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The map label for this gene is yeiG [H]

Identifier: 187927634

GI number: 187927634

Start: 569833

End: 570696

Strand: Reverse

Name: yeiG [H]

Synonym: Rpic_0534

Alternate gene names: 187927634

Gene position: 570696-569833 (Counterclockwise)

Preceding gene: 187927635

Following gene: 187927632

Centisome position: 14.48

GC content: 66.32

Gene sequence:

>864_bases
ATGACGATCCCGGTACCGGCACTTGAACTGCTTTCCGAACACGCCTGCTTTGGTGGCGTGCAGCGCTTCTATCGGCATGC
CTCGACGGCGATCCGGCTGCCGATGCGCTTCTCGGTCTACCTGCCGCCCCAGGCGCTGGCAGGCACGAGCTGCCCCGCGC
TGTTCTATCTGGCGGGCCTGACGTGCACGGAAGAGACGTTCGCCATCAAGGCCGGTGCGCAGCGCGTGGCAGCACGCGAG
GGGCTCATCCTCATCGCGCCCGACACCAGCCCGCGCGACGCGAACGCCCCCGGCGAAACCGACAGCTGGGATTTCGGCAT
TGCCGCCGGCTTCTATCTGGACGCCACGCAGGCGCCATGGCGCGAGCACTACCGCATGGAAAGCTATATCGCCGACGAAC
TGCACCACATCGCGCGCGTGGTCTTTCCGGTGGCGGCCGGGCGCATTGGCATCTTTGGGCACTCGATGGGCGGCCACGGC
GCGTTGACGCTGGCGCTACGCCATCGGGAACGCTTTGCTTCGGTGTCTGCGTTTGCGCCCATTGCGCATCCGTCTGTGTG
CCCGTGGGGCATCAAGGCATTCACCGGGTATCTCGGGGACGATCGCACCGCCTGGGCAGCGCACGATGCCACGCAGTTGA
TGCGGCAGGCGTCGTGCCCCTTCCCGCGCGGCATCCTGATCGATCAGGGCGAGGCCGACAAATTCCTGGCAGAACAGTTG
TACCCGGATGACTTCGCGGCCGCGTGCGCCGCAGCCGGGCAACCGCTGCAACTGCGCCGCCACCCCGGGTACGACCACGG
CTACTACTTCATCGAGACCTTCATCGAAGACCACCTGCTGCACCACGCGGCACAACTGCGTTAG

Upstream 100 bases:

>100_bases
CTGCCGCTGGAGCGCATCAACGAAGGCTTCGAGCTGATGAAGCGCGGTGAATCGATCCGTTCGGTCGTGTTGTATTGATC
CTTGGGGATGGAGCCACGCG

Downstream 100 bases:

>100_bases
CAGCAGGTCAGTGCGGGGCTAGCGGCTGCCTCCGCCGGCACTGCCGCCCGCCGCCCCACCGGCGCCTGCGCCACCCGCAC
CGGCACCCGCACCGCCTGAA

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MTIPVPALELLSEHACFGGVQRFYRHASTAIRLPMRFSVYLPPQALAGTSCPALFYLAGLTCTEETFAIKAGAQRVAARE
GLILIAPDTSPRDANAPGETDSWDFGIAAGFYLDATQAPWREHYRMESYIADELHHIARVVFPVAAGRIGIFGHSMGGHG
ALTLALRHRERFASVSAFAPIAHPSVCPWGIKAFTGYLGDDRTAWAAHDATQLMRQASCPFPRGILIDQGEADKFLAEQL
YPDDFAAACAAAGQPLQLRRHPGYDHGYYFIETFIEDHLLHHAAQLR

Sequences:

>Translated_287_residues
MTIPVPALELLSEHACFGGVQRFYRHASTAIRLPMRFSVYLPPQALAGTSCPALFYLAGLTCTEETFAIKAGAQRVAARE
GLILIAPDTSPRDANAPGETDSWDFGIAAGFYLDATQAPWREHYRMESYIADELHHIARVVFPVAAGRIGIFGHSMGGHG
ALTLALRHRERFASVSAFAPIAHPSVCPWGIKAFTGYLGDDRTAWAAHDATQLMRQASCPFPRGILIDQGEADKFLAEQL
YPDDFAAACAAAGQPLQLRRHPGYDHGYYFIETFIEDHLLHHAAQLR
>Mature_286_residues
TIPVPALELLSEHACFGGVQRFYRHASTAIRLPMRFSVYLPPQALAGTSCPALFYLAGLTCTEETFAIKAGAQRVAAREG
LILIAPDTSPRDANAPGETDSWDFGIAAGFYLDATQAPWREHYRMESYIADELHHIARVVFPVAAGRIGIFGHSMGGHGA
LTLALRHRERFASVSAFAPIAHPSVCPWGIKAFTGYLGDDRTAWAAHDATQLMRQASCPFPRGILIDQGEADKFLAEQLY
PDDFAAACAAAGQPLQLRRHPGYDHGYYFIETFIEDHLLHHAAQLR

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=283, Percent_Identity=53.356890459364, Blast_Score=318, Evalue=3e-87,
Organism=Escherichia coli, GI1788477, Length=279, Percent_Identity=50.5376344086022, Blast_Score=273, Evalue=8e-75,
Organism=Escherichia coli, GI1786551, Length=280, Percent_Identity=45.7142857142857, Blast_Score=261, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17510185, Length=283, Percent_Identity=46.643109540636, Blast_Score=259, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6322393, Length=296, Percent_Identity=37.8378378378378, Blast_Score=191, Evalue=1e-49,
Organism=Drosophila melanogaster, GI45551932, Length=282, Percent_Identity=51.063829787234, Blast_Score=287, Evalue=4e-78,
Organism=Drosophila melanogaster, GI24648347, Length=282, Percent_Identity=51.063829787234, Blast_Score=287, Evalue=7e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31490; Mature: 31359

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPVPALELLSEHACFGGVQRFYRHASTAIRLPMRFSVYLPPQALAGTSCPALFYLAGL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEEEECCHHHCCCCCCHHHHHHCC
TCTEETFAIKAGAQRVAAREGLILIAPDTSPRDANAPGETDSWDFGIAAGFYLDATQAPW
CCCCHHHEEHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCH
REHYRMESYIADELHHIARVVFPVAAGRIGIFGHSMGGHGALTLALRHRERFASVSAFAP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEHHHHHHHHHHHHCC
IAHPSVCPWGIKAFTGYLGDDRTAWAAHDATQLMRQASCPFPRGILIDQGEADKFLAEQL
CCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHC
YPDDFAAACAAAGQPLQLRRHPGYDHGYYFIETFIEDHLLHHAAQLR
CCCHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TIPVPALELLSEHACFGGVQRFYRHASTAIRLPMRFSVYLPPQALAGTSCPALFYLAGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEEEECCHHHCCCCCCHHHHHHCC
TCTEETFAIKAGAQRVAAREGLILIAPDTSPRDANAPGETDSWDFGIAAGFYLDATQAPW
CCCCHHHEEHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCH
REHYRMESYIADELHHIARVVFPVAAGRIGIFGHSMGGHGALTLALRHRERFASVSAFAP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEHHHHHHHHHHHHCC
IAHPSVCPWGIKAFTGYLGDDRTAWAAHDATQLMRQASCPFPRGILIDQGEADKFLAEQL
CCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHC
YPDDFAAACAAAGQPLQLRRHPGYDHGYYFIETFIEDHLLHHAAQLR
CCCHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA