Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 188527486

GI number: 188527486

Start: 676989

End: 678362

Strand: Reverse

Name: hemN [H]

Synonym: HPSH_03530

Alternate gene names: 188527486

Gene position: 678362-676989 (Counterclockwise)

Preceding gene: 188527487

Following gene: 188527485

Centisome position: 42.17

GC content: 39.3

Gene sequence:

>1374_bases
ATGCAAACCATTGATTTTGAAAAATTTTCCCAATATTCAAAGCCTGGGCCGCGATACACCAGCTACCCAACAGCGGTGGA
ATTTAAAGAAAATTTTAATGAAGAGAGCTTGAAAACGGCGTTTTTTAACCATGACCATCTCAAAAACCCCATGCCCTTAT
CGCTTTATACGCATTTGCCCTTTTGCAGGAGTGCGTGCTATTTTTGCGCTTGTTCAGTCATTTACACAAGTTTAGAAGAG
AAAAAAACCCGCTATATCAGCTACCTTAAAAAAGAACTCGCCCTTTTAAAAAACGCGATGGATACCAACAGAGAAGTGGC
GCAATTCCACTATGGAGGCGGTACGCCGACCTTTTTTTCGCCCATTCAATTAGATGAAATCACCCAAAGCATTCAAGAAG
TTTTCCCTAATTTCAGTCAAGATATTGAGATGAGTTGCGAGATTGACCCTAGACATTTCACTAAAGAACACATGCAAACC
TTGTTTGATAGAGGGTTTAACCGCTTGAGTTTTGGGGTGCAAGATTTTGATTTTGAAGTCCAAAAAGCCATTCACCGGAT
TCAGCCTTTTGAAATGGTTCAAGAATCCGTGAAGCTCGCTAGAGATTACGGCATCAAATCCATTAATTTTGATTTGATTT
ATGGCTTACCCAACCAGACTAAAGAGAGTTTTTTAAAAACTTTGGAATTGGTTTTGAAACTGGATCCGGACCGGTTAGCG
GTGTTTAATTACGCGCATGTGCCTTGGGTGAAAAAAACGATGCGTAAAATTGATGAAACCTTATTGCCAAGCCCTAGAGA
CAAGCTAGAGATTTTAGAATCCCTCATTAGTTTTTTAGAAAAAGCCCACTACCAAATGATAGGCATGGATCATTTCGCTA
AAAGCGATAATGAATTGTATATAGCCCTTCAAAAAGCGCAATTGCGTCGTAATTTTCAAGGCTATACCACTAAGAAATTC
ACTCAAACCATTGGCATTGGCGTTACGAGCATTGGCGAAGGGAGCGATTACTACACGCAAAATTATAAAGACTTGCACCA
CTATGAAAAAGCCCTTGATTTGGGGCATTTACCGGTAGAAAGGGGTGTAGCGCTCACCAAAGAAGATGTATTGAGAAAAG
AAGTGATCATGCAAATGATGAGTAATTTAAAACTGGATTACTCTAAGATTGAAGAAAAATTTTCTATTGATTTTAAAGCG
CATTTTAAAAAAGAATTAGAAAAATTAAAGCCTTATGAAGAAGCGGGCTTGCTTTCTTTTAACGCTAAAGGCTTTGAGAT
GACCAAAACAGGGGGCATGCTCGTAAGAAACATGGCTATGGAGTTTGACGCGTATTTGCGTGGGGGCGAAAAACATTTCA
GTAAAACGCTATGA

Upstream 100 bases:

>100_bases
ACCCTAATTTATTTTTTAATTTTGACAACATGTTCAAACAACCCCCTTTTAATGAGAATAATTTTGAAAATTTTGACAAC
AGCGATGAGGAAAATTTTTG

Downstream 100 bases:

>100_bases
ATGAAAATATTTTTGAAGAAGTAGGGGACGCTTGCGTTAAATGCGCTAAATGCGTGCCAGGTTGCACCATATACCGCATC
CATAAAGACGAAACGACTTC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MQTIDFEKFSQYSKPGPRYTSYPTAVEFKENFNEESLKTAFFNHDHLKNPMPLSLYTHLPFCRSACYFCACSVIYTSLEE
KKTRYISYLKKELALLKNAMDTNREVAQFHYGGGTPTFFSPIQLDEITQSIQEVFPNFSQDIEMSCEIDPRHFTKEHMQT
LFDRGFNRLSFGVQDFDFEVQKAIHRIQPFEMVQESVKLARDYGIKSINFDLIYGLPNQTKESFLKTLELVLKLDPDRLA
VFNYAHVPWVKKTMRKIDETLLPSPRDKLEILESLISFLEKAHYQMIGMDHFAKSDNELYIALQKAQLRRNFQGYTTKKF
TQTIGIGVTSIGEGSDYYTQNYKDLHHYEKALDLGHLPVERGVALTKEDVLRKEVIMQMMSNLKLDYSKIEEKFSIDFKA
HFKKELEKLKPYEEAGLLSFNAKGFEMTKTGGMLVRNMAMEFDAYLRGGEKHFSKTL

Sequences:

>Translated_457_residues
MQTIDFEKFSQYSKPGPRYTSYPTAVEFKENFNEESLKTAFFNHDHLKNPMPLSLYTHLPFCRSACYFCACSVIYTSLEE
KKTRYISYLKKELALLKNAMDTNREVAQFHYGGGTPTFFSPIQLDEITQSIQEVFPNFSQDIEMSCEIDPRHFTKEHMQT
LFDRGFNRLSFGVQDFDFEVQKAIHRIQPFEMVQESVKLARDYGIKSINFDLIYGLPNQTKESFLKTLELVLKLDPDRLA
VFNYAHVPWVKKTMRKIDETLLPSPRDKLEILESLISFLEKAHYQMIGMDHFAKSDNELYIALQKAQLRRNFQGYTTKKF
TQTIGIGVTSIGEGSDYYTQNYKDLHHYEKALDLGHLPVERGVALTKEDVLRKEVIMQMMSNLKLDYSKIEEKFSIDFKA
HFKKELEKLKPYEEAGLLSFNAKGFEMTKTGGMLVRNMAMEFDAYLRGGEKHFSKTL
>Mature_457_residues
MQTIDFEKFSQYSKPGPRYTSYPTAVEFKENFNEESLKTAFFNHDHLKNPMPLSLYTHLPFCRSACYFCACSVIYTSLEE
KKTRYISYLKKELALLKNAMDTNREVAQFHYGGGTPTFFSPIQLDEITQSIQEVFPNFSQDIEMSCEIDPRHFTKEHMQT
LFDRGFNRLSFGVQDFDFEVQKAIHRIQPFEMVQESVKLARDYGIKSINFDLIYGLPNQTKESFLKTLELVLKLDPDRLA
VFNYAHVPWVKKTMRKIDETLLPSPRDKLEILESLISFLEKAHYQMIGMDHFAKSDNELYIALQKAQLRRNFQGYTTKKF
TQTIGIGVTSIGEGSDYYTQNYKDLHHYEKALDLGHLPVERGVALTKEDVLRKEVIMQMMSNLKLDYSKIEEKFSIDFKA
HFKKELEKLKPYEEAGLLSFNAKGFEMTKTGGMLVRNMAMEFDAYLRGGEKHFSKTL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Escherichia coli, GI87082341, Length=461, Percent_Identity=42.7331887201735, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1789325, Length=282, Percent_Identity=28.0141843971631, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 53277; Mature: 53277

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIDFEKFSQYSKPGPRYTSYPTAVEFKENFNEESLKTAFFNHDHLKNPMPLSLYTHLP
CCCCCHHHHHHCCCCCCCCCCCCCEEHHHHCCCHHHHHHHHCCHHHCCCCCCCHHHHCCH
FCRSACYFCACSVIYTSLEEKKTRYISYLKKELALLKNAMDTNREVAQFHYGGGTPTFFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCCCC
PIQLDEITQSIQEVFPNFSQDIEMSCEIDPRHFTKEHMQTLFDRGFNRLSFGVQDFDFEV
CCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHH
QKAIHRIQPFEMVQESVKLARDYGIKSINFDLIYGLPNQTKESFLKTLELVLKLDPDRLA
HHHHHHCCHHHHHHHHHHHHHHCCCCEECEEEEECCCCHHHHHHHHHHHHHHHCCCCCEE
VFNYAHVPWVKKTMRKIDETLLPSPRDKLEILESLISFLEKAHYQMIGMDHFAKSDNELY
EECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCEE
IALQKAQLRRNFQGYTTKKFTQTIGIGVTSIGEGSDYYTQNYKDLHHYEKALDLGHLPVE
EEEEHHHHHHCCCCCCHHHHHHHHCCCEEECCCCCCHHHCCHHHHHHHHHHHHCCCCCHH
RGVALTKEDVLRKEVIMQMMSNLKLDYSKIEEKFSIDFKAHFKKELEKLKPYEEAGLLSF
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCHHHCCCEEE
NAKGFEMTKTGGMLVRNMAMEFDAYLRGGEKHFSKTL
CCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure
MQTIDFEKFSQYSKPGPRYTSYPTAVEFKENFNEESLKTAFFNHDHLKNPMPLSLYTHLP
CCCCCHHHHHHCCCCCCCCCCCCCEEHHHHCCCHHHHHHHHCCHHHCCCCCCCHHHHCCH
FCRSACYFCACSVIYTSLEEKKTRYISYLKKELALLKNAMDTNREVAQFHYGGGTPTFFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCCCC
PIQLDEITQSIQEVFPNFSQDIEMSCEIDPRHFTKEHMQTLFDRGFNRLSFGVQDFDFEV
CCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHH
QKAIHRIQPFEMVQESVKLARDYGIKSINFDLIYGLPNQTKESFLKTLELVLKLDPDRLA
HHHHHHCCHHHHHHHHHHHHHHCCCCEECEEEEECCCCHHHHHHHHHHHHHHHCCCCCEE
VFNYAHVPWVKKTMRKIDETLLPSPRDKLEILESLISFLEKAHYQMIGMDHFAKSDNELY
EECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCEE
IALQKAQLRRNFQGYTTKKFTQTIGIGVTSIGEGSDYYTQNYKDLHHYEKALDLGHLPVE
EEEEHHHHHHCCCCCCHHHHHHHHCCCEEECCCCCCHHHCCHHHHHHHHHHHHCCCCCHH
RGVALTKEDVLRKEVIMQMMSNLKLDYSKIEEKFSIDFKAHFKKELEKLKPYEEAGLLSF
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCHHHCCCEEE
NAKGFEMTKTGGMLVRNMAMEFDAYLRGGEKHFSKTL
CCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]