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The map label for this gene is lspA [H]

Identifier: 187928896

GI number: 187928896

Start: 1906166

End: 1907242

Strand: Reverse

Name: lspA [H]

Synonym: Rpic_1814

Alternate gene names: 187928896

Gene position: 1907242-1906166 (Counterclockwise)

Preceding gene: 187928897

Following gene: 187928887

Centisome position: 48.38

GC content: 60.54

Gene sequence:

>1077_bases
ATGAATTGGAAGTTCCTTGTGTACGACTGGGGCGGCTGGAACGTCGCGATGTTCAGTGCCATCAACTCGGCGACGCCAAG
CACCCTTGATCCGGTGGCGTGGTTCTTTAGCCTGATTGGCAACTATTGGACCGCGCCGCTCTTGCTGCTGACGCTCTGGT
GGTGGTCGGTGTCTGTGTCGAATCCGGCACGCGCATGCGCGGTCCGGCAACGTCTCATCACGTTCGGGGTGGCCTTTGTA
CTCGCCTTGCTGGCCGCCTCCACGTTGAAATGGTGGCTGGACTTTCCTCGGCCGCCTGCGGTGCTCGGCCATCTCGTGCA
TGTCATTGGCGTCGCGGAGCTGCATTACAGCCTGCCCAGTGGGCACGCGACCTACGCGGCGCTCGTTGCGGGAGCACTCT
GGCCTTTGGTGGGCTTTCGGGGCCGTCTCGGGTTGGTGCTGTATGCCGCTTCGGTCGGGTGGTCGCGCGTTGCAGCCGGG
ATGCACTTCCCAGCGGACGTGCTGGCGGGTTGGACTCTTGGGACTAGCTGTGTCGCTGTCGCCGGTTACGCCGCGCCGCT
GCTCGCTGCAATGTGGATCAAGCATCGTGGCACACCGAATGTGGCCTGGTATGGGATTGCGGCGTGTTGCTTCATGGCCG
ATCAAGCTGCCAAGTTCGCCATCACGCGGACGTTTGCCTATGGTGAGCGGATTGAGGTCACATCAACCTTTGACCTTGTG
TACGTGCGCAATCCCGGCGCGGCATTTAGTTTCCTCGCCGATGCAGGTGGTTGGCAGCGCTATCTCTTTATGGGCCTAAG
TCTGGTTGTCTCGGTATGGTTGGCCCACGTGTTGCGTAAGCGGTTGTCTAACATGGAAGCCTTGGCCTACAGCCTGATCC
TCGGCGGTGCAGCAGGCAATCTCGCAGACCGCATCTGGCGCGGCCAGGTTGTGGATTTTCTGGATCTGCATTGGATGCAA
CTCCACTGGCCGGCATTCAACCTCGCCGACGTGGCGATCACAACAGGTGCGGGCTGTTTGATGCTGGCAGTATTGATGCA
ACGACAAGGCACCACGGCGAAAAGCCTATCTGGCTGA

Upstream 100 bases:

>100_bases
TGTTGACCTTTACCGGCCAGGCCACCATGTGGATGGCCGTGTTTGCCGACATGGGCGCCAGCCTGCTGGTGGTCGGCAAC
GGGTTGCGGCTGCTGCGCAA

Downstream 100 bases:

>100_bases
TAGTTGCCCGGGTTAGCCGCGCTCTTGGCTTGAAGGATTCACTTAGCCCATGCCGAGGCTCGTGCGGCGAGATGCTTCAA
AAGCAGTAGCCCATATTTGA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MNWKFLVYDWGGWNVAMFSAINSATPSTLDPVAWFFSLIGNYWTAPLLLLTLWWWSVSVSNPARACAVRQRLITFGVAFV
LALLAASTLKWWLDFPRPPAVLGHLVHVIGVAELHYSLPSGHATYAALVAGALWPLVGFRGRLGLVLYAASVGWSRVAAG
MHFPADVLAGWTLGTSCVAVAGYAAPLLAAMWIKHRGTPNVAWYGIAACCFMADQAAKFAITRTFAYGERIEVTSTFDLV
YVRNPGAAFSFLADAGGWQRYLFMGLSLVVSVWLAHVLRKRLSNMEALAYSLILGGAAGNLADRIWRGQVVDFLDLHWMQ
LHWPAFNLADVAITTGAGCLMLAVLMQRQGTTAKSLSG

