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The map label for this gene is pyrC

Identifier: 187927466

GI number: 187927466

Start: 388371

End: 389405

Strand: Direct

Name: pyrC

Synonym: Rpic_0363

Alternate gene names: 187927466

Gene position: 388371-389405 (Clockwise)

Preceding gene: 187927465

Following gene: 187927467

Centisome position: 9.85

GC content: 66.96

Gene sequence:

>1035_bases
ATGACCGACACTCTTACGATCGTCCGCCCCGATGACTGGCACCTGCACCTGCGCGACGGCGATGCGCTCGCCGATGTGGT
GGGCGACACCGCGCGCCAGTTCGGCCGGGCGATCATCATGCCTAACCTCAAGCCGCCGGTGACCACCACCGCCCAGGCAC
GCGCCTACCGCGAGCGCATCCTCGCCGCGTTGCCCGCAGGCACGCAGTTCGAGCCGCTGATGACGCTGTACCTGACCGAC
AACACTTCGCCTGAGGTCATCCGGGAGGCCCGCGCCAGCGGTTTCATCCATGGCGTGAAGCTGTATCCGGCCGGTGCCAC
CACCAACAGCGATGCCGGCGTGACCGACCTGCGCCGCTGCGCCAAGACGCTCGAAGCGATGCAGGAAGTCGGCATGCCGC
TGCTCGTGCACGGCGAGGTGACGGACCCGACCGTCGACATCTTCGATCGCGAGGCGGTCTTCATCGACACCGTGATGCTG
CCGCTGCGCCGCGATTTCCCCGCGCTCAAGGTCGTGTTCGAGCACATCACCACCAAGCATGCCGCCGAATACGTGCGCGA
TGCGGAAGGCCCGGTTGGCGCAACCATCACCGCGCATCATCTGCTGTACAACCGCAATGCGCTGTTCGTCGGCGGCATCC
GCCCGCATTACTACTGCCTGCCGGTGCTCAAGCGTGAAACGCACCGCCTGGCGCTGGTGGCAGCGGCCACCTCGGGCCAC
CCGCGCTTCTTCCTCGGTACCGACAGCGCACCGCACGCCAAGGGTGTGAAGGAACACGCTTGCGGCTGCGCCGGCTGCTA
CACCGCGCTGCACGCGATGGAGCTGTACGCCGAGGCCTTTGAAGACGCCAACGCGCTCGACAAGCTCGAAGGTTTCGCGA
GCCTCCACGGGCCGGACTTCTACGGCCTGCCGCGCAACGCCGGCACGCTCACGCTTACGCGCTCGCAATGGCAGCTTCCC
GCCGAAGTCCCGTTTGGCGAGCAGACGCTGGTGCCGTTGCGTGGCGGCGAGATGCTGCGCTGGAAGTCTGTCTGA

Upstream 100 bases:

>100_bases
TGACTTGATCGTCACCGGCCCGACGCGCACCAACGTCAACGACTACCGCGTCATCCTCATTCTCTGATTCACGTTTTTGC
TGACCGCTTCCGCACGCACC

Downstream 100 bases:

>100_bases
GTTGGTGGCCGCTGATCTCGGTGCGATCGACTGGGGCCATCCGGCGTTCGCACCGCTCGCTGCAGTCGGCGCGCCGCTCG
CAGACGCTATCGCGCGCGGC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MTDTLTIVRPDDWHLHLRDGDALADVVGDTARQFGRAIIMPNLKPPVTTTAQARAYRERILAALPAGTQFEPLMTLYLTD
NTSPEVIREARASGFIHGVKLYPAGATTNSDAGVTDLRRCAKTLEAMQEVGMPLLVHGEVTDPTVDIFDREAVFIDTVML
PLRRDFPALKVVFEHITTKHAAEYVRDAEGPVGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRLALVAAATSGH
PRFFLGTDSAPHAKGVKEHACGCAGCYTALHAMELYAEAFEDANALDKLEGFASLHGPDFYGLPRNAGTLTLTRSQWQLP
AEVPFGEQTLVPLRGGEMLRWKSV

Sequences:

>Translated_344_residues
MTDTLTIVRPDDWHLHLRDGDALADVVGDTARQFGRAIIMPNLKPPVTTTAQARAYRERILAALPAGTQFEPLMTLYLTD
NTSPEVIREARASGFIHGVKLYPAGATTNSDAGVTDLRRCAKTLEAMQEVGMPLLVHGEVTDPTVDIFDREAVFIDTVML
PLRRDFPALKVVFEHITTKHAAEYVRDAEGPVGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRLALVAAATSGH
PRFFLGTDSAPHAKGVKEHACGCAGCYTALHAMELYAEAFEDANALDKLEGFASLHGPDFYGLPRNAGTLTLTRSQWQLP
AEVPFGEQTLVPLRGGEMLRWKSV
>Mature_343_residues
TDTLTIVRPDDWHLHLRDGDALADVVGDTARQFGRAIIMPNLKPPVTTTAQARAYRERILAALPAGTQFEPLMTLYLTDN
TSPEVIREARASGFIHGVKLYPAGATTNSDAGVTDLRRCAKTLEAMQEVGMPLLVHGEVTDPTVDIFDREAVFIDTVMLP
LRRDFPALKVVFEHITTKHAAEYVRDAEGPVGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRLALVAAATSGHP
RFFLGTDSAPHAKGVKEHACGCAGCYTALHAMELYAEAFEDANALDKLEGFASLHGPDFYGLPRNAGTLTLTRSQWQLPA
EVPFGEQTLVPLRGGEMLRWKSV

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1787301, Length=341, Percent_Identity=55.7184750733138, Blast_Score=387, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6323452, Length=355, Percent_Identity=36.6197183098592, Blast_Score=193, Evalue=4e-50,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRC_RALPJ (B2UFJ8)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001897953.1
- ProteinModelPortal:   B2UFJ8
- SMR:   B2UFJ8
- GeneID:   6287683
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_0363
- HOGENOM:   HBG628648
- OMA:   KESACGC
- ProtClustDB:   PRK05451
- HAMAP:   MF_00219
- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195
- PIRSF:   PIRSF001237
- TIGRFAMs:   TIGR00856

Pfam domain/function: PF01979 Amidohydro_1

EC number: =3.5.2.3

Molecular weight: Translated: 37761; Mature: 37629

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTLTIVRPDDWHLHLRDGDALADVVGDTARQFGRAIIMPNLKPPVTTTAQARAYRERI
CCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHH
LAALPAGTQFEPLMTLYLTDNTSPEVIREARASGFIHGVKLYPAGATTNSDAGVTDLRRC
HHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHH
AKTLEAMQEVGMPLLVHGEVTDPTVDIFDREAVFIDTVMLPLRRDFPALKVVFEHITTKH
HHHHHHHHHCCCCEEEECCCCCCCHHHCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHH
AAEYVRDAEGPVGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRLALVAAATSGH
HHHHHHHCCCCCCCEEEEEHEEEECCEEEECCCCCCEEEEHHHHCCCCEEEEEEEECCCC
PRFFLGTDSAPHAKGVKEHACGCAGCYTALHAMELYAEAFEDANALDKLEGFASLHGPDF
CEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
YGLPRNAGTLTLTRSQWQLPAEVPFGEQTLVPLRGGEMLRWKSV
CCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEEECC
>Mature Secondary Structure 
TDTLTIVRPDDWHLHLRDGDALADVVGDTARQFGRAIIMPNLKPPVTTTAQARAYRERI
CCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHH
LAALPAGTQFEPLMTLYLTDNTSPEVIREARASGFIHGVKLYPAGATTNSDAGVTDLRRC
HHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHH
AKTLEAMQEVGMPLLVHGEVTDPTVDIFDREAVFIDTVMLPLRRDFPALKVVFEHITTKH
HHHHHHHHHCCCCEEEECCCCCCCHHHCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHH
AAEYVRDAEGPVGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRLALVAAATSGH
HHHHHHHCCCCCCCEEEEEHEEEECCEEEECCCCCCEEEEHHHHCCCCEEEEEEEECCCC
PRFFLGTDSAPHAKGVKEHACGCAGCYTALHAMELYAEAFEDANALDKLEGFASLHGPDF
CEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
YGLPRNAGTLTLTRSQWQLPAEVPFGEQTLVPLRGGEMLRWKSV
CCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA