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The map label for this gene is clpP [H]

Identifier: 187918471

GI number: 187918471

Start: 644771

End: 645370

Strand: Direct

Name: clpP [H]

Synonym: BH0611

Alternate gene names: 187918471

Gene position: 644771-645370 (Clockwise)

Preceding gene: 187918470

Following gene: 187918472

Centisome position: 69.91

GC content: 33.83

Gene sequence:

>600_bases
ATGATAAGAGAATATATGCATAATTTAGTGCCTACTGTTGTGGAGTATACTGGAAATTATGAGCGCGTATTTGATATATA
TTCAAGATTGTTAAGGGATAGAATAATTTTTTTGAGCGGTGAGATTAATGATATAAGAGCAGATACGGTCATTGCTCAAC
TTCTTTTCTTGGAGTCTGAAGATTCTAAGAAAGATATATATGTTTATATAAATTCTCCTGGAGGTAGTATTACTTCAGGA
CTTGCAATCTATGATACTATGCAGTATATCAAACCAGATGTAAGAACGATTTGCATTGGACAGGCAGCTTCAATGGCTGC
ATTCCTGCTTGCAGGAGGTGCTATAGGCAAACGAGAGTCATTATCATATTCAAGAATAATGATTCATCAGCCTTGGGGTG
GAATAGGCGGTCAAGCTAGTGATATTAGTATACAAGCAAATGAAATTATAAGGCTTAAGAGATTAATAATAGATATTATG
TCTAATAAGATAGGGGTTTCTAAAGAAAAATTATCTCTTGATATCGAGCGAGATTATTTTATGACACCAAAAGATGCTCT
TGATTATGGCATTATTGATGGTATCTTGGTAAGAAATTAG

Upstream 100 bases:

>100_bases
AGAGGCAAAAGGTTAAAGATAAAATTTTGAAAAATGTGAAGGAAATTAAACTTAAAGAAATTGCCTTTAGAGATTTTATT
AATTATAAAACAGGTGAATA

Downstream 100 bases:

>100_bases
TTTTATTTTGGGTGAGATTTTATATGGCAAAAAGTAAAAGTCAAAAAATTGAAGGGTGTTCTTTTTGTGGGCGTACTAAT
GCTGAAGTTGAAGGACGAAT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MIREYMHNLVPTVVEYTGNYERVFDIYSRLLRDRIIFLSGEINDIRADTVIAQLLFLESEDSKKDIYVYINSPGGSITSG
LAIYDTMQYIKPDVRTICIGQAASMAAFLLAGGAIGKRESLSYSRIMIHQPWGGIGGQASDISIQANEIIRLKRLIIDIM
SNKIGVSKEKLSLDIERDYFMTPKDALDYGIIDGILVRN

Sequences:

>Translated_199_residues
MIREYMHNLVPTVVEYTGNYERVFDIYSRLLRDRIIFLSGEINDIRADTVIAQLLFLESEDSKKDIYVYINSPGGSITSG
LAIYDTMQYIKPDVRTICIGQAASMAAFLLAGGAIGKRESLSYSRIMIHQPWGGIGGQASDISIQANEIIRLKRLIIDIM
SNKIGVSKEKLSLDIERDYFMTPKDALDYGIIDGILVRN
>Mature_199_residues
MIREYMHNLVPTVVEYTGNYERVFDIYSRLLRDRIIFLSGEINDIRADTVIAQLLFLESEDSKKDIYVYINSPGGSITSG
LAIYDTMQYIKPDVRTICIGQAASMAAFLLAGGAIGKRESLSYSRIMIHQPWGGIGGQASDISIQANEIIRLKRLIIDIM
SNKIGVSKEKLSLDIERDYFMTPKDALDYGIIDGILVRN

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=55.7894736842105, Blast_Score=215, Evalue=2e-56,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=56.8421052631579, Blast_Score=233, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=51.0526315789474, Blast_Score=194, Evalue=3e-50,
Organism=Drosophila melanogaster, GI20129427, Length=189, Percent_Identity=57.1428571428571, Blast_Score=220, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22363; Mature: 22363

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00381 CLP_PROTEASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIREYMHNLVPTVVEYTGNYERVFDIYSRLLRDRIIFLSGEINDIRADTVIAQLLFLESE
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHCCC
DSKKDIYVYINSPGGSITSGLAIYDTMQYIKPDVRTICIGQAASMAAFLLAGGAIGKRES
CCCCEEEEEEECCCCCHHCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCCCCC
LSYSRIMIHQPWGGIGGQASDISIQANEIIRLKRLIIDIMSNKIGVSKEKLSLDIERDYF
CCEEEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCHHHEEEEECCCEE
MTPKDALDYGIIDGILVRN
ECCHHHHHHHHHCCEEECC
>Mature Secondary Structure
MIREYMHNLVPTVVEYTGNYERVFDIYSRLLRDRIIFLSGEINDIRADTVIAQLLFLESE
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHCCC
DSKKDIYVYINSPGGSITSGLAIYDTMQYIKPDVRTICIGQAASMAAFLLAGGAIGKRES
CCCCEEEEEEECCCCCHHCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCCCCC
LSYSRIMIHQPWGGIGGQASDISIQANEIIRLKRLIIDIMSNKIGVSKEKLSLDIERDYF
CCEEEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCHHHEEEEECCCEE
MTPKDALDYGIIDGILVRN
ECCHHHHHHHHHCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]