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The map label for this gene is metC [H]

Identifier: 187935188

GI number: 187935188

Start: 3492651

End: 3493802

Strand: Reverse

Name: metC [H]

Synonym: CLL_A3320

Alternate gene names: 187935188

Gene position: 3493802-3492651 (Counterclockwise)

Preceding gene: 187934355

Following gene: 187932450

Centisome position: 91.93

GC content: 29.17

Gene sequence:

>1152_bases
ATGAATTTTGAATCAGTTTTAATACACGGAGGAATTGACGGAGATAAGTTTACAGGAGCAGTAAATGTTCCTATATATCA
AACATCTACGTATAAACAAGAGGGCTTAGGAATTAATAAAGGATATGAATATTCAAGAACTGGTAATCCTACAAGAGAAG
CTCTTGAGAAACTTATAGCTGATCTAGAAGACGGTGTTGGTGGATTTGCATTTTCTTCAGGTATGGCAGCCATAACAGCA
ATATTTTCTCTTTTTAAGTCAGGAGATAATATAATAATTTCAGATAATTTATATGGTGGAAGTTTTAGAGTATTAGATAA
AATTTTTAAGAATTTTAATATAGGATATAAGATAGTAAATACAACAGATTTAAAGCAAATTAAAGAAGCTATTGATGAGA
CTGTAAAAGCAATATATATAGAAACACCAACAAATCCATTAATGGATATAACAGATATTGAAGAAGTAGCTAAAATAGCT
AAAGATAATAATCTATTTACAATAGTGGATAATACTTTTATGACACCATACTTGCAAAAGCCACTAACATTAGGAGCAGA
TATAGTTATTCATAGTGGTACTAAGTATCTAGGAGGACATAGTGATTTAATTGCTGGATTAGTAGTAGTAAATAATGAAG
AATTAAAAGAAAAAATTCATTTTATACAAAATTCTACAGGGGGGATACTATCACCATTTGATTCATTCTTACTTATAAGA
GGTATAAAAACTCTTGCAGTTAGAATGGATAGACACAATTTAAATGCTAAATCTATAGCAGAATTTTTGAAAAATAGACC
AGAAATTAATAAAGTTTATTATCCAGGATTTGAAGAACATCCGGGATATAATATTCAATCAAAACAAGCAAAAGGATATG
GTGGAATGATATCTTTTGTATTAAATGATGGATATGATTATAAAAAATTCTTTGAAAAATTAGCAGTTATAACTTTTGGA
GAAAGTTTAGGAGGAGTGGAATCTTTAGCATGCCACCCAGCAAGTATGACTCATGGAGCAATACCATATGAAATAAGACA
AAAGGTAGGTATTGTTGATAATTTGATAAGACTTTCAGTTGGTATAGAAAGTATACAAGATATTATTGAGGATTTAGAAA
AAGCATTAGAATGGGGGAAAATTAATGGTTAA

Upstream 100 bases:

>100_bases
CGGATTTATATTGCAAAGGGTATTCAAGTAAAGGCGAATATACAGAAACAAAAATATTTATAGCAAGTGCTAAAAAATTA
TAAGAGGGGAGAAAAATATT

Downstream 100 bases:

>100_bases
AGTAGAAAGTTTTGAATTAGATCACACAAAGGTAAAAGCCCCATATGTAAGAAAATGTGGTTCAGAAAAGGGTAATAATG
GAGATATAGTTTCTAAATTT

Product: cystathionine gamma-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MNFESVLIHGGIDGDKFTGAVNVPIYQTSTYKQEGLGINKGYEYSRTGNPTREALEKLIADLEDGVGGFAFSSGMAAITA
IFSLFKSGDNIIISDNLYGGSFRVLDKIFKNFNIGYKIVNTTDLKQIKEAIDETVKAIYIETPTNPLMDITDIEEVAKIA
KDNNLFTIVDNTFMTPYLQKPLTLGADIVIHSGTKYLGGHSDLIAGLVVVNNEELKEKIHFIQNSTGGILSPFDSFLLIR
GIKTLAVRMDRHNLNAKSIAEFLKNRPEINKVYYPGFEEHPGYNIQSKQAKGYGGMISFVLNDGYDYKKFFEKLAVITFG
ESLGGVESLACHPASMTHGAIPYEIRQKVGIVDNLIRLSVGIESIQDIIEDLEKALEWGKING

Sequences:

>Translated_383_residues
MNFESVLIHGGIDGDKFTGAVNVPIYQTSTYKQEGLGINKGYEYSRTGNPTREALEKLIADLEDGVGGFAFSSGMAAITA
IFSLFKSGDNIIISDNLYGGSFRVLDKIFKNFNIGYKIVNTTDLKQIKEAIDETVKAIYIETPTNPLMDITDIEEVAKIA
KDNNLFTIVDNTFMTPYLQKPLTLGADIVIHSGTKYLGGHSDLIAGLVVVNNEELKEKIHFIQNSTGGILSPFDSFLLIR
GIKTLAVRMDRHNLNAKSIAEFLKNRPEINKVYYPGFEEHPGYNIQSKQAKGYGGMISFVLNDGYDYKKFFEKLAVITFG
ESLGGVESLACHPASMTHGAIPYEIRQKVGIVDNLIRLSVGIESIQDIIEDLEKALEWGKING
>Mature_383_residues
MNFESVLIHGGIDGDKFTGAVNVPIYQTSTYKQEGLGINKGYEYSRTGNPTREALEKLIADLEDGVGGFAFSSGMAAITA
IFSLFKSGDNIIISDNLYGGSFRVLDKIFKNFNIGYKIVNTTDLKQIKEAIDETVKAIYIETPTNPLMDITDIEEVAKIA
KDNNLFTIVDNTFMTPYLQKPLTLGADIVIHSGTKYLGGHSDLIAGLVVVNNEELKEKIHFIQNSTGGILSPFDSFLLIR
GIKTLAVRMDRHNLNAKSIAEFLKNRPEINKVYYPGFEEHPGYNIQSKQAKGYGGMISFVLNDGYDYKKFFEKLAVITFG
ESLGGVESLACHPASMTHGAIPYEIRQKVGIVDNLIRLSVGIESIQDIIEDLEKALEWGKING

Specific function: The enzymatic degradation of amino acids in cheese is believed to generate aroma compounds and therefore to be essential for flavor development. Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine but is also able to catalyze an alpha

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=363, Percent_Identity=44.3526170798898, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI299473759, Length=363, Percent_Identity=40.771349862259, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI25453487, Length=362, Percent_Identity=38.6740331491713, Blast_Score=256, Evalue=2e-68,
Organism=Escherichia coli, GI1790375, Length=371, Percent_Identity=38.8140161725067, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI1789383, Length=394, Percent_Identity=25.6345177664975, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17560056, Length=381, Percent_Identity=45.1443569553806, Blast_Score=330, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI17538055, Length=367, Percent_Identity=44.4141689373297, Blast_Score=328, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI71980708, Length=370, Percent_Identity=39.1891891891892, Blast_Score=261, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6319307, Length=384, Percent_Identity=42.1875, Blast_Score=298, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6321254, Length=407, Percent_Identity=33.9066339066339, Blast_Score=209, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6323333, Length=442, Percent_Identity=31.9004524886878, Blast_Score=182, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6321170, Length=322, Percent_Identity=32.6086956521739, Blast_Score=172, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6321904, Length=394, Percent_Identity=30.7106598984772, Blast_Score=146, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6322590, Length=267, Percent_Identity=29.2134831460674, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322970, Length=280, Percent_Identity=28.2142857142857, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323557, Length=337, Percent_Identity=24.6290801186944, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19922554, Length=379, Percent_Identity=43.0079155672823, Blast_Score=333, Evalue=9e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42286; Mature: 42286

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFESVLIHGGIDGDKFTGAVNVPIYQTSTYKQEGLGINKGYEYSRTGNPTREALEKLIA
CCCCEEEEECCCCCCCCCCEEECEEEECCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
DLEDGVGGFAFSSGMAAITAIFSLFKSGDNIIISDNLYGGSFRVLDKIFKNFNIGYKIVN
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEC
TTDLKQIKEAIDETVKAIYIETPTNPLMDITDIEEVAKIAKDNNLFTIVDNTFMTPYLQK
CHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHC
PLTLGADIVIHSGTKYLGGHSDLIAGLVVVNNEELKEKIHFIQNSTGGILSPFDSFLLIR
CCCCCCEEEEECCCCCCCCCHHHHEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
GIKTLAVRMDRHNLNAKSIAEFLKNRPEINKVYYPGFEEHPGYNIQSKQAKGYGGMISFV
HHHHHHEECCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEE
LNDGYDYKKFFEKLAVITFGESLGGVESLACHPASMTHGAIPYEIRQKVGIVDNLIRLSV
ECCCCCHHHHHHHHHHHEECCHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
GIESIQDIIEDLEKALEWGKING
CHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNFESVLIHGGIDGDKFTGAVNVPIYQTSTYKQEGLGINKGYEYSRTGNPTREALEKLIA
CCCCEEEEECCCCCCCCCCEEECEEEECCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
DLEDGVGGFAFSSGMAAITAIFSLFKSGDNIIISDNLYGGSFRVLDKIFKNFNIGYKIVN
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEC
TTDLKQIKEAIDETVKAIYIETPTNPLMDITDIEEVAKIAKDNNLFTIVDNTFMTPYLQK
CHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHC
PLTLGADIVIHSGTKYLGGHSDLIAGLVVVNNEELKEKIHFIQNSTGGILSPFDSFLLIR
CCCCCCEEEEECCCCCCCCCHHHHEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
GIKTLAVRMDRHNLNAKSIAEFLKNRPEINKVYYPGFEEHPGYNIQSKQAKGYGGMISFV
HHHHHHEECCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEE
LNDGYDYKKFFEKLAVITFGESLGGVESLACHPASMTHGAIPYEIRQKVGIVDNLIRLSV
ECCCCCHHHHHHHHHHHEECCHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
GIESIQDIIEDLEKALEWGKING
CHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]