Sequences:

>Translated_358_residues
MNWKFLVYDWGGWNVAMFSAINSATPSTLDPVAWFFSLIGNYWTAPLLLLTLWWWSVSVSNPARACAVRQRLITFGVAFV
LALLAASTLKWWLDFPRPPAVLGHLVHVIGVAELHYSLPSGHATYAALVAGALWPLVGFRGRLGLVLYAASVGWSRVAAG
MHFPADVLAGWTLGTSCVAVAGYAAPLLAAMWIKHRGTPNVAWYGIAACCFMADQAAKFAITRTFAYGERIEVTSTFDLV
YVRNPGAAFSFLADAGGWQRYLFMGLSLVVSVWLAHVLRKRLSNMEALAYSLILGGAAGNLADRIWRGQVVDFLDLHWMQ
LHWPAFNLADVAITTGAGCLMLAVLMQRQGTTAKSLSG
>Mature_358_residues
MNWKFLVYDWGGWNVAMFSAINSATPSTLDPVAWFFSLIGNYWTAPLLLLTLWWWSVSVSNPARACAVRQRLITFGVAFV
LALLAASTLKWWLDFPRPPAVLGHLVHVIGVAELHYSLPSGHATYAALVAGALWPLVGFRGRLGLVLYAASVGWSRVAAG
MHFPADVLAGWTLGTSCVAVAGYAAPLLAAMWIKHRGTPNVAWYGIAACCFMADQAAKFAITRTFAYGERIEVTSTFDLV
YVRNPGAAFSFLADAGGWQRYLFMGLSLVVSVWLAHVLRKRLSNMEALAYSLILGGAAGNLADRIWRGQVVDFLDLHWMQ
LHWPAFNLADVAITTGAGCLMLAVLMQRQGTTAKSLSG

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=147, Percent_Identity=41.4965986394558, Blast_Score=116, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 39028; Mature: 39028

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWKFLVYDWGGWNVAMFSAINSATPSTLDPVAWFFSLIGNYWTAPLLLLTLWWWSVSVS
CCCEEEEEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NPARACAVRQRLITFGVAFVLALLAASTLKWWLDFPRPPAVLGHLVHVIGVAELHYSLPS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCC
GHATYAALVAGALWPLVGFRGRLGLVLYAASVGWSRVAAGMHFPADVLAGWTLGTSCVAV
CCHHHHHHHHHHHHHHHCCCCCHHHEEEEHHCCHHHHHCCCCCCHHHHHCCCHHHHHHHH
AGYAAPLLAAMWIKHRGTPNVAWYGIAACCFMADQAAKFAITRTFAYGERIEVTSTFDLV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEEEEEE
YVRNPGAAFSFLADAGGWQRYLFMGLSLVVSVWLAHVLRKRLSNMEALAYSLILGGAAGN
EEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
LADRIWRGQVVDFLDLHWMQLHWPAFNLADVAITTGAGCLMLAVLMQRQGTTAKSLSG
HHHHHHHCHHHHHHHHHHHEEECCCCCHHHHHHCCCCHHHHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure
MNWKFLVYDWGGWNVAMFSAINSATPSTLDPVAWFFSLIGNYWTAPLLLLTLWWWSVSVS
CCCEEEEEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NPARACAVRQRLITFGVAFVLALLAASTLKWWLDFPRPPAVLGHLVHVIGVAELHYSLPS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCC
GHATYAALVAGALWPLVGFRGRLGLVLYAASVGWSRVAAGMHFPADVLAGWTLGTSCVAV
CCHHHHHHHHHHHHHHHCCCCCHHHEEEEHHCCHHHHHCCCCCCHHHHHCCCHHHHHHHH
AGYAAPLLAAMWIKHRGTPNVAWYGIAACCFMADQAAKFAITRTFAYGERIEVTSTFDLV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEEEEEE
YVRNPGAAFSFLADAGGWQRYLFMGLSLVVSVWLAHVLRKRLSNMEALAYSLILGGAAGN
EEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
LADRIWRGQVVDFLDLHWMQLHWPAFNLADVAITTGAGCLMLAVLMQRQGTTAKSLSG
HHHHHHHCHHHHHHHHHHHEEECCCCCHHHHHHCCCCHHHHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA