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The map label for this gene is ydjJ [H]

Identifier: 187932577

GI number: 187932577

Start: 3506799

End: 3507854

Strand: Reverse

Name: ydjJ [H]

Synonym: CLL_A3334

Alternate gene names: 187932577

Gene position: 3507854-3506799 (Counterclockwise)

Preceding gene: 187932917

Following gene: 187935024

Centisome position: 92.3

GC content: 35.7

Gene sequence:

>1056_bases
ATGGAAGGAAAAATGAAAGTTGCAATTATGACTGGAATTGGTCAGATGAAATTTGAGGAACGTGAAATTCCTAAAGTAAA
AGATAATGAGGTTCTAGTAAAACTTGAATATGTAGGTATTTGTGGAAGTGACTTGCATTATTATGAAACTGGTGCTATTG
GTGATTATGTGGTTAAACCACCATTTGTTCTTGGACATGAGCCAGGTGGAACTGTGATAGAGATTGGAAAGAATGTAAAG
GATTTAAAAATTGGAGATAGGGTAGCGTTGGAACCAGGAAAAACATGTGGACATTGTGAATTTTGTAAAACAGGACGATA
TAATCTTTGTCCAGATGTGGAATTCTTTGCTACTCCACCAATAGATGGTATTTTTCAAGAATATGTTGCTCATGATGCTA
GTCTTTGTTTTAAGTTACCTGATAATGTAAGTACCATGGAAGGTGCATTAATAGAACCTTTGGCAGTAGGATTCCATGCC
GCTATGCAGGGAAATGCTAAGGCAGGACAGATAGTGGTAGTTATGGGAGCTGGATGTATAGGTTTAGTTACAATGATGGC
ATTAAAGGCGATGGGAGTTTCAAAGGTATATGTTGTGGATATCATGGAAAAACGTCTTCAGAAAGCATTAGAATTAGGAG
CCGATGCTATTATTAATGGAAGTAAAAAGGATACTGTTGAAGAAATCATGAAACTTACTAATGGAAAAGGTTGTGATTTG
GCAATTGAAACAGCAGGAACACAGACTACAACAATACAGACTATACACATGACTAAGAAAGATGCAACTATTGTACTTGT
AGGTTATAGTAAGACAGGAGAAATGACATTGCCAATGAGTCTGGCATTGGATAAGGAACTGACATTTAAAACTGTATTCC
GTTATCGTCATATTTATCCAATGGCAATTGACGCAGTTGCAGCCGGAAAGGTAAATTTAAAAGGAATTGTGACAAATATA
TTCACATTGGATGAAGCAAAAAAAGCAATGGATTATAGTGTAAATAACAAAGCAGATATTGTAAAGTCAGTTATTCGTAT
TTCTGAAGTAGAGTAA

Upstream 100 bases:

>100_bases
ATTCTATATATTGACAAATATGTGTGTATATAATAAAATATAAACACATAATAAAAGTATTTTAAAAAGTATTTTATTAT
GTGGAAAAGGGGGAAATGTT

Downstream 100 bases:

>100_bases
GAATAGTATTTTATTTTTTTAGAACACCTTTGGAATGATTTTATGAGAATTTCAGAGGTGATTTCTGAAAAGGATTACCA
TAAACTGAAAGGTAAATATA

Product: sorbitol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MEGKMKVAIMTGIGQMKFEEREIPKVKDNEVLVKLEYVGICGSDLHYYETGAIGDYVVKPPFVLGHEPGGTVIEIGKNVK
DLKIGDRVALEPGKTCGHCEFCKTGRYNLCPDVEFFATPPIDGIFQEYVAHDASLCFKLPDNVSTMEGALIEPLAVGFHA
AMQGNAKAGQIVVVMGAGCIGLVTMMALKAMGVSKVYVVDIMEKRLQKALELGADAIINGSKKDTVEEIMKLTNGKGCDL
AIETAGTQTTTIQTIHMTKKDATIVLVGYSKTGEMTLPMSLALDKELTFKTVFRYRHIYPMAIDAVAAGKVNLKGIVTNI
FTLDEAKKAMDYSVNNKADIVKSVIRISEVE

Sequences:

>Translated_351_residues
MEGKMKVAIMTGIGQMKFEEREIPKVKDNEVLVKLEYVGICGSDLHYYETGAIGDYVVKPPFVLGHEPGGTVIEIGKNVK
DLKIGDRVALEPGKTCGHCEFCKTGRYNLCPDVEFFATPPIDGIFQEYVAHDASLCFKLPDNVSTMEGALIEPLAVGFHA
AMQGNAKAGQIVVVMGAGCIGLVTMMALKAMGVSKVYVVDIMEKRLQKALELGADAIINGSKKDTVEEIMKLTNGKGCDL
AIETAGTQTTTIQTIHMTKKDATIVLVGYSKTGEMTLPMSLALDKELTFKTVFRYRHIYPMAIDAVAAGKVNLKGIVTNI
FTLDEAKKAMDYSVNNKADIVKSVIRISEVE
>Mature_351_residues
MEGKMKVAIMTGIGQMKFEEREIPKVKDNEVLVKLEYVGICGSDLHYYETGAIGDYVVKPPFVLGHEPGGTVIEIGKNVK
DLKIGDRVALEPGKTCGHCEFCKTGRYNLCPDVEFFATPPIDGIFQEYVAHDASLCFKLPDNVSTMEGALIEPLAVGFHA
AMQGNAKAGQIVVVMGAGCIGLVTMMALKAMGVSKVYVVDIMEKRLQKALELGADAIINGSKKDTVEEIMKLTNGKGCDL
AIETAGTQTTTIQTIHMTKKDATIVLVGYSKTGEMTLPMSLALDKELTFKTVFRYRHIYPMAIDAVAAGKVNLKGIVTNI
FTLDEAKKAMDYSVNNKADIVKSVIRISEVE

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=326, Percent_Identity=45.7055214723926, Blast_Score=283, Evalue=1e-76,
Organism=Homo sapiens, GI4501929, Length=365, Percent_Identity=26.3013698630137, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI71565152, Length=378, Percent_Identity=26.4550264550265, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71743840, Length=378, Percent_Identity=26.7195767195767, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI262073058, Length=378, Percent_Identity=26.7195767195767, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4501939, Length=360, Percent_Identity=24.4444444444444, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI156523966, Length=360, Percent_Identity=24.4444444444444, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI71565154, Length=374, Percent_Identity=25.4010695187166, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI1788073, Length=353, Percent_Identity=44.4759206798867, Blast_Score=315, Evalue=2e-87,
Organism=Escherichia coli, GI1790718, Length=338, Percent_Identity=30.4733727810651, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1787863, Length=346, Percent_Identity=30.0578034682081, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1790045, Length=332, Percent_Identity=29.8192771084337, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI226510992, Length=346, Percent_Identity=30.0578034682081, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI1788407, Length=311, Percent_Identity=31.5112540192926, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1788075, Length=331, Percent_Identity=26.5861027190332, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI87082125, Length=356, Percent_Identity=26.9662921348315, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87081918, Length=233, Percent_Identity=30.9012875536481, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786825, Length=375, Percent_Identity=26.4, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786552, Length=379, Percent_Identity=25.5936675461741, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082401, Length=226, Percent_Identity=28.3185840707965, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=342, Percent_Identity=45.0292397660819, Blast_Score=305, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17562878, Length=341, Percent_Identity=42.2287390029325, Blast_Score=280, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17562584, Length=309, Percent_Identity=33.0097087378641, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71988145, Length=311, Percent_Identity=30.2250803858521, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17562582, Length=284, Percent_Identity=31.6901408450704, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322619, Length=345, Percent_Identity=38.8405797101449, Blast_Score=249, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6319955, Length=345, Percent_Identity=38.5507246376812, Blast_Score=246, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6323099, Length=342, Percent_Identity=40.3508771929825, Blast_Score=236, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6319257, Length=340, Percent_Identity=29.7058823529412, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6319258, Length=261, Percent_Identity=32.5670498084291, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319621, Length=263, Percent_Identity=32.6996197718631, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323961, Length=261, Percent_Identity=31.4176245210728, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324486, Length=261, Percent_Identity=31.0344827586207, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6323729, Length=261, Percent_Identity=31.0344827586207, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6319520, Length=287, Percent_Identity=26.8292682926829, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=300, Percent_Identity=28.3333333333333, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319949, Length=231, Percent_Identity=29.8701298701299, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=203, Percent_Identity=29.5566502463054, Blast_Score=62, Evalue=1e-10,
Organism=Drosophila melanogaster, GI17137530, Length=344, Percent_Identity=42.7325581395349, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI17737897, Length=344, Percent_Identity=42.1511627906977, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI45551930, Length=324, Percent_Identity=26.2345679012346, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI221457811, Length=324, Percent_Identity=26.2345679012346, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45550770, Length=324, Percent_Identity=26.2345679012346, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 38112; Mature: 38112

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGKMKVAIMTGIGQMKFEEREIPKVKDNEVLVKLEYVGICGSDLHYYETGAIGDYVVKP
CCCCEEEEEEECCCCCEECHHCCCCCCCCCEEEEEEEEEECCCCCEEEECCCCCCEEECC
PFVLGHEPGGTVIEIGKNVKDLKIGDRVALEPGKTCGHCEFCKTGRYNLCPDVEFFATPP
CEEEECCCCCCEEEECCCCCEEECCCEEEECCCCCCCCCHHHCCCCCCCCCCCCEEECCC
IDGIFQEYVAHDASLCFKLPDNVSTMEGALIEPLAVGFHAAMQGNAKAGQIVVVMGAGCI
HHHHHHHHHHCCCCEEEECCCCCCHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCHH
GLVTMMALKAMGVSKVYVVDIMEKRLQKALELGADAIINGSKKDTVEEIMKLTNGKGCDL
HHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHCCCCCEE
AIETAGTQTTTIQTIHMTKKDATIVLVGYSKTGEMTLPMSLALDKELTFKTVFRYRHIYP
EEEECCCCEEEEEEEEEECCCCEEEEEEECCCCCEEEEEEEEECCCHHHHHHHHHHHCCC
MAIDAVAAGKVNLKGIVTNIFTLDEAKKAMDYSVNNKADIVKSVIRISEVE
EEEEEEECCCEEEEEEEEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEGKMKVAIMTGIGQMKFEEREIPKVKDNEVLVKLEYVGICGSDLHYYETGAIGDYVVKP
CCCCEEEEEEECCCCCEECHHCCCCCCCCCEEEEEEEEEECCCCCEEEECCCCCCEEECC
PFVLGHEPGGTVIEIGKNVKDLKIGDRVALEPGKTCGHCEFCKTGRYNLCPDVEFFATPP
CEEEECCCCCCEEEECCCCCEEECCCEEEECCCCCCCCCHHHCCCCCCCCCCCCEEECCC
IDGIFQEYVAHDASLCFKLPDNVSTMEGALIEPLAVGFHAAMQGNAKAGQIVVVMGAGCI
HHHHHHHHHHCCCCEEEECCCCCCHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCHH
GLVTMMALKAMGVSKVYVVDIMEKRLQKALELGADAIINGSKKDTVEEIMKLTNGKGCDL
HHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHCCCCCEE
AIETAGTQTTTIQTIHMTKKDATIVLVGYSKTGEMTLPMSLALDKELTFKTVFRYRHIYP
EEEECCCCEEEEEEEEEECCCCEEEEEEECCCCCEEEEEEEEECCCHHHHHHHHHHHCCC
MAIDAVAAGKVNLKGIVTNIFTLDEAKKAMDYSVNNKADIVKSVIRISEVE
EEEEEEECCCEEEEEEEEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]