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The map label for this gene is hemL [H]

Identifier: 188527112

GI number: 188527112

Start: 308588

End: 309880

Strand: Direct

Name: hemL [H]

Synonym: HPSH_01585

Alternate gene names: 188527112

Gene position: 308588-309880 (Clockwise)

Preceding gene: 188527111

Following gene: 188527113

Centisome position: 19.18

GC content: 43.46

Gene sequence:

>1293_bases
ATGGAGTTGTTGCACAGCATTAATGATTTTAATGAAGCTAAACAGGTGATCGCTGGGGGGGTCAATTCGCCTGTGAGGGC
GTTTAAGAGCGTTAAAGGCACTCCCCCCTTTATTTTAAAGGGTAAGGGGGCGTATCTTTATGATGTGGATAACAACCATT
ATATAGATTTTGTGCAAAGCTGGGGACCTTTGATTTTTGGGCATGCTGATGAAGAGATTGAAGAAAATATTATTAATGTA
TTAAAAAAAGGCACTTCTTTTGGCACTCCCACAGAATTAGAAACCACTTTAGCTAAGGAGATCATTTCTTGTTATGAAGG
CTTAGATAAGGTGCGTTTAGTGAGTAGCGGCACAGAAGCGACCATGAGCGCGATACGACTCGCTAGAGCTTATAGCCAAA
AAGACGATTTGATCAAGTTTGAAGGGTGCTATCATGGGCATAGCGACTCCTTATTGGTGAAAGCGGGTAGCGGGTGCGCG
ACTTTTGGATCGCCTTCTTCTTTAGGCGTGCCGAACGATTTTAGCAAACACACTTTAGTGGCTCGTTATAACGATTTAAA
CTCCACAGAAGAATGCTTTAAAAAAGGCGATGTGGGTTGCGTCATTATTGAACCCATTGCCGGGAATATGGGGTTAGTGC
CGGCTCAAAAAGAGTTTTTATTAGGCTTAAAGGCTTTGTGTGAAAAATACCAAGCGGTGCTGATTTTAGATGAAGTGATG
AGTGGGTTTAGAGCGAGCTTGAGCGGTTCGCAAGAATTTTATGGCGTGGTGCCGGATTTGGTAACCTTTGGTAAGGTGAT
AGGCGCGGGGCTTCCTTTGGCGTGTTTTGGGGGGCGTGCGGAAATTATGGACTTGCTTTCACCCATTGGAGGCGTGTATC
AAGCAGGCACATTGAGCGGTAACCCCCTAGCGGTGTGTGCGGGGTTGAGCGCGCTTTATAAAATCAAAAGAGATAAAACC
CTTTATACCCGCTTAAACGCTTTAGCCGTTCGTTTGGCTCAAGGTTTAAAAAAGAGCGCTCAAAGCTATAACATCGCTTT
AGAAACGCTCAATAGAGGGAGCATGTTTGGCTTTTTCTTTAACGAAAATGCGGTGCGTGATTTTGATGACGCTTTAAAAA
GCGATACGGAAATGTTTGCAAAATTCCACCAAAAAATGCTCTTTAAGGGCGTGTATTTGGCATGTTCAAGCTTTGAAACC
GGCTTTATTTGTGAGCCTATGACTGAAGAGATGATTGATTTAGCGGTTGCAAAAGCCGATGAAAGTTTTGATGAAATCAT
AAAAGGTGTGTGA

Upstream 100 bases:

>100_bases
AGCGAGCTTAGCTAAACGATGCGAGAGTTTTCATGAGGGCTTGACTTGGTCGCAAGTGGAAATCCAATTTGAAAGCATGA
TTAAGGGATAATTTAAAATC

Downstream 100 bases:

>100_bases
ATTTTTGAAAAAGCCAAAGTATTATAAATTCATAGAGGGGGCGAATTATTTGAGCTTGGGGCTTTCTATGGTGGTAGCGA
TCCTTATGGGCGTGGCTATA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MELLHSINDFNEAKQVIAGGVNSPVRAFKSVKGTPPFILKGKGAYLYDVDNNHYIDFVQSWGPLIFGHADEEIEENIINV
LKKGTSFGTPTELETTLAKEIISCYEGLDKVRLVSSGTEATMSAIRLARAYSQKDDLIKFEGCYHGHSDSLLVKAGSGCA
TFGSPSSLGVPNDFSKHTLVARYNDLNSTEECFKKGDVGCVIIEPIAGNMGLVPAQKEFLLGLKALCEKYQAVLILDEVM
SGFRASLSGSQEFYGVVPDLVTFGKVIGAGLPLACFGGRAEIMDLLSPIGGVYQAGTLSGNPLAVCAGLSALYKIKRDKT
LYTRLNALAVRLAQGLKKSAQSYNIALETLNRGSMFGFFFNENAVRDFDDALKSDTEMFAKFHQKMLFKGVYLACSSFET
GFICEPMTEEMIDLAVAKADESFDEIIKGV

Sequences:

>Translated_430_residues
MELLHSINDFNEAKQVIAGGVNSPVRAFKSVKGTPPFILKGKGAYLYDVDNNHYIDFVQSWGPLIFGHADEEIEENIINV
LKKGTSFGTPTELETTLAKEIISCYEGLDKVRLVSSGTEATMSAIRLARAYSQKDDLIKFEGCYHGHSDSLLVKAGSGCA
TFGSPSSLGVPNDFSKHTLVARYNDLNSTEECFKKGDVGCVIIEPIAGNMGLVPAQKEFLLGLKALCEKYQAVLILDEVM
SGFRASLSGSQEFYGVVPDLVTFGKVIGAGLPLACFGGRAEIMDLLSPIGGVYQAGTLSGNPLAVCAGLSALYKIKRDKT
LYTRLNALAVRLAQGLKKSAQSYNIALETLNRGSMFGFFFNENAVRDFDDALKSDTEMFAKFHQKMLFKGVYLACSSFET
GFICEPMTEEMIDLAVAKADESFDEIIKGV
>Mature_430_residues
MELLHSINDFNEAKQVIAGGVNSPVRAFKSVKGTPPFILKGKGAYLYDVDNNHYIDFVQSWGPLIFGHADEEIEENIINV
LKKGTSFGTPTELETTLAKEIISCYEGLDKVRLVSSGTEATMSAIRLARAYSQKDDLIKFEGCYHGHSDSLLVKAGSGCA
TFGSPSSLGVPNDFSKHTLVARYNDLNSTEECFKKGDVGCVIIEPIAGNMGLVPAQKEFLLGLKALCEKYQAVLILDEVM
SGFRASLSGSQEFYGVVPDLVTFGKVIGAGLPLACFGGRAEIMDLLSPIGGVYQAGTLSGNPLAVCAGLSALYKIKRDKT
LYTRLNALAVRLAQGLKKSAQSYNIALETLNRGSMFGFFFNENAVRDFDDALKSDTEMFAKFHQKMLFKGVYLACSSFET
GFICEPMTEEMIDLAVAKADESFDEIIKGV

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=314, Percent_Identity=26.1146496815287, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI13994255, Length=426, Percent_Identity=25.1173708920188, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI284507298, Length=228, Percent_Identity=25.4385964912281, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786349, Length=424, Percent_Identity=50, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI1789016, Length=416, Percent_Identity=29.0865384615385, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1787560, Length=380, Percent_Identity=30, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788044, Length=285, Percent_Identity=34.0350877192982, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789759, Length=334, Percent_Identity=29.0419161676647, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI145693181, Length=333, Percent_Identity=27.027027027027, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71992977, Length=366, Percent_Identity=27.8688524590164, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=298, Percent_Identity=26.1744966442953, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25144274, Length=139, Percent_Identity=31.6546762589928, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=341, Percent_Identity=27.5659824046921, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6324432, Length=348, Percent_Identity=25.8620689655172, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI161085790, Length=367, Percent_Identity=25.3405994550409, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI28574759, Length=367, Percent_Identity=25.3405994550409, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21357415, Length=295, Percent_Identity=23.0508474576271, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46684; Mature: 46684

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLHSINDFNEAKQVIAGGVNSPVRAFKSVKGTPPFILKGKGAYLYDVDNNHYIDFVQS
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCEEEEECCCCCEEHHHHH
WGPLIFGHADEEIEENIINVLKKGTSFGTPTELETTLAKEIISCYEGLDKVRLVSSGTEA
CCCEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCHHHEEEECCCHHH
TMSAIRLARAYSQKDDLIKFEGCYHGHSDSLLVKAGSGCATFGSPSSLGVPNDFSKHTLV
HHHHHHHHHHHCCCCCCEEEECEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEE
ARYNDLNSTEECFKKGDVGCVIIEPIAGNMGLVPAQKEFLLGLKALCEKYQAVLILDEVM
EEECCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SGFRASLSGSQEFYGVVPDLVTFGKVIGAGLPLACFGGRAEIMDLLSPIGGVYQAGTLSG
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHCCHHCCCCCCC
NPLAVCAGLSALYKIKRDKTLYTRLNALAVRLAQGLKKSAQSYNIALETLNRGSMFGFFF
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEE
NENAVRDFDDALKSDTEMFAKFHQKMLFKGVYLACSSFETGFICEPMTEEMIDLAVAKAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
ESFDEIIKGV
CHHHHHHCCC
>Mature Secondary Structure
MELLHSINDFNEAKQVIAGGVNSPVRAFKSVKGTPPFILKGKGAYLYDVDNNHYIDFVQS
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCEEEEECCCCCEEHHHHH
WGPLIFGHADEEIEENIINVLKKGTSFGTPTELETTLAKEIISCYEGLDKVRLVSSGTEA
CCCEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCHHHEEEECCCHHH
TMSAIRLARAYSQKDDLIKFEGCYHGHSDSLLVKAGSGCATFGSPSSLGVPNDFSKHTLV
HHHHHHHHHHHCCCCCCEEEECEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEE
ARYNDLNSTEECFKKGDVGCVIIEPIAGNMGLVPAQKEFLLGLKALCEKYQAVLILDEVM
EEECCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SGFRASLSGSQEFYGVVPDLVTFGKVIGAGLPLACFGGRAEIMDLLSPIGGVYQAGTLSG
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHCCHHCCCCCCC
NPLAVCAGLSALYKIKRDKTLYTRLNALAVRLAQGLKKSAQSYNIALETLNRGSMFGFFF
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEE
NENAVRDFDDALKSDTEMFAKFHQKMLFKGVYLACSSFETGFICEPMTEEMIDLAVAKAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
ESFDEIIKGV
CHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA