| Definition | Helicobacter pylori Shi470, complete genome. |
|---|---|
| Accession | NC_010698 |
| Length | 1,608,548 |
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The map label for this gene is gyrA [H]
Identifier: 188527452
GI number: 188527452
Start: 636147
End: 638627
Strand: Reverse
Name: gyrA [H]
Synonym: HPSH_03350
Alternate gene names: 188527452
Gene position: 638627-636147 (Counterclockwise)
Preceding gene: 188527453
Following gene: 188527451
Centisome position: 39.7
GC content: 41.35
Gene sequence:
>2481_bases ATGCAAGATAATTTAATCAATGAAACAAAAAATATTGTAGAAGTGGGGATTGATTCTTCTATTGAAGAAAGCTATTTAGC TTATTCAATGAGCGTGATCATAGGGCGCGCTTTACCGGACGCTAGAGATGGCTTAAAGCCCGTGCATAGGCGCATTTTGT ATGCGATGCATGAATTAGGTCTCACTTCCAAAGTCGCTTATAAAAAAAGCGCTAGGATCGTGGGTGATGTGATTGGTAAA TACCACCCCCATGGCGATAACGCGGTTTATGATGCGCTAGTGAGAATGGCGCAAGATTTTTCTATGCGTTTGGAATTGGT GGATGGGCAAGGCAACTTTGGCTCTATTGATGGCGATAATGCTGCGGCGATGCGTTACACTGAAGCCAGAATGACCAAGG CGAGTGAAGAAATTTTAAGGGATATTGATAAAGACACCATTGATTTTGTGCCTAATTACGATGACACCTTAAAAGAGCCC GATATTTTACCAAGCCGTCTGCCTAACCTTTTAGTCAATGGGGCTAATGGGATCGCTGTAGGGATGGCGACTTCTATCCC CCCTCACAGGATTGATGAAATCATAGACGCTTTAGTGCATGTCTTAGAAAACCCTAACGCTGGATTAGATGAAATTTTGG AATTTGTCAAAGGGCCTGACTTTCCCACTGGCGGGATCATTTATGGCAAGGCGGGTATTATTGAAGCCTATAAAACGGGG CGAGGGCGCGTGAAAGTGCGCGCCAAAGTGCATGTGGAAAAGACGAAAAATAAAGAAATCATCGTTTTAGATGAAATGCC TTTTCAAACCAATAAAGCCAAATTAGTGGAACAAATCAGCGATTTAGCGCGAGAAAAACAAATTGAAGGCATTAGCGAAG TGCGCGATGAGAGCGATAGAGAGGGCATTAGAGTGGTGATTGAATTAAAAAGAGACGCGATGAGTGAAATTGTCTTAAAC CACCTCTACAAACTCACCACCATGGAGACCACTTTTAGTATCATTTTACTCGCTATTTATAATAAAGAGCCTAAGATTTT CACGCTTTTAGAGTTGTTGCGCCTTTTTTTAAACCACAGAAAAACCATTATTATAAGACGCACTATTTTTGAATTAGAGA AGGCTAAAGCTAGAGCGCATATTTTAGAGGGCTATTTGATCGCATTAGACAATATTGATGAAATCGTGCGACTCATTAAA ACAAGCCAAAGCCCAGAAGCGGCTAAAGACGCCTTAATGGAGCGTTTTACTTTGAGCGAAATCCAGAGCAAAGCCATTTT AGAAATGCGTTTGCAGCGCTTAACAGGCCTTGAAAGAGATAAAATCAAAGAAGAATACCAAAACTTGCTAGAGCTTATTA GTGATCTCAATGGCATTTTAAAGAGCGAAGATCGCTTGAATGAAGTCGTCAAAACAGAGCTTTTAGAAGTCAAAGAGCAA TTTTCTTCTCAAAGGTGCACTGAAATTCAAGAAGTTTATGAAAATATTGACATAGAAGATTTGATCGCTAATGAGCCTAT GGTGGTGAGCATGAGCTATAAAGGCTATGTGAAAAGAGTGGATTTAAAAGCTTATGAAAGGCAAAATCGTGGCGGTAAGG GCAAGCTTTCAGGCAACACTTATGAAGACGATTTCATTGAAAACTTTTTTGTGGCTAACACGCATGATATTTTGCTCTTT ATCACCAACAAGGGGCAGTTGTATCGTTTGAAAGTCTATAAGATCCCAGAAGCGAGCCGGATCGCTATGGGTAAAGCCAT CGTGAATTTAATCTCGCTCGCTCCTGATGAAAAGATCATGGCAACCCTAAGCACCAAAGACTTTAGTGATGAACGCTCTT TAGCTTTCTTCACCAAAAAAGGCGTGGTGAAGCGCACCAATTTGAGCGAATTTGACAGCAACTATAACGGTATGAGAGCG ATTGTTTTAGATGAAGGCGATGAATTGGTGAGCGCAAAAATTGTGGATAAAAACGCTAAACATTTGCTCATCGCATCGTA TTTGGGCATTTTCATTAAATTCTCTTTAGAAGATGTGCGCGAGATCGGAAGAACTACTCGTGGGGTTAGAGGGATCAGGC TGAATGAAAATGATTTTGTTGTCGGCGCGGTCGTTATTAGCGATGACAGCAACAAGCTTTTGAGCGTGAGTGAAAACGGG CTTGGCAAGCAAACTTTAGCCGAAGCGTATAGAGAGCAATCTCGTGGAGGTAAGGGGATTATTGGCATGAAGCTCACTCA AAAGACCGGCAATCTAGTGAGCGTTATCAGTGTGGATGATGAAAACCTGGATTTGATGATCCTTACTGCAAGCGCGAAAA TGATCAGAGTTTCTATTCAAGATATTAAAGAAACCATCGGAAGAAATACTAGTGGGGTAAAACTCATAGACACCGCTGAT AAAGTCGTGTATGCCAATTCTTGCCCTAAAGAAGAAGAGCCAGAAAATTCAGAAAACCCTCCCACACAATTGTTTGAATG A
Upstream 100 bases:
>100_bases GCCAGTTCAGCCCAACTGATAGGGCTTATTTTTTGGGCTTTCATTTGGGGGCATTATCTTTTAACGCTTTATTTGGAGTA ATTAAATTTTAGGGAGACAC
Downstream 100 bases:
>100_bases TGCGTTTCTTTTCATTCTTGTATTTTTTATTGTATTTTTTAGGGGTTTCTTTGCATGCTCTAAACCCCCTAGAAGATCAA GAATTTTTAATTTCGTATCG
Product: DNA gyrase subunit A
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 826; Mature: 826
Protein sequence:
>826_residues MQDNLINETKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELGLTSKVAYKKSARIVGDVIGK YHPHGDNAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDNAAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEP DILPSRLPNLLVNGANGIAVGMATSIPPHRIDEIIDALVHVLENPNAGLDEILEFVKGPDFPTGGIIYGKAGIIEAYKTG RGRVKVRAKVHVEKTKNKEIIVLDEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDREGIRVVIELKRDAMSEIVLN HLYKLTTMETTFSIILLAIYNKEPKIFTLLELLRLFLNHRKTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVRLIK TSQSPEAAKDALMERFTLSEIQSKAILEMRLQRLTGLERDKIKEEYQNLLELISDLNGILKSEDRLNEVVKTELLEVKEQ FSSQRCTEIQEVYENIDIEDLIANEPMVVSMSYKGYVKRVDLKAYERQNRGGKGKLSGNTYEDDFIENFFVANTHDILLF ITNKGQLYRLKVYKIPEASRIAMGKAIVNLISLAPDEKIMATLSTKDFSDERSLAFFTKKGVVKRTNLSEFDSNYNGMRA IVLDEGDELVSAKIVDKNAKHLLIASYLGIFIKFSLEDVREIGRTTRGVRGIRLNENDFVVGAVVISDDSNKLLSVSENG LGKQTLAEAYREQSRGGKGIIGMKLTQKTGNLVSVISVDDENLDLMILTASAKMIRVSIQDIKETIGRNTSGVKLIDTAD KVVYANSCPKEEEPENSENPPTQLFE
Sequences:
>Translated_826_residues MQDNLINETKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELGLTSKVAYKKSARIVGDVIGK YHPHGDNAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDNAAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEP DILPSRLPNLLVNGANGIAVGMATSIPPHRIDEIIDALVHVLENPNAGLDEILEFVKGPDFPTGGIIYGKAGIIEAYKTG RGRVKVRAKVHVEKTKNKEIIVLDEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDREGIRVVIELKRDAMSEIVLN HLYKLTTMETTFSIILLAIYNKEPKIFTLLELLRLFLNHRKTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVRLIK TSQSPEAAKDALMERFTLSEIQSKAILEMRLQRLTGLERDKIKEEYQNLLELISDLNGILKSEDRLNEVVKTELLEVKEQ FSSQRCTEIQEVYENIDIEDLIANEPMVVSMSYKGYVKRVDLKAYERQNRGGKGKLSGNTYEDDFIENFFVANTHDILLF ITNKGQLYRLKVYKIPEASRIAMGKAIVNLISLAPDEKIMATLSTKDFSDERSLAFFTKKGVVKRTNLSEFDSNYNGMRA IVLDEGDELVSAKIVDKNAKHLLIASYLGIFIKFSLEDVREIGRTTRGVRGIRLNENDFVVGAVVISDDSNKLLSVSENG LGKQTLAEAYREQSRGGKGIIGMKLTQKTGNLVSVISVDDENLDLMILTASAKMIRVSIQDIKETIGRNTSGVKLIDTAD KVVYANSCPKEEEPENSENPPTQLFE >Mature_826_residues MQDNLINETKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELGLTSKVAYKKSARIVGDVIGK YHPHGDNAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDNAAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEP DILPSRLPNLLVNGANGIAVGMATSIPPHRIDEIIDALVHVLENPNAGLDEILEFVKGPDFPTGGIIYGKAGIIEAYKTG RGRVKVRAKVHVEKTKNKEIIVLDEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDREGIRVVIELKRDAMSEIVLN HLYKLTTMETTFSIILLAIYNKEPKIFTLLELLRLFLNHRKTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVRLIK TSQSPEAAKDALMERFTLSEIQSKAILEMRLQRLTGLERDKIKEEYQNLLELISDLNGILKSEDRLNEVVKTELLEVKEQ FSSQRCTEIQEVYENIDIEDLIANEPMVVSMSYKGYVKRVDLKAYERQNRGGKGKLSGNTYEDDFIENFFVANTHDILLF ITNKGQLYRLKVYKIPEASRIAMGKAIVNLISLAPDEKIMATLSTKDFSDERSLAFFTKKGVVKRTNLSEFDSNYNGMRA IVLDEGDELVSAKIVDKNAKHLLIASYLGIFIKFSLEDVREIGRTTRGVRGIRLNENDFVVGAVVISDDSNKLLSVSENG LGKQTLAEAYREQSRGGKGIIGMKLTQKTGNLVSVISVDDENLDLMILTASAKMIRVSIQDIKETIGRNTSGVKLIDTAD KVVYANSCPKEEEPENSENPPTQLFE
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913406, Length=343, Percent_Identity=25.6559766763848, Blast_Score=87, Evalue=7e-17, Organism=Homo sapiens, GI19913408, Length=428, Percent_Identity=24.2990654205607, Blast_Score=84, Evalue=8e-16, Organism=Escherichia coli, GI1788562, Length=829, Percent_Identity=47.2858866103739, Blast_Score=763, Evalue=0.0, Organism=Escherichia coli, GI1789396, Length=672, Percent_Identity=37.9464285714286, Blast_Score=426, Evalue=1e-120, Organism=Caenorhabditis elegans, GI17535065, Length=211, Percent_Identity=26.5402843601896, Blast_Score=74, Evalue=3e-13, Organism=Caenorhabditis elegans, GI212645657, Length=210, Percent_Identity=26.1904761904762, Blast_Score=74, Evalue=4e-13, Organism=Caenorhabditis elegans, GI212645845, Length=204, Percent_Identity=27.4509803921569, Blast_Score=72, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6324241, Length=376, Percent_Identity=26.063829787234, Blast_Score=96, Evalue=3e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR005743 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013757 - InterPro: IPR013760 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 92813; Mature: 92813
Theoretical pI: Translated: 5.29; Mature: 5.29
Prosite motif: PS00572 GLYCOSYL_HYDROL_F1_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQDNLINETKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELG CCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHCC LTSKVAYKKSARIVGDVIGKYHPHGDNAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDN CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCC AAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEPDILPSRLPNLLVNGANGIAV CHHEEHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCHHHCCHHEEECCCCEEE GMATSIPPHRIDEIIDALVHVLENPNAGLDEILEFVKGPDFPTGGIIYGKAGIIEAYKTG EEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCCCHHHHHHCC RGRVKVRAKVHVEKTKNKEIIVLDEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDR CCEEEEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCC EGIRVVIELKRDAMSEIVLNHLYKLTTMETTFSIILLAIYNKEPKIFTLLELLRLFLNHR CCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHCCC KTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVRLIKTSQSPEAAKDALMERFTLSE CEEEEHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH IQSKAILEMRLQRLTGLERDKIKEEYQNLLELISDLNGILKSEDRLNEVVKTELLEVKEQ HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH FSSQRCTEIQEVYENIDIEDLIANEPMVVSMSYKGYVKRVDLKAYERQNRGGKGKLSGNT HHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEECCCCEEEECHHHHHHHCCCCCCCCCCCC YEDDFIENFFVANTHDILLFITNKGQLYRLKVYKIPEASRIAMGKAIVNLISLAPDEKIM CCHHHHHHEEEECCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHE ATLSTKDFSDERSLAFFTKKGVVKRTNLSEFDSNYNGMRAIVLDEGDELVSAKIVDKNAK EEECCCCCCCCCCEEEEECCCCEEECCCHHHCCCCCCEEEEEEECCCCEEEEEEECCCCC HLLIASYLGIFIKFSLEDVREIGRTTRGVRGIRLNENDFVVGAVVISDDSNKLLSVSENG HHHHHHHHHHHEEECHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEECCCCCEEEECCCC LGKQTLAEAYREQSRGGKGIIGMKLTQKTGNLVSVISVDDENLDLMILTASAKMIRVSIQ CCHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEECCCCCEEEEEECCCEEEEHHHH DIKETIGRNTSGVKLIDTADKVVYANSCPKEEEPENSENPPTQLFE HHHHHHCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCHHCCC >Mature Secondary Structure MQDNLINETKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELG CCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHCC LTSKVAYKKSARIVGDVIGKYHPHGDNAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDN CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCC AAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEPDILPSRLPNLLVNGANGIAV CHHEEHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCHHHCCHHEEECCCCEEE GMATSIPPHRIDEIIDALVHVLENPNAGLDEILEFVKGPDFPTGGIIYGKAGIIEAYKTG EEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCCCHHHHHHCC RGRVKVRAKVHVEKTKNKEIIVLDEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDR CCEEEEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCC EGIRVVIELKRDAMSEIVLNHLYKLTTMETTFSIILLAIYNKEPKIFTLLELLRLFLNHR CCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHCCC KTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVRLIKTSQSPEAAKDALMERFTLSE CEEEEHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH IQSKAILEMRLQRLTGLERDKIKEEYQNLLELISDLNGILKSEDRLNEVVKTELLEVKEQ HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH FSSQRCTEIQEVYENIDIEDLIANEPMVVSMSYKGYVKRVDLKAYERQNRGGKGKLSGNT HHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEECCCCEEEECHHHHHHHCCCCCCCCCCCC YEDDFIENFFVANTHDILLFITNKGQLYRLKVYKIPEASRIAMGKAIVNLISLAPDEKIM CCHHHHHHEEEECCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHE ATLSTKDFSDERSLAFFTKKGVVKRTNLSEFDSNYNGMRAIVLDEGDELVSAKIVDKNAK EEECCCCCCCCCCEEEEECCCCEEECCCHHHCCCCCCEEEEEEECCCCEEEEEEECCCCC HLLIASYLGIFIKFSLEDVREIGRTTRGVRGIRLNENDFVVGAVVISDDSNKLLSVSENG HHHHHHHHHHHEEECHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEECCCCCEEEECCCC LGKQTLAEAYREQSRGGKGIIGMKLTQKTGNLVSVISVDDENLDLMILTASAKMIRVSIQ CCHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEECCCCCEEEEEECCCEEEEHHHH DIKETIGRNTSGVKLIDTADKVVYANSCPKEEEPENSENPPTQLFE HHHHHHCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9923682 [H]