Click here to switch to the map view.

The map label for this gene is ilvA [H]

Identifier: 187927428

GI number: 187927428

Start: 341853

End: 343373

Strand: Reverse

Name: ilvA [H]

Synonym: Rpic_0325

Alternate gene names: 187927428

Gene position: 343373-341853 (Counterclockwise)

Preceding gene: 187927456

Following gene: 187927427

Centisome position: 8.71

GC content: 62.79

Gene sequence:

>1521_bases
ATGGCCATCGATTACCTCAAGAAAATCCTGACTGCGAAGGTCTATGACGTCGCGGTGGAAACCGAGCTGAAGTTCGCGCC
CAACCTGTCAGTGCGCACCGGCAACCGCGTCTACCTCAAGCGCGAGGATGACCAGCCGGTGTTCTCGTTCAAGCTGCGCG
GCGCCTACAACAAGATGGCCTCGCTCACGCCGGCCGAGCGCAAGCGCGGGGTAATTACGGCATCGGCGGGCAACCACGCG
CAGGGCGTGGCGTTCAGCGCGGCGCGCATGGAATGCAAGGCGGTAATCTGCATGCCAGTGACGACGCCGCAGTTGAAGAT
TGACGGCGTGCGCTCGCGCGGCGGCGATTGGGTCGACGTTGTGCTGCACGGTGAAAGCTATTCCGACGCCTACAACCACG
CCGCCAAGCTGCAGGAAAAACATGGCTACACCTTCGTTCACCCGTTCGACGATCCGGAAGTGATTGCCGGCCAGGGCACG
ATCGCCATGGAAATCCTGCGCCAACATCCGCAGCCGATCCATGCGATCTTTTGCTCGATCGGTGGCGGCGGGCTGATCTC
GGGCATTGCGGCCTACGTGAAGGCCGTGCGACCGGACGTCAAGGTCATCGGCGTGCAGAGCGTGGATTCCGACGCGATGG
CGCGCTCGGTGGCCGCCGGCAAGCGCGTCGAACTGAAGGAGGTGGGCCTGTTTGCGGACGGCACGGCGGTCAAGCTGGTG
GGCAAGGAGACTTTCCGCCTCACGCGCGAACTCGTCGACGAGATCATCACCGTGGATACGGATGCCATCTGCGCGGCGCT
CAAGGACGTGTTCCAGGACACGCGCAGCCTGCTGGAGCCGTCGGGCGCGCTGGCGCTGGCCGGCCTCAAGCAGTATGCCG
AGACGCACAAGCTGAAGAACGAATCGCTCGTGGCCGTGGCGAGCGGGGCGAACATGAACTTCGACCGCCTGCGCTTCGTG
GCCGAGCGCGCCGAAGTGGGCGAGGCCCGCGAAGCCGTGTTTGCCGTGACGATTCCGGAAGAGCGCGGCAGCTTCAAGCG
CTTCTGCGAACTGGTCGGCTGGTCGCGCAACGTGACGGAGTTCAACTACCGCATTGCCAGCAAGGACGCCGCGCATATCT
TCGTGGGCGTGCAAATTGCGTCGCGCGCAGAGGGCGACAAGATTGCCGAGAACTTCCGCAAGCACGGCTTCCCGACACTG
GACCTGTCGAACGACGAACTGGCCAAGCAGCACATCCGCTACATGGTGGGTGGGCGTTCGCCGCTGGCAGAGAACGAGCA
TCTCTACCGCTTCGAGTTTCCTGAGCGGCCAGGCGCGCTGATGAAGTTCCTCTCGAGCATGAGCCCGAACTGGAACATCA
GCCTGTTCCACTACCGTAACCAAGGCGCGGATTCGAGCAACATCCTCGTCGGCATCCAGGTACCGAAGAACGAGAAGCGC
GAGTTCAAGGCGTTCCTCGCCACGCTGGGCTATACCTATTGGGACGAAAGCGAGAACCCCGTCTACAGCCTGTTTTTGTG
A

Upstream 100 bases:

>100_bases
GCCGGGGCAGTGTACCGACCGGCACGCCAGTCCGGCAAGGCGGGCCAGGCGCCGCGTGATAGGCTTACGGGCTCTGTTCA
CGTCCAACCCGGTCCGCACC

Downstream 100 bases:

