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The map label for this gene is gltA [H]

Identifier: 187935105

GI number: 187935105

Start: 3346956

End: 3348347

Strand: Reverse

Name: gltA [H]

Synonym: CLL_A3213

Alternate gene names: 187935105

Gene position: 3348347-3346956 (Counterclockwise)

Preceding gene: 187933886

Following gene: 187934202

Centisome position: 88.11

GC content: 34.12

Gene sequence:

>1392_bases
ATGAATATGCAAGATAGAATGAAAAGAACACCTGTTACTGAACAAGCTCCAGAATTAAGAGCTAAGAATTTTGAAGAAGT
ATGTTTAGGATATAATGAAGAAGAGGCTATAAAAGAAGCTAATAGATGTTTAGGATGTAAAAACCCTAAATGCGTTGAAG
GATGTCCTGTATCAATTGATATTCCAGGATTTATAGCTAAAGCTAAAGATGGAGATTTTGAAAATGCAGCTAAAGAAATA
GCTAAATATAGTGCATTACCAGCGGTTTGTGGTAGAGTATGTCCACAAGAAAGTCAATGTGAAGGTAAATGTGTATTAGG
AATAAAAGGTGAACCTGTAGCAATAGGTAAATTAGAAAAATTTACTGCTGATTGGTCAAGAAAAAATAATATAGATTTAG
CAAAAACAGAAGCATTAAATGGTAAGAAAATTGCTGTTATTGGAAGTGGTCCAGCAGGGCTTACTTGTGCAGGGGATTTA
GCTAAAAGAGGATATGATGTTACTATATTTGAAGCTTTACATGAAGCAGGTGGAGTTTTAGTTTATGGTATACCTGAATT
TAGATTACCTAAAGAAAAAGTTGTTAAAGCTGAAATTGAAAACATTAAGAAATTAGGAGTAAAGATTGAAACTAATGTTA
TTATAGGTAGAACTATAACAATAGATGAATTAATGAAAGAAGAGGGATTTGATGCTGTATTTATTGGATCAGGTGCTGGA
CTTCCTAAATTCATGGGTATAAATGGAGAAAATGCAAATGGTGTATTCTCTGCAAATGAATTTTTAACAAGAGTTAACTT
AATGAAAGCTTTTAAAGAAGGATATAATACACCTGTTAGAGCAGGTAAAAAGGTAGCTGTAGTTGGTGGCGGAAATGTTG
CTATGGATGCTGCAAGAACTGCTTTAAGATTAGGTGCAGAAGCGCATATAGTTTATAGAAGAGGTGAATCTGAACTTCCA
GCAAGAGCAGAAGAAGTACATCACGCTAAAGAAGAAGGAATAATATTTGACGTTTTAACAAATCCAACTGAAATATTAAG
TGATGAAAATGGATGGGTTAAAGGAATGAAATGCGTAAAAATGGAACTTGGAGAGCCAGATGCATCTGGAAGAAGAAGAC
CAGTTGAAGTTGAAGGATCAGAATTTGTTATGGATGTTGATACTGTAATAATGTCACTTGGAACATCTCCAAATCCACTA
ATATCTTCAACAACTGAGGGTTTAGATATTAATAAGTGGAAATGTATAGTTGCAGATGAAGATGGATTAACTACTAAAGA
AGGCGTTTATGCTGGCGGAGATGCCGTTACAGGTGCTGCAACAGTAATACTTGCTATGGGCGCTGGTAAAAAAGCTGCAG
AAGCTATAGATGGATATTTACAAGATAAATAA

Upstream 100 bases:

>100_bases
GACAAACTATGTACAAAAGTGAAGAGGGAAGAGCGCAATTAAAGATTGAAGAAGGGGACACTCATAGCCACGGTGGTTGT
GGATGTAAAGGTGATAAATA

Downstream 100 bases:

>100_bases
TTATATGATGTACAATATTATTTTCCGATATGAGGAAAATATAGAATTATTAAAGTTTAAAGCTTGATGAAATATAGCTT
TAATTAAGTATTAGTTAAAA

Product: oxidoreductase

Products: L-glutamine; 2-oxoglutarate; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MNMQDRMKRTPVTEQAPELRAKNFEEVCLGYNEEEAIKEANRCLGCKNPKCVEGCPVSIDIPGFIAKAKDGDFENAAKEI
AKYSALPAVCGRVCPQESQCEGKCVLGIKGEPVAIGKLEKFTADWSRKNNIDLAKTEALNGKKIAVIGSGPAGLTCAGDL
AKRGYDVTIFEALHEAGGVLVYGIPEFRLPKEKVVKAEIENIKKLGVKIETNVIIGRTITIDELMKEEGFDAVFIGSGAG
LPKFMGINGENANGVFSANEFLTRVNLMKAFKEGYNTPVRAGKKVAVVGGGNVAMDAARTALRLGAEAHIVYRRGESELP
ARAEEVHHAKEEGIIFDVLTNPTEILSDENGWVKGMKCVKMELGEPDASGRRRPVEVEGSEFVMDVDTVIMSLGTSPNPL
ISSTTEGLDINKWKCIVADEDGLTTKEGVYAGGDAVTGAATVILAMGAGKKAAEAIDGYLQDK

Sequences:

>Translated_463_residues
MNMQDRMKRTPVTEQAPELRAKNFEEVCLGYNEEEAIKEANRCLGCKNPKCVEGCPVSIDIPGFIAKAKDGDFENAAKEI
AKYSALPAVCGRVCPQESQCEGKCVLGIKGEPVAIGKLEKFTADWSRKNNIDLAKTEALNGKKIAVIGSGPAGLTCAGDL
AKRGYDVTIFEALHEAGGVLVYGIPEFRLPKEKVVKAEIENIKKLGVKIETNVIIGRTITIDELMKEEGFDAVFIGSGAG
LPKFMGINGENANGVFSANEFLTRVNLMKAFKEGYNTPVRAGKKVAVVGGGNVAMDAARTALRLGAEAHIVYRRGESELP
ARAEEVHHAKEEGIIFDVLTNPTEILSDENGWVKGMKCVKMELGEPDASGRRRPVEVEGSEFVMDVDTVIMSLGTSPNPL
ISSTTEGLDINKWKCIVADEDGLTTKEGVYAGGDAVTGAATVILAMGAGKKAAEAIDGYLQDK
>Mature_463_residues
MNMQDRMKRTPVTEQAPELRAKNFEEVCLGYNEEEAIKEANRCLGCKNPKCVEGCPVSIDIPGFIAKAKDGDFENAAKEI
AKYSALPAVCGRVCPQESQCEGKCVLGIKGEPVAIGKLEKFTADWSRKNNIDLAKTEALNGKKIAVIGSGPAGLTCAGDL
AKRGYDVTIFEALHEAGGVLVYGIPEFRLPKEKVVKAEIENIKKLGVKIETNVIIGRTITIDELMKEEGFDAVFIGSGAG
LPKFMGINGENANGVFSANEFLTRVNLMKAFKEGYNTPVRAGKKVAVVGGGNVAMDAARTALRLGAEAHIVYRRGESELP
ARAEEVHHAKEEGIIFDVLTNPTEILSDENGWVKGMKCVKMELGEPDASGRRRPVEVEGSEFVMDVDTVIMSLGTSPNPL
ISSTTEGLDINKWKCIVADEDGLTTKEGVYAGGDAVTGAATVILAMGAGKKAAEAIDGYLQDK

Specific function: Unknown

COG id: COG0493

COG function: function code ER; NADPH-dependent glutamate synthase beta chain and related oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=472, Percent_Identity=33.6864406779661, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI237757300, Length=93, Percent_Identity=37.6344086021505, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1788811, Length=475, Percent_Identity=37.4736842105263, Blast_Score=299, Evalue=3e-82,
Organism=Escherichia coli, GI1789606, Length=470, Percent_Identity=36.5957446808511, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI87082180, Length=450, Percent_Identity=36.8888888888889, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI1788468, Length=442, Percent_Identity=32.8054298642534, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1789243, Length=416, Percent_Identity=33.6538461538462, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71984108, Length=451, Percent_Identity=33.0376940133038, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17570289, Length=491, Percent_Identity=28.9205702647658, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17543860, Length=179, Percent_Identity=35.195530726257, Blast_Score=85, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320030, Length=482, Percent_Identity=29.253112033195, Blast_Score=177, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24665547, Length=468, Percent_Identity=30.1282051282051, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24665543, Length=468, Percent_Identity=30.1282051282051, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI28574881, Length=468, Percent_Identity=30.1282051282051, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24665539, Length=468, Percent_Identity=30.1282051282051, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24640763, Length=446, Percent_Identity=32.2869955156951, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI18858217, Length=446, Percent_Identity=32.2869955156951, Blast_Score=178, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013027
- InterPro:   IPR012285
- InterPro:   IPR006006 [H]

Pfam domain/function: PF00037 Fer4; PF07992 Pyr_redox_2 [H]

EC number: 1.4.1.13

Molecular weight: Translated: 49587; Mature: 49587

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMQDRMKRTPVTEQAPELRAKNFEEVCLGYNEEEAIKEANRCLGCKNPKCVEGCPVSID
CCHHHHHHCCCCCCCCCHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEE
IPGFIAKAKDGDFENAAKEIAKYSALPAVCGRVCPQESQCEGKCVLGIKGEPVAIGKLEK
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEECCHHH
FTADWSRKNNIDLAKTEALNGKKIAVIGSGPAGLTCAGDLAKRGYDVTIFEALHEAGGVL
HHCCCCCCCCCCEEHHHCCCCCEEEEEECCCCCCEECCHHHHCCCCCHHHHHHHHHCCEE
VYGIPEFRLPKEKVVKAEIENIKKLGVKIETNVIIGRTITIDELMKEEGFDAVFIGSGAG
EECCCCCCCCHHHHHHHHHHHHHHCCEEEECCEEEEEEEEHHHHHHHCCCCEEEEECCCC
LPKFMGINGENANGVFSANEFLTRVNLMKAFKEGYNTPVRAGKKVAVVGGGNVAMDAART
CCCEECCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHH
ALRLGAEAHIVYRRGESELPARAEEVHHAKEEGIIFDVLTNPTEILSDENGWVKGMKCVK
HHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCHHHHCCCCCCCCCEEEEE
MELGEPDASGRRRPVEVEGSEFVMDVDTVIMSLGTSPNPLISSTTEGLDINKWKCIVADE
EECCCCCCCCCCCCEEECCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECC
DGLTTKEGVYAGGDAVTGAATVILAMGAGKKAAEAIDGYLQDK
CCCCCCCCEEECCCCHHHHEEEEEEECCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNMQDRMKRTPVTEQAPELRAKNFEEVCLGYNEEEAIKEANRCLGCKNPKCVEGCPVSID
CCHHHHHHCCCCCCCCCHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEE
IPGFIAKAKDGDFENAAKEIAKYSALPAVCGRVCPQESQCEGKCVLGIKGEPVAIGKLEK
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEECCHHH
FTADWSRKNNIDLAKTEALNGKKIAVIGSGPAGLTCAGDLAKRGYDVTIFEALHEAGGVL
HHCCCCCCCCCCEEHHHCCCCCEEEEEECCCCCCEECCHHHHCCCCCHHHHHHHHHCCEE
VYGIPEFRLPKEKVVKAEIENIKKLGVKIETNVIIGRTITIDELMKEEGFDAVFIGSGAG
EECCCCCCCCHHHHHHHHHHHHHHCCEEEECCEEEEEEEEHHHHHHHCCCCEEEEECCCC
LPKFMGINGENANGVFSANEFLTRVNLMKAFKEGYNTPVRAGKKVAVVGGGNVAMDAART
CCCEECCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHH
ALRLGAEAHIVYRRGESELPARAEEVHHAKEEGIIFDVLTNPTEILSDENGWVKGMKCVK
HHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCHHHHCCCCCCCCCEEEEE
MELGEPDASGRRRPVEVEGSEFVMDVDTVIMSLGTSPNPLISSTTEGLDINKWKCIVADE
EECCCCCCCCCCCCEEECCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECC
DGLTTKEGVYAGGDAVTGAATVILAMGAGKKAAEAIDGYLQDK
CCCCCCCCEEECCCCHHHHEEEEEEECCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-glutamate; NADP+

Specific reaction: 2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8955321; 9205837; 9278503 [H]