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The map label for this gene is kdsC [H]

Identifier: 187927374

GI number: 187927374

Start: 281436

End: 282032

Strand: Reverse

Name: kdsC [H]

Synonym: Rpic_0267

Alternate gene names: 187927374

Gene position: 282032-281436 (Counterclockwise)

Preceding gene: 187927375

Following gene: 187927373

Centisome position: 7.15

GC content: 67.34

Gene sequence:

>597_bases
ATGATCACCCTGGCCCCATTTCCCACCGACAGCGTCCACAGCAACATCGACGCGCGCTTTCCGCAAGCAATGGAACGCGC
CGCGCGCGTGCGCCTGATGGTGTTCGATGTGGATGGCGTGCTGACCGACGGCCGCTTGCTCGTTGGACCGGAGGGTGAGA
TCAGCAAGGCTTTCGACACCCTCGACGGCCACGGCATCAAACTGCTGGCACAGGCCGGCGTCACGCCGGCCATCATTACC
GGACGGCAATCCGAAATCGTGGCCTGGCGCGCCGGGGAACTCGGCATCGAACATCTGTACCAAGGCGTAGCCGACAAGCG
CGAGGCGTTTGCCCACCTGCTGGCGGCAACGCAACTGCAAGCCGCCGACGCCGGCTACATGGGCGACGACTGGCCCGACC
TGCCGGTGATGACGATGGCGGGCTTTACCGCCTGCCCTGCCCAGGCCCATGCCGAACTGCGCAGCCGTGCCCACTACGTC
GCCCAGGCCACGGGCGGGCGCGGCGCGGTGCGCGAAGTGGCCGACCTGATCCTCAAGGCCCAAGGCGCCTACGACGCCCT
GCTCGCGCAACTGCTGCAGGCCCCGCAACCTTTCTGA

Upstream 100 bases:

>100_bases
AACCAGTTGCTGGTGGTCGATGCCGCCGGCCTGCTGGTGGGCGCGCTGCACATCCACGACCTGACGCGGGCCAAGGTCAT
CTGACCAGCCCACGCCGCTG

Downstream 100 bases:

>100_bases
CTCCATGGCCAGCGAACGCTCCCAACGCCTCGTCTCCTCCGTGCTGCAGATCATGCTGCGCGGGCTGCCGATCCTGCTGA
TGGCAATCGTCTGCGGCGTC

Product: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase

Products: NA

Alternate protein names: KDO 8-P phosphatase [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MITLAPFPTDSVHSNIDARFPQAMERAARVRLMVFDVDGVLTDGRLLVGPEGEISKAFDTLDGHGIKLLAQAGVTPAIIT
GRQSEIVAWRAGELGIEHLYQGVADKREAFAHLLAATQLQAADAGYMGDDWPDLPVMTMAGFTACPAQAHAELRSRAHYV
AQATGGRGAVREVADLILKAQGAYDALLAQLLQAPQPF

Sequences:

>Translated_198_residues
MITLAPFPTDSVHSNIDARFPQAMERAARVRLMVFDVDGVLTDGRLLVGPEGEISKAFDTLDGHGIKLLAQAGVTPAIIT
GRQSEIVAWRAGELGIEHLYQGVADKREAFAHLLAATQLQAADAGYMGDDWPDLPVMTMAGFTACPAQAHAELRSRAHYV
AQATGGRGAVREVADLILKAQGAYDALLAQLLQAPQPF
>Mature_198_residues
MITLAPFPTDSVHSNIDARFPQAMERAARVRLMVFDVDGVLTDGRLLVGPEGEISKAFDTLDGHGIKLLAQAGVTPAIIT
GRQSEIVAWRAGELGIEHLYQGVADKREAFAHLLAATQLQAADAGYMGDDWPDLPVMTMAGFTACPAQAHAELRSRAHYV
AQATGGRGAVREVADLILKAQGAYDALLAQLLQAPQPF

Specific function: Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate [H]

COG id: COG1778

COG function: function code R; Low specificity phosphatase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsC family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=179, Percent_Identity=25.6983240223464, Blast_Score=70, Evalue=9e-13,
Organism=Escherichia coli, GI2367202, Length=160, Percent_Identity=46.875, Blast_Score=145, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR013200
- InterPro:   IPR006549
- InterPro:   IPR010023 [H]

Pfam domain/function: PF08282 Hydrolase_3 [H]

EC number: =3.1.3.45 [H]

Molecular weight: Translated: 21143; Mature: 21143

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLAPFPTDSVHSNIDARFPQAMERAARVRLMVFDVDGVLTDGRLLVGPEGEISKAFDT
CEEECCCCCCHHHCCCCCCCHHHHHHHHHEEEEEEECCCEEECCEEEECCCCCHHHHHHC
LDGHGIKLLAQAGVTPAIITGRQSEIVAWRAGELGIEHLYQGVADKREAFAHLLAATQLQ
CCCCCEEEEECCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AADAGYMGDDWPDLPVMTMAGFTACPAQAHAELRSRAHYVAQATGGRGAVREVADLILKA
HCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
QGAYDALLAQLLQAPQPF
CCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MITLAPFPTDSVHSNIDARFPQAMERAARVRLMVFDVDGVLTDGRLLVGPEGEISKAFDT
CEEECCCCCCHHHCCCCCCCHHHHHHHHHEEEEEEECCCEEECCEEEECCCCCHHHHHHC
LDGHGIKLLAQAGVTPAIITGRQSEIVAWRAGELGIEHLYQGVADKREAFAHLLAATQLQ
CCCCCEEEEECCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AADAGYMGDDWPDLPVMTMAGFTACPAQAHAELRSRAHYVAQATGGRGAVREVADLILKA
HCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
QGAYDALLAQLLQAPQPF
CCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]