>100_bases
TGAGCAACCAACCCGAACATTCGCCGCTGGGCAAGACGTCCGCCTACAAGACGGAGTACGACCCGCACCTGCTGTTTCCG
ATTCCGCGCCAGGGCAAGCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MAIDYLKKILTAKVYDVAVETELKFAPNLSVRTGNRVYLKREDDQPVFSFKLRGAYNKMASLTPAERKRGVITASAGNHA
QGVAFSAARMECKAVICMPVTTPQLKIDGVRSRGGDWVDVVLHGESYSDAYNHAAKLQEKHGYTFVHPFDDPEVIAGQGT
IAMEILRQHPQPIHAIFCSIGGGGLISGIAAYVKAVRPDVKVIGVQSVDSDAMARSVAAGKRVELKEVGLFADGTAVKLV
GKETFRLTRELVDEIITVDTDAICAALKDVFQDTRSLLEPSGALALAGLKQYAETHKLKNESLVAVASGANMNFDRLRFV
AERAEVGEAREAVFAVTIPEERGSFKRFCELVGWSRNVTEFNYRIASKDAAHIFVGVQIASRAEGDKIAENFRKHGFPTL
DLSNDELAKQHIRYMVGGRSPLAENEHLYRFEFPERPGALMKFLSSMSPNWNISLFHYRNQGADSSNILVGIQVPKNEKR
EFKAFLATLGYTYWDESENPVYSLFL

Sequences:

>Translated_506_residues
MAIDYLKKILTAKVYDVAVETELKFAPNLSVRTGNRVYLKREDDQPVFSFKLRGAYNKMASLTPAERKRGVITASAGNHA
QGVAFSAARMECKAVICMPVTTPQLKIDGVRSRGGDWVDVVLHGESYSDAYNHAAKLQEKHGYTFVHPFDDPEVIAGQGT
IAMEILRQHPQPIHAIFCSIGGGGLISGIAAYVKAVRPDVKVIGVQSVDSDAMARSVAAGKRVELKEVGLFADGTAVKLV
GKETFRLTRELVDEIITVDTDAICAALKDVFQDTRSLLEPSGALALAGLKQYAETHKLKNESLVAVASGANMNFDRLRFV
AERAEVGEAREAVFAVTIPEERGSFKRFCELVGWSRNVTEFNYRIASKDAAHIFVGVQIASRAEGDKIAENFRKHGFPTL
DLSNDELAKQHIRYMVGGRSPLAENEHLYRFEFPERPGALMKFLSSMSPNWNISLFHYRNQGADSSNILVGIQVPKNEKR
EFKAFLATLGYTYWDESENPVYSLFL
>Mature_505_residues
AIDYLKKILTAKVYDVAVETELKFAPNLSVRTGNRVYLKREDDQPVFSFKLRGAYNKMASLTPAERKRGVITASAGNHAQ
GVAFSAARMECKAVICMPVTTPQLKIDGVRSRGGDWVDVVLHGESYSDAYNHAAKLQEKHGYTFVHPFDDPEVIAGQGTI
AMEILRQHPQPIHAIFCSIGGGGLISGIAAYVKAVRPDVKVIGVQSVDSDAMARSVAAGKRVELKEVGLFADGTAVKLVG
KETFRLTRELVDEIITVDTDAICAALKDVFQDTRSLLEPSGALALAGLKQYAETHKLKNESLVAVASGANMNFDRLRFVA
ERAEVGEAREAVFAVTIPEERGSFKRFCELVGWSRNVTEFNYRIASKDAAHIFVGVQIASRAEGDKIAENFRKHGFPTLD
LSNDELAKQHIRYMVGGRSPLAENEHLYRFEFPERPGALMKFLSSMSPNWNISLFHYRNQGADSSNILVGIQVPKNEKRE
FKAFLATLGYTYWDESENPVYSLFL

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=291, Percent_Identity=35.7388316151203, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI33469958, Length=321, Percent_Identity=30.8411214953271, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790207, Length=504, Percent_Identity=51.3888888888889, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1789505, Length=321, Percent_Identity=37.0716510903427, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71991565, Length=325, Percent_Identity=31.3846153846154, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17508781, Length=285, Percent_Identity=30.1754385964912, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17537387, Length=350, Percent_Identity=30.2857142857143, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320930, Length=519, Percent_Identity=48.5549132947977, Blast_Score=463, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322631, Length=293, Percent_Identity=33.7883959044369, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6319788, Length=271, Percent_Identity=26.5682656826568, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355833, Length=319, Percent_Identity=30.4075235109718, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24645328, Length=255, Percent_Identity=28.6274509803922, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55974; Mature: 55843

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIDYLKKILTAKVYDVAVETELKFAPNLSVRTGNRVYLKREDDQPVFSFKLRGAYNKMA
CCHHHHHHHHHHHHHEEEEEEEEEECCCCEEECCCEEEEEECCCCCEEEEEECCHHHHHH
SLTPAERKRGVITASAGNHAQGVAFSAARMECKAVICMPVTTPQLKIDGVRSRGGDWVDV
CCCHHHHHCCEEEECCCCCCCCEEEHHHHEEEEEEEEEECCCCCEEECCCCCCCCCEEEE
VLHGESYSDAYNHAAKLQEKHGYTFVHPFDDPEVIAGQGTIAMEILRQHPQPIHAIFCSI
EEECCCCCHHHHHHHHHHHHCCEEEEECCCCCCEEECCCHHHHHHHHHCCCCEEEEEEEC
GGGGLISGIAAYVKAVRPDVKVIGVQSVDSDAMARSVAAGKRVELKEVGLFADGTAVKLV
CCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCEEHHHCCEEECCCEEEEE
GKETFRLTRELVDEIITVDTDAICAALKDVFQDTRSLLEPSGALALAGLKQYAETHKLKN
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCC
ESLVAVASGANMNFDRLRFVAERAEVGEAREAVFAVTIPEERGSFKRFCELVGWSRNVTE
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCCHHHHHHHHCCCCCCEE
FNYRIASKDAAHIFVGVQIASRAEGDKIAENFRKHGFPTLDLSNDELAKQHIRYMVGGRS
EEEEEECCCCEEEEEEEEEECCCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCC
PLAENEHLYRFEFPERPGALMKFLSSMSPNWNISLFHYRNQGADSSNILVGIQVPKNEKR
CCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEECCCCHHH
EFKAFLATLGYTYWDESENPVYSLFL
HHHHHHHHHCCCEECCCCCCEEEEEC
>Mature Secondary Structure 
AIDYLKKILTAKVYDVAVETELKFAPNLSVRTGNRVYLKREDDQPVFSFKLRGAYNKMA
CHHHHHHHHHHHHHEEEEEEEEEECCCCEEECCCEEEEEECCCCCEEEEEECCHHHHHH
SLTPAERKRGVITASAGNHAQGVAFSAARMECKAVICMPVTTPQLKIDGVRSRGGDWVDV
CCCHHHHHCCEEEECCCCCCCCEEEHHHHEEEEEEEEEECCCCCEEECCCCCCCCCEEEE
VLHGESYSDAYNHAAKLQEKHGYTFVHPFDDPEVIAGQGTIAMEILRQHPQPIHAIFCSI
EEECCCCCHHHHHHHHHHHHCCEEEEECCCCCCEEECCCHHHHHHHHHCCCCEEEEEEEC
GGGGLISGIAAYVKAVRPDVKVIGVQSVDSDAMARSVAAGKRVELKEVGLFADGTAVKLV
CCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCEEHHHCCEEECCCEEEEE
GKETFRLTRELVDEIITVDTDAICAALKDVFQDTRSLLEPSGALALAGLKQYAETHKLKN
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCC
ESLVAVASGANMNFDRLRFVAERAEVGEAREAVFAVTIPEERGSFKRFCELVGWSRNVTE
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCCHHHHHHHHCCCCCCEE
FNYRIASKDAAHIFVGVQIASRAEGDKIAENFRKHGFPTLDLSNDELAKQHIRYMVGGRS
EEEEEECCCCEEEEEEEEEECCCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCC
PLAENEHLYRFEFPERPGALMKFLSSMSPNWNISLFHYRNQGADSSNILVGIQVPKNEKR
CCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEECCCCHHH
EFKAFLATLGYTYWDESENPVYSLFL
HHHHHHHHHCCCEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA