCTTATTGGATCAGTCGTTATCATTTCTAGGCTCGGGTGAGCAGTTAAAAGTGGACCATGTACTT
GAGGTTACTGGTACAGTTTCCGAGGATACCTTCTATGATTTATTAATGGCTTTGAAAGAGGGAGATTTAGCCCAAATTCT
AAACATAGTCCAACAGCTTTCGGATAGTGGAAAAGATTTTGGCCAATTTTTAAATGATTTGATTGTATACTTAAGAGATT
TATTGTTATTTAAATTAAAAGGGCCATCTGATCAATTGTTATGGGGTAGTGTTGATAGTGTAAAAAAACTTCATAAATAC
TTTACTAAGGACGAACTTATTTCTATGATAGATTTTCTTTCAGAAAAGCAACAGGCAATGAAATGGTCGCAAAATCGAAG
ATTAATTGTTGAAATGGCTTTTTATCGAATAATTAACAAATATAATACTTCTTTTGAGGCAGAATACAAAGAAAAGGAAA
CAAAACAAAAAAATAATGAAGAAACAAATGATAAATCACTAAAAGTGCAACAGACAACATCTATCGAGTCAGTCGAATCA
GAGAATAAAGAGAATGCAAAGCTCCAGGATCAGAGTTCTCTACCAAAACAAACAGATGACCAAAGTAATAAGAATAATGA
TAGTAGTAAACTATCTAGGGAAGACAGCGATATTCAACAATCAGAGACAAAAAAAGATAAGATGACAGAGCAACAAGAGG
CAACAGTACAAAATGATTTGAATTTAAAAATAGTTACAGAGCAATGGGATGCAGTGCTGGAAAAATTGAAACAGAGAAAA
GTTACTGCTCATGCACTAGTTTTTGAAGGGAAACCGGTGGATGTTAAAGAAAATACACTGTATCTAGGGTTTAAAAAGCT
GCATAAACTACACAAGGAACGGGTGGAACAAAAAGAAAAAGGCCTCCTAGAGGAGGTATTAAGTGAGTTTTTTGGAGATA
TTAAGGTTAAATGTATAATTGTTGAGGAAACAGATCTATCTAAGCAAAATACTAAACAGGGAAATGATCACAAAGGTAAC
TCCCAAAATGAAGAGATGGATGACCTTACGGGGATAGCTAAACAAAAATTCGGCCCCGATAAGGTTGAAATATATAATAA
ACAAATTTAA

Upstream 100 bases:

>100_bases
TGTTTTGTTCAAATTTAATCACAATTTGTGATAATATGATATAATAAAATGAGAATTTTTTGGATTTGTTTATGATAATA
ATAAAGGAGATTGTGATACT

Downstream 100 bases:

>100_bases
GCAGGAGGGATTTGAAAATGGGCGGTAAAATGCAAAAAATGATGAAACAAGTACAAAAAATGCAAAGTGAAATGCAAAAA
GTTCAAGAAGAATTAAAAGA

Product: DNA polymerase III, subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MDYQALYRQWRPKYFRDLVGQEHVVTTLKNAISQSRISHAYLFSGPRGTGKTSVAKVFAKALNCDHSQDNEPCGQCSRCI
EHDRGTFMDILEIDAASNRGIDEIREIRDHVAYSPSEGNYKVYIVDEVHMLTTEAFNALLKTLEEPPDYVIFILATTEPH
KLPMTVLSRCQRFDFYRLSTSKIEKQLQNVIDSKNLSATKESLSIIAKKSDGGMRDALSLLDQSLSFLGSGEQLKVDHVL
EVTGTVSEDTFYDLLMALKEGDLAQILNIVQQLSDSGKDFGQFLNDLIVYLRDLLLFKLKGPSDQLLWGSVDSVKKLHKY
FTKDELISMIDFLSEKQQAMKWSQNRRLIVEMAFYRIINKYNTSFEAEYKEKETKQKNNEETNDKSLKVQQTTSIESVES
ENKENAKLQDQSSLPKQTDDQSNKNNDSSKLSREDSDIQQSETKKDKMTEQQEATVQNDLNLKIVTEQWDAVLEKLKQRK
VTAHALVFEGKPVDVKENTLYLGFKKLHKLHKERVEQKEKGLLEEVLSEFFGDIKVKCIIVEETDLSKQNTKQGNDHKGN
SQNEEMDDLTGIAKQKFGPDKVEIYNKQI

Sequences:

>Translated_589_residues
MDYQALYRQWRPKYFRDLVGQEHVVTTLKNAISQSRISHAYLFSGPRGTGKTSVAKVFAKALNCDHSQDNEPCGQCSRCI
EHDRGTFMDILEIDAASNRGIDEIREIRDHVAYSPSEGNYKVYIVDEVHMLTTEAFNALLKTLEEPPDYVIFILATTEPH
KLPMTVLSRCQRFDFYRLSTSKIEKQLQNVIDSKNLSATKESLSIIAKKSDGGMRDALSLLDQSLSFLGSGEQLKVDHVL
EVTGTVSEDTFYDLLMALKEGDLAQILNIVQQLSDSGKDFGQFLNDLIVYLRDLLLFKLKGPSDQLLWGSVDSVKKLHKY
FTKDELISMIDFLSEKQQAMKWSQNRRLIVEMAFYRIINKYNTSFEAEYKEKETKQKNNEETNDKSLKVQQTTSIESVES
ENKENAKLQDQSSLPKQTDDQSNKNNDSSKLSREDSDIQQSETKKDKMTEQQEATVQNDLNLKIVTEQWDAVLEKLKQRK
VTAHALVFEGKPVDVKENTLYLGFKKLHKLHKERVEQKEKGLLEEVLSEFFGDIKVKCIIVEETDLSKQNTKQGNDHKGN
SQNEEMDDLTGIAKQKFGPDKVEIYNKQI
>Mature_589_residues
MDYQALYRQWRPKYFRDLVGQEHVVTTLKNAISQSRISHAYLFSGPRGTGKTSVAKVFAKALNCDHSQDNEPCGQCSRCI
EHDRGTFMDILEIDAASNRGIDEIREIRDHVAYSPSEGNYKVYIVDEVHMLTTEAFNALLKTLEEPPDYVIFILATTEPH
KLPMTVLSRCQRFDFYRLSTSKIEKQLQNVIDSKNLSATKESLSIIAKKSDGGMRDALSLLDQSLSFLGSGEQLKVDHVL
EVTGTVSEDTFYDLLMALKEGDLAQILNIVQQLSDSGKDFGQFLNDLIVYLRDLLLFKLKGPSDQLLWGSVDSVKKLHKY
FTKDELISMIDFLSEKQQAMKWSQNRRLIVEMAFYRIINKYNTSFEAEYKEKETKQKNNEETNDKSLKVQQTTSIESVES
ENKENAKLQDQSSLPKQTDDQSNKNNDSSKLSREDSDIQQSETKKDKMTEQQEATVQNDLNLKIVTEQWDAVLEKLKQRK
VTAHALVFEGKPVDVKENTLYLGFKKLHKLHKERVEQKEKGLLEEVLSEFFGDIKVKCIIVEETDLSKQNTKQGNDHKGN
SQNEEMDDLTGIAKQKFGPDKVEIYNKQI

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=288, Percent_Identity=26.7361111111111, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI31881687, Length=288, Percent_Identity=26.7361111111111, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI6677723, Length=263, Percent_Identity=26.9961977186312, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI194306571, Length=266, Percent_Identity=26.6917293233083, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI194306567, Length=266, Percent_Identity=26.6917293233083, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI31563534, Length=224, Percent_Identity=27.6785714285714, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1786676, Length=362, Percent_Identity=38.121546961326, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI1787341, Length=227, Percent_Identity=29.5154185022026, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554730, Length=275, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71986063, Length=324, Percent_Identity=26.5432098765432, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17541988, Length=250, Percent_Identity=26.4, Blast_Score=78, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322528, Length=303, Percent_Identity=29.042904290429, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324039, Length=262, Percent_Identity=27.4809160305344, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324478, Length=263, Percent_Identity=25.4752851711027, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI18859927, Length=292, Percent_Identity=23.2876712328767, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921076, Length=306, Percent_Identity=26.797385620915, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17647857, Length=224, Percent_Identity=26.7857142857143, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 67478; Mature: 67478

