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The map label for this gene is thrS

Identifier: 187918575

GI number: 187918575

Start: 765125

End: 766876

Strand: Direct

Name: thrS

Synonym: BH0720

Alternate gene names: 187918575

Gene position: 765125-766876 (Clockwise)

Preceding gene: 187918574

Following gene: 187918576

Centisome position: 82.96

GC content: 33.22

Gene sequence:

>1752_bases
ATGAGTGAAAAATTAGATAGAGAGAGTATTCTTTATAAGAAGAGACATTCAATCGCACATGTTATGGCAGAAGCTGTGCT
TGAGTTATTTCCAAATACTAAGATTGCTATAGGGCCTCCGATTAAAGATGGATTTTATTATGATTTTGATTTTGAAAAAC
ATATTACAGAAGATGATCTTTTGTTAATAGAACAGAAAATGAGAGAAATACTAAAAACAGGGAGTCCTTTTGTAAAGGAA
GTGATAACTAAAGAACAGGCTTTAATGCTTTTCAAAGATGAACCTTATAAAATGGATTTAATTCGCGGACTTGCGATTAC
AGATGAGATTTCAATATATAAAAGTCATAATTTTACTGATCTTTGTAAAGGTCCTCATGTTGATAATATGGGTAAAATTG
ATCCAAAGGCATTTAAGTTAACTAGTATTGCTGGTGCTTATTGGCGTGGCGATGAGAAAAATAAGATGCTTACTCGTATT
TATGGAACTTTATGGAATAATGAAAAAGATTTAAAAGCGTACCTTAAATTACGAGAAGAGATAAAAAGGCGAGACCATAG
AAAACTTGGTCGTGAACTTGATTTGTTTTCTGTTCATGAAGACATAGGGCCTGGTCTTATATTTTTTCATCCAAATGGTG
CTAGAATAAGAGCTATAATAGAAGATTTTTGGAGAGAAGAGCATTTTAAAAATGGTTATGATGTACTCTTTACTCCTCAT
ATTGGTAAGTCTTGTCTTTGGGAGACTTCTGGGCATTTAGATTTTTATAAAGAAAGTATGTTTGAGAAAATGGAGATGGA
TAAAAGTAATTATTATGTTAAGCCTATGAATTGTCCATTTCATATTGCGATTTATAATACCGGCAAGCATTCTTATAGAG
ATTTGCCGTTTAGGTGGGCTGAACTTGGTACTGTGTATCGTTATGAGAAGATTGGCGCTCTTCATGGTACTATGCGTGTT
AGAGGATTTACTCAAGATGATGCACACATTATATGTGCTTATGAGCAAGTTAAGTCTGAAGTTCAAGAGGTTTTAAGATT
TGCTCTTTATATGTGGAATCAATTTGGATTTGCTGATTTAAAGGCATATCTCTCGACAAAGCCAGAAAAAGCTGTAGGGG
ATAAGGATGATTGGGAAATGTCTGTAAAAGTTTTAGAGGAAGCTTTGATTGATCTAAATATTGCTTATGATATTGATGAG
GGAGGCGGGGCTTTTTATGGGCCTAAAATTGATCTTAAAATAATTGATTCTCTTGGGAGAGAATGGCAGATGAGCACAAT
TCAATTTGATTTTAATCTTCCTGAAAGATTTAAGATGACTTATACAGCAGAGGATGGTAAAGAAAAGCGGCCTTTTATGA
TTCATAGAGCCCTTCTTGGTTCTATTGAGAGATTTTTTGGAATTTTGGTAGAACATTATGGCGGAGCGTTTCCTGTGTGG
TTGGCGCCTCTTCAAGTTATAATTATTCCTGTAAACAATGTTGTAGAAGAATATGCATTAGAGATATTATCTTTGTTTAA
AAATGAAGGGATTAGAATAAAGCTTGATAATGATTGCAATATGAGGATGAATGCAAAAATTAGACAATATCAATCCAAAA
AAGTTCCCTATATGTTTATTATAGGAGAAAAAGAGGTAGTAGAGGGAAAAATTTCGATTAGAACCAGGACAAATGATCAG
ATTAATGGACTTGAACTTAAAGAAGCACTTGAATTTGTGAGACTAAAGGTAAAGAATAAGGAGATTTTATAA

Upstream 100 bases:

>100_bases
TGTATATTTTATTGAGAAGATTTATTGTTTGTCTATAACTGTGATTGGAGCTTAAATTTATTATAATAATTAATATTTAG
AATCTTAGTAAGGGGTTTTT

Downstream 100 bases:

>100_bases
ATTGAATAGCAAGAGTATAATTAGTCCAAATAAAATAACTTTTTTTAGAATTATATTATCTTTTGTTATCTTATTTATAT
TCTGTCTTGAAGATTTTTGG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 583; Mature: 582

Protein sequence:

>583_residues
MSEKLDRESILYKKRHSIAHVMAEAVLELFPNTKIAIGPPIKDGFYYDFDFEKHITEDDLLLIEQKMREILKTGSPFVKE
VITKEQALMLFKDEPYKMDLIRGLAITDEISIYKSHNFTDLCKGPHVDNMGKIDPKAFKLTSIAGAYWRGDEKNKMLTRI
YGTLWNNEKDLKAYLKLREEIKRRDHRKLGRELDLFSVHEDIGPGLIFFHPNGARIRAIIEDFWREEHFKNGYDVLFTPH
IGKSCLWETSGHLDFYKESMFEKMEMDKSNYYVKPMNCPFHIAIYNTGKHSYRDLPFRWAELGTVYRYEKIGALHGTMRV
RGFTQDDAHIICAYEQVKSEVQEVLRFALYMWNQFGFADLKAYLSTKPEKAVGDKDDWEMSVKVLEEALIDLNIAYDIDE
GGGAFYGPKIDLKIIDSLGREWQMSTIQFDFNLPERFKMTYTAEDGKEKRPFMIHRALLGSIERFFGILVEHYGGAFPVW
LAPLQVIIIPVNNVVEEYALEILSLFKNEGIRIKLDNDCNMRMNAKIRQYQSKKVPYMFIIGEKEVVEGKISIRTRTNDQ
INGLELKEALEFVRLKVKNKEIL

Sequences:

>Translated_583_residues
MSEKLDRESILYKKRHSIAHVMAEAVLELFPNTKIAIGPPIKDGFYYDFDFEKHITEDDLLLIEQKMREILKTGSPFVKE
VITKEQALMLFKDEPYKMDLIRGLAITDEISIYKSHNFTDLCKGPHVDNMGKIDPKAFKLTSIAGAYWRGDEKNKMLTRI
YGTLWNNEKDLKAYLKLREEIKRRDHRKLGRELDLFSVHEDIGPGLIFFHPNGARIRAIIEDFWREEHFKNGYDVLFTPH
IGKSCLWETSGHLDFYKESMFEKMEMDKSNYYVKPMNCPFHIAIYNTGKHSYRDLPFRWAELGTVYRYEKIGALHGTMRV
RGFTQDDAHIICAYEQVKSEVQEVLRFALYMWNQFGFADLKAYLSTKPEKAVGDKDDWEMSVKVLEEALIDLNIAYDIDE
GGGAFYGPKIDLKIIDSLGREWQMSTIQFDFNLPERFKMTYTAEDGKEKRPFMIHRALLGSIERFFGILVEHYGGAFPVW
LAPLQVIIIPVNNVVEEYALEILSLFKNEGIRIKLDNDCNMRMNAKIRQYQSKKVPYMFIIGEKEVVEGKISIRTRTNDQ
INGLELKEALEFVRLKVKNKEIL
>Mature_582_residues
SEKLDRESILYKKRHSIAHVMAEAVLELFPNTKIAIGPPIKDGFYYDFDFEKHITEDDLLLIEQKMREILKTGSPFVKEV
ITKEQALMLFKDEPYKMDLIRGLAITDEISIYKSHNFTDLCKGPHVDNMGKIDPKAFKLTSIAGAYWRGDEKNKMLTRIY
GTLWNNEKDLKAYLKLREEIKRRDHRKLGRELDLFSVHEDIGPGLIFFHPNGARIRAIIEDFWREEHFKNGYDVLFTPHI
GKSCLWETSGHLDFYKESMFEKMEMDKSNYYVKPMNCPFHIAIYNTGKHSYRDLPFRWAELGTVYRYEKIGALHGTMRVR
GFTQDDAHIICAYEQVKSEVQEVLRFALYMWNQFGFADLKAYLSTKPEKAVGDKDDWEMSVKVLEEALIDLNIAYDIDEG
GGAFYGPKIDLKIIDSLGREWQMSTIQFDFNLPERFKMTYTAEDGKEKRPFMIHRALLGSIERFFGILVEHYGGAFPVWL
APLQVIIIPVNNVVEEYALEILSLFKNEGIRIKLDNDCNMRMNAKIRQYQSKKVPYMFIIGEKEVVEGKISIRTRTNDQI
NGLELKEALEFVRLKVKNKEIL

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=545, Percent_Identity=41.1009174311927, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI38202255, Length=558, Percent_Identity=40.6810035842294, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI20070344, Length=588, Percent_Identity=35.7142857142857, Blast_Score=388, Evalue=1e-108,
Organism=Escherichia coli, GI1788013, Length=571, Percent_Identity=42.7320490367776, Blast_Score=500, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI71984192, Length=545, Percent_Identity=40.7339449541284, Blast_Score=423, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71984184, Length=545, Percent_Identity=40.7339449541284, Blast_Score=423, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6322112, Length=594, Percent_Identity=38.5521885521886, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6322654, Length=431, Percent_Identity=35.4988399071926, Blast_Score=251, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24583842, Length=563, Percent_Identity=39.9644760213144, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI28574141, Length=563, Percent_Identity=39.9644760213144, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24583839, Length=563, Percent_Identity=39.9644760213144, Blast_Score=439, Evalue=1e-123,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_BORHD (B2S162)

Other databases:

- EMBL:   CP000048
- RefSeq:   YP_001884138.1
- ProteinModelPortal:   B2S162
- EnsemblBacteria:   EBBORT00000006378
- GeneID:   6276606
- GenomeReviews:   CP000048_GR
- KEGG:   bhr:BH0720
- GeneTree:   EBGT00050000007426
- HOGENOM:   HBG352811
- OMA:   FHPKGMV
- ProtClustDB:   PRK12305
- BioCyc:   BHER314723:BH0720-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 68116; Mature: 67984

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKLDRESILYKKRHSIAHVMAEAVLELFPNTKIAIGPPIKDGFYYDFDFEKHITEDDL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCHHCCCCCHH
LLIEQKMREILKTGSPFVKEVITKEQALMLFKDEPYKMDLIRGLAITDEISIYKSHNFTD
HHHHHHHHHHHHCCCHHHHHHHCHHHEEEEECCCCCEEHHHHCEEEECCEEEEECCCCHH
LCKGPHVDNMGKIDPKAFKLTSIAGAYWRGDEKNKMLTRIYGTLWNNEKDLKAYLKLREE
HHCCCCCCCCCCCCCCCEEEEHHCCHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
IKRRDHRKLGRELDLFSVHEDIGPGLIFFHPNGARIRAIIEDFWREEHFKNGYDVLFTPH
HHHHHHHHHCCCCCEEEEHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEECCC
IGKSCLWETSGHLDFYKESMFEKMEMDKSNYYVKPMNCPFHIAIYNTGKHSYRDLPFRWA
CCCCCEECCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCHHH
ELGTVYRYEKIGALHGTMRVRGFTQDDAHIICAYEQVKSEVQEVLRFALYMWNQFGFADL
HHCHHHHHHHHHHHCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHH
KAYLSTKPEKAVGDKDDWEMSVKVLEEALIDLNIAYDIDEGGGAFYGPKIDLKIIDSLGR
HHHHCCCCHHHCCCCCCHHHHHHHHHHHHHEEEEEEEECCCCCEEECCEEEHHHHHHCCC
EWQMSTIQFDFNLPERFKMTYTAEDGKEKRPFMIHRALLGSIERFFGILVEHYGGAFPVW
CEEEEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LAPLQVIIIPVNNVVEEYALEILSLFKNEGIRIKLDNDCNMRMNAKIRQYQSKKVPYMFI
HCCEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEECCHHHHHHCCCCCEEEE
IGEKEVVEGKISIRTRTNDQINGLELKEALEFVRLKVKNKEIL
ECCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SEKLDRESILYKKRHSIAHVMAEAVLELFPNTKIAIGPPIKDGFYYDFDFEKHITEDDL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCHHCCCCCHH
LLIEQKMREILKTGSPFVKEVITKEQALMLFKDEPYKMDLIRGLAITDEISIYKSHNFTD
HHHHHHHHHHHHCCCHHHHHHHCHHHEEEEECCCCCEEHHHHCEEEECCEEEEECCCCHH
LCKGPHVDNMGKIDPKAFKLTSIAGAYWRGDEKNKMLTRIYGTLWNNEKDLKAYLKLREE
HHCCCCCCCCCCCCCCCEEEEHHCCHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
IKRRDHRKLGRELDLFSVHEDIGPGLIFFHPNGARIRAIIEDFWREEHFKNGYDVLFTPH
HHHHHHHHHCCCCCEEEEHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEECCC
IGKSCLWETSGHLDFYKESMFEKMEMDKSNYYVKPMNCPFHIAIYNTGKHSYRDLPFRWA
CCCCCEECCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCHHH
ELGTVYRYEKIGALHGTMRVRGFTQDDAHIICAYEQVKSEVQEVLRFALYMWNQFGFADL
HHCHHHHHHHHHHHCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHH
KAYLSTKPEKAVGDKDDWEMSVKVLEEALIDLNIAYDIDEGGGAFYGPKIDLKIIDSLGR
HHHHCCCCHHHCCCCCCHHHHHHHHHHHHHEEEEEEEECCCCCEEECCEEEHHHHHHCCC
EWQMSTIQFDFNLPERFKMTYTAEDGKEKRPFMIHRALLGSIERFFGILVEHYGGAFPVW
CEEEEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LAPLQVIIIPVNNVVEEYALEILSLFKNEGIRIKLDNDCNMRMNAKIRQYQSKKVPYMFI
HCCEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEECCHHHHHHCCCCCEEEE
IGEKEVVEGKISIRTRTNDQINGLELKEALEFVRLKVKNKEIL
ECCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA