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The map label for this gene is lplA [H]

Identifier: 187933780

GI number: 187933780

Start: 3569407

End: 3570342

Strand: Reverse

Name: lplA [H]

Synonym: CLL_A3388

Alternate gene names: 187933780

Gene position: 3570342-3569407 (Counterclockwise)

Preceding gene: 187932434

Following gene: 187933247

Centisome position: 93.95

GC content: 25.32

Gene sequence:

>936_bases
ATGAATAAAGTTATCATTTCAAAAGAGGTAGATCCAGCTTATAATTTAGCTTTAGAAGAAGAACTACTTAGAAATTTGAA
GGATAATGAAAATATACTATATCTTTGGCAGAATGATAGAACTGTAGTTATAGGTAGAAATCAAAATCCATATTCTGAAT
GTAATTTAGATTATATGAAAGAAAATAATATTACATTAGTCAGAAGGATATCTGGAGGAGGAACAGTTTTCCATGATCTT
GGAAATCTTAATTTTACCTTTTTAACTAAAGAAGCAGATGCAAATTTAGAAAAGCAGCTTAAAGTAATAATAGATGGAAT
TGAAAAATTAGGATTGGTTGCAGAAGTATCAGGAAGAAATGATTTGCTTATAGATAATAAGAAATTTTCTGGTCATGCAT
TTTATTCAGAGGATGGAAACTATTTTCATCATGGAACTATAATGATTGATATAAACTTAAATGAACTTTCTAAAGCATTA
AATCCATCTAAATTAAAATTACAATCTAAAGGAATAAAGTCTGTTAGAAGTAGAGTTGTTAATCTTAAGGATTTAGATAA
AAAAATTGATTCTAATATTGTTAAGGAAGCTTTAATTAATGGATTTTTAAATGTATATGGAGAATTTGCAAATATAAAAG
AATATAGCAAAAAAGATTATATTCCAAGTCATTTTCAAAAATATAATGATAGAAAGTGGAATTTTGGAGAAAGTCCTAAT
TACAATATAACATTAGAAAGAAAACTTTCCATTGGAAATGTTGAAATTAATTTAGATATTGTGAATGGGATTATAAAGGA
TTGTAAAATATTCACTGATTCACTTATGTTAGTAGATTTAAACAAAATTCAAGAATGCTTAAAGGGAATTGAATTTAATG
AAGAAGTAGTAATTGAAATCATTAAGGTTACATGTAAACATATCATTCGTATATGA

Upstream 100 bases:

>100_bases
AGTGAAGAGAAAATTTGTGAAACTATCTTCGCACATCCAACTACAGGTGAAGTAATACATGAAAGTTTCCTAGGATTATC
TATTGGAGCTATACACAATC

Downstream 100 bases:

>100_bases
AAGTAACCAATAAATGAAATTAATTTTATGGTTTAGAATAAATATAGATTTTAAATTATAAAAATATATTAAAAAATATT
CTGGTCACTATAATATGTAG

Product: lipoate-protein ligase A

Products: NA

Alternate protein names: Lipoate--protein ligase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MNKVIISKEVDPAYNLALEEELLRNLKDNENILYLWQNDRTVVIGRNQNPYSECNLDYMKENNITLVRRISGGGTVFHDL
GNLNFTFLTKEADANLEKQLKVIIDGIEKLGLVAEVSGRNDLLIDNKKFSGHAFYSEDGNYFHHGTIMIDINLNELSKAL
NPSKLKLQSKGIKSVRSRVVNLKDLDKKIDSNIVKEALINGFLNVYGEFANIKEYSKKDYIPSHFQKYNDRKWNFGESPN
YNITLERKLSIGNVEINLDIVNGIIKDCKIFTDSLMLVDLNKIQECLKGIEFNEEVVIEIIKVTCKHIIRI

Sequences:

>Translated_311_residues
MNKVIISKEVDPAYNLALEEELLRNLKDNENILYLWQNDRTVVIGRNQNPYSECNLDYMKENNITLVRRISGGGTVFHDL
GNLNFTFLTKEADANLEKQLKVIIDGIEKLGLVAEVSGRNDLLIDNKKFSGHAFYSEDGNYFHHGTIMIDINLNELSKAL
NPSKLKLQSKGIKSVRSRVVNLKDLDKKIDSNIVKEALINGFLNVYGEFANIKEYSKKDYIPSHFQKYNDRKWNFGESPN
YNITLERKLSIGNVEINLDIVNGIIKDCKIFTDSLMLVDLNKIQECLKGIEFNEEVVIEIIKVTCKHIIRI
>Mature_311_residues
MNKVIISKEVDPAYNLALEEELLRNLKDNENILYLWQNDRTVVIGRNQNPYSECNLDYMKENNITLVRRISGGGTVFHDL
GNLNFTFLTKEADANLEKQLKVIIDGIEKLGLVAEVSGRNDLLIDNKKFSGHAFYSEDGNYFHHGTIMIDINLNELSKAL
NPSKLKLQSKGIKSVRSRVVNLKDLDKKIDSNIVKEALINGFLNVYGEFANIKEYSKKDYIPSHFQKYNDRKWNFGESPN
YNITLERKLSIGNVEINLDIVNGIIKDCKIFTDSLMLVDLNKIQECLKGIEFNEEVVIEIIKVTCKHIIRI

Specific function: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes [H]

COG id: COG0095

COG function: function code H; Lipoate-protein ligase A

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lplA family [H]

Homologues:

Organism=Homo sapiens, GI7706252, Length=273, Percent_Identity=32.2344322344322, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI21729884, Length=273, Percent_Identity=32.2344322344322, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI21729882, Length=273, Percent_Identity=32.2344322344322, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI21729880, Length=273, Percent_Identity=32.2344322344322, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI21729878, Length=273, Percent_Identity=32.2344322344322, Blast_Score=130, Evalue=1e-30,
Organism=Escherichia coli, GI1790846, Length=304, Percent_Identity=38.8157894736842, Blast_Score=234, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI71981909, Length=246, Percent_Identity=37.8048780487805, Blast_Score=141, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6322415, Length=283, Percent_Identity=30.7420494699647, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28573464, Length=317, Percent_Identity=29.9684542586751, Blast_Score=131, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR005107
- InterPro:   IPR019491
- InterPro:   IPR004562 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB; PF10437 Lip_prot_lig_C [H]

EC number: =2.7.7.63 [H]

Molecular weight: Translated: 35672; Mature: 35672

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVIISKEVDPAYNLALEEELLRNLKDNENILYLWQNDRTVVIGRNQNPYSECNLDYMK
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEECCCCCCCCCCCEEEE
ENNITLVRRISGGGTVFHDLGNLNFTFLTKEADANLEKQLKVIIDGIEKLGLVAEVSGRN
CCCEEEEEEECCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCC
DLLIDNKKFSGHAFYSEDGNYFHHGTIMIDINLNELSKALNPSKLKLQSKGIKSVRSRVV
CEEEECCCCCCCEEECCCCCEEEEEEEEEEEEHHHHHHHCCCCCEEEHHHHHHHHHHHHC
NLKDLDKKIDSNIVKEALINGFLNVYGEFANIKEYSKKDYIPSHFQKYNDRKWNFGESPN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCC
YNITLERKLSIGNVEINLDIVNGIIKDCKIFTDSLMLVDLNKIQECLKGIEFNEEVVIEI
EEEEEEEEEEECEEEEEEHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCCCHHHHHHH
IKVTCKHIIRI
HHHHHHHHHCC
>Mature Secondary Structure
MNKVIISKEVDPAYNLALEEELLRNLKDNENILYLWQNDRTVVIGRNQNPYSECNLDYMK
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEECCCCCCCCCCCEEEE
ENNITLVRRISGGGTVFHDLGNLNFTFLTKEADANLEKQLKVIIDGIEKLGLVAEVSGRN
CCCEEEEEEECCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCC
DLLIDNKKFSGHAFYSEDGNYFHHGTIMIDINLNELSKALNPSKLKLQSKGIKSVRSRVV
CEEEECCCCCCCEEECCCCCEEEEEEEEEEEEHHHHHHHCCCCCEEEHHHHHHHHHHHHC
NLKDLDKKIDSNIVKEALINGFLNVYGEFANIKEYSKKDYIPSHFQKYNDRKWNFGESPN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCC
YNITLERKLSIGNVEINLDIVNGIIKDCKIFTDSLMLVDLNKIQECLKGIEFNEEVVIEI
EEEEEEEEEEECEEEEEEHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCCCHHHHHHH
IKVTCKHIIRI
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA