Click here to switch to the map view.

The map label for this gene is hbd [H]

Identifier: 187927200

GI number: 187927200

Start: 107696

End: 108550

Strand: Direct

Name: hbd [H]

Synonym: Rpic_0090

Alternate gene names: 187927200

Gene position: 107696-108550 (Clockwise)

Preceding gene: 187927199

Following gene: 187927201

Centisome position: 2.73

GC content: 63.04

Gene sequence:

>855_bases
ATGGCAATTCAAGTCGTCGGCATCGTCGGTGCCGGAACAATGGGCAACGGCATTGCGCAAGCGTGCGCCGTGGTCGGGCT
GGATGTGGTGATGGTGGACATCAGCGATGCCGCCGTGCAGAAGGGCATTGCTACCGTGGCCGGCAGCCTGGACCGCCTCA
TCAAGAAGGAAAAACTGACCGAAGCCGACAAGGCCGCAGCGCTCGCCCGCATTCAGGGCTCAACTTCGTACGACGACCTC
AAGCGCGCCGACCTCGTCATCGAGGCCGCCACCGAGAACTTCGACCTGAAAGTGAAGATCCTCAAGCAGCTCGAAGCTGC
TGCTGCGCCGCACGCCATCGTGGCGTCGAACACGTCGTCCATCTCGATCACCAAGCTGGCCGCCGTGCTGCAAGACGCGA
GCCGCTTCATCGGCATGCACTTCTTCAACCCGGTGCCGATGATGGCGCTGGTGGAAGTCATCCGTGGCCTGCAGACGAGC
GATGCCACGCATGCGGCTGTCGAAGCGCTGGCCAAGCAGCTCGGCAAGACGCCGATCACGGTCAAGAACAGCCCGGGCTT
TGTCGTCAACCGCATCCTGTGCCCGATGATCAACGAGGCGTTCTGCGTGCTGGGTGAAGGCTTGGCCTCGCCCGAGGAAA
TCGACGAGGGCATGAAGCTCGGCTGCAATCACCCGATCGGGCCGCTGGCGCTGGCCGACATGATCGGCCTGGACACCATG
CTGGCCGTGATGGAAGTGCTGTACACCGAATTCGGCGACCCGAAATACCGCCCCGCCATGCTGATGCGCGAAATGGTGGC
CGCCGGCTATCTCGGCCGCAAGACCGGCCGCGGCGTGTACGACTATCGCAAGTAA

Upstream 100 bases:

>100_bases
GCGAGCGTCAGCCAGGCTTTTCTGCCCGTCGCTGCGTCGTTTATCCTCTGCAATCTGTTTCATCCCATCTTTCATTCCAA
CACCAAGCGAGGAGCAGTTC

Downstream 100 bases:

>100_bases
GCCGCGACGCTTCACGGCGTTCGCGCTGTCCGCCAACTGTCAGGCTGGATTCGCGCAAACTGTCTGCAAGTGTGCATGGA
GACGGTGTAGCGGTGCGTTG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MAIQVVGIVGAGTMGNGIAQACAVVGLDVVMVDISDAAVQKGIATVAGSLDRLIKKEKLTEADKAAALARIQGSTSYDDL
KRADLVIEAATENFDLKVKILKQLEAAAAPHAIVASNTSSISITKLAAVLQDASRFIGMHFFNPVPMMALVEVIRGLQTS
DATHAAVEALAKQLGKTPITVKNSPGFVVNRILCPMINEAFCVLGEGLASPEEIDEGMKLGCNHPIGPLALADMIGLDTM
LAVMEVLYTEFGDPKYRPAMLMREMVAAGYLGRKTGRGVYDYRK

Sequences:

>Translated_284_residues
MAIQVVGIVGAGTMGNGIAQACAVVGLDVVMVDISDAAVQKGIATVAGSLDRLIKKEKLTEADKAAALARIQGSTSYDDL
KRADLVIEAATENFDLKVKILKQLEAAAAPHAIVASNTSSISITKLAAVLQDASRFIGMHFFNPVPMMALVEVIRGLQTS
DATHAAVEALAKQLGKTPITVKNSPGFVVNRILCPMINEAFCVLGEGLASPEEIDEGMKLGCNHPIGPLALADMIGLDTM
LAVMEVLYTEFGDPKYRPAMLMREMVAAGYLGRKTGRGVYDYRK
>Mature_283_residues
AIQVVGIVGAGTMGNGIAQACAVVGLDVVMVDISDAAVQKGIATVAGSLDRLIKKEKLTEADKAAALARIQGSTSYDDLK
RADLVIEAATENFDLKVKILKQLEAAAAPHAIVASNTSSISITKLAAVLQDASRFIGMHFFNPVPMMALVEVIRGLQTSD
ATHAAVEALAKQLGKTPITVKNSPGFVVNRILCPMINEAFCVLGEGLASPEEIDEGMKLGCNHPIGPLALADMIGLDTML
AVMEVLYTEFGDPKYRPAMLMREMVAAGYLGRKTGRGVYDYRK

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=40.1384083044983, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=38.562091503268, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI20127408, Length=285, Percent_Identity=36.8421052631579, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI261878539, Length=299, Percent_Identity=32.4414715719064, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI68989263, Length=299, Percent_Identity=32.4414715719064, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI115430219, Length=230, Percent_Identity=30.4347826086957, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1787661, Length=282, Percent_Identity=39.3617021276596, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1788682, Length=263, Percent_Identity=38.4030418250951, Blast_Score=167, Evalue=5e-43,
Organism=Escherichia coli, GI1790281, Length=266, Percent_Identity=36.8421052631579, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17549919, Length=291, Percent_Identity=43.6426116838488, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17553560, Length=291, Percent_Identity=43.6426116838488, Blast_Score=229, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI17563036, Length=289, Percent_Identity=35.6401384083045, Blast_Score=190, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI25144276, Length=284, Percent_Identity=36.9718309859155, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17558304, Length=283, Percent_Identity=36.3957597173145, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17508951, Length=284, Percent_Identity=36.9718309859155, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17508953, Length=284, Percent_Identity=36.9718309859155, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71985923, Length=286, Percent_Identity=32.1678321678322, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71985930, Length=285, Percent_Identity=29.8245614035088, Blast_Score=130, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI193203623, Length=202, Percent_Identity=27.2277227722772, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115533614, Length=202, Percent_Identity=27.2277227722772, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=37.2340425531915, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=37.2340425531915, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=37.2340425531915, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI45549573, Length=238, Percent_Identity=30.672268907563, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI20129993, Length=224, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30076; Mature: 29944

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQVVGIVGAGTMGNGIAQACAVVGLDVVMVDISDAAVQKGIATVAGSLDRLIKKEKLT
CEEEEEEEEECCCCCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
EADKAAALARIQGSTSYDDLKRADLVIEAATENFDLKVKILKQLEAAAAPHAIVASNTSS
HHHHHHHHHHHCCCCCHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCC
ISITKLAAVLQDASRFIGMHFFNPVPMMALVEVIRGLQTSDATHAAVEALAKQLGKTPIT
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEE
VKNSPGFVVNRILCPMINEAFCVLGEGLASPEEIDEGMKLGCNHPIGPLALADMIGLDTM
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAVMEVLYTEFGDPKYRPAMLMREMVAAGYLGRKTGRGVYDYRK
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AIQVVGIVGAGTMGNGIAQACAVVGLDVVMVDISDAAVQKGIATVAGSLDRLIKKEKLT
EEEEEEEEECCCCCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
EADKAAALARIQGSTSYDDLKRADLVIEAATENFDLKVKILKQLEAAAAPHAIVASNTSS
HHHHHHHHHHHCCCCCHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCC
ISITKLAAVLQDASRFIGMHFFNPVPMMALVEVIRGLQTSDATHAAVEALAKQLGKTPIT
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEE
VKNSPGFVVNRILCPMINEAFCVLGEGLASPEEIDEGMKLGCNHPIGPLALADMIGLDTM
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAVMEVLYTEFGDPKYRPAMLMREMVAAGYLGRKTGRGVYDYRK
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA