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The map label for this gene is cusS [H]

Identifier: 187928824

GI number: 187928824

Start: 1835821

End: 1837206

Strand: Reverse

Name: cusS [H]

Synonym: Rpic_1741

Alternate gene names: 187928824

Gene position: 1837206-1835821 (Counterclockwise)

Preceding gene: 187928825

Following gene: 187928823

Centisome position: 46.6

GC content: 61.69

Gene sequence:

>1386_bases
ATGAAGCGCCGTATGTCGCTGACCATGCGGCTGACGTTGTTGTTTTCTCTGACGTCGGCATTGGTGCTACTTGGCCTCGG
AATACTGATCTGGCTTTCCATGGACCGGCATTTTGCCGACGAAGATTATGTGGTGCTTGGGGACAACGTTCGTCTGATTC
AAAAGATCGCTCAGGAGCAATCCAGCACGCACCTGCCGAGCCGTCTTGCGGAAATGGTGGAACATCACCCCGGTTTTGTC
GCCCATGTGAGCACCGCGAAAGGTGACGTCATTTACCGCACCAATGGGTTCGATTTTGGCGCCATGCTCAACGTTATTGG
CCGGCTTGGACCGGATGAGACGACCTTGAGCTGGCAGCAGGGAGACAAGGAATACCGAGGTATGCGCGCGCACGCGACAG
TGCCCGGCGAGTCGGTGCCCTTGGCGGTGATGGTCGGCATGGACACCGAAATCCATGCCCACTTTATGCACGCGTTTCGT
CGCTCGCTGGCCTTCTATACCACGTTGGCGGTGCTCGCCAGCGGCTTGTTCGGCTGGTGGGCAGCCAGGCGCGGTCTGGC
GCCGTTGCGAACGATGGCCTCTCGCGCCAAGGGTGTCACGTCGAATCACCTTGACGCCCGCATGCCCGTGGAGACCGTGC
CGGTGGAGATGGCCGATCTGGCGGCGACGCTGAATGCCATGCTCGAGCGCTTGCAGGACGATTTCCGGCGATTGTCCGAA
TTCTCGTCCGACCTGGCTCACGAATTGCGCACGCCGATCACCAACCTGATGACCCAGACCCATGTCGTGTTGTCGCAGCC
GCGCGAGGCCGCCAAGTACCGCGACGTGTTGGCCTCCAACGCCGAGGAGCTGCTGCGCCTTGGCCGCATGGTGTCCGATA
TGCTTTACTTGGCCAAGATGGAGCACGGCATCACGCTGCCCAACGAGGAGTCGATCCATGTCGGCGACGAGGCCCGCGCG
CTGTTTGATTTCTACGACGCCTTGGCCGAGGACAAGGGTGTGCAGCTGCGCCTGCAGGGCGACGCCAGCATCGTGGGCGA
TCGCCTGATGTTGCGCCGCGCACTGAGCAATCTGCTGTCGAACGCACTGCGGTATACGCCCAGCGGCAAAGCGATTGTGA
TCAAGGCATGCGAGCAAGACGGCGGCGCCACCATCGTGGTCGAGAACCAGGGCGAGGGGATCGATCCCGAGCTGTTGCCG
TCGTTGTTCGACCGGTTCTTTCGGGCCGACAAGTCCAGGGCGCGCGCTGATTCGGACAGCGTGGGGCTTGGCTTGTCGAT
CACGCAAGCCATCATGGTGGCGCACCGCGGTGGAATCTCGGCTGAGTCGTCAGGCGGTCTCACCCGCTTTATTCTGACCT
TCCCGCGGCGCCAGCCACGAGCTTAG

Upstream 100 bases:

>100_bases
TTCGCCGCTTGCGAGCCAAGATCGACGACGACTTCGACGCCAAGCTGATTCAGACGGTGCGAGGCATGGGGTACGTGCTG
GAAGCGCCCGAGGGGCAAGA

Downstream 100 bases:

>100_bases
GGAGGCCGGTCCCCCATGGCGAGCTGCGAGGCACGTGCTGATGCCAGCAAGATCGGCATACTGTTAGGCCATGTGCCGGA
TCCCGCTGCCAATAGCGACG

Product: heavy metal sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MKRRMSLTMRLTLLFSLTSALVLLGLGILIWLSMDRHFADEDYVVLGDNVRLIQKIAQEQSSTHLPSRLAEMVEHHPGFV
AHVSTAKGDVIYRTNGFDFGAMLNVIGRLGPDETTLSWQQGDKEYRGMRAHATVPGESVPLAVMVGMDTEIHAHFMHAFR
RSLAFYTTLAVLASGLFGWWAARRGLAPLRTMASRAKGVTSNHLDARMPVETVPVEMADLAATLNAMLERLQDDFRRLSE
FSSDLAHELRTPITNLMTQTHVVLSQPREAAKYRDVLASNAEELLRLGRMVSDMLYLAKMEHGITLPNEESIHVGDEARA
LFDFYDALAEDKGVQLRLQGDASIVGDRLMLRRALSNLLSNALRYTPSGKAIVIKACEQDGGATIVVENQGEGIDPELLP
SLFDRFFRADKSRARADSDSVGLGLSITQAIMVAHRGGISAESSGGLTRFILTFPRRQPRA

Sequences:

>Translated_461_residues
MKRRMSLTMRLTLLFSLTSALVLLGLGILIWLSMDRHFADEDYVVLGDNVRLIQKIAQEQSSTHLPSRLAEMVEHHPGFV
AHVSTAKGDVIYRTNGFDFGAMLNVIGRLGPDETTLSWQQGDKEYRGMRAHATVPGESVPLAVMVGMDTEIHAHFMHAFR
RSLAFYTTLAVLASGLFGWWAARRGLAPLRTMASRAKGVTSNHLDARMPVETVPVEMADLAATLNAMLERLQDDFRRLSE
FSSDLAHELRTPITNLMTQTHVVLSQPREAAKYRDVLASNAEELLRLGRMVSDMLYLAKMEHGITLPNEESIHVGDEARA
LFDFYDALAEDKGVQLRLQGDASIVGDRLMLRRALSNLLSNALRYTPSGKAIVIKACEQDGGATIVVENQGEGIDPELLP
SLFDRFFRADKSRARADSDSVGLGLSITQAIMVAHRGGISAESSGGLTRFILTFPRRQPRA
>Mature_461_residues
MKRRMSLTMRLTLLFSLTSALVLLGLGILIWLSMDRHFADEDYVVLGDNVRLIQKIAQEQSSTHLPSRLAEMVEHHPGFV
AHVSTAKGDVIYRTNGFDFGAMLNVIGRLGPDETTLSWQQGDKEYRGMRAHATVPGESVPLAVMVGMDTEIHAHFMHAFR
RSLAFYTTLAVLASGLFGWWAARRGLAPLRTMASRAKGVTSNHLDARMPVETVPVEMADLAATLNAMLERLQDDFRRLSE
FSSDLAHELRTPITNLMTQTHVVLSQPREAAKYRDVLASNAEELLRLGRMVSDMLYLAKMEHGITLPNEESIHVGDEARA
LFDFYDALAEDKGVQLRLQGDASIVGDRLMLRRALSNLLSNALRYTPSGKAIVIKACEQDGGATIVVENQGEGIDPELLP
SLFDRFFRADKSRARADSDSVGLGLSITQAIMVAHRGGISAESSGGLTRFILTFPRRQPRA

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=475, Percent_Identity=36, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI1788279, Length=383, Percent_Identity=31.5926892950392, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790346, Length=276, Percent_Identity=31.8840579710145, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1790551, Length=302, Percent_Identity=28.476821192053, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788393, Length=267, Percent_Identity=27.7153558052434, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1787894, Length=321, Percent_Identity=28.9719626168224, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1789403, Length=292, Percent_Identity=28.7671232876712, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789149, Length=320, Percent_Identity=25.625, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI87081816, Length=234, Percent_Identity=29.4871794871795, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787374, Length=310, Percent_Identity=24.8387096774194, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786912, Length=217, Percent_Identity=27.1889400921659, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=227, Percent_Identity=27.3127753303965, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788549, Length=227, Percent_Identity=26.8722466960352, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI48994928, Length=237, Percent_Identity=24.8945147679325, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790436, Length=244, Percent_Identity=25, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790861, Length=284, Percent_Identity=23.943661971831, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50996; Mature: 50996

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRMSLTMRLTLLFSLTSALVLLGLGILIWLSMDRHFADEDYVVLGDNVRLIQKIAQEQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHH
SSTHLPSRLAEMVEHHPGFVAHVSTAKGDVIYRTNGFDFGAMLNVIGRLGPDETTLSWQQ
HCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCCCEECHHC
GDKEYRGMRAHATVPGESVPLAVMVGMDTEIHAHFMHAFRRSLAFYTTLAVLASGLFGWW
CCHHHCCCEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARRGLAPLRTMASRAKGVTSNHLDARMPVETVPVEMADLAATLNAMLERLQDDFRRLSE
HHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FSSDLAHELRTPITNLMTQTHVVLSQPREAAKYRDVLASNAEELLRLGRMVSDMLYLAKM
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
EHGITLPNEESIHVGDEARALFDFYDALAEDKGVQLRLQGDASIVGDRLMLRRALSNLLS
HCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
NALRYTPSGKAIVIKACEQDGGATIVVENQGEGIDPELLPSLFDRFFRADKSRARADSDS
HHHHCCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
VGLGLSITQAIMVAHRGGISAESSGGLTRFILTFPRRQPRA
CCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MKRRMSLTMRLTLLFSLTSALVLLGLGILIWLSMDRHFADEDYVVLGDNVRLIQKIAQEQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHH
SSTHLPSRLAEMVEHHPGFVAHVSTAKGDVIYRTNGFDFGAMLNVIGRLGPDETTLSWQQ
HCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCCCEECHHC
GDKEYRGMRAHATVPGESVPLAVMVGMDTEIHAHFMHAFRRSLAFYTTLAVLASGLFGWW
CCHHHCCCEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARRGLAPLRTMASRAKGVTSNHLDARMPVETVPVEMADLAATLNAMLERLQDDFRRLSE
HHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FSSDLAHELRTPITNLMTQTHVVLSQPREAAKYRDVLASNAEELLRLGRMVSDMLYLAKM
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
EHGITLPNEESIHVGDEARALFDFYDALAEDKGVQLRLQGDASIVGDRLMLRRALSNLLS
HCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
NALRYTPSGKAIVIKACEQDGGATIVVENQGEGIDPELLPSLFDRFFRADKSRARADSDS
HHHHCCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
VGLGLSITQAIMVAHRGGISAESSGGLTRFILTFPRRQPRA
CCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]