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The map label for this gene is fadA [H]

Identifier: 187927453

GI number: 187927453

Start: 374150

End: 375349

Strand: Direct

Name: fadA [H]

Synonym: Rpic_0350

Alternate gene names: 187927453

Gene position: 374150-375349 (Clockwise)

Preceding gene: 187927452

Following gene: 187927454

Centisome position: 9.49

GC content: 65.58

Gene sequence:

>1200_bases
ATGACCAAGCAATTGCAAGACGCCTATATCGTCGCAGCGACGCGTTCCCCGATCGGCAAGGCGCCCAAGGGCACGCTCAA
GAACCTGCGCCCGGATGACCTGCTGGCGACCATCCTCAAGAGTGCTGTCGCCCAGGTGCCGAACCTGGACCCGGCGTTGA
TCGAAGACGCCATCGTCGGCTGTGCGATTCCGGAAGCGCAGCAGGGCCTGAACGTGGCGCGTATCGGCGCGCTGCTGGCC
GGCCTGCCCAACTCTGTGGGCGGTGTAACCGTCAACCGCTTCTGCGCCTCTGGCCTGACCGCCGTGGCCATGGCGGCTGA
CCGCATCCGGGTGGGCGAATCCGACGTGATGATCGCCGCCGGTGTCGAATCGATGAGCATGGTGCCGATGATGGGCAACT
CGCCGTCAATGTCGCCGGAGATTTTCACGCGCGACGAGAACGTCGGCATCGCCTACGGCATGGGCCTGACGGCGGAGAAG
GTCGCCCAGCAATGGAAGATCTCGCGCGAGGCGCAGGACGCCTTCTCGCTGGCTTCGCACCAGAAGGCGCTGGCCGCGCA
GCAAGCCGGCGAGTTCAAGGACGAGATCACCCCGATCGAGATCATCGAGAAGTTCCCGAACCTGGGTACGGGCGCAATCG
ACATCAGGACGCGCACGATGTCGCTGGATGAAGGCCCGCGTGCCGATACGTCGGTCGAAGGCCTGGGCAAGCTGCGCGCC
GTGTTCGCGAATAAGGGCAGCGTGACGGCCGGCAATAGCTCGCAGACGTCGGACGGCTCGGGCGCGTTGATCCTGGTGTC
GGAGAAGATCCTCAAGCAGTTCAACCTGGTGCCGCTGGCGCGCTTTGTGTCGTTTGCGGTGCGCGGTGTGCCGCCGGAGA
TCATGGGGATTGGTCCGAAGGAAGCGATTCCTGCCGCGCTGAAGGCGGGCGGCCTGACGCAGGACCAGATCGACTGGATC
GAGCTGAACGAAGCGTTCGCCGCGCAGTCTCTGGCCGTGATCCAGGACCTGGGCCTGGACACCAGCAAGATCAACCCGCT
GGGTGGCGCGATCGCGCTGGGCCACCCGCTGGGCGCCACCGGTGCCATTCGTGCGGCCACGGTGGTGCACGGCCTGCGCC
GTCGCAACCAGAAGTACGGCATGGTGACGATGTGCGTCGGCACCGGCATGGGCGCTGCGGGCATTTTCGAACGCATGTGA

Upstream 100 bases:

>100_bases
CGGCAGCGCCAAGACCCAGGAACGCATCATGGGCATGCTGCAGACCGGCAAGCCGGTGCGTAACTAATCGCCGCGACGAC
AGAGAAACAGGAGTTTCATC

Downstream 100 bases:

>100_bases
CCCCACGTCAGGGGGAAGGATTAAGTTCTTCCCCCTGCTTGTAAATCGCCCGTCTCAACACGCATGATTGCGCAGGCGCG
CGCAGTACTACATCAACAAG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTKQLQDAYIVAATRSPIGKAPKGTLKNLRPDDLLATILKSAVAQVPNLDPALIEDAIVGCAIPEAQQGLNVARIGALLA
GLPNSVGGVTVNRFCASGLTAVAMAADRIRVGESDVMIAAGVESMSMVPMMGNSPSMSPEIFTRDENVGIAYGMGLTAEK
VAQQWKISREAQDAFSLASHQKALAAQQAGEFKDEITPIEIIEKFPNLGTGAIDIRTRTMSLDEGPRADTSVEGLGKLRA
VFANKGSVTAGNSSQTSDGSGALILVSEKILKQFNLVPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAGGLTQDQIDWI
ELNEAFAAQSLAVIQDLGLDTSKINPLGGAIALGHPLGATGAIRAATVVHGLRRRNQKYGMVTMCVGTGMGAAGIFERM

Sequences:

>Translated_399_residues
MTKQLQDAYIVAATRSPIGKAPKGTLKNLRPDDLLATILKSAVAQVPNLDPALIEDAIVGCAIPEAQQGLNVARIGALLA
GLPNSVGGVTVNRFCASGLTAVAMAADRIRVGESDVMIAAGVESMSMVPMMGNSPSMSPEIFTRDENVGIAYGMGLTAEK
VAQQWKISREAQDAFSLASHQKALAAQQAGEFKDEITPIEIIEKFPNLGTGAIDIRTRTMSLDEGPRADTSVEGLGKLRA
VFANKGSVTAGNSSQTSDGSGALILVSEKILKQFNLVPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAGGLTQDQIDWI
ELNEAFAAQSLAVIQDLGLDTSKINPLGGAIALGHPLGATGAIRAATVVHGLRRRNQKYGMVTMCVGTGMGAAGIFERM
>Mature_398_residues
TKQLQDAYIVAATRSPIGKAPKGTLKNLRPDDLLATILKSAVAQVPNLDPALIEDAIVGCAIPEAQQGLNVARIGALLAG
LPNSVGGVTVNRFCASGLTAVAMAADRIRVGESDVMIAAGVESMSMVPMMGNSPSMSPEIFTRDENVGIAYGMGLTAEKV
AQQWKISREAQDAFSLASHQKALAAQQAGEFKDEITPIEIIEKFPNLGTGAIDIRTRTMSLDEGPRADTSVEGLGKLRAV
FANKGSVTAGNSSQTSDGSGALILVSEKILKQFNLVPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAGGLTQDQIDWIE
LNEAFAAQSLAVIQDLGLDTSKINPLGGAIALGHPLGATGAIRAATVVHGLRRRNQKYGMVTMCVGTGMGAAGIFERM

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=44.1326530612245, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=39.2059553349876, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI148539872, Length=400, Percent_Identity=36, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=34.4059405940594, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4504327, Length=441, Percent_Identity=29.4784580498866, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=31.1224489795918, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1787663, Length=413, Percent_Identity=43.0992736077482, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=42.75, Blast_Score=278, Evalue=3e-76,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=39.6551724137931, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=39.1089108910891, Blast_Score=255, Evalue=4e-69,
Organism=Escherichia coli, GI1788683, Length=380, Percent_Identity=33.1578947368421, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=39.6508728179551, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=30.5970149253731, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=32.0987654320988, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17551802, Length=447, Percent_Identity=28.1879194630872, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17535917, Length=402, Percent_Identity=27.1144278606965, Blast_Score=135, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=43.7810945273632, Blast_Score=292, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6325229, Length=407, Percent_Identity=37.5921375921376, Blast_Score=225, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24655093, Length=408, Percent_Identity=39.9509803921569, Blast_Score=271, Evalue=4e-73,
Organism=Drosophila melanogaster, GI17648125, Length=408, Percent_Identity=39.4607843137255, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24640423, Length=409, Percent_Identity=32.0293398533007, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI17137578, Length=448, Percent_Identity=31.0267857142857, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41613; Mature: 41481

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQLQDAYIVAATRSPIGKAPKGTLKNLRPDDLLATILKSAVAQVPNLDPALIEDAIVG
CCCCCCCEEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAQQGLNVARIGALLAGLPNSVGGVTVNRFCASGLTAVAMAADRIRVGESDVMIAA
CCCCHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHEECCCCEEEEE
GVESMSMVPMMGNSPSMSPEIFTRDENVGIAYGMGLTAEKVAQQWKISREAQDAFSLASH
CCCCCEECEECCCCCCCCCCEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
QKALAAQQAGEFKDEITPIEIIEKFPNLGTGAIDIRTRTMSLDEGPRADTSVEGLGKLRA
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHH
VFANKGSVTAGNSSQTSDGSGALILVSEKILKQFNLVPLARFVSFAVRGVPPEIMGIGPK
HHCCCCCEECCCCCCCCCCCCEEEEEEHHHHHHHCCHHHHHHHHHHHCCCCHHHHCCCCH
EAIPAALKAGGLTQDQIDWIELNEAFAAQSLAVIQDLGLDTSKINPLGGAIALGHPLGAT
HHHHHHHHHCCCCHHCCHHEEHHHHHHHHHHHHHHHCCCCHHCCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNQKYGMVTMCVGTGMGAAGIFERM
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHCC
>Mature Secondary Structure 
TKQLQDAYIVAATRSPIGKAPKGTLKNLRPDDLLATILKSAVAQVPNLDPALIEDAIVG
CCCCCCEEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAQQGLNVARIGALLAGLPNSVGGVTVNRFCASGLTAVAMAADRIRVGESDVMIAA
CCCCHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHEECCCCEEEEE
GVESMSMVPMMGNSPSMSPEIFTRDENVGIAYGMGLTAEKVAQQWKISREAQDAFSLASH
CCCCCEECEECCCCCCCCCCEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
QKALAAQQAGEFKDEITPIEIIEKFPNLGTGAIDIRTRTMSLDEGPRADTSVEGLGKLRA
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHH
VFANKGSVTAGNSSQTSDGSGALILVSEKILKQFNLVPLARFVSFAVRGVPPEIMGIGPK
HHCCCCCEECCCCCCCCCCCCEEEEEEHHHHHHHCCHHHHHHHHHHHCCCCHHHHCCCCH
EAIPAALKAGGLTQDQIDWIELNEAFAAQSLAVIQDLGLDTSKINPLGGAIALGHPLGAT
HHHHHHHHHCCCCHHCCHHEEHHHHHHHHHHHHHHHCCCCHHCCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNQKYGMVTMCVGTGMGAAGIFERM
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]