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The map label for this gene is pucD [H]

Identifier: 187933411

GI number: 187933411

Start: 3498996

End: 3501125

Strand: Reverse

Name: pucD [H]

Synonym: CLL_A3328

Alternate gene names: 187933411

Gene position: 3501125-3498996 (Counterclockwise)

Preceding gene: 187933795

Following gene: 187934488

Centisome position: 92.13

GC content: 34.46

Gene sequence:

>2130_bases
ATGGAGAAGATTAGTAAATCAGTGGTTAAAAGAGACCATAGTTCAAAAATTTCAGGAAAAGCTATCTACGTAGGAGATTA
TGAAGAAGATGATATTTTAATAGGTAAAATGCTAAGGTCAACAAAGGCAAAAGCAAAAATTATTAATGTAAAGGTTCCTA
AATTATTAGATGGATATTGTTATGTTGATAAAACAGATGTACCTGGTGATAACAAGGTTAACATAGTTAAAGATGATACA
CCTGTTTATGCAACAGATACAGTAGAATATATTGGAGAGCCTATAGGTATGGTTTGTGGGCCTAATGAAGAAATTGTAAA
TAAGATATTATCTGAAATTGAAGTTATATATGAAGAATTAGAACCTGTTATTAATATAAGAGACTTTGATACAGTATTTT
TTGATTATAGTTTTGGAAAGGGAGATGTTGAAAAAGCATTTTCAGAGGCAGATAAAATATATGAAGAAGAGTTCGAAACA
GGTTATCAAGATCAGACTTATTTAGAAACTCAAGGACTCATGGCTGAAGTTATGGATGATGAAAAGGTTTACGTACATGG
TTCTATGCAATGTCCATATTATGTTAAGGGATCAGTTATGAGAGCTATGAATCTTGGTCCAGATAAAGTCAGAATAGCGC
AAGATGCTACAGGCGGTGGATTTGGAGGAAAAGAAGCATTTCCATCTATCTTAGCATGTCAAGTTGCTGTAGCTGCAAAA
AAGGCTGGGAAAAAAGTTCGTTGTATCTTTGATAGAAGAGAAGACTTGGAGTTTACATCAAAGCGACATCCTTCATTAAA
TACTTATAAAGTAGCTGTAAAGGATGGAAAAGTTACAGCTATGGATATAGATGTAAAATTTAACGGAGGAGCTTATACAA
CTTTATCAGCGGTTGTTCTTCAAAGGGGAATTATATGTGCAAATGGTATTTATAATATTCCAAACCTTAAAGTACGTGGA
AGAGCTGTAAAAACTAATACAACTCCTAGTGGAGCGTATAGAGGATTTGGAGCACCACAAACATTTTTCTCTGCTGAAGT
GATGATGAATCATATTGCAAAGGATTTAGGAAAAGATTCTTTAGAATTTAAGGAAATGCATTTAGTAAAACAAGGAGATA
GTACTTCAACTTCTGGTAAATATCATTTTCCAGTACCAATTCCAAATATGATTGAACGCATCGATAAAGCTTGCGACTTT
AGAAGAAAACATAAAGAATATTCTAATGATCAAAATGGAAGATATAGAAAAGGAATAGGAATATCTATGTATTTTCATGG
AGCTGGTTTTACAGGTTCAGGTGAAAGAGATATTATTAAGGCCGTTGCTAAATTGCACAAATACCCTGATGGAAGAGTTC
AAGTACTTGCTTCAAATACAGATATAGGACAAGGTCTTCGTACAACCTTTCCTAAGATAGTGGCAAAAGAGTTAAATTTA
CCTCTAGAAAATGTATTTTATGAATACCCAGATACTGATGTAGTACCAGATTCAGGTCCTACAGTTGCCTCTCGTAGTTT
AATGACTGTTGGAGAACTTTTACGTCGTGCAGCTATAAAACTTCGTGATCAATGGGTAGAAGGAGAAGAACAAATTATAG
AAGAGCATTATAAAGAACCAGATTTTATGATTCCATTTTATATTGATAAATTCCAAGGTGATGCTTATCCAACTTATTCT
TGGGCAGTTAATGCAATAGAAGTTGAAGTTGATACTTATACAGGACTTGCAAAGATACTAGGAGCATATGGATGCTTTGA
TATAGGAACGCCTATGGATTACAACATTGCTGTTGGTCAAATGGAGGGTGGATTCTTACAAGGTATAGGATATGCTTCAA
CAGAATATATGGTGGCAGATGCTAAGGGTCATATCAGAAACAACTCTTTCTCAGATTATATTATACCAACAGCAGTTGAT
GTACCTAATCTTAAAGTAGATATGTATGTAGATGAAAAATATCCTTATGGACCTTATGGAGCTAAGGGGGCAGGAGAATT
ACCTTTAGTTGGAGCACCAGGGGCTTATGCTGAAGCTATTGAACAGGCACTTGGACATGGAGCAAAAGTTAATCATGCAC
CATTTACAGCAGAAGATACAATAAAAGTTTTAAGCGAGGAGAGAGAGTAA

Upstream 100 bases:

>100_bases
TTCTTTTGAAGAAGAATTTGATGCTATTTTTTTGTTGCAATATAATATAACATATATTAACAAAAGTGCTGGGGCATTAA
AGGGTAAAGGAGAGGTAGAT

Downstream 100 bases:

>100_bases
GATGAGTAATAATATAACATTCAAATTAAATGGTAACGAGGTAGTATATGATGGAAGTGCTACTGATAGATTATTAGATG
TGCTTAGAGATTATTATCAT

Product: xanthine dehydrogenase, molybdenum-binding subunit

Products: NA

Alternate protein names: XDHase subunit D [H]

Number of amino acids: Translated: 709; Mature: 709

Protein sequence:

>709_residues
MEKISKSVVKRDHSSKISGKAIYVGDYEEDDILIGKMLRSTKAKAKIINVKVPKLLDGYCYVDKTDVPGDNKVNIVKDDT
PVYATDTVEYIGEPIGMVCGPNEEIVNKILSEIEVIYEELEPVINIRDFDTVFFDYSFGKGDVEKAFSEADKIYEEEFET
GYQDQTYLETQGLMAEVMDDEKVYVHGSMQCPYYVKGSVMRAMNLGPDKVRIAQDATGGGFGGKEAFPSILACQVAVAAK
KAGKKVRCIFDRREDLEFTSKRHPSLNTYKVAVKDGKVTAMDIDVKFNGGAYTTLSAVVLQRGIICANGIYNIPNLKVRG
RAVKTNTTPSGAYRGFGAPQTFFSAEVMMNHIAKDLGKDSLEFKEMHLVKQGDSTSTSGKYHFPVPIPNMIERIDKACDF
RRKHKEYSNDQNGRYRKGIGISMYFHGAGFTGSGERDIIKAVAKLHKYPDGRVQVLASNTDIGQGLRTTFPKIVAKELNL
PLENVFYEYPDTDVVPDSGPTVASRSLMTVGELLRRAAIKLRDQWVEGEEQIIEEHYKEPDFMIPFYIDKFQGDAYPTYS
WAVNAIEVEVDTYTGLAKILGAYGCFDIGTPMDYNIAVGQMEGGFLQGIGYASTEYMVADAKGHIRNNSFSDYIIPTAVD
VPNLKVDMYVDEKYPYGPYGAKGAGELPLVGAPGAYAEAIEQALGHGAKVNHAPFTAEDTIKVLSEERE

Sequences:

>Translated_709_residues
MEKISKSVVKRDHSSKISGKAIYVGDYEEDDILIGKMLRSTKAKAKIINVKVPKLLDGYCYVDKTDVPGDNKVNIVKDDT
PVYATDTVEYIGEPIGMVCGPNEEIVNKILSEIEVIYEELEPVINIRDFDTVFFDYSFGKGDVEKAFSEADKIYEEEFET
GYQDQTYLETQGLMAEVMDDEKVYVHGSMQCPYYVKGSVMRAMNLGPDKVRIAQDATGGGFGGKEAFPSILACQVAVAAK
KAGKKVRCIFDRREDLEFTSKRHPSLNTYKVAVKDGKVTAMDIDVKFNGGAYTTLSAVVLQRGIICANGIYNIPNLKVRG
RAVKTNTTPSGAYRGFGAPQTFFSAEVMMNHIAKDLGKDSLEFKEMHLVKQGDSTSTSGKYHFPVPIPNMIERIDKACDF
RRKHKEYSNDQNGRYRKGIGISMYFHGAGFTGSGERDIIKAVAKLHKYPDGRVQVLASNTDIGQGLRTTFPKIVAKELNL
PLENVFYEYPDTDVVPDSGPTVASRSLMTVGELLRRAAIKLRDQWVEGEEQIIEEHYKEPDFMIPFYIDKFQGDAYPTYS
WAVNAIEVEVDTYTGLAKILGAYGCFDIGTPMDYNIAVGQMEGGFLQGIGYASTEYMVADAKGHIRNNSFSDYIIPTAVD
VPNLKVDMYVDEKYPYGPYGAKGAGELPLVGAPGAYAEAIEQALGHGAKVNHAPFTAEDTIKVLSEERE
>Mature_709_residues
MEKISKSVVKRDHSSKISGKAIYVGDYEEDDILIGKMLRSTKAKAKIINVKVPKLLDGYCYVDKTDVPGDNKVNIVKDDT
PVYATDTVEYIGEPIGMVCGPNEEIVNKILSEIEVIYEELEPVINIRDFDTVFFDYSFGKGDVEKAFSEADKIYEEEFET
GYQDQTYLETQGLMAEVMDDEKVYVHGSMQCPYYVKGSVMRAMNLGPDKVRIAQDATGGGFGGKEAFPSILACQVAVAAK
KAGKKVRCIFDRREDLEFTSKRHPSLNTYKVAVKDGKVTAMDIDVKFNGGAYTTLSAVVLQRGIICANGIYNIPNLKVRG
RAVKTNTTPSGAYRGFGAPQTFFSAEVMMNHIAKDLGKDSLEFKEMHLVKQGDSTSTSGKYHFPVPIPNMIERIDKACDF
RRKHKEYSNDQNGRYRKGIGISMYFHGAGFTGSGERDIIKAVAKLHKYPDGRVQVLASNTDIGQGLRTTFPKIVAKELNL
PLENVFYEYPDTDVVPDSGPTVASRSLMTVGELLRRAAIKLRDQWVEGEEQIIEEHYKEPDFMIPFYIDKFQGDAYPTYS
WAVNAIEVEVDTYTGLAKILGAYGCFDIGTPMDYNIAVGQMEGGFLQGIGYASTEYMVADAKGHIRNNSFSDYIIPTAVD
VPNLKVDMYVDEKYPYGPYGAKGAGELPLVGAPGAYAEAIEQALGHGAKVNHAPFTAEDTIKVLSEERE

Specific function: Oxidizes hypoxanthine and xanthine to uric acid [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=712, Percent_Identity=30.1966292134831, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI71773480, Length=739, Percent_Identity=27.6048714479026, Blast_Score=243, Evalue=7e-64,
Organism=Escherichia coli, GI1789246, Length=801, Percent_Identity=26.2172284644195, Blast_Score=215, Evalue=8e-57,
Organism=Escherichia coli, GI1789230, Length=749, Percent_Identity=25.5006675567423, Blast_Score=210, Evalue=3e-55,
Organism=Escherichia coli, GI1786478, Length=595, Percent_Identity=23.5294117647059, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17540638, Length=640, Percent_Identity=28.59375, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI32566215, Length=731, Percent_Identity=25.9917920656635, Blast_Score=197, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17539860, Length=719, Percent_Identity=25.5910987482615, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17737937, Length=715, Percent_Identity=30.9090909090909, Blast_Score=278, Evalue=7e-75,
Organism=Drosophila melanogaster, GI24647193, Length=723, Percent_Identity=23.9280774550484, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24647195, Length=728, Percent_Identity=21.978021978022, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24647197, Length=662, Percent_Identity=22.809667673716, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24647199, Length=726, Percent_Identity=23.6914600550964, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24647201, Length=725, Percent_Identity=22.2068965517241, Blast_Score=90, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR017609 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 78567; Mature: 78567

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00559 MOLYBDOPTERIN_EUK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKISKSVVKRDHSSKISGKAIYVGDYEEDDILIGKMLRSTKAKAKIINVKVPKLLDGYC
CCHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCHHHCCEE
YVDKTDVPGDNKVNIVKDDTPVYATDTVEYIGEPIGMVCGPNEEIVNKILSEIEVIYEEL
EEECCCCCCCCEEEEEECCCCEEECCCHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHH
EPVINIRDFDTVFFDYSFGKGDVEKAFSEADKIYEEEFETGYQDQTYLETQGLMAEVMDD
HHHEEEEECEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCC
EKVYVHGSMQCPYYVKGSVMRAMNLGPDKVRIAQDATGGGFGGKEAFPSILACQVAVAAK
CEEEEEECCCCCEEECCCHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
KAGKKVRCIFDRREDLEFTSKRHPSLNTYKVAVKDGKVTAMDIDVKFNGGAYTTLSAVVL
HCCCEEEEEECCCCCCCHHHCCCCCCCEEEEEEECCEEEEEEEEEEECCCCHHHHHHHHH
QRGIICANGIYNIPNLKVRGRAVKTNTTPSGAYRGFGAPQTFFSAEVMMNHIAKDLGKDS
HCCCEEECCCCCCCCCEEECEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
LEFKEMHLVKQGDSTSTSGKYHFPVPIPNMIERIDKACDFRRKHKEYSNDQNGRYRKGIG
CHHHHHHHEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCE
ISMYFHGAGFTGSGERDIIKAVAKLHKYPDGRVQVLASNTDIGQGLRTTFPKIVAKELNL
EEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCC
PLENVFYEYPDTDVVPDSGPTVASRSLMTVGELLRRAAIKLRDQWVEGEEQIIEEHYKEP
CHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
DFMIPFYIDKFQGDAYPTYSWAVNAIEVEVDTYTGLAKILGAYGCFDIGTPMDYNIAVGQ
CEEEEEEEEEECCCCCCCHHEEEEEEEEEEECHHHHHHHHHHCCCEECCCCCCCEEEEEC
MEGGFLQGIGYASTEYMVADAKGHIRNNSFSDYIIPTAVDVPNLKVDMYVDEKYPYGPYG
CCCCEEECCCCCCCEEEEECCCCCCCCCCCCCEECCCCCCCCCEEEEEEECCCCCCCCCC
AKGAGELPLVGAPGAYAEAIEQALGHGAKVNHAPFTAEDTIKVLSEERE
CCCCCCCCEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MEKISKSVVKRDHSSKISGKAIYVGDYEEDDILIGKMLRSTKAKAKIINVKVPKLLDGYC
CCHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCHHHCCEE
YVDKTDVPGDNKVNIVKDDTPVYATDTVEYIGEPIGMVCGPNEEIVNKILSEIEVIYEEL
EEECCCCCCCCEEEEEECCCCEEECCCHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHH
EPVINIRDFDTVFFDYSFGKGDVEKAFSEADKIYEEEFETGYQDQTYLETQGLMAEVMDD
HHHEEEEECEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCC
EKVYVHGSMQCPYYVKGSVMRAMNLGPDKVRIAQDATGGGFGGKEAFPSILACQVAVAAK
CEEEEEECCCCCEEECCCHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
KAGKKVRCIFDRREDLEFTSKRHPSLNTYKVAVKDGKVTAMDIDVKFNGGAYTTLSAVVL
HCCCEEEEEECCCCCCCHHHCCCCCCCEEEEEEECCEEEEEEEEEEECCCCHHHHHHHHH
QRGIICANGIYNIPNLKVRGRAVKTNTTPSGAYRGFGAPQTFFSAEVMMNHIAKDLGKDS
HCCCEEECCCCCCCCCEEECEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
LEFKEMHLVKQGDSTSTSGKYHFPVPIPNMIERIDKACDFRRKHKEYSNDQNGRYRKGIG
CHHHHHHHEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCE
ISMYFHGAGFTGSGERDIIKAVAKLHKYPDGRVQVLASNTDIGQGLRTTFPKIVAKELNL
EEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCC
PLENVFYEYPDTDVVPDSGPTVASRSLMTVGELLRRAAIKLRDQWVEGEEQIIEEHYKEP
CHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
DFMIPFYIDKFQGDAYPTYSWAVNAIEVEVDTYTGLAKILGAYGCFDIGTPMDYNIAVGQ
CEEEEEEEEEECCCCCCCHHEEEEEEEEEEECHHHHHHHHHHCCCEECCCCCCCEEEEEC
MEGGFLQGIGYASTEYMVADAKGHIRNNSFSDYIIPTAVDVPNLKVDMYVDEKYPYGPYG
CCCCEEECCCCCCCEEEEECCCCCCCCCCCCCEECCCCCCCCCEEEEEEECCCCCCCCCC
AKGAGELPLVGAPGAYAEAIEQALGHGAKVNHAPFTAEDTIKVLSEERE
CCCCCCCCEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 11344136 [H]