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The map label for this gene is rnc

Identifier: 188527489

GI number: 188527489

Start: 680009

End: 680725

Strand: Reverse

Name: rnc

Synonym: HPSH_03545

Alternate gene names: 188527489

Gene position: 680725-680009 (Counterclockwise)

Preceding gene: 188527490

Following gene: 188527488

Centisome position: 42.32

GC content: 38.91

Gene sequence:

>717_bases
ATGAAAAACAAACGCTCTCAAAATAGCCCTTATATAACGAATAGCCCTTATGCAACGCTAGAAAAAGCTTTGGGGTATTC
TTTTAAAGACAAGCGTTTATTGGAGCAAGCCTTAACGCATAAATCATGCAAGCTCGCTTTAAACAATGAGCGCTTGGAAT
TTTTAGGCGATGCGGTGTTGGGTTTGGTGATAGGGGAGTTGCTATACCATAAATTCTATCAATACGATGAGGGCAAACTC
TCTAAATTAAGGGCTTCTATTGTGAGCGCGCATGGTTTTACTAAATTAGCGAAAGTGATCGCTTTACAAGATTATTTGCA
CATTTCTTCTTCTGAAGAAATTTCTAATGGGAGAGAAAAACCCTCTATTTTATCAAGCGCTTTTGAGGCTTTAATGGCCG
GGGTGTATTTAGAAGCGGGGTTAGCTAAGGTGCAAAAAATCATACAAAATTTACTCAATCGCGCTTACAAGCGTTTGGAT
TTGGAGCATTTGTTTATGGACTATAAAACCGCTTTACAGGAATTAACCCAAGCGCAATTTTGCGTGATCCCCACTTACCA
ATTGCTCAAAGAAAAAGGCCCCGATCACCATAAAGAATTTGAAATGGCTCTATACATTCAAGATAAAATATACGCGACCG
CTAAAGGCAAAAGCAAAAAAGAAGCCGAACAGCAATGCGCTTATCAAGCGCTTCAAAAACTTAAGGAAGTAAAATGA

Upstream 100 bases:

>100_bases
TGGATCAAGGGGCATAATGGGCATGCCGAGAATGAACGATGCGATAGCCTCGCTAAATTAGAGGCACAAAAACGGGTAAA
AACGACCAAAGGGAAAAACG

Downstream 100 bases:

>100_bases
ACACTTTGGGGCGTTTTTTAAGGCTCACGACTTTTGGGGAATCGCATGGGGATGTGATAGGGGGGGTATTAGACGGCATG
CCTAGTGGGATTAAAATAGA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKNKRSQNSPYITNSPYATLEKALGYSFKDKRLLEQALTHKSCKLALNNERLEFLGDAVLGLVIGELLYHKFYQYDEGKL
SKLRASIVSAHGFTKLAKVIALQDYLHISSSEEISNGREKPSILSSAFEALMAGVYLEAGLAKVQKIIQNLLNRAYKRLD
LEHLFMDYKTALQELTQAQFCVIPTYQLLKEKGPDHHKEFEMALYIQDKIYATAKGKSKKEAEQQCAYQALQKLKEVK

Sequences:

>Translated_238_residues
MKNKRSQNSPYITNSPYATLEKALGYSFKDKRLLEQALTHKSCKLALNNERLEFLGDAVLGLVIGELLYHKFYQYDEGKL
SKLRASIVSAHGFTKLAKVIALQDYLHISSSEEISNGREKPSILSSAFEALMAGVYLEAGLAKVQKIIQNLLNRAYKRLD
LEHLFMDYKTALQELTQAQFCVIPTYQLLKEKGPDHHKEFEMALYIQDKIYATAKGKSKKEAEQQCAYQALQKLKEVK
>Mature_238_residues
MKNKRSQNSPYITNSPYATLEKALGYSFKDKRLLEQALTHKSCKLALNNERLEFLGDAVLGLVIGELLYHKFYQYDEGKL
SKLRASIVSAHGFTKLAKVIALQDYLHISSSEEISNGREKPSILSSAFEALMAGVYLEAGLAKVQKIIQNLLNRAYKRLD
LEHLFMDYKTALQELTQAQFCVIPTYQLLKEKGPDHHKEFEMALYIQDKIYATAKGKSKKEAEQQCAYQALQKLKEVK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=229, Percent_Identity=29.6943231441048, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI155030236, Length=229, Percent_Identity=29.6943231441048, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1788920, Length=230, Percent_Identity=36.5217391304348, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI193202651, Length=244, Percent_Identity=26.2295081967213, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17506883, Length=244, Percent_Identity=26.2295081967213, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17137682, Length=231, Percent_Identity=29.004329004329, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27114; Mature: 27114

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKRSQNSPYITNSPYATLEKALGYSFKDKRLLEQALTHKSCKLALNNERLEFLGDAVL
CCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GLVIGELLYHKFYQYDEGKLSKLRASIVSAHGFTKLAKVIALQDYLHISSSEEISNGREK
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCC
PSILSSAFEALMAGVYLEAGLAKVQKIIQNLLNRAYKRLDLEHLFMDYKTALQELTQAQF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
CVIPTYQLLKEKGPDHHKEFEMALYIQDKIYATAKGKSKKEAEQQCAYQALQKLKEVK
HCCCCHHHHHCCCCCHHHHHHHHEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNKRSQNSPYITNSPYATLEKALGYSFKDKRLLEQALTHKSCKLALNNERLEFLGDAVL
CCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GLVIGELLYHKFYQYDEGKLSKLRASIVSAHGFTKLAKVIALQDYLHISSSEEISNGREK
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCC
PSILSSAFEALMAGVYLEAGLAKVQKIIQNLLNRAYKRLDLEHLFMDYKTALQELTQAQF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
CVIPTYQLLKEKGPDHHKEFEMALYIQDKIYATAKGKSKKEAEQQCAYQALQKLKEVK
HCCCCHHHHHCCCCCHHHHHHHHEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA