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The map label for this gene is ndoA [H]

Identifier: 187932987

GI number: 187932987

Start: 3546779

End: 3547132

Strand: Reverse

Name: ndoA [H]

Synonym: CLL_A3362

Alternate gene names: 187932987

Gene position: 3547132-3546779 (Counterclockwise)

Preceding gene: 187934260

Following gene: 187934013

Centisome position: 93.34

GC content: 31.36

Gene sequence:

>354_bases
ATGGCAACTATGGTAGTAAAAAGAGGAGATATATTTTACGCAGATTTAAGTCCTGTTATAGGATCTGAACAAGGTGGAAT
ACGTCCCGTTATTATAATACAAAATGATATAGGAAATAGATACAGTCCTACTGTTATTGTAGCGGCAATAACATCACAAA
TAAACAAGGCTAAACTACCTACTCATGTTGAGATATCTTCAGAAGAGTATGGGTTAAATAGAGATTCAGTTGTATTATTA
GAACAAATAAGGACTTTAGACAAACGAAGATTAAAAGAAAAAATTGGACATATGACTGACTGTGATATGAAGAAGGTAAA
CAAATCTTTGACTATAAGTCTAAACCTTAATTAA

Upstream 100 bases:

>100_bases
GGCAGAGTTAAATTTGGAACTTTCTAGAGATGGGGTTGAAAAGCTATTAAGTGATATTAATGAATATGAGATATGGCTTT
GCGGAGAGTGATTATTTGAA

Downstream 100 bases:

>100_bases
AAAAAGGATAGAGTAAATCTATCCTTTTAAAGCATACAGAGATACTATTAATAAAGACACTTTCTAGAGTAAGAGCATAC
AAACTAAAGAAAGTGTCTTT

Product: endoribonuclease EndoA

Products: NA

Alternate protein names: Endoribonuclease EndoA; Toxin EndoA [H]

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MATMVVKRGDIFYADLSPVIGSEQGGIRPVIIIQNDIGNRYSPTVIVAAITSQINKAKLPTHVEISSEEYGLNRDSVVLL
EQIRTLDKRRLKEKIGHMTDCDMKKVNKSLTISLNLN

Sequences:

>Translated_117_residues
MATMVVKRGDIFYADLSPVIGSEQGGIRPVIIIQNDIGNRYSPTVIVAAITSQINKAKLPTHVEISSEEYGLNRDSVVLL
EQIRTLDKRRLKEKIGHMTDCDMKKVNKSLTISLNLN
>Mature_116_residues
ATMVVKRGDIFYADLSPVIGSEQGGIRPVIIIQNDIGNRYSPTVIVAAITSQINKAKLPTHVEISSEEYGLNRDSVVLLE
QIRTLDKRRLKEKIGHMTDCDMKKVNKSLTISLNLN

Specific function: Part of a toxin-antitoxin (TA) module. Has specificity for UAC sequences, yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single

COG id: COG2337

COG function: function code T; Growth inhibitor

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PemK/MazF family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003477
- InterPro:   IPR011067 [H]

Pfam domain/function: PF02452 PemK [H]

EC number: NA

Molecular weight: Translated: 13037; Mature: 12906

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATMVVKRGDIFYADLSPVIGSEQGGIRPVIIIQNDIGNRYSPTVIVAAITSQINKAKLP
CCEEEEECCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEHHHHCCCCCC
THVEISSEEYGLNRDSVVLLEQIRTLDKRRLKEKIGHMTDCDMKKVNKSLTISLNLN
EEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEEEECC
>Mature Secondary Structure 
ATMVVKRGDIFYADLSPVIGSEQGGIRPVIIIQNDIGNRYSPTVIVAAITSQINKAKLP
CEEEEECCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEHHHHCCCCCC
THVEISSEEYGLNRDSVVLLEQIRTLDKRRLKEKIGHMTDCDMKKVNKSLTISLNLN
EEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]