Click here to switch to the map view.

The map label for this gene is 187927641

Identifier: 187927641

GI number: 187927641

Start: 578529

End: 579773

Strand: Reverse

Name: 187927641

Synonym: Rpic_0541

Alternate gene names: NA

Gene position: 579773-578529 (Counterclockwise)

Preceding gene: 187927645

Following gene: 187927639

Centisome position: 14.71

GC content: 64.74

Gene sequence:

>1245_bases
ATGCCCGCTCCTCACTATGACGTTGTCGTGTTTGGCGCCACGAGCTTTGTCGGCCAGATCCTGACCCGCTACCTGGCCGA
ACACTTTTCGGGGGATGCGGAAACGCTGCGCTGGGCCATCGCCGGACGATCCGAAGCGAAGCTCCAGGAGGTCAAATGTT
CGCTGGGTGCGGCAGGCGAGTCCATCCCGATCATCGTGGCAGATGCTGCCAACGAAGCACAGTTGCAGGCCCTGTGCGCA
CAGACGCGGGTGGTGGTGTCCACGGTCGGCCCCTATGCCCTATATGGCGAGCCGTTGATCAAGGTCTGCGCCGAAAGCGG
AACGGACTACTGCGACCTCACCGGAGAGACGCAGTGGATCAGGCGCATGATCGGCACATATGAAGCGACGGCGCAGCAGT
CCGGGGCGCGCATCGTGCATTGCTGCGGCTTCGACTCGGTGCCGTCGGACATGGGTGTCTACTTCCTGCAGCAACACGCC
ATGCGGCAATGGGGGACGCCCGCCACGCAGGTGAAGTTGCGCGTCAAGACGCTAAAGGGCGGCGCATCGGGCGGCACGAT
CGCCAGCCTGATCAACGTCGTGCAGGAAGCCGCAGCCGACCCCGCCTTGCGCAAGGAGCTGGCCGATCCCTATGCGCTCT
GCCCCAAGGGTCACGGCTTCACGGCGCGCCAGCGCTCTGTCCGGGGCGCGGCGTTCGATGCCGATTTCGATGCGTGGATT
GCGCCCTTTGTCATGGCCGCCATCAACGAGCGCGTGGTGCACCGCTCCAACGCCTTGTCCGGCAACGCCTATGGCAATCC
ATTCCTCTATGACGAAGCGGTGATCACCGGGCACGGCCTGAGCGGCCGCATGAAAGCCATGACGATGGTGGCCGGCCTGG
GTGCATTCATGCTGGGCATTGTCATCAAGCCCGCTCGCATCGTGATGCAGCGCTTTCTGTTGCCCAAACCCGGCGAAGGC
CCCACGCCGGCGGCGCAACTGGCTGGCCGCTACGACCTGCGGCTGTTCGGCCGAACCGATCAAGGCAACACCTTGCGCGT
GAAGGTGAGCGGCGATCGCGACCCGGGCTACGGCTCGACCGGCAAGATGCTCGGTCAGGCCGCTGCCAGCCTCGCGCTGG
ACCACGTGAAAGACGGCATCAAGATCGGGCGACCGGGCGGTTTCTGGACGCCGGCCACGATGTTCGATGAACGCTTTATC
GAGCGCCTGACCCGCCACGCAGGTCTGCGGTTCGAGCGCATATGA

Upstream 100 bases:

>100_bases
TCTGCCCAGGTCGAGCGATGCCGGCGCCGTGAGTTGCTCGACGGGTCCGGCGCCTTCACTATTGCTTGCTGCCGAACGAT
GGAACAAAAAGGAAGACCCC

Downstream 100 bases:

>100_bases
GCGGGACGCGCCGCCCATTCGGCCGAAGCATCATTCGTTCTGCCCGCGCGCAAAGATGTCCCAGCTGGCCATGAACAATG
CGGCGACCAGCGGGCCGATC

Product: Saccharopine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MPAPHYDVVVFGATSFVGQILTRYLAEHFSGDAETLRWAIAGRSEAKLQEVKCSLGAAGESIPIIVADAANEAQLQALCA
QTRVVVSTVGPYALYGEPLIKVCAESGTDYCDLTGETQWIRRMIGTYEATAQQSGARIVHCCGFDSVPSDMGVYFLQQHA
MRQWGTPATQVKLRVKTLKGGASGGTIASLINVVQEAAADPALRKELADPYALCPKGHGFTARQRSVRGAAFDADFDAWI
APFVMAAINERVVHRSNALSGNAYGNPFLYDEAVITGHGLSGRMKAMTMVAGLGAFMLGIVIKPARIVMQRFLLPKPGEG
PTPAAQLAGRYDLRLFGRTDQGNTLRVKVSGDRDPGYGSTGKMLGQAAASLALDHVKDGIKIGRPGGFWTPATMFDERFI
ERLTRHAGLRFERI

Sequences:

>Translated_414_residues
MPAPHYDVVVFGATSFVGQILTRYLAEHFSGDAETLRWAIAGRSEAKLQEVKCSLGAAGESIPIIVADAANEAQLQALCA
QTRVVVSTVGPYALYGEPLIKVCAESGTDYCDLTGETQWIRRMIGTYEATAQQSGARIVHCCGFDSVPSDMGVYFLQQHA
MRQWGTPATQVKLRVKTLKGGASGGTIASLINVVQEAAADPALRKELADPYALCPKGHGFTARQRSVRGAAFDADFDAWI
APFVMAAINERVVHRSNALSGNAYGNPFLYDEAVITGHGLSGRMKAMTMVAGLGAFMLGIVIKPARIVMQRFLLPKPGEG
PTPAAQLAGRYDLRLFGRTDQGNTLRVKVSGDRDPGYGSTGKMLGQAAASLALDHVKDGIKIGRPGGFWTPATMFDERFI
ERLTRHAGLRFERI
>Mature_413_residues
PAPHYDVVVFGATSFVGQILTRYLAEHFSGDAETLRWAIAGRSEAKLQEVKCSLGAAGESIPIIVADAANEAQLQALCAQ
TRVVVSTVGPYALYGEPLIKVCAESGTDYCDLTGETQWIRRMIGTYEATAQQSGARIVHCCGFDSVPSDMGVYFLQQHAM
RQWGTPATQVKLRVKTLKGGASGGTIASLINVVQEAAADPALRKELADPYALCPKGHGFTARQRSVRGAAFDADFDAWIA
PFVMAAINERVVHRSNALSGNAYGNPFLYDEAVITGHGLSGRMKAMTMVAGLGAFMLGIVIKPARIVMQRFLLPKPGEGP
TPAAQLAGRYDLRLFGRTDQGNTLRVKVSGDRDPGYGSTGKMLGQAAASLALDHVKDGIKIGRPGGFWTPATMFDERFIE
RLTRHAGLRFERI

Specific function: Unknown

COG id: COG3268

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the saccharopine dehydrogenase family. Enoyl reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI55770836, Length=445, Percent_Identity=30.561797752809, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17560066, Length=210, Percent_Identity=38.0952380952381, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32567112, Length=210, Percent_Identity=38.0952380952381, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71991033, Length=159, Percent_Identity=35.8490566037736, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646278, Length=453, Percent_Identity=28.6975717439294, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24644140, Length=163, Percent_Identity=38.0368098159509, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24644142, Length=163, Percent_Identity=38.0368098159509, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI21356081, Length=163, Percent_Identity=38.0368098159509, Blast_Score=128, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR005097 [H]

Pfam domain/function: PF03435 Saccharop_dh [H]

EC number: NA

Molecular weight: Translated: 44538; Mature: 44406

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPHYDVVVFGATSFVGQILTRYLAEHFSGDAETLRWAIAGRSEAKLQEVKCSLGAAGE
CCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHCCCCC
SIPIIVADAANEAQLQALCAQTRVVVSTVGPYALYGEPLIKVCAESGTDYCDLTGETQWI
CCCEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHCCCCEEECCCCHHHH
RRMIGTYEATAQQSGARIVHCCGFDSVPSDMGVYFLQQHAMRQWGTPATQVKLRVKTLKG
HHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEEEEEECC
GASGGTIASLINVVQEAAADPALRKELADPYALCPKGHGFTARQRSVRGAAFDADFDAWI
CCCCCHHHHHHHHHHHHHCCHHHHHHHCCCHHCCCCCCCCCHHHHCCCCCCCCCCHHHHH
APFVMAAINERVVHRSNALSGNAYGNPFLYDEAVITGHGLSGRMKAMTMVAGLGAFMLGI
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHH
VIKPARIVMQRFLLPKPGEGPTPAAQLAGRYDLRLFGRTDQGNTLRVKVSGDRDPGYGST
HHCHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCH
GKMLGQAAASLALDHVKDGIKIGRPGGFWTPATMFDERFIERLTRHAGLRFERI
HHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCEECCC
>Mature Secondary Structure 
PAPHYDVVVFGATSFVGQILTRYLAEHFSGDAETLRWAIAGRSEAKLQEVKCSLGAAGE
CCCCEEEEEECHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHCCCCC
SIPIIVADAANEAQLQALCAQTRVVVSTVGPYALYGEPLIKVCAESGTDYCDLTGETQWI
CCCEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHCCCCEEECCCCHHHH
RRMIGTYEATAQQSGARIVHCCGFDSVPSDMGVYFLQQHAMRQWGTPATQVKLRVKTLKG
HHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEEEEEECC
GASGGTIASLINVVQEAAADPALRKELADPYALCPKGHGFTARQRSVRGAAFDADFDAWI
CCCCCHHHHHHHHHHHHHCCHHHHHHHCCCHHCCCCCCCCCHHHHCCCCCCCCCCHHHHH
APFVMAAINERVVHRSNALSGNAYGNPFLYDEAVITGHGLSGRMKAMTMVAGLGAFMLGI
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHH
VIKPARIVMQRFLLPKPGEGPTPAAQLAGRYDLRLFGRTDQGNTLRVKVSGDRDPGYGST
HHCHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCH
GKMLGQAAASLALDHVKDGIKIGRPGGFWTPATMFDERFIERLTRHAGLRFERI
HHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]