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The map label for this gene is ndhS [H]

Identifier: 187934488

GI number: 187934488

Start: 3498518

End: 3498994

Strand: Reverse

Name: ndhS [H]

Synonym: CLL_A3327

Alternate gene names: 187934488

Gene position: 3498994-3498518 (Counterclockwise)

Preceding gene: 187933411

Following gene: 187935032

Centisome position: 92.07

GC content: 33.96

Gene sequence:

>477_bases
ATGAGTAATAATATAACATTCAAATTAAATGGTAACGAGGTAGTATATGATGGAAGTGCTACTGATAGATTATTAGATGT
GCTTAGAGATTATTATCATTTAAAAGGAGTAAAATGTGGTTGCAAGGAAGGTGAATGTGGAGCATGTTCTATTCTTATGG
ATGGTGAACTAATTAATTCTTGTATGGTAGCAATGGGAAGATGTGAAGGAAGTGAAATTGTTACTATAGAGGGGTTTAGA
GAAACAGAACGTTTTAAAGTAATAGATAAAGCTTATGCTGATGTGTCAGCAGTGCAATGTGGATATTGTATTCCAGGAAT
GGTACTAGCTACAGAAGCTATATTATCTAAGACTCCAAATCCTACATTAGAACAAATTAGAGAGGGGATTTCTGGGAATT
TATGTCGTTGCACAGGATATAATGCTATTGTAAAGGCAATTAAAATTTCAGCAGAGGAGGGAAAAGGATTATGGTAA

Upstream 100 bases:

>100_bases
GAAGCTATTGAACAGGCACTTGGACATGGAGCAAAAGTTAATCATGCACCATTTACAGCAGAAGATACAATAAAAGTTTT
AAGCGAGGAGAGAGAGTAAG

Downstream 100 bases:

>100_bases
ATGGTTTTATGCCTAAATCTTTAAAAGAAGCTTTAGATATTCGTTCAAATTATGATGTTGTTCCATATGGTGGGGGAACA
GATTTAATGATTGAAGGACA

Product: xanthine dehydrogenase, iron-sulfur binding subunit

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase small FeS subunit; NAH [H]

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MSNNITFKLNGNEVVYDGSATDRLLDVLRDYYHLKGVKCGCKEGECGACSILMDGELINSCMVAMGRCEGSEIVTIEGFR
ETERFKVIDKAYADVSAVQCGYCIPGMVLATEAILSKTPNPTLEQIREGISGNLCRCTGYNAIVKAIKISAEEGKGLW

Sequences:

>Translated_158_residues
MSNNITFKLNGNEVVYDGSATDRLLDVLRDYYHLKGVKCGCKEGECGACSILMDGELINSCMVAMGRCEGSEIVTIEGFR
ETERFKVIDKAYADVSAVQCGYCIPGMVLATEAILSKTPNPTLEQIREGISGNLCRCTGYNAIVKAIKISAEEGKGLW
>Mature_157_residues
SNNITFKLNGNEVVYDGSATDRLLDVLRDYYHLKGVKCGCKEGECGACSILMDGELINSCMVAMGRCEGSEIVTIEGFRE
TERFKVIDKAYADVSAVQCGYCIPGMVLATEAILSKTPNPTLEQIREGISGNLCRCTGYNAIVKAIKISAEEGKGLW

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=91, Percent_Identity=38.4615384615385, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI91823271, Length=162, Percent_Identity=32.0987654320988, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1789232, Length=150, Percent_Identity=42, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1786480, Length=166, Percent_Identity=34.9397590361446, Blast_Score=108, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17539860, Length=154, Percent_Identity=36.3636363636364, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32566215, Length=162, Percent_Identity=34.5679012345679, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17540638, Length=157, Percent_Identity=38.2165605095541, Blast_Score=105, Evalue=8e-24,
Organism=Drosophila melanogaster, GI17737937, Length=168, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24647197, Length=161, Percent_Identity=32.2981366459627, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24647195, Length=161, Percent_Identity=32.2981366459627, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24647193, Length=161, Percent_Identity=34.7826086956522, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24647199, Length=155, Percent_Identity=32.258064516129, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24647201, Length=154, Percent_Identity=33.7662337662338, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 17162; Mature: 17031

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
9.5 %Cys+Met (Translated Protein)
6.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
8.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNITFKLNGNEVVYDGSATDRLLDVLRDYYHLKGVKCGCKEGECGACSILMDGELINS
CCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECHHHHHH
CMVAMGRCEGSEIVTIEGFRETERFKVIDKAYADVSAVQCGYCIPGMVLATEAILSKTPN
HHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
PTLEQIREGISGNLCRCTGYNAIVKAIKISAEEGKGLW
CHHHHHHCCCCCCEEEECCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SNNITFKLNGNEVVYDGSATDRLLDVLRDYYHLKGVKCGCKEGECGACSILMDGELINS
CCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECHHHHHH
CMVAMGRCEGSEIVTIEGFRETERFKVIDKAYADVSAVQCGYCIPGMVLATEAILSKTPN
HHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
PTLEQIREGISGNLCRCTGYNAIVKAIKISAEEGKGLW
CHHHHHHCCCCCCEEEECCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA