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The map label for this gene is licA [H]

Identifier: 187933046

GI number: 187933046

Start: 3326652

End: 3328511

Strand: Reverse

Name: licA [H]

Synonym: CLL_A3199

Alternate gene names: 187933046

Gene position: 3328511-3326652 (Counterclockwise)

Preceding gene: 187935556

Following gene: 187932580

Centisome position: 87.58

GC content: 26.94

Gene sequence:

>1860_bases
ATGTTAGAAGATAGATTAGAAATATTAAAAATATTAAACAATAATTTTAATATTAATCAAAGAGAGTTATCAAAAAGAAC
AAATATTTCATTAGGAAAAGTGAATTCAATTTTAAAGGATTTTACCATTGATGGAACTATAGAAAGAGTTATAAATAATA
GAGGGATTTTATATAGGGTAACTGAAAAAGGCATGAAAATATTAGAAGAGAATCTTGCATCAGCTAAAAACACTAGATTA
AAAATTCATGAAGAGGACAATAAATCTGTTAAAGAAGCTGTTATTCTTGCAGCTGGAAGAGCTAGGGATTTTGGAAGACC
TGTTGGAATGCTTGAAATAGAAGATTTTAAATTAATAGATAGAACATTAAATATACTTAAAGAAAATGGAATTAATAAAA
TTACTATAATAACAGGTTATGAAAGTGTTTGTTATGAAGAGTACTTTAAGAATAATAAGAATATAAATCTAGTTAAAAGT
GATAAATACAAATGGACTGGAACTATGTATTCATTATCTTTGGCTAGAGAATATGTTAAAGATGACTTTTTATTAATAGA
AAATGATTTGATTTTTGAAAAAAGAGCAATTAAAGAGCTTATAGAAAGTAATAGTAGGGATTGTATCCTTCTTACTAATG
AAAGTGGCTCAGGGGATGAGGCTTTTGTTGAAATAAGAAATAATCATTTATTCAAGATGTCTAAGGATATACATCAATTT
AATAGGATTGATGGTGAAATGATTGGTATAACTAAAGTATCTCATAAATTATATCAGATGATGCTTGAGGAATTTAAAGA
TAATATAAATCCATATTTGAATTATGAATATGTATTATTAGATGTTGCTAGAGATTATAATATTGGATTTGTAAAAATAG
ATGATCTTGCTTGGGGAGATGCAGATACTAAAAAAGAATATGAAAATATTTTAAATCATCTTTATCCAACTATAAGAAGG
CGTGAGCTAAATTATGAAATTAACACTGTAAAGACTATAGTTAGAGAAGCTATGAAAGTATCTGAAGATGAGATAAGTGA
AGTTGTAGCTGCTGGCGGTATGACTAATAAAAATTATAGAATTTGCGTTAAAGGAAAAAGATATATATTAAGAGTTGCAG
GTATTGGAACTGAATGTATGATAAGTAGAAAAAATGAAATGTTTAATTCTTCAATTGCTTCAGAGAGAGAATACAACGTT
GAAACTCCATATTTCAATGTTGAAACTGGAATAAAAATATCTACTTTTATAGAGAATGCAGAAACTTTAACTCCAAGAAG
TGTTAAAAAGGAAGAGAATCTAAAACAAGTTACTAGAATATTAAGGGATTTACATGAAGATAATGAATTTCCAATGAAAA
ATGAATTTAATGTGTTTAGAGAACTTGAAAAATATGAGGATATTTTAAAGACTTCTGATGGAGAATTTTTTCATGACTAT
GATGAAGTAAGAGAAAGATTTATGAAATTAGAACAAGTTCTAAAAGAGTGTGATAGAGTTTTTGTTCCATCTCATAATGA
TTTGGTATCAGAAAATTTAGTGAAGGATACAGAAGGTAGAATTTATTTAATAGACTGGGAATATAGCGGTATAAATGATG
ACATGTGGGATTTAGCAGCACTTTCTTTAGAAAATAATTTTTCAGAAGATGATACGGAATTAATGTTTAGACTTTATTTT
AATGGTGAAGCAGATGATAACTCAAGAAAAAGGTTATTAATTCATCAAATAAGTCAAGATTTATTATGGGCTGTATGGAC
ATTGATTAAAGAGAATGAAGGCGATGATTTTGGTACCTATGGAATAGATAGATATAATAGGGGAAAAGAAAATTTAAATA
AACTAGAAGCTGAATTTTAA

Upstream 100 bases:

>100_bases
TAAACTGTAAAGCAGAGAAATGTTAAAAGGCATAAGCCTAAAAATTAAAATTTTGGATAATATAATTTAGATACATATAA
ATAAAAGGGGGAGAGCTTGT

Downstream 100 bases:

>100_bases
GGAGAGAAAAACATATGAGAGCAATATTAGTAGCAGCGGGGATGGGTACTAGACTTAGACCACTTACAAATACAATACCA
AAGTCCTTAGTTGAGGTTAA

Product: choline/ethanolamine kinase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MLEDRLEILKILNNNFNINQRELSKRTNISLGKVNSILKDFTIDGTIERVINNRGILYRVTEKGMKILEENLASAKNTRL
KIHEEDNKSVKEAVILAAGRARDFGRPVGMLEIEDFKLIDRTLNILKENGINKITIITGYESVCYEEYFKNNKNINLVKS
DKYKWTGTMYSLSLAREYVKDDFLLIENDLIFEKRAIKELIESNSRDCILLTNESGSGDEAFVEIRNNHLFKMSKDIHQF
NRIDGEMIGITKVSHKLYQMMLEEFKDNINPYLNYEYVLLDVARDYNIGFVKIDDLAWGDADTKKEYENILNHLYPTIRR
RELNYEINTVKTIVREAMKVSEDEISEVVAAGGMTNKNYRICVKGKRYILRVAGIGTECMISRKNEMFNSSIASEREYNV
ETPYFNVETGIKISTFIENAETLTPRSVKKEENLKQVTRILRDLHEDNEFPMKNEFNVFRELEKYEDILKTSDGEFFHDY
DEVRERFMKLEQVLKECDRVFVPSHNDLVSENLVKDTEGRIYLIDWEYSGINDDMWDLAALSLENNFSEDDTELMFRLYF
NGEADDNSRKRLLIHQISQDLLWAVWTLIKENEGDDFGTYGIDRYNRGKENLNKLEAEF

Sequences:

>Translated_619_residues
MLEDRLEILKILNNNFNINQRELSKRTNISLGKVNSILKDFTIDGTIERVINNRGILYRVTEKGMKILEENLASAKNTRL
KIHEEDNKSVKEAVILAAGRARDFGRPVGMLEIEDFKLIDRTLNILKENGINKITIITGYESVCYEEYFKNNKNINLVKS
DKYKWTGTMYSLSLAREYVKDDFLLIENDLIFEKRAIKELIESNSRDCILLTNESGSGDEAFVEIRNNHLFKMSKDIHQF
NRIDGEMIGITKVSHKLYQMMLEEFKDNINPYLNYEYVLLDVARDYNIGFVKIDDLAWGDADTKKEYENILNHLYPTIRR
RELNYEINTVKTIVREAMKVSEDEISEVVAAGGMTNKNYRICVKGKRYILRVAGIGTECMISRKNEMFNSSIASEREYNV
ETPYFNVETGIKISTFIENAETLTPRSVKKEENLKQVTRILRDLHEDNEFPMKNEFNVFRELEKYEDILKTSDGEFFHDY
DEVRERFMKLEQVLKECDRVFVPSHNDLVSENLVKDTEGRIYLIDWEYSGINDDMWDLAALSLENNFSEDDTELMFRLYF
NGEADDNSRKRLLIHQISQDLLWAVWTLIKENEGDDFGTYGIDRYNRGKENLNKLEAEF
>Mature_619_residues
MLEDRLEILKILNNNFNINQRELSKRTNISLGKVNSILKDFTIDGTIERVINNRGILYRVTEKGMKILEENLASAKNTRL
KIHEEDNKSVKEAVILAAGRARDFGRPVGMLEIEDFKLIDRTLNILKENGINKITIITGYESVCYEEYFKNNKNINLVKS
DKYKWTGTMYSLSLAREYVKDDFLLIENDLIFEKRAIKELIESNSRDCILLTNESGSGDEAFVEIRNNHLFKMSKDIHQF
NRIDGEMIGITKVSHKLYQMMLEEFKDNINPYLNYEYVLLDVARDYNIGFVKIDDLAWGDADTKKEYENILNHLYPTIRR
RELNYEINTVKTIVREAMKVSEDEISEVVAAGGMTNKNYRICVKGKRYILRVAGIGTECMISRKNEMFNSSIASEREYNV
ETPYFNVETGIKISTFIENAETLTPRSVKKEENLKQVTRILRDLHEDNEFPMKNEFNVFRELEKYEDILKTSDGEFFHDY
DEVRERFMKLEQVLKECDRVFVPSHNDLVSENLVKDTEGRIYLIDWEYSGINDDMWDLAALSLENNFSEDDTELMFRLYF
NGEADDNSRKRLLIHQISQDLLWAVWTLIKENEGDDFGTYGIDRYNRGKENLNKLEAEF

Specific function: Mediates phase variation of the LOS 6A2 and 12D9 epitopes. Phase variation of H.influenza LOS epitopes expressed by licA is determined by a translational switch [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Caenorhabditis elegans, GI71997462, Length=299, Percent_Identity=25.752508361204, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002573
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01633 Choline_kinase [H]

EC number: NA

Molecular weight: Translated: 72548; Mature: 72548

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEDRLEILKILNNNFNINQRELSKRTNISLGKVNSILKDFTIDGTIERVINNRGILYRV
CCHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCCCCEEEEE
TEKGMKILEENLASAKNTRLKIHEEDNKSVKEAVILAAGRARDFGRPVGMLEIEDFKLID
HHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHH
RTLNILKENGINKITIITGYESVCYEEYFKNNKNINLVKSDKYKWTGTMYSLSLAREYVK
HHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCEEEEECCCCEEEEHHHHHHHHHHHHC
DDFLLIENDLIFEKRAIKELIESNSRDCILLTNESGSGDEAFVEIRNNHLFKMSKDIHQF
CCEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCEEEHHHHHHHH
NRIDGEMIGITKVSHKLYQMMLEEFKDNINPYLNYEYVLLDVARDYNIGFVKIDDLAWGD
HCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCC
ADTKKEYENILNHLYPTIRRRELNYEINTVKTIVREAMKVSEDEISEVVAAGGMTNKNYR
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEE
ICVKGKRYILRVAGIGTECMISRKNEMFNSSIASEREYNVETPYFNVETGIKISTFIENA
EEEECCEEEEEEECCCHHHHEECHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCC
ETLTPRSVKKEENLKQVTRILRDLHEDNEFPMKNEFNVFRELEKYEDILKTSDGEFFHDY
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCH
DEVRERFMKLEQVLKECDRVFVPSHNDLVSENLVKDTEGRIYLIDWEYSGINDDMWDLAA
HHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHH
LSLENNFSEDDTELMFRLYFNGEADDNSRKRLLIHQISQDLLWAVWTLIKENEGDDFGTY
HHHCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GIDRYNRGKENLNKLEAEF
CCCHHCCCHHHHHHHCCCC
>Mature Secondary Structure
MLEDRLEILKILNNNFNINQRELSKRTNISLGKVNSILKDFTIDGTIERVINNRGILYRV
CCHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCCCCEEEEE
TEKGMKILEENLASAKNTRLKIHEEDNKSVKEAVILAAGRARDFGRPVGMLEIEDFKLID
HHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHH
RTLNILKENGINKITIITGYESVCYEEYFKNNKNINLVKSDKYKWTGTMYSLSLAREYVK
HHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCEEEEECCCCEEEEHHHHHHHHHHHHC
DDFLLIENDLIFEKRAIKELIESNSRDCILLTNESGSGDEAFVEIRNNHLFKMSKDIHQF
CCEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCEEEHHHHHHHH
NRIDGEMIGITKVSHKLYQMMLEEFKDNINPYLNYEYVLLDVARDYNIGFVKIDDLAWGD
HCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCC
ADTKKEYENILNHLYPTIRRRELNYEINTVKTIVREAMKVSEDEISEVVAAGGMTNKNYR
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEE
ICVKGKRYILRVAGIGTECMISRKNEMFNSSIASEREYNVETPYFNVETGIKISTFIENA
EEEECCEEEEEEECCCHHHHEECHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCC
ETLTPRSVKKEENLKQVTRILRDLHEDNEFPMKNEFNVFRELEKYEDILKTSDGEFFHDY
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCH
DEVRERFMKLEQVLKECDRVFVPSHNDLVSENLVKDTEGRIYLIDWEYSGINDDMWDLAA
HHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHH
LSLENNFSEDDTELMFRLYFNGEADDNSRKRLLIHQISQDLLWAVWTLIKENEGDDFGTY
HHHCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GIDRYNRGKENLNKLEAEF
CCCHHCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2479481; 8861214 [H]