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The map label for this gene is lon2 [H]

Identifier: 187918473

GI number: 187918473

Start: 646628

End: 649063

Strand: Direct

Name: lon2 [H]

Synonym: BH0613

Alternate gene names: 187918473

Gene position: 646628-649063 (Clockwise)

Preceding gene: 187918472

Following gene: 187918476

Centisome position: 70.11

GC content: 30.87

Gene sequence:

>2436_bases
ATGTTCATAAGCCTTGGGCAAAAGAACTTTATGAAATCAATTCTAAATCTAATTAATTCTAAGAGAGATGATCTTCCAGT
TATTCTCTTAAGACAAAATGTTTTTTTCCCCAATGTAACTTTATGGGTTAATTTTGATGATAGTGTTTCGATTAATGCAA
TATATCAGTCTATGTTGGAAGGTAGATTGATCTTATTTTTTTGTGTTAATGATCTTAAATCTGATAATAATGGCAAAATC
AGTTTAGAAAATTTATATTCTATTGGTACTTATGCAAAAATTATTCAAGTTGTAAAGGTTACTGAAACTTTGATAAAAAT
TTTAGTCAACTTTCAGGATAGAGTTATTATCAAAAATTTTTTAAAAAAGAAGAATTACTTTAGAGCAAAGGTTGATTTTA
TATCTGATAAATGCGAATTTAATAGCGAACTTTTTACTTATTCTAAATTTTTAAGAGAAGCTTATGATACTTATAAATCT
TATTTGTCCGTTAACACATTAGAAGATGATGAGAGTAATAATTTGTTTGATAGTCCAGCTAAGCTTGTTGATGTTATAGC
GTCTAATATGAATTTGGAATATAAGGTCAAGGTAGAACTTTTACAAGAATTAGATGTCAAAGTTAGGATAGAAAAATTGA
TCATAAATTTAAGTGTTGAGACTGAGCTTTTAATGCTTAAAAAAGATATTAAGACCAAGGTTAAGACTAGACTTGATAAG
GGGCAAAAAGAATATTTTTTGAATGAGCAACTTAAGGAGATTCAGAAGAGATTAGGTAGGGATGAGAACGATTATCTTGA
GAGATTGAACTGTAAAGATATTCCTGAGGATATTAAACCTAGAATTGAAAAGGAAATCTCTAGATTGACTCGTATGAATA
CAAATTCACCGGATGCTAATATTGTTAGGAATTATGTTGAATTGTTACTTGACCTGCCTTGGAATGAAAATACTGTGATG
AATAATTCTTTAAGAGAAATTGAATTTATTTTAAAGAATGCTCATTATGGTATGGATAAGGCTAAAGAAAAAATAATGAA
TTTTTTAGCTGTTTATCATATTAATTCTAAGGTTCAAGCACCTATTTTGTGTTTAGTTGGTCCACCCGGTACTGGGAAAA
CTTCTGTTGCATTATCTATTGCTAAGTCTCTTTCTAGAGAATTTGCAAAAATTTCTCTTGGTGGGTTAAGAGATGAAACG
GAGATTAGAGGACATCGGAGATCTTATGTTGGAGCTCTCCCGGGGGTTTTTATTAATGCAATCAAAGTTGCGGGGAAATC
TAATCCCGTGATTCTTCTTGATGAAATAGATAAGATTAACAGTACTTATAAGGGAAATCCGGAATCAGCACTTTTAGAAG
TTTTAGATGCTGAGCAAAACTCTAAATTTGTTGATCATTATTTAGAAATTCCTTATGACCTCTCTAATGTGTTATTTGTA
GCAACGGCCAATTCTCTACATGAGATTTCTAGACCTCTTCTTGACAGGATGGAGATCATTAAGATAGAAGGATATTCTTG
TGTTGAAAAATTAGAAATTGCAAAAAATTTTTTAATACCAAAGATAATTAAAGAAAGTTTTTTAAGTAAAGTTTATATAA
AAATAGAGGATGATGTTGTTTTGCATATAATTAGAAACTATACTATGGAGTCTGGAGTTAGGAGTTTGAAGAGAGTTTTG
ACTAATTTGTTTAGAATGGTTGTAAGAGAATTGCTTTATGTTTACTCAAGGGAAGATATAATTGAAGGAAATTTTTATTT
TCCAAGTTCCTTGATGCATGGCAATAATTCACTCTTTACTCATGATCCTGATATTCCTGGTATTTACAAAATAATTAATA
TGAGTAATTTTCATTTTTATGTGGATTGTGAATATAAATTTAATTTAATTAGGATTGATTCTTCTGGATTTGTTTATGGG
CTTGCCTGGACAAGTTATGGGGGTGCTGTACTTCCTGTTGAGGCTATTAAATTTGATAGAAAAGGAGATATCATTTTAAC
AGGTAGTCTTGGCGCTGTTATGAAGGAAAGTGCACAATTAGCTTATTCTGTTGTAAAGACCTATTCTTCTGAACTTAATT
TGGATATAAATGAGATTCCCGAAATTCATCTTCATTTTCCAGAAGGAGCGACACCAAAAGATGGCCCTTCTGCTGGAATT
ACTATTGCAACAGCCATAGCTTCTGTCTTGTCTGATAAAAAAGTGCCCCTAGATCTCGCTATGACGGGAGAGGTTACTCT
TAAAGGTTCAGTTCTTCCTGTGGGAGGCATTAAGGAAAAAGTGCTTGCAGCTTATAGGCATGGTATAAATAGAATTATTA
TTCCAAGGGATAATGAGAAAGATTATATTAAGCTCCCAGAAGATATTAGGGATAATATTAATGTTAAATATGTATCTCAT
TTAGGAGAAGTGTTTGATTATTTAAATATCATTTAG

Upstream 100 bases:

>100_bases
ATGTTTGAGATACCTTCAACTAAGCAAATTAAAAAAGTTATTGTTACTAAAGAGTCTGTTTTAAATAGCAATATTGAGCC
CTTTATTTTGACAGGAAGGC

Downstream 100 bases:

>100_bases
TAGAATTATTTAGAGTTTTATGTGTTAAAATTTATTAAGGAGTAAATATGAAAGATGGAGTTAGAAAGCCTTCAGGTAGT
AGGGCGGCATTTAATTCTCA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 811; Mature: 811

Protein sequence:

>811_residues
MFISLGQKNFMKSILNLINSKRDDLPVILLRQNVFFPNVTLWVNFDDSVSINAIYQSMLEGRLILFFCVNDLKSDNNGKI
SLENLYSIGTYAKIIQVVKVTETLIKILVNFQDRVIIKNFLKKKNYFRAKVDFISDKCEFNSELFTYSKFLREAYDTYKS
YLSVNTLEDDESNNLFDSPAKLVDVIASNMNLEYKVKVELLQELDVKVRIEKLIINLSVETELLMLKKDIKTKVKTRLDK
GQKEYFLNEQLKEIQKRLGRDENDYLERLNCKDIPEDIKPRIEKEISRLTRMNTNSPDANIVRNYVELLLDLPWNENTVM
NNSLREIEFILKNAHYGMDKAKEKIMNFLAVYHINSKVQAPILCLVGPPGTGKTSVALSIAKSLSREFAKISLGGLRDET
EIRGHRRSYVGALPGVFINAIKVAGKSNPVILLDEIDKINSTYKGNPESALLEVLDAEQNSKFVDHYLEIPYDLSNVLFV
ATANSLHEISRPLLDRMEIIKIEGYSCVEKLEIAKNFLIPKIIKESFLSKVYIKIEDDVVLHIIRNYTMESGVRSLKRVL
TNLFRMVVRELLYVYSREDIIEGNFYFPSSLMHGNNSLFTHDPDIPGIYKIINMSNFHFYVDCEYKFNLIRIDSSGFVYG
LAWTSYGGAVLPVEAIKFDRKGDIILTGSLGAVMKESAQLAYSVVKTYSSELNLDINEIPEIHLHFPEGATPKDGPSAGI
TIATAIASVLSDKKVPLDLAMTGEVTLKGSVLPVGGIKEKVLAAYRHGINRIIIPRDNEKDYIKLPEDIRDNINVKYVSH
LGEVFDYLNII

Sequences:

>Translated_811_residues
MFISLGQKNFMKSILNLINSKRDDLPVILLRQNVFFPNVTLWVNFDDSVSINAIYQSMLEGRLILFFCVNDLKSDNNGKI
SLENLYSIGTYAKIIQVVKVTETLIKILVNFQDRVIIKNFLKKKNYFRAKVDFISDKCEFNSELFTYSKFLREAYDTYKS
YLSVNTLEDDESNNLFDSPAKLVDVIASNMNLEYKVKVELLQELDVKVRIEKLIINLSVETELLMLKKDIKTKVKTRLDK
GQKEYFLNEQLKEIQKRLGRDENDYLERLNCKDIPEDIKPRIEKEISRLTRMNTNSPDANIVRNYVELLLDLPWNENTVM
NNSLREIEFILKNAHYGMDKAKEKIMNFLAVYHINSKVQAPILCLVGPPGTGKTSVALSIAKSLSREFAKISLGGLRDET
EIRGHRRSYVGALPGVFINAIKVAGKSNPVILLDEIDKINSTYKGNPESALLEVLDAEQNSKFVDHYLEIPYDLSNVLFV
ATANSLHEISRPLLDRMEIIKIEGYSCVEKLEIAKNFLIPKIIKESFLSKVYIKIEDDVVLHIIRNYTMESGVRSLKRVL
TNLFRMVVRELLYVYSREDIIEGNFYFPSSLMHGNNSLFTHDPDIPGIYKIINMSNFHFYVDCEYKFNLIRIDSSGFVYG
LAWTSYGGAVLPVEAIKFDRKGDIILTGSLGAVMKESAQLAYSVVKTYSSELNLDINEIPEIHLHFPEGATPKDGPSAGI
TIATAIASVLSDKKVPLDLAMTGEVTLKGSVLPVGGIKEKVLAAYRHGINRIIIPRDNEKDYIKLPEDIRDNINVKYVSH
LGEVFDYLNII
>Mature_811_residues
MFISLGQKNFMKSILNLINSKRDDLPVILLRQNVFFPNVTLWVNFDDSVSINAIYQSMLEGRLILFFCVNDLKSDNNGKI
SLENLYSIGTYAKIIQVVKVTETLIKILVNFQDRVIIKNFLKKKNYFRAKVDFISDKCEFNSELFTYSKFLREAYDTYKS
YLSVNTLEDDESNNLFDSPAKLVDVIASNMNLEYKVKVELLQELDVKVRIEKLIINLSVETELLMLKKDIKTKVKTRLDK
GQKEYFLNEQLKEIQKRLGRDENDYLERLNCKDIPEDIKPRIEKEISRLTRMNTNSPDANIVRNYVELLLDLPWNENTVM
NNSLREIEFILKNAHYGMDKAKEKIMNFLAVYHINSKVQAPILCLVGPPGTGKTSVALSIAKSLSREFAKISLGGLRDET
EIRGHRRSYVGALPGVFINAIKVAGKSNPVILLDEIDKINSTYKGNPESALLEVLDAEQNSKFVDHYLEIPYDLSNVLFV
ATANSLHEISRPLLDRMEIIKIEGYSCVEKLEIAKNFLIPKIIKESFLSKVYIKIEDDVVLHIIRNYTMESGVRSLKRVL
TNLFRMVVRELLYVYSREDIIEGNFYFPSSLMHGNNSLFTHDPDIPGIYKIINMSNFHFYVDCEYKFNLIRIDSSGFVYG
LAWTSYGGAVLPVEAIKFDRKGDIILTGSLGAVMKESAQLAYSVVKTYSSELNLDINEIPEIHLHFPEGATPKDGPSAGI
TIATAIASVLSDKKVPLDLAMTGEVTLKGSVLPVGGIKEKVLAAYRHGINRIIIPRDNEKDYIKLPEDIRDNINVKYVSH
LGEVFDYLNII

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=828, Percent_Identity=37.0772946859903, Blast_Score=482, Evalue=1e-136,
Organism=Homo sapiens, GI21396489, Length=654, Percent_Identity=38.3792048929664, Blast_Score=452, Evalue=1e-127,
Organism=Escherichia coli, GI1786643, Length=807, Percent_Identity=39.6530359355638, Blast_Score=574, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI17505831, Length=667, Percent_Identity=38.3808095952024, Blast_Score=454, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17556486, Length=797, Percent_Identity=33.6260978670013, Blast_Score=429, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319449, Length=718, Percent_Identity=38.0222841225627, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24666867, Length=658, Percent_Identity=40.5775075987842, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI221513036, Length=658, Percent_Identity=40.5775075987842, Blast_Score=462, Evalue=1e-130,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 92474; Mature: 92474

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFISLGQKNFMKSILNLINSKRDDLPVILLRQNVFFPNVTLWVNFDDSVSINAIYQSMLE
CEEECCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHC
GRLILFFCVNDLKSDNNGKISLENLYSIGTYAKIIQVVKVTETLIKILVNFQDRVIIKNF
CCEEEEEEEHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LKKKNYFRAKVDFISDKCEFNSELFTYSKFLREAYDTYKSYLSVNTLEDDESNNLFDSPA
HHHCCCCEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHH
KLVDVIASNMNLEYKVKVELLQELDVKVRIEKLIINLSVETELLMLKKDIKTKVKTRLDK
HHHHHHHHCCCCEEEEHHHHHHHCCHHEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCC
GQKEYFLNEQLKEIQKRLGRDENDYLERLNCKDIPEDIKPRIEKEISRLTRMNTNSPDAN
CHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHH
IVRNYVELLLDLPWNENTVMNNSLREIEFILKNAHYGMDKAKEKIMNFLAVYHINSKVQA
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCCCCC
PILCLVGPPGTGKTSVALSIAKSLSREFAKISLGGLRDETEIRGHRRSYVGALPGVFINA
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHH
IKVAGKSNPVILLDEIDKINSTYKGNPESALLEVLDAEQNSKFVDHYLEIPYDLSNVLFV
HHCCCCCCCEEEEECCHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEE
ATANSLHEISRPLLDRMEIIKIEGYSCVEKLEIAKNFLIPKIIKESFLSKVYIKIEDDVV
EECHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHH
LHIIRNYTMESGVRSLKRVLTNLFRMVVRELLYVYSREDIIEGNFYFPSSLMHGNNSLFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEECCCHHCCCCCCEEE
HDPDIPGIYKIINMSNFHFYVDCEYKFNLIRIDSSGFVYGLAWTSYGGAVLPVEAIKFDR
CCCCCCCHHHEEECCCEEEEEEEEEEEEEEEECCCCEEEEEEEECCCCEEEEHHHHEECC
KGDIILTGSLGAVMKESAQLAYSVVKTYSSELNLDINEIPEIHLHFPEGATPKDGPSAGI
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEECCCCCCCCCCCCCCH
TIATAIASVLSDKKVPLDLAMTGEVTLKGSVLPVGGIKEKVLAAYRHGINRIIIPRDNEK
HHHHHHHHHHCCCCCCEEEEEECCEEEECCEEECCCHHHHHHHHHHCCCCEEEEECCCCC
DYIKLPEDIRDNINVKYVSHLGEVFDYLNII
CCEECCHHHHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFISLGQKNFMKSILNLINSKRDDLPVILLRQNVFFPNVTLWVNFDDSVSINAIYQSMLE
CEEECCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHC
GRLILFFCVNDLKSDNNGKISLENLYSIGTYAKIIQVVKVTETLIKILVNFQDRVIIKNF
CCEEEEEEEHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LKKKNYFRAKVDFISDKCEFNSELFTYSKFLREAYDTYKSYLSVNTLEDDESNNLFDSPA
HHHCCCCEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHH
KLVDVIASNMNLEYKVKVELLQELDVKVRIEKLIINLSVETELLMLKKDIKTKVKTRLDK
HHHHHHHHCCCCEEEEHHHHHHHCCHHEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCC
GQKEYFLNEQLKEIQKRLGRDENDYLERLNCKDIPEDIKPRIEKEISRLTRMNTNSPDAN
CHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHH
IVRNYVELLLDLPWNENTVMNNSLREIEFILKNAHYGMDKAKEKIMNFLAVYHINSKVQA
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCCCCC
PILCLVGPPGTGKTSVALSIAKSLSREFAKISLGGLRDETEIRGHRRSYVGALPGVFINA
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHH
IKVAGKSNPVILLDEIDKINSTYKGNPESALLEVLDAEQNSKFVDHYLEIPYDLSNVLFV
HHCCCCCCCEEEEECCHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEE
ATANSLHEISRPLLDRMEIIKIEGYSCVEKLEIAKNFLIPKIIKESFLSKVYIKIEDDVV
EECHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHH
LHIIRNYTMESGVRSLKRVLTNLFRMVVRELLYVYSREDIIEGNFYFPSSLMHGNNSLFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEECCCHHCCCCCCEEE
HDPDIPGIYKIINMSNFHFYVDCEYKFNLIRIDSSGFVYGLAWTSYGGAVLPVEAIKFDR
CCCCCCCHHHEEECCCEEEEEEEEEEEEEEEECCCCEEEEEEEECCCCEEEEHHHHEECC
KGDIILTGSLGAVMKESAQLAYSVVKTYSSELNLDINEIPEIHLHFPEGATPKDGPSAGI
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEECCCCCCCCCCCCCCH
TIATAIASVLSDKKVPLDLAMTGEVTLKGSVLPVGGIKEKVLAAYRHGINRIIIPRDNEK
HHHHHHHHHHCCCCCCEEEEEECCEEEECCEEECCCHHHHHHHHHHCCCCEEEEECCCCC
DYIKLPEDIRDNINVKYVSHLGEVFDYLNII
CCEECCHHHHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]