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYQALYRQWRPKYFRDLVGQEHVVTTLKNAISQSRISHAYLFSGPRGTGKTSVAKVFAK
CCHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHCCHHEEECCCCCCCHHHHHHHHHH
ALNCDHSQDNEPCGQCSRCIEHDRGTFMDILEIDAASNRGIDEIREIRDHVAYSPSEGNY
HHCCCCCCCCCHHHHHHHHHHCCCCCEEHHHEECCCCCCCHHHHHHHHHHHCCCCCCCCE
KVYIVDEVHMLTTEAFNALLKTLEEPPDYVIFILATTEPHKLPMTVLSRCQRFDFYRLST
EEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCHHCCCH
SKIEKQLQNVIDSKNLSATKESLSIIAKKSDGGMRDALSLLDQSLSFLGSGEQLKVDHVL
HHHHHHHHHHHCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCEEHHHHE
EVTGTVSEDTFYDLLMALKEGDLAQILNIVQQLSDSGKDFGQFLNDLIVYLRDLLLFKLK
EECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
GPSDQLLWGSVDSVKKLHKYFTKDELISMIDFLSEKQQAMKWSQNRRLIVEMAFYRIINK
CCCCCEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YNTSFEAEYKEKETKQKNNEETNDKSLKVQQTTSIESVESENKENAKLQDQSSLPKQTDD
HCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCHHCCCCCCCC
QSNKNNDSSKLSREDSDIQQSETKKDKMTEQQEATVQNDLNLKIVTEQWDAVLEKLKQRK
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHH
VTAHALVFEGKPVDVKENTLYLGFKKLHKLHKERVEQKEKGLLEEVLSEFFGDIKVKCII
HHHHEEEECCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
VEETDLSKQNTKQGNDHKGNSQNEEMDDLTGIAKQKFGPDKVEIYNKQI
EECCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCC
>Mature Secondary Structure
MDYQALYRQWRPKYFRDLVGQEHVVTTLKNAISQSRISHAYLFSGPRGTGKTSVAKVFAK
CCHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHCCHHEEECCCCCCCHHHHHHHHHH
ALNCDHSQDNEPCGQCSRCIEHDRGTFMDILEIDAASNRGIDEIREIRDHVAYSPSEGNY
HHCCCCCCCCCHHHHHHHHHHCCCCCEEHHHEECCCCCCCHHHHHHHHHHHCCCCCCCCE
KVYIVDEVHMLTTEAFNALLKTLEEPPDYVIFILATTEPHKLPMTVLSRCQRFDFYRLST
EEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCHHCCCH
SKIEKQLQNVIDSKNLSATKESLSIIAKKSDGGMRDALSLLDQSLSFLGSGEQLKVDHVL
HHHHHHHHHHHCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCEEHHHHE
EVTGTVSEDTFYDLLMALKEGDLAQILNIVQQLSDSGKDFGQFLNDLIVYLRDLLLFKLK
EECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
GPSDQLLWGSVDSVKKLHKYFTKDELISMIDFLSEKQQAMKWSQNRRLIVEMAFYRIINK
CCCCCEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YNTSFEAEYKEKETKQKNNEETNDKSLKVQQTTSIESVESENKENAKLQDQSSLPKQTDD
HCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCHHCCCCCCCC
QSNKNNDSSKLSREDSDIQQSETKKDKMTEQQEATVQNDLNLKIVTEQWDAVLEKLKQRK
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHH
VTAHALVFEGKPVDVKENTLYLGFKKLHKLHKERVEQKEKGLLEEVLSEFFGDIKVKCII
HHHHEEEECCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
VEETDLSKQNTKQGNDHKGNSQNEEMDDLTGIAKQKFGPDKVEIYNKQI
EECCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]