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The map label for this gene is cusR [H]

Identifier: 187928825

GI number: 187928825

Start: 1837203

End: 1837889

Strand: Reverse

Name: cusR [H]

Synonym: Rpic_1742

Alternate gene names: 187928825

Gene position: 1837889-1837203 (Counterclockwise)

Preceding gene: 187928827

Following gene: 187928824

Centisome position: 46.62

GC content: 60.99

Gene sequence:

>687_bases
ATGAAACTGCTCGTCGTAGAGGACGAATCCAAGACAGGCCAGTACCTGCGCCAGGGATTGACCGAGGCCGGATTCGTTGT
CGACCTGGTTGGCAACGGGCTTGATGGACAACACCTGGCGCTCAACGAGTCTTACGATCTGATTATTCTCGACGTCATGC
TGCCGGACCTCGATGGCTGGAGAATTCTGCTGAGCCTGCGCGCGGCCGAGAGCGCGGTTCCGGTCTTGTTCCTTACTGCC
CGCGACAGCGTCGCTGATCGGGTCAAGGGACTGGAGCTCGGCGCGGACGATTACCTGGTAAAGCCATTTGCATTCTCCGA
ACTGTTGGCTCGCGTCCGGACGCTGCTGCGCCGCGGCACTGTGCAGATGGGGCTGGACCGCATTCAGGTGGGCGACCTGG
TGCTTGATCTTAGTCGACGTCGCGCTTCGCGCGGAGGTCGCCGGATAGCGCTGACCAGCAAGGAGTTTGCGCTGCTCGAA
CTGCTCGCCCGCAGGCGGGGAGAAGTTCTGCCCCGCTCGTTGATTGCGTCCCAGGTGTGGGATATGAACTTCGACAGCGA
CAGCAATGTGATCGACGTTGCGATTCGCCGCTTGCGAGCCAAGATCGACGACGACTTCGACGCCAAGCTGATTCAGACGG
TGCGAGGCATGGGGTACGTGCTGGAAGCGCCCGAGGGGCAAGAATGA

Upstream 100 bases:

>100_bases
TACATTCCGGTAATGTCCGGGCCACTCGGAGCAGGGCTGCGTAGACTCGCCATGGGCTGACCCAAGCGCAGCCATACAAT
CGGAAAAAGGAAGCTCGAAC

Downstream 100 bases:

>100_bases
AGCGCCGTATGTCGCTGACCATGCGGCTGACGTTGTTGTTTTCTCTGACGTCGGCATTGGTGCTACTTGGCCTCGGAATA
CTGATCTGGCTTTCCATGGA

Product: winged helix family two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKLLVVEDESKTGQYLRQGLTEAGFVVDLVGNGLDGQHLALNESYDLIILDVMLPDLDGWRILLSLRAAESAVPVLFLTA
RDSVADRVKGLELGADDYLVKPFAFSELLARVRTLLRRGTVQMGLDRIQVGDLVLDLSRRRASRGGRRIALTSKEFALLE
LLARRRGEVLPRSLIASQVWDMNFDSDSNVIDVAIRRLRAKIDDDFDAKLIQTVRGMGYVLEAPEGQE

Sequences:

>Translated_228_residues
MKLLVVEDESKTGQYLRQGLTEAGFVVDLVGNGLDGQHLALNESYDLIILDVMLPDLDGWRILLSLRAAESAVPVLFLTA
RDSVADRVKGLELGADDYLVKPFAFSELLARVRTLLRRGTVQMGLDRIQVGDLVLDLSRRRASRGGRRIALTSKEFALLE
LLARRRGEVLPRSLIASQVWDMNFDSDSNVIDVAIRRLRAKIDDDFDAKLIQTVRGMGYVLEAPEGQE
>Mature_228_residues
MKLLVVEDESKTGQYLRQGLTEAGFVVDLVGNGLDGQHLALNESYDLIILDVMLPDLDGWRILLSLRAAESAVPVLFLTA
RDSVADRVKGLELGADDYLVKPFAFSELLARVRTLLRRGTVQMGLDRIQVGDLVLDLSRRRASRGGRRIALTSKEFALLE
LLARRRGEVLPRSLIASQVWDMNFDSDSNVIDVAIRRLRAKIDDDFDAKLIQTVRGMGYVLEAPEGQE

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=68.2819383259912, Blast_Score=320, Evalue=7e-89,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=56.25, Blast_Score=246, Evalue=1e-66,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=42.5339366515837, Blast_Score=166, Evalue=9e-43,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=39.5555555555556, Blast_Score=153, Evalue=9e-39,
Organism=Escherichia coli, GI1789809, Length=234, Percent_Identity=38.034188034188, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=40.1826484018265, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=35.1351351351351, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=36.1607142857143, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=35.2941176470588, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=37.2727272727273, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=39.0350877192982, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=33.6244541484716, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.9559471365639, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI145693140, Length=238, Percent_Identity=30.2521008403361, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=32.7102803738318, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=34.2105263157895, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25421; Mature: 25421

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVVEDESKTGQYLRQGLTEAGFVVDLVGNGLDGQHLALNESYDLIILDVMLPDLDGW
CEEEEEECCCCHHHHHHHCCCCCCEEEEEECCCCCCCEEEECCCCCEEEEEEECCCCCCC
RILLSLRAAESAVPVLFLTARDSVADRVKGLELGADDYLVKPFAFSELLARVRTLLRRGT
EEEEEHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHCC
VQMGLDRIQVGDLVLDLSRRRASRGGRRIALTSKEFALLELLARRRGEVLPRSLIASQVW
HHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCHHHHHHHHHH
DMNFDSDSNVIDVAIRRLRAKIDDDFDAKLIQTVRGMGYVLEAPEGQE
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCC
>Mature Secondary Structure
MKLLVVEDESKTGQYLRQGLTEAGFVVDLVGNGLDGQHLALNESYDLIILDVMLPDLDGW
CEEEEEECCCCHHHHHHHCCCCCCEEEEEECCCCCCCEEEECCCCCEEEEEEECCCCCCC
RILLSLRAAESAVPVLFLTARDSVADRVKGLELGADDYLVKPFAFSELLARVRTLLRRGT
EEEEEHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHCC
VQMGLDRIQVGDLVLDLSRRRASRGGRRIALTSKEFALLELLARRRGEVLPRSLIASQVW
HHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCHHHHHHHHHH
DMNFDSDSNVIDVAIRRLRAKIDDDFDAKLIQTVRGMGYVLEAPEGQE
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]