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The map label for this gene is pepP [H]

Identifier: 187927488

GI number: 187927488

Start: 408437

End: 409816

Strand: Reverse

Name: pepP [H]

Synonym: Rpic_0385

Alternate gene names: 187927488

Gene position: 409816-408437 (Counterclockwise)

Preceding gene: 187927490

Following gene: 187927487

Centisome position: 10.39

GC content: 67.75

Gene sequence:

>1380_bases
ATGTCCGCCACCGAACTCGCTTTCCTCCAGACCTATCGCCAGCGCCGCGAGCGCATCGTGCAGTGGCTGCGCGCGGCGGG
TGGCGGGGTCGCCATCGTGCCGACCGCGCCCGAGGCGATGCGCAACCGCGACAGCGATTATCCCTACCGGCACGACAGCT
ACTTCTATTACCTGACCGGCTTCACCGAGCCCGAAGCGGTACTCGCCATCGTGGTACCCGCAGGCAGCGCACCGGCGCGC
AGCGTGCTGTTCTGCCGCCCGAAGCACGAAGAGCGTGAAATCTGGGACGGCTTCCGCTTCGGCCCCGAAGCAGCGAAGGA
CGCCTTCGGCCTGGATGAGGCGCACTCGGTGGAAGAGATCGATGCGACGTTGCCAAAGCTGCTCGCCAACGCCGCCGCCG
TGGCATGTCCGCTGGCCGAGAGCAGCGCGTTCGACCGCCGCATGCGCCGCTGGCTCGATGCAGTGCGCATGCAAGGCCGC
GCGGGGGTGTCGTCGCCGCACCAGGCGCTGGACGTGCGCGCCATCCTCGATGAGATGCGGCTGTTCAAGGACGCAAGCGA
ACTCGACATCATGCGCCGTGCCGGACGCATTTCCGCCGGAGCGCACGTGCGCGCCATGCAGGCGTCGCGTGCCGGGCTGC
GTGAATACCATCTCGAAGCGGAGCTGCTATATGAATTCCGCCGCCACGGTGCGCAAAGCGTTGCCTATAACTCCATCGTG
GCGACGGGCCCGAACGCGTGCGTACTGCACTACCGCGCCGGCAACGCAGAACTGCGCGACGGCGATCTCTGCCTGATCGA
TGCCGGCTGTGAGCTGGATGGCTACGCGTCAGACATCACCCGCACGTTCCCGGTCAATGGCCGCTTCACCGGCCCGCAAC
GCGAGCTGTATGCGCTGGTGGTGGCCGCGCAGGAAGCCGCCCTTGCCGAGACGCGCCCCGGCGTGCCTTACAACGTGCCG
CACGATGCCGCCACGCGCGTGCTGGCGCAAGGCATGCTCGACACCGGCCTGCTCGACGCCGACAAGGTCGGCACGCTCGA
CGACGTGATCGCCGGCGGCCAATACCGCCAGTTCTACATGCACCGCACCGGCCATTGGCTCGGCATGGACGTGCACGATG
TGGGCGAATACCGCACGCCCGGCACCGCTGCTCCGGCTGAAGGCGAACGCCCGTGGCGCCCGCTGGAAGCCGGCATGGTG
CTGACCGTCGAACCCGGCATCTACGTGCGCCCCGCGCCCGGCGTGCCGGAACAGTACTGGCACATCGGCATCCGCATTGA
AGACGACGCCATCGTCACGCCCGAAGGCTGCGAAATCATCACGCGCGACGTGCCCGTAGCCCCGGACGAAATCGAACTGG
TGATGCGGGGCCAGGCATGA

Upstream 100 bases:

>100_bases
CGCACAAGTCTCCTTTTGGATGTGGCAATGCCCCTCCCTGAATGACCGCCAGGCGCGGCGTTACAATCGACACATCCTTT
CTGCTGCTGGAAAACACGAC

Downstream 100 bases:

>100_bases
CCGACAGCATCACAGCGAGCAGCGCCGCACCGGACTTCGACGTGGCCATCGTTGGCGCCGGGCCCGTCGGGCTGGCGCTG
GCCAACTGGTTGCTGCGCGA

Product: peptidase M24

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSATELAFLQTYRQRRERIVQWLRAAGGGVAIVPTAPEAMRNRDSDYPYRHDSYFYYLTGFTEPEAVLAIVVPAGSAPAR
SVLFCRPKHEEREIWDGFRFGPEAAKDAFGLDEAHSVEEIDATLPKLLANAAAVACPLAESSAFDRRMRRWLDAVRMQGR
AGVSSPHQALDVRAILDEMRLFKDASELDIMRRAGRISAGAHVRAMQASRAGLREYHLEAELLYEFRRHGAQSVAYNSIV
ATGPNACVLHYRAGNAELRDGDLCLIDAGCELDGYASDITRTFPVNGRFTGPQRELYALVVAAQEAALAETRPGVPYNVP
HDAATRVLAQGMLDTGLLDADKVGTLDDVIAGGQYRQFYMHRTGHWLGMDVHDVGEYRTPGTAAPAEGERPWRPLEAGMV
LTVEPGIYVRPAPGVPEQYWHIGIRIEDDAIVTPEGCEIITRDVPVAPDEIELVMRGQA

Sequences:

>Translated_459_residues
MSATELAFLQTYRQRRERIVQWLRAAGGGVAIVPTAPEAMRNRDSDYPYRHDSYFYYLTGFTEPEAVLAIVVPAGSAPAR
SVLFCRPKHEEREIWDGFRFGPEAAKDAFGLDEAHSVEEIDATLPKLLANAAAVACPLAESSAFDRRMRRWLDAVRMQGR
AGVSSPHQALDVRAILDEMRLFKDASELDIMRRAGRISAGAHVRAMQASRAGLREYHLEAELLYEFRRHGAQSVAYNSIV
ATGPNACVLHYRAGNAELRDGDLCLIDAGCELDGYASDITRTFPVNGRFTGPQRELYALVVAAQEAALAETRPGVPYNVP
HDAATRVLAQGMLDTGLLDADKVGTLDDVIAGGQYRQFYMHRTGHWLGMDVHDVGEYRTPGTAAPAEGERPWRPLEAGMV
LTVEPGIYVRPAPGVPEQYWHIGIRIEDDAIVTPEGCEIITRDVPVAPDEIELVMRGQA
>Mature_458_residues
SATELAFLQTYRQRRERIVQWLRAAGGGVAIVPTAPEAMRNRDSDYPYRHDSYFYYLTGFTEPEAVLAIVVPAGSAPARS
VLFCRPKHEEREIWDGFRFGPEAAKDAFGLDEAHSVEEIDATLPKLLANAAAVACPLAESSAFDRRMRRWLDAVRMQGRA
GVSSPHQALDVRAILDEMRLFKDASELDIMRRAGRISAGAHVRAMQASRAGLREYHLEAELLYEFRRHGAQSVAYNSIVA
TGPNACVLHYRAGNAELRDGDLCLIDAGCELDGYASDITRTFPVNGRFTGPQRELYALVVAAQEAALAETRPGVPYNVPH
DAATRVLAQGMLDTGLLDADKVGTLDDVIAGGQYRQFYMHRTGHWLGMDVHDVGEYRTPGTAAPAEGERPWRPLEAGMVL
TVEPGIYVRPAPGVPEQYWHIGIRIEDDAIVTPEGCEIITRDVPVAPDEIELVMRGQA

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=452, Percent_Identity=32.7433628318584, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI149589008, Length=486, Percent_Identity=30.0411522633745, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI260593665, Length=305, Percent_Identity=35.7377049180328, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI260593663, Length=478, Percent_Identity=27.4058577405858, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI1789275, Length=446, Percent_Identity=44.6188340807175, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1788728, Length=334, Percent_Identity=30.2395209580838, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1790282, Length=321, Percent_Identity=30.5295950155763, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17508215, Length=477, Percent_Identity=31.8658280922432, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI71989583, Length=384, Percent_Identity=26.8229166666667, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320922, Length=419, Percent_Identity=28.8782816229117, Blast_Score=192, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6321118, Length=440, Percent_Identity=30.6818181818182, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI19920384, Length=467, Percent_Identity=33.4047109207709, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21357079, Length=451, Percent_Identity=30.5986696230599, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 50641; Mature: 50510

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATELAFLQTYRQRRERIVQWLRAAGGGVAIVPTAPEAMRNRDSDYPYRHDSYFYYLTG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCCCCCCCCCEEEEEEC
FTEPEAVLAIVVPAGSAPARSVLFCRPKHEEREIWDGFRFGPEAAKDAFGLDEAHSVEEI
CCCCCEEEEEEEECCCCCCCCEEEECCCCCHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
DATLPKLLANAAAVACPLAESSAFDRRMRRWLDAVRMQGRAGVSSPHQALDVRAILDEMR
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LFKDASELDIMRRAGRISAGAHVRAMQASRAGLREYHLEAELLYEFRRHGAQSVAYNSIV
HHHCCHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCEE
ATGPNACVLHYRAGNAELRDGDLCLIDAGCELDGYASDITRTFPVNGRFTGPQRELYALV
ECCCCEEEEEEECCCCEECCCCEEEEECCCCCCCCHHHCEEECCCCCCCCCCHHHHEEEE
VAAQEAALAETRPGVPYNVPHDAATRVLAQGMLDTGLLDADKVGTLDDVIAGGQYRQFYM
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHEEEE
HRTGHWLGMDVHDVGEYRTPGTAAPAEGERPWRPLEAGMVLTVEPGIYVRPAPGVPEQYW
ECCCCEECCCHHHCCCCCCCCCCCCCCCCCCCCCHHCCEEEEECCCEEEECCCCCCCCCE
HIGIRIEDDAIVTPEGCEIITRDVPVAPDEIELVMRGQA
EEEEEECCCEEECCCCCEEEECCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
SATELAFLQTYRQRRERIVQWLRAAGGGVAIVPTAPEAMRNRDSDYPYRHDSYFYYLTG
CCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCCCCCCCCCEEEEEEC
FTEPEAVLAIVVPAGSAPARSVLFCRPKHEEREIWDGFRFGPEAAKDAFGLDEAHSVEEI
CCCCCEEEEEEEECCCCCCCCEEEECCCCCHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
DATLPKLLANAAAVACPLAESSAFDRRMRRWLDAVRMQGRAGVSSPHQALDVRAILDEMR
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LFKDASELDIMRRAGRISAGAHVRAMQASRAGLREYHLEAELLYEFRRHGAQSVAYNSIV
HHHCCHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCEE
ATGPNACVLHYRAGNAELRDGDLCLIDAGCELDGYASDITRTFPVNGRFTGPQRELYALV
ECCCCEEEEEEECCCCEECCCCEEEEECCCCCCCCHHHCEEECCCCCCCCCCHHHHEEEE
VAAQEAALAETRPGVPYNVPHDAATRVLAQGMLDTGLLDADKVGTLDDVIAGGQYRQFYM
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHEEEE
HRTGHWLGMDVHDVGEYRTPGTAAPAEGERPWRPLEAGMVLTVEPGIYVRPAPGVPEQYW
ECCCCEECCCHHHCCCCCCCCCCCCCCCCCCCCCHHCCEEEEECCCEEEECCCCCCCCCE
HIGIRIEDDAIVTPEGCEIITRDVPVAPDEIELVMRGQA
EEEEEECCCEEECCCCCEEEECCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]