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The map label for this gene is qor [C]

Identifier: 187927176

GI number: 187927176

Start: 80154

End: 81167

Strand: Direct

Name: qor [C]

Synonym: Rpic_0066

Alternate gene names: 187927176

Gene position: 80154-81167 (Clockwise)

Preceding gene: 187927175

Following gene: 187927180

Centisome position: 2.03

GC content: 66.27

Gene sequence:

>1014_bases
ATGAAAGCCGTTGCCTACTACCAAAGTCTGCCCATCGACCGCCCCGAGGCGCTCGTCGACCTGACCCTGCCCGAACCCAC
GCCAGGCCCGCGCGATCTGCTTGTGGAAGTGCGCGCCATCTCCGTCAACCCGGTGGATGTGAAGGTGCGCCTCGGCATGC
CGCCGGTGGATGGTCAGCCCCGCGTGCTGGGCTGGGATGCTGCGGGCGTGGTGCGCGCCGTCGGCGCCGAGGTGTCGCTC
TTCAAGCCGGGCGATGCGGTCTGGTATGCCGGTGCCCTGCAGCGCCCTGGCACCAATAGCGAGCTGCATGTCGTAGACGA
ACGCGTGGTCGGCGCGATGCCCGCCACGCTTGGGTTTGCGCAGGCAGCTGCGCTGCCGCTCACCGCCATCACCGCCTGGG
AATTGCTCTTCGACCGGCTGCAGGTGCCGGAATCTGCAGCGCCCAGCGGGAAGACGGTGTTGATTGTCGGCGCGGCGGGC
GGTGTTGGGTCGGTGCTCGTGCAGCTCGCGCGCCGGTTGACGGGCCTGACCGTGATCGGCACCGCCTCGCGCCCGGAGAC
GGCCGCCTGGGTGCGCGAGCTGGGCGCTCACCATGTGATCAACCATGCGCAGCCGCTGGCCGCAGAACTGCATCGCATTG
GTGTGCCGGCAGTGGACTACGTCGCCAGCCTGAACCAGACCGAACACCACTTCGAGCAGATCGTCGAGGCGCTCAAGCCG
CAAGGTCGCCTTGCGTTGATCGACGATCCGGCGCAGCTCGACGTGCGCAAGCTCAAGGCGAAGAGCCTGTCGCTGCACTG
GGAGTTCATGTACACGCGCTCCATGTTCGGCACGGACGACCAGATCGAGCAGCACCGCCTGCTCAATCGCGTAGCCGCGC
TCATCGACGAAGGCGCGTTGCGCTCCACCATGAACGAGCACTTCGGCACCATCAATGCCGCCAACCTCAAGCGCGCACAA
GCCTTTATTGAAAGCAATCAGGCGCGCGGCAAGATCGTGCTGGAAGGGTTTTGA

Upstream 100 bases:

>100_bases
TCCGGCGTTGAAACTGAATCTGCGCGGCGCGGCTGTTTCCCCTGGCGTGGCGCGCCCATGATGCGGCTATCCAACGATCC
AAATCACTGGGAAGCCTGCC

Downstream 100 bases:

>100_bases
TTCAGGCGTCGGCCAGATAACCGGCGATGCGCTCTTGCAGGAAGTCGCGCAGCCGCATCAGCGTGGGCGACAGCGCGAGG
CGGTGCGTGCAGATCAAATG

Product: zinc-binding alcohol dehydrogenase family protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKAVAYYQSLPIDRPEALVDLTLPEPTPGPRDLLVEVRAISVNPVDVKVRLGMPPVDGQPRVLGWDAAGVVRAVGAEVSL
FKPGDAVWYAGALQRPGTNSELHVVDERVVGAMPATLGFAQAAALPLTAITAWELLFDRLQVPESAAPSGKTVLIVGAAG
GVGSVLVQLARRLTGLTVIGTASRPETAAWVRELGAHHVINHAQPLAAELHRIGVPAVDYVASLNQTEHHFEQIVEALKP
QGRLALIDDPAQLDVRKLKAKSLSLHWEFMYTRSMFGTDDQIEQHRLLNRVAALIDEGALRSTMNEHFGTINAANLKRAQ
AFIESNQARGKIVLEGF

Sequences:

>Translated_337_residues
MKAVAYYQSLPIDRPEALVDLTLPEPTPGPRDLLVEVRAISVNPVDVKVRLGMPPVDGQPRVLGWDAAGVVRAVGAEVSL
FKPGDAVWYAGALQRPGTNSELHVVDERVVGAMPATLGFAQAAALPLTAITAWELLFDRLQVPESAAPSGKTVLIVGAAG
GVGSVLVQLARRLTGLTVIGTASRPETAAWVRELGAHHVINHAQPLAAELHRIGVPAVDYVASLNQTEHHFEQIVEALKP
QGRLALIDDPAQLDVRKLKAKSLSLHWEFMYTRSMFGTDDQIEQHRLLNRVAALIDEGALRSTMNEHFGTINAANLKRAQ
AFIESNQARGKIVLEGF
>Mature_337_residues
MKAVAYYQSLPIDRPEALVDLTLPEPTPGPRDLLVEVRAISVNPVDVKVRLGMPPVDGQPRVLGWDAAGVVRAVGAEVSL
FKPGDAVWYAGALQRPGTNSELHVVDERVVGAMPATLGFAQAAALPLTAITAWELLFDRLQVPESAAPSGKTVLIVGAAG
GVGSVLVQLARRLTGLTVIGTASRPETAAWVRELGAHHVINHAQPLAAELHRIGVPAVDYVASLNQTEHHFEQIVEALKP
QGRLALIDDPAQLDVRKLKAKSLSLHWEFMYTRSMFGTDDQIEQHRLLNRVAALIDEGALRSTMNEHFGTINAANLKRAQ
AFIESNQARGKIVLEGF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=339, Percent_Identity=29.7935103244838, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI194239676, Length=180, Percent_Identity=35.5555555555556, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI194239674, Length=180, Percent_Identity=35.5555555555556, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI13236495, Length=180, Percent_Identity=35.5555555555556, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI24308257, Length=301, Percent_Identity=26.578073089701, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI18379349, Length=196, Percent_Identity=37.2448979591837, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI28557745, Length=233, Percent_Identity=30.9012875536481, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790485, Length=189, Percent_Identity=34.3915343915344, Blast_Score=85, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17507255, Length=237, Percent_Identity=31.6455696202532, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71987554, Length=233, Percent_Identity=30.0429184549356, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36364; Mature: 36364

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVAYYQSLPIDRPEALVDLTLPEPTPGPRDLLVEVRAISVNPVDVKVRLGMPPVDGQP
CCCCHHHHHCCCCCCCEEEEEECCCCCCCCHHEEEEEEEEEECCEEEEEEECCCCCCCCC
RVLGWDAAGVVRAVGAEVSLFKPGDAVWYAGALQRPGTNSELHVVDERVVGAMPATLGFA
CEEEECHHHHHHHHCCCEEEECCCCCEEEECCCCCCCCCCCEEEEHHHHHHCCCHHHHHH
QAAALPLTAITAWELLFDRLQVPESAAPSGKTVLIVGAAGGVGSVLVQLARRLTGLTVIG
HHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEE
TASRPETAAWVRELGAHHVINHAQPLAAELHRIGVPAVDYVASLNQTEHHFEQIVEALKP
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHCC
QGRLALIDDPAQLDVRKLKAKSLSLHWEFMYTRSMFGTDDQIEQHRLLNRVAALIDEGAL
CCCEEEECCCHHHHHHHHHHHHEEEEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHCHHH
RSTMNEHFGTINAANLKRAQAFIESNQARGKIVLEGF
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure
MKAVAYYQSLPIDRPEALVDLTLPEPTPGPRDLLVEVRAISVNPVDVKVRLGMPPVDGQP
CCCCHHHHHCCCCCCCEEEEEECCCCCCCCHHEEEEEEEEEECCEEEEEEECCCCCCCCC
RVLGWDAAGVVRAVGAEVSLFKPGDAVWYAGALQRPGTNSELHVVDERVVGAMPATLGFA
CEEEECHHHHHHHHCCCEEEECCCCCEEEECCCCCCCCCCCEEEEHHHHHHCCCHHHHHH
QAAALPLTAITAWELLFDRLQVPESAAPSGKTVLIVGAAGGVGSVLVQLARRLTGLTVIG
HHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEE
TASRPETAAWVRELGAHHVINHAQPLAAELHRIGVPAVDYVASLNQTEHHFEQIVEALKP
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHCC
QGRLALIDDPAQLDVRKLKAKSLSLHWEFMYTRSMFGTDDQIEQHRLLNRVAALIDEGAL
CCCEEEECCCHHHHHHHHHHHHEEEEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHCHHH
RSTMNEHFGTINAANLKRAQAFIESNQARGKIVLEGF
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA