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The map label for this gene is natA [H]

Identifier: 187918437

GI number: 187918437

Start: 596810

End: 597628

Strand: Direct

Name: natA [H]

Synonym: BH0573

Alternate gene names: 187918437

Gene position: 596810-597628 (Clockwise)

Preceding gene: 187918436

Following gene: 187918438

Centisome position: 64.71

GC content: 28.21

Gene sequence:

>819_bases
TTGAAAATAGAATTTAGAGATGTTTCGTTTTCTTATCGTAAGACTAAAGTTTATTTAGACTTGCATTTAAATTTCTCAAA
GCCACAAACTTATTTGATTCTTGGCAAGAACGGAATAGGAAAAACTACTCTACTTAAGCTTATTAGTGGGCTTTTAAATC
CATTAAAAGGGGAAGTTTTATTTAATTCTTTGAAAGTTTTTCCAAGAGATCCTCTAAATTTAGTGAATTTGTTTTTTGTG
CCTGAAGAATTTGACTTACCTAATGTTTCTTTAAATGATTATTATAGGTCTTTGTGTAGATTTTATCCAAATTTTAGGGA
AAAGGATTTTAAAGAGTACTTATTGAAATTTGAGATAGATATTGATCTAAAGTTTGCGTCTTCTTCATACGGCCAGAAAA
AAAAGAGTATTATTGCCTTTTCTATTGCTACAGATGTTCCTATTTTGATCTTTGATGAACCAACGAATGGTCTTGATATT
GCTTCAAAGAATGTTTTTAGAGATATTATAAGTGGATTGGAAAATAAAATAGTTTTTGTTACAGGGCATAATGTTAGAGA
TTTAGTAGACATTGTAGAGCATCTGACCATTATTGGTAATAATAATATTCTTTTTTCAAATTCAATTTCTTATATTAATA
ATAATTATAAAGTTAAGATTGTAGATAAATTACGCGGGGAAGAGCTTTATTATGAAAAGATAAAAGATGGATTCAAGGCA
ATTTACTTGGAGAGTGGGTCTTGCGATAATGATGTTGATCTTGAGTTTTTCTTTTTGTATATCACTAACAATAAATTAAA
GGATTTGGTTGATGTTTAG

Upstream 100 bases:

>100_bases
TTTTTCTATATTTATTTATAGATCTTTTTTAAAAAATTAGTGTTTTATTCTTGTATTTATCATAGACTCTTTTTACAATT
AACATAAAGGAGAATTTTGA

Downstream 100 bases:

>100_bases
TTTAAAAAGATTTTTTGGGCTATTTAATGTTGATTTTGCCTATAATAGAAAATTATATTTGTATTTTATTATTTCAATCT
TTTTAGTTTTTCCTTTAGTC

Product: ABC transporter ATP-binding protein

Products: ADP; phosphate; arabinose [Cytoplasm] [C]

Alternate protein names: Na(+) ABC transporter [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MKIEFRDVSFSYRKTKVYLDLHLNFSKPQTYLILGKNGIGKTTLLKLISGLLNPLKGEVLFNSLKVFPRDPLNLVNLFFV
PEEFDLPNVSLNDYYRSLCRFYPNFREKDFKEYLLKFEIDIDLKFASSSYGQKKKSIIAFSIATDVPILIFDEPTNGLDI
ASKNVFRDIISGLENKIVFVTGHNVRDLVDIVEHLTIIGNNNILFSNSISYINNNYKVKIVDKLRGEELYYEKIKDGFKA
IYLESGSCDNDVDLEFFFLYITNNKLKDLVDV

Sequences:

>Translated_272_residues
MKIEFRDVSFSYRKTKVYLDLHLNFSKPQTYLILGKNGIGKTTLLKLISGLLNPLKGEVLFNSLKVFPRDPLNLVNLFFV
PEEFDLPNVSLNDYYRSLCRFYPNFREKDFKEYLLKFEIDIDLKFASSSYGQKKKSIIAFSIATDVPILIFDEPTNGLDI
ASKNVFRDIISGLENKIVFVTGHNVRDLVDIVEHLTIIGNNNILFSNSISYINNNYKVKIVDKLRGEELYYEKIKDGFKA
IYLESGSCDNDVDLEFFFLYITNNKLKDLVDV
>Mature_272_residues
MKIEFRDVSFSYRKTKVYLDLHLNFSKPQTYLILGKNGIGKTTLLKLISGLLNPLKGEVLFNSLKVFPRDPLNLVNLFFV
PEEFDLPNVSLNDYYRSLCRFYPNFREKDFKEYLLKFEIDIDLKFASSSYGQKKKSIIAFSIATDVPILIFDEPTNGLDI
ASKNVFRDIISGLENKIVFVTGHNVRDLVDIVEHLTIIGNNNILFSNSISYINNNYKVKIVDKLRGEELYYEKIKDGFKA
IYLESGSCDNDVDLEFFFLYITNNKLKDLVDV

Specific function: Involved in ATP-dependent electrogenic sodium extrusion [H]

COG id: COG1131

COG function: function code V; ABC-type multidrug transport system, ATPase component

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI46592915, Length=231, Percent_Identity=26.4069264069264, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI46592898, Length=231, Percent_Identity=25.974025974026, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI46592978, Length=231, Percent_Identity=25.974025974026, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI46592964, Length=231, Percent_Identity=25.974025974026, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI46592971, Length=231, Percent_Identity=25.974025974026, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI46592956, Length=231, Percent_Identity=25.974025974026, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI30795238, Length=203, Percent_Identity=28.0788177339901, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI27881501, Length=203, Percent_Identity=28.0788177339901, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1788210, Length=214, Percent_Identity=26.6355140186916, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787112, Length=219, Percent_Identity=23.7442922374429, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788165, Length=210, Percent_Identity=22.3809523809524, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87081709, Length=251, Percent_Identity=22.7091633466135, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17559834, Length=236, Percent_Identity=29.6610169491525, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321121, Length=187, Percent_Identity=27.807486631016, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24666836, Length=204, Percent_Identity=25.9803921568627, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24666092, Length=217, Percent_Identity=23.0414746543779, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 31471; Mature: 31471

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIEFRDVSFSYRKTKVYLDLHLNFSKPQTYLILGKNGIGKTTLLKLISGLLNPLKGEVL
CEEEEEECCEEEEEEEEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHCHHCHHHH
FNSLKVFPRDPLNLVNLFFVPEEFDLPNVSLNDYYRSLCRFYPNFREKDFKEYLLKFEID
HHHHCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHEEEEEEEE
IDLKFASSSYGQKKKSIIAFSIATDVPILIFDEPTNGLDIASKNVFRDIISGLENKIVFV
EEEEECCCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEE
TGHNVRDLVDIVEHLTIIGNNNILFSNSISYINNNYKVKIVDKLRGEELYYEKIKDGFKA
ECCCHHHHHHHHHHEEEEECCCEEEECCHHHHCCCEEEEEEECCCCCHHHHHHHHCCEEE
IYLESGSCDNDVDLEFFFLYITNNKLKDLVDV
EEEECCCCCCCCCEEEEEEEEECCCHHHHHCC
>Mature Secondary Structure
MKIEFRDVSFSYRKTKVYLDLHLNFSKPQTYLILGKNGIGKTTLLKLISGLLNPLKGEVL
CEEEEEECCEEEEEEEEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHCHHCHHHH
FNSLKVFPRDPLNLVNLFFVPEEFDLPNVSLNDYYRSLCRFYPNFREKDFKEYLLKFEID
HHHHCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHEEEEEEEE
IDLKFASSSYGQKKKSIIAFSIATDVPILIFDEPTNGLDIASKNVFRDIISGLENKIVFV
EEEEECCCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEE
TGHNVRDLVDIVEHLTIIGNNNILFSNSISYINNNYKVKIVDKLRGEELYYEKIKDGFKA
ECCCHHHHHHHHHHEEEEECCCEEEECCHHHHCCCEEEEEEECCCCCHHHHHHHHCCEEE
IYLESGSCDNDVDLEFFFLYITNNKLKDLVDV
EEEECCCCCCCCCEEEEEEEEECCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; arabinose [Periplasm]; H2O [C]

Specific reaction: ATP + arabinose [Periplasm] + H2O = ADP + phosphate + arabinose [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9106203; 9274031; 9384377 [H]